Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
CoopGuard: Stateful Cooperative Agents Safeguarding LLMs Against Evolving Multi-Round Attacks
arXiv:2604.04060v1 Announce Type: cross Abstract: As Large Language Models (LLMs) are increasingly deployed in complex applications, their vulnerability to adversarial attacks raises urgent safety concerns, especially those evolving over multi-round interactions. Existing defenses are largely reactive and struggle to adapt as adversaries refine strategies across rounds. In this work, we propose CoopGuard , a stateful multi-round LLM defense framework based on cooperative agents that maintains a
-
cs.AI, q-bio.NC updates on arXiv.org
-
Embedding Enhancement via Fine-Tuned Language Models for Learner-Item Cognitive Modeling
arXiv:2604.04088v1 Announce Type: cross Abstract: Learner-item cognitive modeling plays a central role in the web-based online intelligent education system by enabling cognitive diagnosis (CD) across diverse online educational scenarios. Although ID embedding remains the mainstream approach in cognitive modeling due to its effectiveness and flexibility, recent advances in language models (LMs) have introduced new possibilities for incorporating rich semantic representations to enhance CD perfor
Embedding Enhancement via Fine-Tuned Language Models for Learner-Item Cognitive Modeling
-
cs.AI, q-bio.NC updates on arXiv.org
-
Justified or Just Convincing? Error Verifiability as a Dimension of LLM Quality
arXiv:2604.04418v1 Announce Type: cross Abstract: As LLMs are deployed in high-stakes settings, users must judge the correctness of individual responses, often relying on model-generated justifications such as reasoning chains or explanations. Yet, no standard measure exists for whether these justifications help users distinguish correct answers from incorrect ones. We formalize this idea as error verifiability and propose $v_{\text{bal}}$, a balanced metric that measures whether justifications
Justified or Just Convincing? Error Verifiability as a Dimension of LLM Quality
-
cs.AI, q-bio.NC updates on arXiv.org
-
Trace2Skill: Distill Trajectory-Local Lessons into Transferable Agent Skills
arXiv:2603.25158v3 Announce Type: replace Abstract: Equipping Large Language Model (LLM) agents with domain-specific skills is critical for tackling complex tasks. Yet, manual authoring creates a severe scalability bottleneck. Conversely, automated skill generation often yields fragile or fragmented results because it either relies on shallow parametric knowledge or sequentially overfits to non-generalizable trajectory-local lessons. To overcome this, we introduce Trace2Skill, a framework that
Trace2Skill: Distill Trajectory-Local Lessons into Transferable Agent Skills
-
Cell Death Discovery nature.com science feeds
-
Doxorubicin promotes the production of inflammatory cytokines in tumor-associated macrophages through activating lactate dehydrogenase A
Cell Death Discovery, Published online: 31 March 2026; doi:10.1038/s41420-026-03014-0Doxorubicin promotes the production of inflammatory cytokines in tumor-associated macrophages through activating lactate dehydrogenase A
Doxorubicin promotes the production of inflammatory cytokines in tumor-associated macrophages through activating lactate dehydrogenase A
Cell Death Discovery, Published online: 31 March 2026; doi:10.1038/s41420-026-03014-0
Doxorubicin promotes the production of inflammatory cytokines in tumor-associated macrophages through activating lactate dehydrogenase A-
Omics in Gastric
-
Multi-omics analysis reveals AR as a potential prognostic factor and immune-related therapeutic target in gastric cancer
Biochem Biophys Rep. 2026 Mar 16;46:102537. doi: 10.1016/j.bbrep.2026.102537. eCollection 2026 Jun.ABSTRACTBACKGROUND: Although studies have shown that the androgen receptor (AR) is associated with tumor progression and malignant regulation, its role in the tumor immune microenvironment and predictive value for prognosis and immunotherapy response in various cancer types have not been systematically analyzed.METHODS: In this paper, multi-omics techniques was used to analyze AR comprehensively.RE
Multi-omics analysis reveals AR as a potential prognostic factor and immune-related therapeutic target in gastric cancer
Biochem Biophys Rep. 2026 Mar 16;46:102537. doi: 10.1016/j.bbrep.2026.102537. eCollection 2026 Jun.
ABSTRACT
BACKGROUND: Although studies have shown that the androgen receptor (AR) is associated with tumor progression and malignant regulation, its role in the tumor immune microenvironment and predictive value for prognosis and immunotherapy response in various cancer types have not been systematically analyzed.
METHODS: In this paper, multi-omics techniques was used to analyze AR comprehensively.
RESULTS: A comprehensive pan-cancer analysis revealed that the AR was expressed in a variety of tumors, especially as a risk factor for poor prognosis in gastric cancer. In addition, gene set enrichment analysis showed that the AR promotes cell proliferation and tumor cell invasion and regulates anti-tumor response. Immune score, immune cell infiltration, and anticancer immune cycle analysis showed that high AR levels were correlated with low infiltration of CD4+ T cells and NKT cells, high infiltration of Th2 cells and MDSCs, negatively correlated with antigen-presenting molecules, and positively correlated with various immune-negative regulatory molecules. Single-cell sequencing highlighted the heterogeneous expression of ARs in different cell types, particularly in epithelial cells, where high AR levels were associated with the enhanced activity of tumor-promoting pathways.
CONCLUSIONS: In conclusion, this study highlights the potential of the AR as a novel biomarker for gastric cancer prognosis and immunotherapy efficacy, expanding its applicability in the development of new antitumor drugs.
PMID:41890218 | PMC:PMC13014673 | DOI:10.1016/j.bbrep.2026.102537
-
Omics in Hepatocellular
-
SVNeoPP: A Workflow for Structural-Variant-Derived Neoantigen Prediction and Prioritization Using Multi-Omics Data
Biology (Basel). 2026 Mar 19;15(6):492. doi: 10.3390/biology15060492.ABSTRACTBACKGROUND: Tumor neoantigens are key targets for personalized vaccines and T-cell therapies, yet most pipelines focus on neoantigens derived from SNV/small indel and often yield a limited number of high-quality candidates. SVs are prevalent in tumors and can generate novel chimeric sequences and neopeptides, making them a promising additional source of neoantigens. However, SV-derived neoantigen prediction remains chal
SVNeoPP: A Workflow for Structural-Variant-Derived Neoantigen Prediction and Prioritization Using Multi-Omics Data
Biology (Basel). 2026 Mar 19;15(6):492. doi: 10.3390/biology15060492.
ABSTRACT
BACKGROUND: Tumor neoantigens are key targets for personalized vaccines and T-cell therapies, yet most pipelines focus on neoantigens derived from SNV/small indel and often yield a limited number of high-quality candidates. SVs are prevalent in tumors and can generate novel chimeric sequences and neopeptides, making them a promising additional source of neoantigens. However, SV-derived neoantigen prediction remains challenging due to breakpoint uncertainty, isoform-dependent coding inference, and limited integration of multi-dimensional evidence and reproducibility.
METHODS: We developed SVNeoPP (Structural Variant Neoantigen Prediction and Prioritization), an end-to-end workflow for SV-derived neoantigen analysis. SVNeoPP takes WGS and RNA-seq as inputs, performs SV calling and annotation, and reconstructs altered transcripts and coding sequences in a traceable, isoform-aware manner to generate candidate peptides. Candidates are prescreened by integrating antigen-processing features with HLA binding prediction, and then hierarchically filtered and prioritized based on transcript expression, LC-MS/MS proteomics evidence, immunogenicity predictions, and sequence similarity to experimentally validated neoantigen databases. SVNeoPP is implemented in Snakemake to enable modular extension, checkpoint-based restarts, and end-to-end reproducibility.
RESULTS: Using a hepatocellular carcinoma (HCC) multi-omics dataset as a proof of concept, we demonstrated the performance of SVNeoPP and obtained a high-priority shortlist of candidate peptides. Compared with other methods, SVNeoPP substantially expanded the candidate search space for SV-derived neoantigens and showed more favorable distributions of antigen-processing and HLA binding features.
CONCLUSIONS: SVNeoPP provides a reusable, traceable, and interpretable multi-dimensional evidence-driven framework for SV-derived neoantigens. As a complementary module to SNV/small-indel pipelines, it broadens the neoantigen candidate repertoire and generates ranked candidates with interpretable evidence to facilitate downstream prioritization and decision-making.
PMID:41892252 | PMC:PMC13024079 | DOI:10.3390/biology15060492
-
Journal of Medical Internet Research
-
Suicidal Thoughts and Behaviors Among Chinese Adolescents in Relation to Negative Life Events, Internet Addiction, and Sexual Abuse: Cross-Sectional Study
Background: Increasing suicidal thoughts and behaviors (STB) among adolescents raise social concerns and have a well-recognized association with sexual abuse (SA). However, research regarding the mechanisms explaining the association between SA and STB remains limited. Objective: This study aims to examine the chained mediating effects of negative life events (NLE) and internet addiction (IA) between SA and STB among adolescents in China. Methods: This cross-sectional study used data from the Sc
Suicidal Thoughts and Behaviors Among Chinese Adolescents in Relation to Negative Life Events, Internet Addiction, and Sexual Abuse: Cross-Sectional Study
-
(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
-
Spatial Omics in Gastrointestinal Oncology: Recent Advances, Therapeutic Insights, and Clinical Translation
J Cancer. 2026 Jan 30;17(3):515-523. doi: 10.7150/jca.127381. eCollection 2026.ABSTRACTGastrointestinal (GI) cancers remain a leading cause of cancer-related morbidity and mortality worldwide, largely due to their molecular heterogeneity, complex tumor microenvironment (TME), and variable treatment responses. In recent years, the emergence of spatially resolved omics technologies-encompassing spatial transcriptomics, proteomics, metabolomics, and epigenomics-has revolutionized the ability to int
Spatial Omics in Gastrointestinal Oncology: Recent Advances, Therapeutic Insights, and Clinical Translation
J Cancer. 2026 Jan 30;17(3):515-523. doi: 10.7150/jca.127381. eCollection 2026.
ABSTRACT
Gastrointestinal (GI) cancers remain a leading cause of cancer-related morbidity and mortality worldwide, largely due to their molecular heterogeneity, complex tumor microenvironment (TME), and variable treatment responses. In recent years, the emergence of spatially resolved omics technologies-encompassing spatial transcriptomics, proteomics, metabolomics, and epigenomics-has revolutionized the ability to interrogate tumor architecture with unprecedented resolution. These methods enable precise mapping of cellular and molecular interactions within intact tissue contexts, thereby uncovering spatially defined niches that influence tumor progression, immune evasion, and therapeutic resistance. In GI malignancies such as colorectal, gastric, and esophageal cancers, spatial omics have provided critical insights into cancer-stromal-immune crosstalk, identified predictive biomarkers for immunotherapy and targeted agents, and guided the development of novel therapeutic strategies. This review synthesizes the latest advances in spatial omics applied to GI oncology over the past five years, with an emphasis on their integration into early diagnosis, treatment stratification, and real-time monitoring of therapeutic efficacy. We also discuss current challenges, including standardization, data integration, and clinical validation, as well as future directions for incorporating spatial profiling into routine oncology practice. By bridging the gap between bench discoveries and bedside applications, spatial omics hold transformative potential for achieving truly personalized treatment in gastrointestinal cancers.
PMID:41869445 | PMC:PMC13003551 | DOI:10.7150/jca.127381
-
Nature - Issue - nature.com science feeds
-
Assembly of helper NLR resistosome clusters upon activation of a coiled-coil NLR
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10215-1SUMM2, a coiled-coil NLR, promotes the assembly of higher-order resistosome clusters to initiate cell death in plants.
Assembly of helper NLR resistosome clusters upon activation of a coiled-coil NLR
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10215-1
SUMM2, a coiled-coil NLR, promotes the assembly of higher-order resistosome clusters to initiate cell death in plants.-
cs.AI, q-bio.NC updates on arXiv.org
-
Task learning increases information redundancy of neural responses in macaque visual cortex
arXiv:2603.07369v1 Announce Type: new Abstract: How does the brain optimize sensory information for decision-making in new tasks? One hypothesis suggests learning reduces redundancy in neural representations to improve efficiency, while another, based on Bayesian inference, predicts learning increases redundancy by distributing information across neurons. We tested these hypotheses by tracking population responses in macaque cortical area V4 as monkeys learned visual discrimination tasks. We fo
Task learning increases information redundancy of neural responses in macaque visual cortex
-
cs.AI, q-bio.NC updates on arXiv.org
-
Merlin: A Computed Tomography Vision-Language Foundation Model and Dataset
arXiv:2406.06512v2 Announce Type: replace-cross Abstract: The large volume of abdominal computed tomography (CT) scans coupled with the shortage of radiologists have intensified the need for automated medical image analysis tools. Previous state-of-the-art approaches for automated analysis leverage vision-language models (VLMs) that jointly model images and radiology reports. However, current medical VLMs are generally limited to 2D images and short reports. Here to overcome these shortcomings
Merlin: A Computed Tomography Vision-Language Foundation Model and Dataset
-
cs.AI, q-bio.NC updates on arXiv.org
-
Towards Personalized Deep Research: Benchmarks and Evaluations
arXiv:2509.25106v3 Announce Type: replace-cross Abstract: Deep Research Agents (DRAs) can autonomously conduct complex investigations and generate comprehensive reports, demonstrating strong real-world potential. However, existing evaluations mostly rely on close-ended benchmarks, while open-ended deep research benchmarks remain scarce and typically neglect personalized scenarios. To bridge this gap, we introduce Personalized Deep Research Bench (PDR-Bench), the first benchmark for evaluating p
Towards Personalized Deep Research: Benchmarks and Evaluations
-
cs.AI, q-bio.NC updates on arXiv.org
-
Rigidity-Aware Geometric Pretraining for Protein Design and Conformational Ensembles
arXiv:2603.02406v1 Announce Type: cross Abstract: Generative models have recently advanced $\textit{de novo}$ protein design by learning the statistical regularities of natural structures. However, current approaches face three key limitations: (1) Existing methods cannot jointly learn protein geometry and design tasks, where pretraining can be a solution; (2) Current pretraining methods mostly rely on local, non-rigid atomic representations for property prediction downstream tasks, limiting gl
Rigidity-Aware Geometric Pretraining for Protein Design and Conformational Ensembles
-
cs.AI, q-bio.NC updates on arXiv.org
-
Skywork-Reward-V2: Scaling Preference Data Curation via Human-AI Synergy
arXiv:2507.01352v3 Announce Type: replace-cross Abstract: Despite the critical role of reward models (RMs) in Reinforcement Learning from Human Feedback (RLHF), current state-of-the-art open RMs perform poorly on most existing evaluation benchmarks, failing to capture nuanced human preferences. We hypothesize that this brittleness stems primarily from limitations in preference datasets, which are often narrowly scoped, synthetically labeled, or lack rigorous quality control. To address these ch
Skywork-Reward-V2: Scaling Preference Data Curation via Human-AI Synergy
-
cs.AI, q-bio.NC updates on arXiv.org
-
ScaleDoc: Scaling LLM-based Predicates over Large Document Collections
arXiv:2509.12610v2 Announce Type: replace-cross Abstract: Predicates are foundational components in data analysis systems. However, modern workloads increasingly involve unstructured documents, which demands semantic understanding, beyond traditional value-based predicates. Given enormous documents and ad-hoc queries, while Large Language Models (LLMs) demonstrate powerful zero-shot capabilities, their high inference cost leads to unacceptable overhead. Therefore, we introduce \textsc{ScaleDoc}
ScaleDoc: Scaling LLM-based Predicates over Large Document Collections
-
cs.AI, q-bio.NC updates on arXiv.org
-
AgentCAT: An LLM Agent for Extracting and Analyzing Catalytic Reaction Data from Chemical Engineering Literature
arXiv:2602.18479v1 Announce Type: cross Abstract: This paper presents a large language model (LLM) agent named AgentCAT, which extracts and analyzes catalytic reaction data from chemical engineering papers, %and supports natural language based interactive analysis of the extracted data. AgentCAT serves as an alternative to overcome the long-standing data bottleneck in chemical engineering field, and its natural language based interactive data analysis functionality is friendly to the community.
AgentCAT: An LLM Agent for Extracting and Analyzing Catalytic Reaction Data from Chemical Engineering Literature
-
cs.AI, q-bio.NC updates on arXiv.org
-
EIDOS: Latent-Space Predictive Learning for Time Series Foundation Models
arXiv:2602.14024v1 Announce Type: cross Abstract: Most time series foundation models are pretrained by directly predicting future observations, which often yields weakly structured latent representations that capture surface noise rather than coherent and predictable temporal dynamics. In this work, we introduce EIDOS, a foundation model family that shifts pretraining from future value prediction to latent-space predictive learning. We train a causal Transformer to predict the evolution of late
EIDOS: Latent-Space Predictive Learning for Time Series Foundation Models
-
cs.AI, q-bio.NC updates on arXiv.org
-
OmniVideoBench: Towards Audio-Visual Understanding Evaluation for Omni MLLMs
arXiv:2510.10689v2 Announce Type: replace Abstract: Recent advances in multimodal large language models (MLLMs) have demonstrated substantial potential in video understanding. However, existing benchmarks fail to comprehensively evaluate synergistic reasoning capabilities across audio and visual modalities, often neglecting either one of the modalities or integrating them in a logically inconsistent manner. To bridge this gap, we introduce OmniVideoBench, a large-scale and rigorously designed b
OmniVideoBench: Towards Audio-Visual Understanding Evaluation for Omni MLLMs
-
cs.AI, q-bio.NC updates on arXiv.org
-
Vision-Based Early Fault Diagnosis and Self-Recovery for Strawberry Harvesting Robots
arXiv:2601.02085v2 Announce Type: replace-cross Abstract: Strawberry harvesting robots faced persistent challenges such as low integration of visual perception, fruit-gripper misalignment, empty grasping/misgrasp, and strawberry slippage from the gripper due to insufficient gripping force, all of which compromised harvesting stability and efficiency in orchard environments. To overcome these issues, this paper proposed a visual fault diagnosis and self-recovery framework that integrated multi-t