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Russian government hackers broke into thousands of home routers to steal passwords
Fancy Bear, also known as APT28, has taken over thousands of residential home routers to steal passwords and authentication tokens in a wide-ranging espionage operation.
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report
Allergy. 2026 Apr 6. doi: 10.1111/all.70325. Online ahead of print.ABSTRACTIron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing to increased morbidity and mortality. This review outlines normal iron physiolo
Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report
Allergy. 2026 Apr 6. doi: 10.1111/all.70325. Online ahead of print.
ABSTRACT
Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing to increased morbidity and mortality. This review outlines normal iron physiology, distribution and absorption pathways and on the consequences of deficiency across body compartments, with particular attention to type 2-driven diseases. Beyond anemia, insufficient iron availability disrupts immune homeostasis by promoting type 2 inflammation, elevating IgE, and activating mast cells and eosinophils. Regulatory macrophages, the central hub of iron cycling, adopt an inflammatory, iron-sequestering state that reinforces malabsorption and redistribution. Epidemiology studies show higher iron-deficiency risk in allergic individuals; low maternal iron or early-life iron predisposes to eczema, wheeze, and asthma, while food-allergen elimination (notably cow's milk) further worsens anemia risk. Clinical evidence indicates that restoring iron status through diet, supplementation, or fortification lowers IgE levels, improves lung function, and alleviates symptoms of rhinitis, urticaria, and asthma. Iron may therefore represent a modifiable determinant of allergic disease development and severity. Integrating iron assessment and nutritional care into allergy management may reduce disease burden and slow the progression of allergic march.
PMID:41943501 | DOI:10.1111/all.70325
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cs.AI, q-bio.NC updates on arXiv.org
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A Multimodal Foundation Model of Spatial Transcriptomics and Histology for Biological Discovery and Clinical Prediction
arXiv:2604.03630v1 Announce Type: new Abstract: Spatial transcriptomics (ST) enables gene expression mapping within anatomical context but remains costly and low-throughput. Hematoxylin and eosin (H\&E) staining offers rich morphology yet lacks molecular resolution. We present \textbf{\ours} (\textbf{S}patial \textbf{T}ranscriptomics and hist\textbf{O}logy \textbf{R}epresentation \textbf{M}odel), a foundation model trained on 1.2 million spatially resolved transcriptomic profiles with match
A Multimodal Foundation Model of Spatial Transcriptomics and Histology for Biological Discovery and Clinical Prediction
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cs.AI, q-bio.NC updates on arXiv.org
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CODE-GEN: A Human-in-the-Loop RAG-Based Agentic AI System for Multiple-Choice Question Generation
arXiv:2604.03926v1 Announce Type: new Abstract: We present CODE-GEN, a human-in-the-Loop, retrieval-augmented generation (RAG)-based agentic AI system for generating context-aligned multiple-choice questions to develop student code reasoning and comprehension abilities. CODE-GEN employs an agentic AI architecture in which a Generator agent produces multiple-choice coding comprehension questions aligned with course-specific learning objectives, while a Validator agent independently assesses cont
CODE-GEN: A Human-in-the-Loop RAG-Based Agentic AI System for Multiple-Choice Question Generation
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cs.AI, q-bio.NC updates on arXiv.org
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A Model of Understanding in Deep Learning Systems
arXiv:2604.04171v1 Announce Type: new Abstract: I propose a model of systematic understanding, suitable for machine learning systems. On this account, an agent understands a property of a target system when it contains an adequate internal model that tracks real regularities, is coupled to the target by stable bridge principles, and supports reliable prediction. I argue that contemporary deep learning systems often can and do achieve such understanding. However they generally fall short of the
A Model of Understanding in Deep Learning Systems
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cs.AI, q-bio.NC updates on arXiv.org
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IPSL-AID: Generative Diffusion Models for Climate Downscaling from Global to Regional Scales
arXiv:2604.03275v1 Announce Type: cross Abstract: Effective adaptation and mitigation strategies for climate change require high-resolution projections to inform strategic decision-making. Conventional global climate models, which typically operate at resolutions of 150 to 200 kilometers, lack the capacity to represent essential regional processes. IPSL-AID is a global to regional downscaling tool based on a denoising diffusion probabilistic model designed to address this limitation. Trained on
IPSL-AID: Generative Diffusion Models for Climate Downscaling from Global to Regional Scales
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cs.AI, q-bio.NC updates on arXiv.org
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Event-Driven Neuromorphic Vision Enables Energy-Efficient Visual Place Recognition
arXiv:2604.03277v1 Announce Type: cross Abstract: Reliable visual place recognition (VPR) under dynamic real-world conditions is critical for autonomous robots, yet conventional deep networks remain limited by high computational and energy demands. Inspired by the mammalian navigation system, we introduce SpikeVPR, a bio-inspired and neuromorphic approach combining event-based cameras with spiking neural networks (SNNs) to generate compact, invariant place descriptors from few exemplars, achiev
Event-Driven Neuromorphic Vision Enables Energy-Efficient Visual Place Recognition
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cs.AI, q-bio.NC updates on arXiv.org
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Downscaling weather forecasts from Low- to High-Resolution with Diffusion Models
arXiv:2604.03303v1 Announce Type: cross Abstract: We introduce a probabilistic diffusion-based method for global atmospheric downscaling implemented within the Anemoi framework. The approach transforms low-resolution ensemble forecasts into high-resolution ensembles by learning the conditional distribution of finer-scale residuals, defined as the difference between the high-resolution fields and the interpolated low-resolution inputs. The system is trained on reforecast pairs from ECMWF IFS, us
Downscaling weather forecasts from Low- to High-Resolution with Diffusion Models
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cs.AI, q-bio.NC updates on arXiv.org
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ExpressEdit: Fast Editing of Stylized Facial Expressions with Diffusion Models in Photoshop
arXiv:2604.03448v1 Announce Type: cross Abstract: Facial expressions of characters are a vital component of visual storytelling. While current AI image editing models hold promise for assisting artists in the task of stylized expression editing, these models introduce global noise and pixel drift into the edited image, preventing the integration of these models into professional image editing software and workflows. To bridge this gap, we introduce ExpressEdit, a fully open-source Photoshop plu
ExpressEdit: Fast Editing of Stylized Facial Expressions with Diffusion Models in Photoshop
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cs.AI, q-bio.NC updates on arXiv.org
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VisionClaw: Always-On AI Agents through Smart Glasses
arXiv:2604.03486v1 Announce Type: cross Abstract: We present VisionClaw, an always-on wearable AI agent that integrates live egocentric perception with agentic task execution. Running on Meta Ray-Ban smart glasses, VisionClaw continuously perceives real-world context and enables in-situ, speech-driven action initiation and delegation via OpenClaw AI agents. Therefore, users can directly execute tasks through the smart glasses, such as adding real-world objects to an Amazon cart, generating note
VisionClaw: Always-On AI Agents through Smart Glasses
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cs.AI, q-bio.NC updates on arXiv.org
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An Improved Last-Iterate Convergence Rate for Anchored Gradient Descent Ascent
arXiv:2604.03782v1 Announce Type: cross Abstract: We analyze the last-iterate convergence of the Anchored Gradient Descent Ascent algorithm for smooth convex-concave min-max problems. While previous work established a last-iterate rate of $\mathcal{O}(1/t^{2-2p})$ for the squared gradient norm, where $p \in (1/2, 1)$, it remained an open problem whether the improved exact $\mathcal{O}(1/t)$ rate is achievable. In this work, we resolve this question in the affirmative. This result was discovered
An Improved Last-Iterate Convergence Rate for Anchored Gradient Descent Ascent
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cs.AI, q-bio.NC updates on arXiv.org
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InCaRPose: In-Cabin Relative Camera Pose Estimation Model and Dataset
arXiv:2604.03814v1 Announce Type: cross Abstract: Camera extrinsic calibration is a fundamental task in computer vision. However, precise relative pose estimation in constrained, highly distorted environments, such as in-cabin automotive monitoring (ICAM), remains challenging. We present InCaRPose, a Transformer-based architecture designed for robust relative pose prediction between image pairs, which can be used for camera extrinsic calibration. By leveraging frozen backbone features such as D
InCaRPose: In-Cabin Relative Camera Pose Estimation Model and Dataset
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cs.AI, q-bio.NC updates on arXiv.org
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Commercial Persuasion in AI-Mediated Conversations
arXiv:2604.04263v1 Announce Type: cross Abstract: As Large Language Models (LLMs) become a primary interface between users and the web, companies face growing economic incentives to embed commercial influence into AI-mediated conversations. We present two preregistered experiments (N = 2,012) in which participants selected a book to receive from a large eBook catalog using either a traditional search engine or a conversational LLM agent powered by one of five frontier models. Unbeknownst to par
Commercial Persuasion in AI-Mediated Conversations
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cs.AI, q-bio.NC updates on arXiv.org
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How Alignment Routes: Localizing, Scaling, and Controlling Policy Circuits in Language Models
arXiv:2604.04385v2 Announce Type: cross Abstract: This paper identifies a recurring sparse routing mechanism in alignment-trained language models: a gate attention head reads detected content and triggers downstream amplifier heads that boost the signal toward refusal. Using political censorship and safety refusal as natural experiments, the mechanism is traced across 9 models from 6 labs, all validated on corpora of 120 prompt pairs. The gate head passes necessity and sufficiency interchange t
How Alignment Routes: Localizing, Scaling, and Controlling Policy Circuits in Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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The Infinite-Dimensional Nature of Spectroscopy and Why Models Succeed, Fail, and Mislead
arXiv:2604.04717v1 Announce Type: cross Abstract: Machine learning (ML) models have achieved strikingly high accuracies in spectroscopic classification tasks, often without a clear proof that those models used chemically meaningful features. Existing studies have linked these results to data preprocessing choices, noise sensitivity, and model complexity, but no unifying explanation is available so far. In this work, we show that these phenomena arise naturally from the intrinsic high dimensiona
The Infinite-Dimensional Nature of Spectroscopy and Why Models Succeed, Fail, and Mislead
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cs.AI, q-bio.NC updates on arXiv.org
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IV Co-Scientist: Multi-Agent LLM Framework for Causal Instrumental Variable Discovery
arXiv:2602.07943v2 Announce Type: replace Abstract: In the presence of confounding between an endogenous variable and the outcome, instrumental variables (IVs) are used to isolate the causal effect of the endogenous variable. Identifying valid instruments requires interdisciplinary knowledge, creativity, and contextual understanding, making it a non-trivial task. In this paper, we investigate whether large language models (LLMs) can aid in this task. We perform a two-stage evaluation framework.
IV Co-Scientist: Multi-Agent LLM Framework for Causal Instrumental Variable Discovery
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cs.AI, q-bio.NC updates on arXiv.org
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Voxtral Realtime
arXiv:2602.11298v3 Announce Type: replace Abstract: We introduce Voxtral Realtime, a natively streaming automatic speech recognition model that matches offline transcription quality at sub-second latency. Unlike approaches that adapt offline models through chunking or sliding windows, Voxtral Realtime is trained end-to-end for streaming, with explicit alignment between audio and text streams. Our architecture builds on the Delayed Streams Modeling framework, introducing a new causal audio encod
Voxtral Realtime
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cs.AI, q-bio.NC updates on arXiv.org
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Voxtral TTS
arXiv:2603.25551v2 Announce Type: replace Abstract: We introduce Voxtral TTS, an expressive multilingual text-to-speech model that generates natural speech from as little as 3 seconds of reference audio. Voxtral TTS adopts a hybrid architecture that combines auto-regressive generation of semantic speech tokens with flow-matching for acoustic tokens. These tokens are encoded and decoded with Voxtral Codec, a speech tokenizer trained from scratch with a hybrid VQ-FSQ quantization scheme. In human
Voxtral TTS
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cs.AI, q-bio.NC updates on arXiv.org
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Bayesian Hierarchical Invariant Prediction
arXiv:2505.11211v3 Announce Type: replace-cross Abstract: We propose Bayesian Hierarchical Invariant Prediction (BHIP) reframing Invariant Causal Prediction (ICP) through the lens of Hierarchical Bayes. We leverage the hierarchical structure to explicitly test invariance of causal mechanisms under heterogeneous data, resulting in improved computational scalability for a larger number of predictors compared to ICP. Moreover, given its Bayesian nature BHIP enables the use of prior information. We
Bayesian Hierarchical Invariant Prediction
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cs.AI, q-bio.NC updates on arXiv.org
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Measuring Competency, Not Performance: Item-Aware Evaluation Across Medical Benchmarks
arXiv:2509.24186v2 Announce Type: replace-cross Abstract: Accuracy-based evaluation of Large Language Models (LLMs) measures benchmark-specific performance rather than underlying medical competency: it treats all questions as equally informative, conflates model ability with item characteristics, and thereby produces rankings that vary with benchmark choice. To address this, we introduce MedIRT, a psychometric evaluation framework grounded in Item Response Theory (IRT) that (1) jointly models l