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cs.AI, q-bio.NC updates on arXiv.org
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LiteInception: A Lightweight and Interpretable Deep Learning Framework for General Aviation Fault Diagnosis
arXiv:2604.01725v1 Announce Type: new Abstract: General aviation fault diagnosis and efficient maintenance are critical to flight safety; however, deploying deep learning models on resource-constrained edge devices poses dual challenges in computational capacity and interpretability. This paper proposes LiteInception--a lightweight interpretable fault diagnosis framework designed for edge deployment. The framework adopts a two-stage cascaded architecture aligned with standard maintenance workfl
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cs.AI, q-bio.NC updates on arXiv.org
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Tex3D: Objects as Attack Surfaces via Adversarial 3D Textures for Vision-Language-Action Models
arXiv:2604.01618v1 Announce Type: cross Abstract: Vision-language-action (VLA) models have shown strong performance in robotic manipulation, yet their robustness to physically realizable adversarial attacks remains underexplored. Existing studies reveal vulnerabilities through language perturbations and 2D visual attacks, but these attack surfaces are either less representative of real deployment or limited in physical realism. In contrast, adversarial 3D textures pose a more physically plausib
Tex3D: Objects as Attack Surfaces via Adversarial 3D Textures for Vision-Language-Action Models
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cs.AI, q-bio.NC updates on arXiv.org
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InCoder-32B: Code Foundation Model for Industrial Scenarios
arXiv:2603.16790v3 Announce Type: replace-cross Abstract: Recent code large language models have achieved remarkable progress on general programming tasks. Nevertheless, their performance degrades significantly in industrial scenarios that require reasoning about hardware semantics, specialized language constructs, and strict resource constraints. To address these challenges, we introduce InCoder-32B (Industrial-Coder-32B), the first 32B-parameter code foundation model unifying code intelligenc
InCoder-32B: Code Foundation Model for Industrial Scenarios
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Omics In Lung
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Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis
Nat Commun. 2026 Mar 20;17(1):2655. doi: 10.1038/s41467-026-70193-w.ABSTRACTPulmonary fibrosis represents a progressive interstitial lung disease marked by excessive extracellular matrix deposition and architectural distortion. Vascular endothelial cells critically contribute to fibrogenesis through paracrine secretion of pro-fibrotic mediators, yet their mechanobiological regulation remains elusive. Using integrated single-cell multi-omics profiling of human pulmonary fibrosis specimens and exp
Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis
Nat Commun. 2026 Mar 20;17(1):2655. doi: 10.1038/s41467-026-70193-w.
ABSTRACT
Pulmonary fibrosis represents a progressive interstitial lung disease marked by excessive extracellular matrix deposition and architectural distortion. Vascular endothelial cells critically contribute to fibrogenesis through paracrine secretion of pro-fibrotic mediators, yet their mechanobiological regulation remains elusive. Using integrated single-cell multi-omics profiling of human pulmonary fibrosis specimens and experimental fibrosis models induced by bleomycin or silica, we identify mechanosensitive Piezo1 upregulation in Endothelial cells as a hallmark of fibrotic progression. Endothelial-specific Piezo1 knockout significantly attenuates Bleomycin-induced fibrotic remodeling in male mice, establishing its pathogenic necessity. Mechanistically, PIEZO1 activation promotes pulmonary fibrosis development via CAPN2-mediated STAT3 phosphorylation, which may regulate the secretion of the pro-fibrotic molecule interleukin-33. These findings suggest that the endothelial PIEZO1-CAPN2-STAT3-IL33 axis is a potential therapeutic target for PF intervention.
PMID:41862476 | PMC:PMC13004862 | DOI:10.1038/s41467-026-70193-w
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Omics In Lung
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Trem1 regulates neutrophil metabolism and recruitment in lung ischemia-reperfusion injury
Redox Biol. 2026 Jan 14;92:104026. doi: 10.1016/j.redox.2026.104026. Online ahead of print.ABSTRACTPrimary graft dysfunction (PGD) caused by ischemia-reperfusion injury (IRI) is a major complication after lung transplantation, yet its underlying mechanisms remain unclear. Triggering receptor expressed on myeloid cells 1 (Trem1) is an important mediator of inflammation, but its role in neutrophil function and metabolic reprogramming during lung IRI is not well understood. In this study, we used a
Trem1 regulates neutrophil metabolism and recruitment in lung ischemia-reperfusion injury
Redox Biol. 2026 Jan 14;92:104026. doi: 10.1016/j.redox.2026.104026. Online ahead of print.
ABSTRACT
Primary graft dysfunction (PGD) caused by ischemia-reperfusion injury (IRI) is a major complication after lung transplantation, yet its underlying mechanisms remain unclear. Triggering receptor expressed on myeloid cells 1 (Trem1) is an important mediator of inflammation, but its role in neutrophil function and metabolic reprogramming during lung IRI is not well understood. In this study, we used a murine orthotopic lung transplantation model with cold ischemia and reperfusion, and Trem1 knockout (Trem1-/-) and myeloid-specific Trem1 conditional knockout mice (LysmCreTrem1fl) to explore the role of Trem1 in neutrophil recruitment, neutrophil extracellular trap (NET) formation, and metabolism. Our results show that Trem1 expression increases in both mouse and human lungs after reperfusion and correlates with neutrophil infiltration and lung injury. Trem1 deficiency significantly reduced neutrophil and macrophage recruitment, NET formation, and tissue damage. Multi-omics analysis revealed that Trem1 deletion suppressed oxidative phosphorylation (OXPHOS) and induced a metabolic shift in neutrophils toward glycolysis. In clinical samples, the abundance of TREM1+ neutrophils was correlated with PGD severity and OXPHOS activity. These findings identify Trem1 as a key regulator of neutrophil metabolism and recruitment in lung IRI, and suggest that targeting Trem1 may provide a novel therapeutic strategy to mitigate PGD and improve lung transplant outcomes.
PMID:41861599 | DOI:10.1016/j.redox.2026.104026
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cs.AI, q-bio.NC updates on arXiv.org
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DSH-Bench: A Difficulty- and Scenario-Aware Benchmark with Hierarchical Subject Taxonomy for Subject-Driven Text-to-Image Generation
arXiv:2603.08090v1 Announce Type: cross Abstract: Significant progress has been achieved in subject-driven text-to-image (T2I) generation, which aims to synthesize new images depicting target subjects according to user instructions. However, evaluating these models remains a significant challenge. Existing benchmarks exhibit critical limitations: 1) insufficient diversity and comprehensiveness in subject images, 2) inadequate granularity in assessing model performance across different subject d
DSH-Bench: A Difficulty- and Scenario-Aware Benchmark with Hierarchical Subject Taxonomy for Subject-Driven Text-to-Image Generation
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cs.AI, q-bio.NC updates on arXiv.org
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City Editing: Hierarchical Agentic Execution for Dependency-Aware Urban Geospatial Modification
arXiv:2602.19326v1 Announce Type: cross Abstract: As cities evolve over time, challenges such as traffic congestion and functional imbalance increasingly necessitate urban renewal through efficient modification of existing plans, rather than complete re-planning. In practice, even minor urban changes require substantial manual effort to redraw geospatial layouts, slowing the iterative planning and decision-making procedure. Motivated by recent advances in agentic systems and multimodal reasonin
City Editing: Hierarchical Agentic Execution for Dependency-Aware Urban Geospatial Modification
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cs.AI, q-bio.NC updates on arXiv.org
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Cautious Optimizers: Improving Training with One Line of Code
arXiv:2411.16085v4 Announce Type: replace-cross Abstract: AdamW has been the default optimizer for transformer pretraining. For many years, our community searched for faster and more stable optimizers with only constrained positive outcomes. In this work, we propose a \textbf{one-line modification in Pytorch} to any momentum-based optimizer, which we rename cautious optimizer, e.g. C-AdamW and C-Lion. Our theoretical result shows that this modification preserves Adam's Hamiltonian function and
Cautious Optimizers: Improving Training with One Line of Code
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cs.AI, q-bio.NC updates on arXiv.org
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IntentMiner: Intent Inversion Attack via Tool Call Analysis in the Model Context Protocol
arXiv:2512.14166v2 Announce Type: replace-cross Abstract: The evolution of Large Language Models (LLMs) into Agentic AI has established the Model Context Protocol (MCP) as the standard for connecting reasoning engines with external tools. Although this decoupled architecture fosters modularity, it simultaneously shatters the traditional trust boundary. We uncover a novel privacy vector inherent to this paradigm: the Intent Inversion Attack. We show that semi-honest third-party MCP servers can a