arXiv:2603.23447v1 Announce Type: cross Abstract: While multi-modality large language models excel in object-centric or indoor scenarios, scaling them to 3D city-scale environments remains a formidable challenge. To bridge this gap, we propose 3DCity-LLM, a unified framework designed for 3D city-scale vision-language perception and understanding. 3DCity-LLM employs a coarse-to-fine feature encoding strategy comprising three parallel branches for target object, inter-object relationship, and global scene. To facilitate large-scale training, we introduce 3DCity-LLM-1.2M dataset that comprises approximately 1.2 million high-quality samples across seven representative task categories, ranging from fine-grained object analysis to multi-faceted scene planning. This strictly quality-controlled dataset integrates explicit 3D numerical information and diverse user-oriented simulations, enriching the question-answering diversity and realism of urban scenarios. Furthermore, we apply a multi-dimensional protocol based on text-similarity metrics and LLM-based semantic assessment to ensure faithful and comprehensive evaluations for all methods. Extensive experiments on two benchmarks demonstrate that 3DCity-LLM significantly outperforms existing state-of-the-art methods, offering a promising and meaningful direction for advancing spatial reasoning and urban intelligence. The source code and dataset are available at https://github.com/SYSU-3DSTAILab/3D-City-LLM.

arXiv:2603.12581v1 Announce Type: cross Abstract: Although diffusion models have achieved remarkable progress in multi-modal magnetic resonance imaging (MRI) translation tasks, existing methods still tend to suffer from anatomical inconsistencies or degraded texture details when handling arbitrary missing-modality scenarios. To address these issues, we propose a latent diffusion-based multi-modal MRI translation framework, termed MSG-LDM. By leveraging the available modalities, the proposed method infers complete structural information, which preserves reliable boundary details. Specifically, we introduce a style--structure disentanglement mechanism in the latent space, which explicitly separates modality-specific style features from shared structural representations, and jointly models low-frequency anatomical layouts and high-frequency boundary details in a multi-scale feature space. During the structure disentanglement stage, high-frequency structural information is explicitly incorporated to enhance feature representations, guiding the model to focus on fine-grained structural cues while learning modality-invariant low-frequency anatomical representations. Furthermore, to reduce interference from modality-specific styles and improve the stability of structure representations, we design a style consistency loss and a structure-aware loss. Extensive experiments on the BraTS2020 and WMH datasets demonstrate that the proposed method outperforms existing MRI synthesis approaches, particularly in reconstructing complete structures. The source code is publicly available at https://github.com/ziyi-start/MSG-LDM.

Nature Cancer, Published online: 05 March 2026; doi:10.1038/s43018-026-01135-0

Dong and colleagues report that blockade of T cell-expressed cytotoxic and regulatory T cell molecule results in selective mitigation of immune-related toxicities without affecting antitumor efficacy of immune checkpoint inhibitors.

arXiv:2512.15829v2 Announce Type: replace-cross Abstract: Working memory enables the brain to integrate transient information for rapid decision-making. Artificial networks typically replicate this via recurrent or parallel architectures, yet incur high energy costs and noise sensitivity. Here we report IPNet, a hardware-software co-designed neuromorphic architecture realizing human-like working memory via neuronal intrinsic plasticity. Exploiting Joule-heating dynamics of Magnetic Tunnel Junctions (MTJs), IPNet physically emulates biological memory volatility. The memory behavior of the proposed architecture shows similar trends in n-back, free recall and memory interference tasks to that of reported human subjects. Implemented exclusively with MTJ neurons, the architecture with human-like working memory achieves 99.65% accuracy on 11-class DVS gesture datasets and maintains 99.48% on a novel 22-class time-reversed benchmark, outperforming RNN, LSTM, and 2+1D CNN baselines sharing identical backbones. For autonomous driving (DDD-20), IPNet reduces steering prediction error by 14.4% compared to ResNet-LSTM. Architecturally, we identify a 'Memory-at-the-Frontier' effect where performance is maximized at the sensing interface, validating a bio-plausible near-sensor processing paradigm. Crucially, all results rely on raw parameters from fabricated devices without optimization. Hardware-in-the-loop validation confirms the system's physical realizability. Separately, energy analysis reveals a reduction in memory power of 2,874x compared to LSTMs and 90,920x versus parallel 3D-CNNs. This capacitor-free design enables a compact ~1.5um2 footprint (28 nm CMOS): a >20-fold reduction over standard LIF neurons. Ultimately, we demonstrate that instantiating human-like working memory via intrinsic neuronal plasticity endows neural networks with the dual biological advantages of superior dynamic vision processing and minimal metabolic cost.