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cs.AI, q-bio.NC updates on arXiv.org
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Can LLMs Learn to Reason Robustly under Noisy Supervision?
arXiv:2604.03993v1 Announce Type: cross Abstract: Reinforcement Learning with Verifiable Rewards (RLVR) effectively trains reasoning models that rely on abundant perfect labels, but its vulnerability to unavoidable noisy labels due to expert scarcity remains critically underexplored. In this work, we take the first step toward a systematic analysis of noisy label mechanisms in RLVR. In contrast to supervised classification, most RLVR algorithms incorporate a rollout-based condition: a label's i
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cs.AI, q-bio.NC updates on arXiv.org
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VLBiasBench: A Comprehensive Benchmark for Evaluating Bias in Large Vision-Language Model
arXiv:2406.14194v3 Announce Type: replace-cross Abstract: The emergence of Large Vision-Language Models (LVLMs) marks significant strides towards achieving general artificial intelligence. However, these advancements are accompanied by concerns about biased outputs, a challenge that has yet to be thoroughly explored. Existing benchmarks are not sufficiently comprehensive in evaluating biases due to their limited data scale, single questioning format and narrow sources of bias. To address this p
VLBiasBench: A Comprehensive Benchmark for Evaluating Bias in Large Vision-Language Model
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cs.AI, q-bio.NC updates on arXiv.org
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TRACE-Bot: Detecting Emerging LLM-Driven Social Bots via Implicit Semantic Representations and AIGC-Enhanced Behavioral Patterns
arXiv:2604.02147v1 Announce Type: new Abstract: Large Language Model-driven (LLM-driven) social bots pose a growing threat to online discourse by generating human-like content that evades conventional detection. Existing methods suffer from limited detection accuracy due to overreliance on single-modality signals, insufficient sensitivity to the specific generative patterns of Artificial Intelligence-Generated Content (AIGC), and a failure to adequately model the interplay between linguistic pa
TRACE-Bot: Detecting Emerging LLM-Driven Social Bots via Implicit Semantic Representations and AIGC-Enhanced Behavioral Patterns
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cs.AI, q-bio.NC updates on arXiv.org
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SHOE: Semantic HOI Open-Vocabulary Evaluation Metric
arXiv:2604.01586v1 Announce Type: cross Abstract: Open-vocabulary human-object interaction (HOI) detection is a step towards building scalable systems that generalize to unseen interactions in real-world scenarios and support grounded multimodal systems that reason about human-object relationships. However, standard evaluation metrics, such as mean Average Precision (mAP), treat HOI classes as discrete categorical labels and fail to credit semantically valid but lexically different predictions
SHOE: Semantic HOI Open-Vocabulary Evaluation Metric
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cs.AI, q-bio.NC updates on arXiv.org
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Think, Act, Build: An Agentic Framework with Vision Language Models for Zero-Shot 3D Visual Grounding
arXiv:2604.00528v2 Announce Type: replace-cross Abstract: 3D Visual Grounding (3D-VG) aims to localize objects in 3D scenes via natural language descriptions. While recent advancements leveraging Vision-Language Models (VLMs) have explored zero-shot possibilities, they typically suffer from a static workflow relying on preprocessed 3D point clouds, essentially degrading grounding into proposal matching. To bypass this reliance, our core motivation is to decouple the task: leveraging 2D VLMs to
Think, Act, Build: An Agentic Framework with Vision Language Models for Zero-Shot 3D Visual Grounding
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cs.AI, q-bio.NC updates on arXiv.org
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Do Phone-Use Agents Respect Your Privacy?
arXiv:2604.00986v2 Announce Type: replace-cross Abstract: We study whether phone-use agents respect privacy while completing benign mobile tasks. This question has remained hard to answer because privacy-compliant behavior is not operationalized for phone-use agents, and ordinary apps do not reveal exactly what data agents type into which form entries during execution. To make this question measurable, we introduce MyPhoneBench, a verifiable evaluation framework for privacy behavior in mobile a
Do Phone-Use Agents Respect Your Privacy?
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cs.AI, q-bio.NC updates on arXiv.org
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FlowPIE: Test-Time Scientific Idea Evolution with Flow-Guided Literature Exploration
arXiv:2603.29557v1 Announce Type: new Abstract: Scientific idea generation (SIG) is critical to AI-driven autonomous research, yet existing approaches are often constrained by a static retrieval-then-generation paradigm, leading to homogeneous and insufficiently divergent ideas. In this work, we propose FlowPIE, a tightly coupled retrieval-generation framework that treats literature exploration and idea generation as a co-evolving process. FlowPIE expands literature trajectories via a flow-guid
FlowPIE: Test-Time Scientific Idea Evolution with Flow-Guided Literature Exploration
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cs.AI, q-bio.NC updates on arXiv.org
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Owl-AuraID 1.0: An Intelligent System for Autonomous Scientific Instrumentation and Scientific Data Analysis
arXiv:2603.29828v1 Announce Type: new Abstract: Scientific discovery increasingly depends on high-throughput characterization, yet automation is hindered by proprietary GUIs and the limited generalizability of existing API-based systems. We present Owl-AuraID, a software-hardware collaborative embodied agent system that adopts a GUI-native paradigm to operate instruments through the same interfaces as human experts. Its skill-centric framework integrates Type-1 (GUI operation) and Type-2 (data
Owl-AuraID 1.0: An Intelligent System for Autonomous Scientific Instrumentation and Scientific Data Analysis
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cs.AI, q-bio.NC updates on arXiv.org
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WAter: A Workload-Adaptive Knob Tuning System based on Workload Compression
arXiv:2603.28809v1 Announce Type: cross Abstract: Selecting appropriate values for the configurable parameters of Database Management Systems (DBMS) to improve performance is a significant challenge. Recent machine learning (ML)-based tuning systems have shown strong potential, but their practical adoption is often limited by the high tuning cost. This cost arises from two main factors: (1) the system needs to evaluate a large number of configurations to identify a satisfactory one, and (2) for
WAter: A Workload-Adaptive Knob Tuning System based on Workload Compression
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cs.AI, q-bio.NC updates on arXiv.org
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InCoder-32B: Code Foundation Model for Industrial Scenarios
arXiv:2603.16790v3 Announce Type: replace-cross Abstract: Recent code large language models have achieved remarkable progress on general programming tasks. Nevertheless, their performance degrades significantly in industrial scenarios that require reasoning about hardware semantics, specialized language constructs, and strict resource constraints. To address these challenges, we introduce InCoder-32B (Industrial-Coder-32B), the first 32B-parameter code foundation model unifying code intelligenc
InCoder-32B: Code Foundation Model for Industrial Scenarios
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Nature - Issue - nature.com science feeds
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Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10264-6Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.
Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10264-6
Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.-
Omics In Lung
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Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis
Nat Commun. 2026 Mar 20;17(1):2655. doi: 10.1038/s41467-026-70193-w.ABSTRACTPulmonary fibrosis represents a progressive interstitial lung disease marked by excessive extracellular matrix deposition and architectural distortion. Vascular endothelial cells critically contribute to fibrogenesis through paracrine secretion of pro-fibrotic mediators, yet their mechanobiological regulation remains elusive. Using integrated single-cell multi-omics profiling of human pulmonary fibrosis specimens and exp
Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis
Nat Commun. 2026 Mar 20;17(1):2655. doi: 10.1038/s41467-026-70193-w.
ABSTRACT
Pulmonary fibrosis represents a progressive interstitial lung disease marked by excessive extracellular matrix deposition and architectural distortion. Vascular endothelial cells critically contribute to fibrogenesis through paracrine secretion of pro-fibrotic mediators, yet their mechanobiological regulation remains elusive. Using integrated single-cell multi-omics profiling of human pulmonary fibrosis specimens and experimental fibrosis models induced by bleomycin or silica, we identify mechanosensitive Piezo1 upregulation in Endothelial cells as a hallmark of fibrotic progression. Endothelial-specific Piezo1 knockout significantly attenuates Bleomycin-induced fibrotic remodeling in male mice, establishing its pathogenic necessity. Mechanistically, PIEZO1 activation promotes pulmonary fibrosis development via CAPN2-mediated STAT3 phosphorylation, which may regulate the secretion of the pro-fibrotic molecule interleukin-33. These findings suggest that the endothelial PIEZO1-CAPN2-STAT3-IL33 axis is a potential therapeutic target for PF intervention.
PMID:41862476 | PMC:PMC13004862 | DOI:10.1038/s41467-026-70193-w
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Nature Biotechnology - Issue - nature.com science feeds
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Generalist biological artificial intelligence in modeling the language of life
Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03064-wThis Review discusses the promises and pitfalls of biological AI algorithms and presents a vision for generalist biological artificial intelligence, in which models can perform diverse tasks across biological domains.
Generalist biological artificial intelligence in modeling the language of life
Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03064-w
This Review discusses the promises and pitfalls of biological AI algorithms and presents a vision for generalist biological artificial intelligence, in which models can perform diverse tasks across biological domains.-
Cell
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LUMI-lab: A foundation model-driven autonomous platform enabling discovery of ionizable lipid designs for mRNA delivery
LUMI lab is a foundation model-driven self-driving platform that autonomously discovers ionizable lipids for mRNA delivery. Iterative active learning uncovered brominated tails as a potent structural motif that enables efficient and safe pulmonary mRNA delivery.
LUMI-lab: A foundation model-driven autonomous platform enabling discovery of ionizable lipid designs for mRNA delivery
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Omics In Lung
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Elucidating genetic backgrounds of myasthenia gravis in Japanese by genome-wide association studies and multi-omics analyses of thymoma
Nat Commun. 2026 Mar 12. doi: 10.1038/s41467-026-70376-5. Online ahead of print.ABSTRACTMyasthenia gravis (MG) is an autoimmune disorder characterized by impaired neuromuscular transmission and motor symptoms. Its genetic background remains unclear, particularly beyond specific subtypes reported in European populations. Here, we perform a genome-wide association study (GWAS) of 1,434 MG cases covering all disease subtypes and 42,913 controls of Japanese, which newly identify the TERT locus (odds
Elucidating genetic backgrounds of myasthenia gravis in Japanese by genome-wide association studies and multi-omics analyses of thymoma
Nat Commun. 2026 Mar 12. doi: 10.1038/s41467-026-70376-5. Online ahead of print.
ABSTRACT
Myasthenia gravis (MG) is an autoimmune disorder characterized by impaired neuromuscular transmission and motor symptoms. Its genetic background remains unclear, particularly beyond specific subtypes reported in European populations. Here, we perform a genome-wide association study (GWAS) of 1,434 MG cases covering all disease subtypes and 42,913 controls of Japanese, which newly identify the TERT locus (odds ratio [OR] = 1.31, P = 1.7×10-10). Subtype-stratified GWASs show stronger signals for generalized MG (gMG; OR = 1.38, P = 1.6×10-12), anti AChR antibody-positive gMG (g-AChR-Ab(+)MG; OR= 1.49, P = 2.1×10-15), and thymoma-associated gMG (g-TAMG; OR = 1.92, P = 1.1×10-15). Fine-mapping of the major histocompatibility complex region reveal distinct associations of HLA-DRB1 with late onset gMG (g-LOMG) and HLA-A with early onset gMG (g-EOMG). The MG risk TERT lead variant rs2736099 is associated with poor treatment response, especially in g-AChR-Ab(+)MG and g-EOMG (P < 0.0042). The biobank-based phenome-wide association study identify pleiotropic effects on lung cancer, hematological traits, and telomere length. Single cell transcriptomics and immunohistochemistry identified immature lymphocyte-specific TERT expression in thymoma specimens. Full-length transcriptomics reveal allele-specific decreasing effect of rs2736099-A on TERT expression. Our study unveils genetics of MG distinctly across disease subtypes, and involvement of TERT in its pathogenesis.
PMID:41820352 | DOI:10.1038/s41467-026-70376-5
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Cell Death Discovery nature.com science feeds
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MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism
Cell Death Discovery, Published online: 11 March 2026; doi:10.1038/s41420-026-02990-7MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism
MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism
Cell Death Discovery, Published online: 11 March 2026; doi:10.1038/s41420-026-02990-7
MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism-
cs.AI, q-bio.NC updates on arXiv.org
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A Robust Incomplete Multimodal Low-Rank Adaptation Approach for Emotion Recognition
arXiv:2507.11202v1 Announce Type: cross Abstract: Multimodal Emotion Recognition (MER) often encounters incomplete multimodality in practical applications due to sensor failures or privacy protection requirements. While existing methods attempt to address various incomplete multimodal scenarios by balancing the training of each modality combination through additional gradients, these approaches face a critical limitation: training gradients from different modality combinations conflict with eac
A Robust Incomplete Multimodal Low-Rank Adaptation Approach for Emotion Recognition
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cs.AI, q-bio.NC updates on arXiv.org
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Stabilizing Reinforcement Learning for Diffusion Language Models
arXiv:2603.06743v1 Announce Type: cross Abstract: Group Relative Policy Optimization (GRPO) is highly effective for post-training autoregressive (AR) language models, yet its direct application to diffusion large language models (dLLMs) often triggers reward collapse. We identify two sources of incompatibility. First, GRPO relies on importance ratios defined by sequence probabilities, which are intractable in dLLMs and must be estimated (e.g., via ELBO-based or mean-field likelihood proxies), y
Stabilizing Reinforcement Learning for Diffusion Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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Not All Candidates are Created Equal: A Heterogeneity-Aware Approach to Pre-ranking in Recommender Systems
arXiv:2603.03770v1 Announce Type: cross Abstract: Most large-scale recommender systems follow a multi-stage cascade of retrieval, pre-ranking, ranking, and re-ranking. A key challenge at the pre-ranking stage arises from the heterogeneity of training instances sampled from coarse-grained retrieval results, fine-grained ranking signals, and exposure feedback. Our analysis reveals that prevailing pre-ranking methods, which indiscriminately mix heterogeneous samples, suffer from gradient conflicts
Not All Candidates are Created Equal: A Heterogeneity-Aware Approach to Pre-ranking in Recommender Systems
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cs.AI, q-bio.NC updates on arXiv.org
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Relational In-Context Learning via Synthetic Pre-training with Structural Prior
arXiv:2603.03805v1 Announce Type: cross Abstract: Relational Databases (RDBs) are the backbone of modern business, yet they lack foundation models comparable to those in text or vision. A key obstacle is that high-quality RDBs are private, scarce and structurally heterogeneous, making internet-scale pre-training infeasible. To overcome this data scarcity, We introduce $\textbf{RDB-PFN}$, the first relational foundation model trained purely via $\textbf{synthetic data}$. Inspired by Prior-Data F