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Gene regulatory landscape dissected by single-cell four-omics sequencing

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10322-z

Combining single-cell parallel profiling of genome conformation, histone modifications, chromatin accessibility and gene expression reveals dynamics and intranuclear spatial clustering of epigenome profiles, enabling sophisticated analysis of the regulatory landscape across cell types and tissues.

DropVLA: An Action-Level Backdoor Attack on Vision-Language-Action Models

arXiv:2510.10932v4 Announce Type: replace-cross Abstract: Vision-Language-Action (VLA) models map multimodal perception and language instructions to executable robot actions, making them particularly vulnerable to behavioral backdoor manipulation: a hidden trigger introduced during training can induce unintended physical actions while nominal task performance remains intact. Prior work on VLA backdoors primarily studies untargeted attacks or task-level hijacking, leaving fine-grained control over individual actions largely unexplored. In this work, we present DropVLA, an action-level backdoor attack that forces a reusable action primitive (e.g., open_gripper) to execute at attacker-chosen decision points under a realistic pipeline-black-box setting with limited data-poisoning access, using a window-consistent relabeling scheme for chunked fine-tuning. On OpenVLA-7B evaluated with LIBERO, vision-only poisoning achieves 98.67%-99.83% attack success rate (ASR) with only 0.31% poisoned episodes while preserving 98.50%-99.17% clean-task retention, and successfully triggers the targeted action within 25 control steps at 500 Hz (0.05 s). Text-only triggers are unstable at low poisoning budgets, and combining text with vision provides no consistent ASR improvement over vision-only attacks. The backdoor remains robust to moderate trigger variations and transfers across evaluation suites (96.27%, 99.09%), whereas text-only largely fails (0.72%). We further validate physical-world feasibility on a 7-DoF Franka arm with pi0-fast, demonstrating non-trivial attack efficacy under camera-relative motion that induces image-plane trigger drift. These results reveal that VLA models can be covertly steered at the granularity of safety-critical actions with minimal poisoning and without observable degradation of nominal performance.

Step 3.5 Flash: Open Frontier-Level Intelligence with 11B Active Parameters

arXiv:2602.10604v2 Announce Type: replace-cross Abstract: We introduce Step 3.5 Flash, a sparse Mixture-of-Experts (MoE) model that bridges frontier-level agentic intelligence and computational efficiency. We focus on what matters most when building agents: sharp reasoning and fast, reliable execution. Step 3.5 Flash pairs a 196B-parameter foundation with 11B active parameters for efficient inference. It is optimized with interleaved 3:1 sliding-window/full attention and Multi-Token Prediction (MTP-3) to reduce the latency and cost of multi-round agentic interactions. To reach frontier-level intelligence, we design a scalable reinforcement learning framework that combines verifiable signals with preference feedback, while remaining stable under large-scale off-policy training, enabling consistent self-improvement across mathematics, code, and tool use. Step 3.5 Flash demonstrates strong performance across agent, coding, and math tasks, achieving 85.4% on IMO-AnswerBench, 86.4% on LiveCodeBench-v6 (2024.08-2025.05), 88.2% on tau2-Bench, 69.0% on BrowseComp (with context management), and 51.0% on Terminal-Bench 2.0, comparable to frontier models such as GPT-5.2 xHigh and Gemini 3.0 Pro. By redefining the efficiency frontier, Step 3.5 Flash provides a high-density foundation for deploying sophisticated agents in real-world industrial environments.
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