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cs.AI, q-bio.NC updates on arXiv.org
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InCoder-32B: Code Foundation Model for Industrial Scenarios
arXiv:2603.16790v3 Announce Type: replace-cross Abstract: Recent code large language models have achieved remarkable progress on general programming tasks. Nevertheless, their performance degrades significantly in industrial scenarios that require reasoning about hardware semantics, specialized language constructs, and strict resource constraints. To address these challenges, we introduce InCoder-32B (Industrial-Coder-32B), the first 32B-parameter code foundation model unifying code intelligenc
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy
Nat Commun. 2026 Mar 23. doi: 10.1038/s41467-026-70798-1. Online ahead of print.ABSTRACTGlioblastoma (GBM) remains a lethal brain tumor due to therapy resistance. While autophagy contributes to temozolomide (TMZ) resistance, its regulation is incompletely understood. This study investigates the role of replication factor RFC4, which is associated with poor prognosis and TMZ resistance in GBM. Multi-omics analyses and molecular experiments reveal that TMZ-induced chromatin accessibility enables t
RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy
Nat Commun. 2026 Mar 23. doi: 10.1038/s41467-026-70798-1. Online ahead of print.
ABSTRACT
Glioblastoma (GBM) remains a lethal brain tumor due to therapy resistance. While autophagy contributes to temozolomide (TMZ) resistance, its regulation is incompletely understood. This study investigates the role of replication factor RFC4, which is associated with poor prognosis and TMZ resistance in GBM. Multi-omics analyses and molecular experiments reveal that TMZ-induced chromatin accessibility enables transcription factor YY1 to bind the RFC4 promoter and upregulate its expression. RFC4, in turn, stabilizes the kinase STK38, which is essential for autophagosome formation. The RFC4-STK38 interaction facilitates BECN1 recruitment, thereby activating autophagy. Phosphorylation of STK38 at T444 stabilizes this complex, whereas a phospho-deficient mutant impairs autophagy. In vivo, RFC4 overexpression confers TMZ resistance, reversible by autophagy inhibition. Thus, our findings identify the RFC4-STK38-BECN1 axis as a mechanism underlying TMZ resistance and a potential target for precision therapy in GBM.
PMID:41872171 | DOI:10.1038/s41467-026-70798-1
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Nature - Issue - nature.com science feeds
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Direct conversion from alkenes to alkynes
Nature, Published online: 16 March 2026; doi:10.1038/s41586-026-10372-3Direct conversion from alkenes to alkynes
Direct conversion from alkenes to alkynes
Nature, Published online: 16 March 2026; doi:10.1038/s41586-026-10372-3
Direct conversion from alkenes to alkynes-
cs.AI, q-bio.NC updates on arXiv.org
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DARC: Disagreement-Aware Alignment via Risk-Constrained Decoding
arXiv:2603.08145v1 Announce Type: cross Abstract: Preference-based alignment methods (e.g., RLHF, DPO) typically optimize a single scalar objective, implicitly averaging over heterogeneous human preferences. In practice, systematic annotator and user-group disagreement makes mean-reward maximization brittle and susceptible to proxy over-optimization. We propose **Disagreement-Aware Alignment via Risk-Constrained Decoding (DARC)**, a retraining-free inference-time method that frames response sel
DARC: Disagreement-Aware Alignment via Risk-Constrained Decoding
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cs.AI, q-bio.NC updates on arXiv.org
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Efficient Semi-Supervised Adversarial Training via Latent Clustering-Based Data Reduction
arXiv:2501.10466v4 Announce Type: replace-cross Abstract: Learning robust models under adversarial settings is widely recognized as requiring a considerably large number of training samples. Recent work proposes semi-supervised adversarial training (SSAT), which utilizes external unlabeled or synthetically generated data and is currently the state of the art. However, SSAT requires substantial extra data to attain high robustness, resulting in prolonged training time and increased memory usage.
Efficient Semi-Supervised Adversarial Training via Latent Clustering-Based Data Reduction
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cs.AI, q-bio.NC updates on arXiv.org
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Discern Truth from Falsehood: Reducing Over-Refusal via Contrastive Refinement
arXiv:2603.03323v1 Announce Type: cross Abstract: Large language models (LLMs) aligned for safety often suffer from over-refusal, the tendency to reject seemingly toxic or benign prompts by misclassifying them as toxic. This behavior undermines models' helpfulness and restricts usability in sensitive or nuanced contexts. While prior work has proposed mitigation strategies such as data augmentation and activation steering, these approaches often face a trade-off: reducing over-refusal typically