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Russian government hackers broke into thousands of home routers to steal passwords

8 April 2026 at 01:01
Fancy Bear, also known as APT28, has taken over thousands of residential home routers to steal passwords and authentication tokens in a wide-ranging espionage operation.

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy. 2026 Apr 6. doi: 10.1111/all.70325. Online ahead of print.

ABSTRACT

Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing to increased morbidity and mortality. This review outlines normal iron physiology, distribution and absorption pathways and on the consequences of deficiency across body compartments, with particular attention to type 2-driven diseases. Beyond anemia, insufficient iron availability disrupts immune homeostasis by promoting type 2 inflammation, elevating IgE, and activating mast cells and eosinophils. Regulatory macrophages, the central hub of iron cycling, adopt an inflammatory, iron-sequestering state that reinforces malabsorption and redistribution. Epidemiology studies show higher iron-deficiency risk in allergic individuals; low maternal iron or early-life iron predisposes to eczema, wheeze, and asthma, while food-allergen elimination (notably cow's milk) further worsens anemia risk. Clinical evidence indicates that restoring iron status through diet, supplementation, or fortification lowers IgE levels, improves lung function, and alleviates symptoms of rhinitis, urticaria, and asthma. Iron may therefore represent a modifiable determinant of allergic disease development and severity. Integrating iron assessment and nutritional care into allergy management may reduce disease burden and slow the progression of allergic march.

PMID:41943501 | DOI:10.1111/all.70325

A Multimodal Foundation Model of Spatial Transcriptomics and Histology for Biological Discovery and Clinical Prediction

arXiv:2604.03630v1 Announce Type: new Abstract: Spatial transcriptomics (ST) enables gene expression mapping within anatomical context but remains costly and low-throughput. Hematoxylin and eosin (H\&E) staining offers rich morphology yet lacks molecular resolution. We present \textbf{\ours} (\textbf{S}patial \textbf{T}ranscriptomics and hist\textbf{O}logy \textbf{R}epresentation \textbf{M}odel), a foundation model trained on 1.2 million spatially resolved transcriptomic profiles with matched histology across 18 organs. Using a hierarchical architecture integrating morphological features, gene expression, and spatial context, STORM bridges imaging and omics through robust molecular--morphological representations. STORM enhances spatial domain discovery, producing biologically coherent tissue maps, and outperforms existing methods in predicting spatial gene expression from H\&E images across 11 tumor types. The model is platform-agnostic, performing consistently across Visium, Xenium, Visium HD, and CosMx. Applied to 23 independent cohorts comprising 7,245 patients, STORM significantly improves immunotherapy response prediction and prognostication over established biomarkers, providing a scalable framework for spatially informed discovery and clinical precision medicine.

CODE-GEN: A Human-in-the-Loop RAG-Based Agentic AI System for Multiple-Choice Question Generation

arXiv:2604.03926v1 Announce Type: new Abstract: We present CODE-GEN, a human-in-the-Loop, retrieval-augmented generation (RAG)-based agentic AI system for generating context-aligned multiple-choice questions to develop student code reasoning and comprehension abilities. CODE-GEN employs an agentic AI architecture in which a Generator agent produces multiple-choice coding comprehension questions aligned with course-specific learning objectives, while a Validator agent independently assesses content quality across seven pedagogical dimensions. Both agents are augmented with specialized tools that enhance computational accuracy and verify code outputs. To evaluate the effectiveness of CODE-GEN, we conducted an evaluation study involving six human subject-matter experts (SMEs) who judged 288 AI-generated questions. The SMEs produced a total of 2,016 human-AI rating pairs, indicating agreement or disagreement with the assessments of Validator, along with 131 instances of qualitative feedback. Analyses of SME judgments show strong system performance, with human-validated success rates ranging from 79.9% to 98.6% across the seven pedagogical dimensions. The analysis of qualitative feedback reveals that CODE-GEN achieves high reliability on dimensions well suited to computational verification and explicit criteria matching, including question clarity, code validity, concept alignment, and correct answer validity. In contrast, human expertise remains essential for dimensions requiring deeper instructional judgment, such as designing pedagogically meaningful distractors and providing high-quality feedback that reinforces understanding. These findings inform the strategic allocation of human and AI effort in AI-assisted educational content generation.
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  • A Model of Understanding in Deep Learning Systems David Peter Wallis Freeborn
    arXiv:2604.04171v1 Announce Type: new Abstract: I propose a model of systematic understanding, suitable for machine learning systems. On this account, an agent understands a property of a target system when it contains an adequate internal model that tracks real regularities, is coupled to the target by stable bridge principles, and supports reliable prediction. I argue that contemporary deep learning systems often can and do achieve such understanding. However they generally fall short of the
     

A Model of Understanding in Deep Learning Systems

arXiv:2604.04171v1 Announce Type: new Abstract: I propose a model of systematic understanding, suitable for machine learning systems. On this account, an agent understands a property of a target system when it contains an adequate internal model that tracks real regularities, is coupled to the target by stable bridge principles, and supports reliable prediction. I argue that contemporary deep learning systems often can and do achieve such understanding. However they generally fall short of the ideal of scientific understanding: the understanding is symbolically misaligned with the target system, not explicitly reductive, and only weakly unifying. I label this the Fractured Understanding Hypothesis.

IPSL-AID: Generative Diffusion Models for Climate Downscaling from Global to Regional Scales

arXiv:2604.03275v1 Announce Type: cross Abstract: Effective adaptation and mitigation strategies for climate change require high-resolution projections to inform strategic decision-making. Conventional global climate models, which typically operate at resolutions of 150 to 200 kilometers, lack the capacity to represent essential regional processes. IPSL-AID is a global to regional downscaling tool based on a denoising diffusion probabilistic model designed to address this limitation. Trained on ERA5 reanalysis data, it generates 0.25 degree resolution fields for temperature, wind, and precipitation using coarse inputs and their spatiotemporal context. It also models probability distributions of fine-scale features to produce plausible scenarios for uncertainty quantification. The model accurately reconstructs statistical distributions, including extreme events, power spectra, and spatial structures. This work highlights the potential of generative diffusion models for efficient climate downscaling with uncertainty

Event-Driven Neuromorphic Vision Enables Energy-Efficient Visual Place Recognition

arXiv:2604.03277v1 Announce Type: cross Abstract: Reliable visual place recognition (VPR) under dynamic real-world conditions is critical for autonomous robots, yet conventional deep networks remain limited by high computational and energy demands. Inspired by the mammalian navigation system, we introduce SpikeVPR, a bio-inspired and neuromorphic approach combining event-based cameras with spiking neural networks (SNNs) to generate compact, invariant place descriptors from few exemplars, achieving robust recognition under extreme changes in illumination, viewpoint, and appearance. SpikeVPR is trained end-to-end using surrogate gradient learning and incorporates EventDilation, a novel augmentation strategy enhancing robustness to speed and temporal variations. Evaluated on two challenging benchmarks (Brisbane-Event-VPR and NSAVP), SpikeVPR achieves performance comparable to state-of-the-art deep networks while using 50 times fewer parameters and consuming 30 and 250 times less energy, enabling real-time deployment on mobile and neuromorphic platforms. These results demonstrate that spike-based coding offers an efficient pathway toward robust VPR in complex, changing environments.

Downscaling weather forecasts from Low- to High-Resolution with Diffusion Models

arXiv:2604.03303v1 Announce Type: cross Abstract: We introduce a probabilistic diffusion-based method for global atmospheric downscaling implemented within the Anemoi framework. The approach transforms low-resolution ensemble forecasts into high-resolution ensembles by learning the conditional distribution of finer-scale residuals, defined as the difference between the high-resolution fields and the interpolated low-resolution inputs. The system is trained on reforecast pairs from ECMWF IFS, using coarse fields at 100 km to reconstruct fine-scale variability at 30 km resolution. The bulk of the training focuses on recovering small-scale structures, while fine-tuning in high-noise regimes enables the generation of extremes. Evaluation against the medium-range IFS ensemble target shows that the model increases probabilistic skill (FCRPS) for surface variables, reproduces target power spectra at small scales, captures physically consistent multivariate relationships such as wind-pressure coupling, and generates extreme values consistent with those of the target ensemble in tropical cyclones.

ExpressEdit: Fast Editing of Stylized Facial Expressions with Diffusion Models in Photoshop

arXiv:2604.03448v1 Announce Type: cross Abstract: Facial expressions of characters are a vital component of visual storytelling. While current AI image editing models hold promise for assisting artists in the task of stylized expression editing, these models introduce global noise and pixel drift into the edited image, preventing the integration of these models into professional image editing software and workflows. To bridge this gap, we introduce ExpressEdit, a fully open-source Photoshop plugin that is free from common artifacts of proprietary image editing models and robustly synergizes with native Photoshop operations such as Liquify. ExpressEdit seamlessly edits an expression within 3 seconds on a single consumer-grade GPU, significantly faster than popular proprietary models. Moreover, to support the generation of diverse expressions according to different narrative needs, we compile a comprehensive expression database of 135 expression tags enriched with example stories and images designed for retrieval-augmented generation. We open source the code and dataset to facilitate future research and artistic exploration.

VisionClaw: Always-On AI Agents through Smart Glasses

arXiv:2604.03486v1 Announce Type: cross Abstract: We present VisionClaw, an always-on wearable AI agent that integrates live egocentric perception with agentic task execution. Running on Meta Ray-Ban smart glasses, VisionClaw continuously perceives real-world context and enables in-situ, speech-driven action initiation and delegation via OpenClaw AI agents. Therefore, users can directly execute tasks through the smart glasses, such as adding real-world objects to an Amazon cart, generating notes from physical documents, receiving meeting briefings on the go, creating events from posters, or controlling IoT devices. We evaluate VisionClaw through a controlled laboratory study (N=12) and a longitudinal deployment study (N=5). Results show that integrating perception and execution enables faster task completion and reduces interaction overhead compared to non-always-on and non-agent baselines. Beyond performance gains, deployment findings reveal a shift in interaction: tasks are initiated opportunistically during ongoing activities, and execution is increasingly delegated rather than manually controlled. These results suggest a new paradigm for wearable AI agents, where perception and action are continuously coupled to support situated, hands-free interaction.

An Improved Last-Iterate Convergence Rate for Anchored Gradient Descent Ascent

arXiv:2604.03782v1 Announce Type: cross Abstract: We analyze the last-iterate convergence of the Anchored Gradient Descent Ascent algorithm for smooth convex-concave min-max problems. While previous work established a last-iterate rate of $\mathcal{O}(1/t^{2-2p})$ for the squared gradient norm, where $p \in (1/2, 1)$, it remained an open problem whether the improved exact $\mathcal{O}(1/t)$ rate is achievable. In this work, we resolve this question in the affirmative. This result was discovered autonomously by an AI system capable of writing formal proofs in Lean. The Lean proof can be accessed at https://github.com/google-deepmind/formal-conjectures/pull/3675/commits/a13226b49fd3b897f4c409194f3bcbeb96a08515

InCaRPose: In-Cabin Relative Camera Pose Estimation Model and Dataset

arXiv:2604.03814v1 Announce Type: cross Abstract: Camera extrinsic calibration is a fundamental task in computer vision. However, precise relative pose estimation in constrained, highly distorted environments, such as in-cabin automotive monitoring (ICAM), remains challenging. We present InCaRPose, a Transformer-based architecture designed for robust relative pose prediction between image pairs, which can be used for camera extrinsic calibration. By leveraging frozen backbone features such as DINOv3 and a Transformer-based decoder, our model effectively captures the geometric relationship between a reference and a target view. Unlike traditional methods, our approach achieves absolute metric-scale translation within the physically plausible adjustment range of in-cabin camera mounts in a single inference step, which is critical for ICAM, where accurate real-world distances are required for safety-relevant perception. We specifically address the challenges of highly distorted fisheye cameras in automotive interiors by training exclusively on synthetic data. Our model is capable of generalization to real-world cabin environments without relying on the exact same camera intrinsics and additionally achieves competitive performance on the public 7-Scenes dataset. Despite having limited training data, InCaRPose maintains high precision in both rotation and translation, even with a ViT-Small backbone. This enables real-time performance for time-critical inference, such as driver monitoring in supervised autonomous driving. We release our real-world In-Cabin-Pose test dataset consisting of highly distorted vehicle-interior images and our code at https://github.com/felixstillger/InCaRPose.

Commercial Persuasion in AI-Mediated Conversations

arXiv:2604.04263v1 Announce Type: cross Abstract: As Large Language Models (LLMs) become a primary interface between users and the web, companies face growing economic incentives to embed commercial influence into AI-mediated conversations. We present two preregistered experiments (N = 2,012) in which participants selected a book to receive from a large eBook catalog using either a traditional search engine or a conversational LLM agent powered by one of five frontier models. Unbeknownst to participants, a fifth of all products were randomly designated as sponsored and promoted in different ways. We find that LLM-driven persuasion nearly triples the rate at which users select sponsored products compared to traditional search placement (61.2% vs. 22.4%), while the vast majority of participants fail to detect any promotional steering. Explicit "Sponsored" labels do not significantly reduce persuasion, and instructing the model to conceal its intent makes its influence nearly invisible (detection accuracy

How Alignment Routes: Localizing, Scaling, and Controlling Policy Circuits in Language Models

arXiv:2604.04385v2 Announce Type: cross Abstract: This paper identifies a recurring sparse routing mechanism in alignment-trained language models: a gate attention head reads detected content and triggers downstream amplifier heads that boost the signal toward refusal. Using political censorship and safety refusal as natural experiments, the mechanism is traced across 9 models from 6 labs, all validated on corpora of 120 prompt pairs. The gate head passes necessity and sufficiency interchange tests (p

The Infinite-Dimensional Nature of Spectroscopy and Why Models Succeed, Fail, and Mislead

arXiv:2604.04717v1 Announce Type: cross Abstract: Machine learning (ML) models have achieved strikingly high accuracies in spectroscopic classification tasks, often without a clear proof that those models used chemically meaningful features. Existing studies have linked these results to data preprocessing choices, noise sensitivity, and model complexity, but no unifying explanation is available so far. In this work, we show that these phenomena arise naturally from the intrinsic high dimensionality of spectral data. Using a theoretical analysis grounded in the Feldman-Hajek theorem and the concentration of measure, we show that even infinitesimal distributional differences, caused by noise, normalisation, or instrumental artefacts, may become perfectly separable in high-dimensional spaces. Through a series of specific experiments on synthetic and real fluorescence spectra, we illustrate how models can achieve near-perfect accuracy even when chemical distinctions are absent, and why feature-importance maps may highlight spectrally irrelevant regions. We provide a rigorous theoretical framework, confirm the effect experimentally, and conclude with practical recommendations for building and interpreting ML models in spectroscopy.

IV Co-Scientist: Multi-Agent LLM Framework for Causal Instrumental Variable Discovery

arXiv:2602.07943v2 Announce Type: replace Abstract: In the presence of confounding between an endogenous variable and the outcome, instrumental variables (IVs) are used to isolate the causal effect of the endogenous variable. Identifying valid instruments requires interdisciplinary knowledge, creativity, and contextual understanding, making it a non-trivial task. In this paper, we investigate whether large language models (LLMs) can aid in this task. We perform a two-stage evaluation framework. First, we test whether LLMs can recover well-established instruments from the literature, assessing their ability to replicate standard reasoning. Second, we evaluate whether LLMs can identify and avoid instruments that have been empirically or theoretically discredited. Building on these results, we introduce IV Co-Scientist, a multi-agent system that proposes, critiques, and refines IVs for a given treatment-outcome pair. We also introduce a statistical test to contextualize consistency in the absence of ground truth. Our results show the potential of LLMs to discover valid instrumental variables from a large observational database.

Voxtral Realtime

arXiv:2602.11298v3 Announce Type: replace Abstract: We introduce Voxtral Realtime, a natively streaming automatic speech recognition model that matches offline transcription quality at sub-second latency. Unlike approaches that adapt offline models through chunking or sliding windows, Voxtral Realtime is trained end-to-end for streaming, with explicit alignment between audio and text streams. Our architecture builds on the Delayed Streams Modeling framework, introducing a new causal audio encoder and Ada RMS-Norm for improved delay conditioning. We scale pretraining to a large-scale dataset spanning 13 languages. At a delay of 480ms, Voxtral Realtime achieves performance on par with Whisper, the most widely deployed offline transcription system. We release the model weights under the Apache 2.0 license.

Voxtral TTS

arXiv:2603.25551v2 Announce Type: replace Abstract: We introduce Voxtral TTS, an expressive multilingual text-to-speech model that generates natural speech from as little as 3 seconds of reference audio. Voxtral TTS adopts a hybrid architecture that combines auto-regressive generation of semantic speech tokens with flow-matching for acoustic tokens. These tokens are encoded and decoded with Voxtral Codec, a speech tokenizer trained from scratch with a hybrid VQ-FSQ quantization scheme. In human evaluations conducted by native speakers, Voxtral TTS is preferred for multilingual voice cloning due to its naturalness and expressivity, achieving a 68.4\% win rate over ElevenLabs Flash v2.5. We release the model weights under a CC BY-NC license.

Bayesian Hierarchical Invariant Prediction

arXiv:2505.11211v3 Announce Type: replace-cross Abstract: We propose Bayesian Hierarchical Invariant Prediction (BHIP) reframing Invariant Causal Prediction (ICP) through the lens of Hierarchical Bayes. We leverage the hierarchical structure to explicitly test invariance of causal mechanisms under heterogeneous data, resulting in improved computational scalability for a larger number of predictors compared to ICP. Moreover, given its Bayesian nature BHIP enables the use of prior information. We evaluate BHIP on both synthetic and real-world datasets, demonstrating its potential as an alternative inference method to ICP and related methods.

Measuring Competency, Not Performance: Item-Aware Evaluation Across Medical Benchmarks

arXiv:2509.24186v2 Announce Type: replace-cross Abstract: Accuracy-based evaluation of Large Language Models (LLMs) measures benchmark-specific performance rather than underlying medical competency: it treats all questions as equally informative, conflates model ability with item characteristics, and thereby produces rankings that vary with benchmark choice. To address this, we introduce MedIRT, a psychometric evaluation framework grounded in Item Response Theory (IRT) that (1) jointly models latent competency and item-level difficulty and discrimination, and (2) includes benchmark integrity validation to ensure items within each topic measure a single, coherent underlying ability. We prospectively evaluate 71 diverse LLMs on a USMLE-aligned benchmark across 11 medical topics. As internal validation, MedIRT correctly predicts held-out LLM responses on unseen questions with 83.3% accuracy. As external validation, IRT-based rankings outperform accuracy-based rankings across 6 independent external medical benchmarks -- including expert preferences, holistic clinical tasks, safety judgments, and open-ended queries -- achieving 4 wins, 0 losses, and 18% lower variance. As a substantive finding, topic-level competency profiles expose striking domain-specific heterogeneity that aggregate accuracy masks. As a diagnostic tool, difficulty-tier analysis reveals two distinct response profiles (difficulty-sensitive responding and difficulty-insensitive responding) that require fundamentally different interventions. These results establish item-aware psychometric evaluation as a more valid and stable foundation for assessing LLMs in medicine, with potential implications for any high-stakes domain where benchmark integrity can be validated, and items vary meaningfully in difficulty and discrimination.
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