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Stabilizing Unsupervised Self-Evolution of MLLMs via Continuous Softened Retracing reSampling

arXiv:2604.03647v1 Announce Type: cross Abstract: In the unsupervised self-evolution of Multimodal Large Language Models, the quality of feedback signals during post-training is pivotal for stable and effective learning. However, existing self-evolution methods predominantly rely on majority voting to select the most frequent output as the pseudo-golden answer, which may stem from the model's intrinsic biases rather than guaranteeing the objective correctness of the reasoning paths. To counteract the degradation, we propose \textbf{C}ontinuous \textbf{S}oftened \textbf{R}etracing re\textbf{S}ampling (\textbf{CSRS}) in MLLM self-evolution. Specifically, we introduce a Retracing Re-inference Mechanism (\textbf{RRM}) that the model re-inferences from anchor points to expand the exploration of long-tail reasoning paths. Simultaneously, we propose Softened Frequency Reward (\textbf{SFR}), which replaces binary rewards with continuous signals, calibrating reward based on the answers' frequency across sampled reasoning sets. Furthermore, incorporated with Visual Semantic Perturbation (\textbf{VSP}), CSRS ensures the model prioritizes mathematical logic over visual superficiality. Experimental results demonstrate that CSRS significantly enhances the reasoning performance of Qwen2.5-VL-7B on benchmarks such as MathVision. We achieve state-of-the-art (SOTA) results in unsupervised self-evolution on geometric tasks. Our code is avaible at https://github.com/yyy195/CSRS.

A Self-Evolving Defect Detection Framework for Industrial Photovoltaic Systems

arXiv:2603.14869v2 Announce Type: replace Abstract: Reliable photovoltaic (PV) power generation requires timely detection of module defects that may reduce energy yield, accelerate degradation, and increase lifecycle operation and maintenance costs during field operation. Electroluminescence (EL) imaging has therefore been widely adopted for PV module inspection. However, automated defect detection in real operational environments remains challenging due to heterogeneous module geometries, low-resolution imaging conditions, subtle defect morphology, long-tailed defect distributions, and continual data shifts introduced by evolving inspection and labeling processes. These factors significantly limit the robustness and long-term maintainability of conventional deep-learning inspection pipelines. To address these challenges, this paper proposes SEPDD, a Self-Evolving Photovoltaic Defect Detection framework designed for evolving industrial PV inspection scenarios. SEPDD integrates automated model optimization with a continual self-evolving learning mechanism, enabling the inspection system to progressively adapt to distribution shifts and newly emerging defect patterns during long-term deployment. Experiments conducted on both a public PV defect benchmark and a private industrial EL dataset demonstrate the effectiveness of the proposed framework. Both datasets exhibit severe class imbalance and significant domain shift. SEPDD achieves a leading mAP50 of 91.4% on the public dataset and 49.5% on the private dataset. It surpasses the autonomous baseline by 14.8% and human experts by 4.7% on the public dataset, and by 4.9% and 2.5%, respectively, on the private dataset.

Advances in Metabolic Reprogramming and Immune Regulatory Mechanisms in Lung Cancer

Oncol Res. 2026 Mar 23;34(4):11. doi: 10.32604/or.2026.076176. eCollection 2026.

ABSTRACT

Lung cancer remains the leading cause of cancer-related mortality worldwide, primarily driven by metabolic reprogramming and immune evasion mechanisms within tumor cells. To adapt to the nutrient-deprived tumor microenvironment (TME), lung cancer cells undergo profound metabolic reprogramming, characterized by enhanced glycolysis (the Warburg effect), increased glutamine dependency (mediated by GLS1), and accelerated lipid synthesis (involving enzymes such as FASN). These metabolic alterations not only remodel the TME but also dampen antitumor immune responses by promoting immunosuppressive cell populations (e.g., Tregs and M2 macrophages) and inhibiting effector functions of CD8+ T cells and natural killer (NK) cells. Critically, a bidirectional crosstalk operates between tumor cell metabolism and the immunosuppressive TME: metabolic reprogramming drives immune suppression through metabolite accumulation, whereas the immunosuppressive TME, in turn, promotes tumor cell adaptability-thus forming a positive feedback loop that reinforces immune evasion and therapy resistance. This review elucidates key molecular pathways governing metabolic reprogramming in lung cancer-spanning glucose, amino acid, and lipid metabolism-and their dynamic crosstalk with immune regulation, including epigenetic modifications and non-coding RNA-mediated mechanisms. Additionally, it evaluates emerging therapeutic strategies targeting the metabolic-immune axis, such as inhibitors of HK2 or GLS1 combined with anti-PD-1/PD-L1 agents, which aim to reverse immunosuppression and improve clinical outcomes. By synthesizing recent advances, this work provides a theoretical framework for precision oncology interventions, highlighting the potential of metabolic immunotherapies and future directions integrating AI and multi-omics data to overcome resistance in lung cancer.

PMID:41930159 | PMC:PMC13040304 | DOI:10.32604/or.2026.076176

Advances in Metabolic Reprogramming and Immune Regulatory Mechanisms in Lung Cancer

3 April 2026 at 18:00

Oncol Res. 2026 Mar 23;34(4):11. doi: 10.32604/or.2026.076176. eCollection 2026.

ABSTRACT

Lung cancer remains the leading cause of cancer-related mortality worldwide, primarily driven by metabolic reprogramming and immune evasion mechanisms within tumor cells. To adapt to the nutrient-deprived tumor microenvironment (TME), lung cancer cells undergo profound metabolic reprogramming, characterized by enhanced glycolysis (the Warburg effect), increased glutamine dependency (mediated by GLS1), and accelerated lipid synthesis (involving enzymes such as FASN). These metabolic alterations not only remodel the TME but also dampen antitumor immune responses by promoting immunosuppressive cell populations (e.g., Tregs and M2 macrophages) and inhibiting effector functions of CD8+ T cells and natural killer (NK) cells. Critically, a bidirectional crosstalk operates between tumor cell metabolism and the immunosuppressive TME: metabolic reprogramming drives immune suppression through metabolite accumulation, whereas the immunosuppressive TME, in turn, promotes tumor cell adaptability-thus forming a positive feedback loop that reinforces immune evasion and therapy resistance. This review elucidates key molecular pathways governing metabolic reprogramming in lung cancer-spanning glucose, amino acid, and lipid metabolism-and their dynamic crosstalk with immune regulation, including epigenetic modifications and non-coding RNA-mediated mechanisms. Additionally, it evaluates emerging therapeutic strategies targeting the metabolic-immune axis, such as inhibitors of HK2 or GLS1 combined with anti-PD-1/PD-L1 agents, which aim to reverse immunosuppression and improve clinical outcomes. By synthesizing recent advances, this work provides a theoretical framework for precision oncology interventions, highlighting the potential of metabolic immunotherapies and future directions integrating AI and multi-omics data to overcome resistance in lung cancer.

PMID:41930159 | PMC:PMC13040304 | DOI:10.32604/or.2026.076176

CORAL: Towards Autonomous Multi-Agent Evolution for Open-Ended Discovery

arXiv:2604.01658v1 Announce Type: new Abstract: Large language model (LLM)-based evolution is a promising approach for open-ended discovery, where progress requires sustained search and knowledge accumulation. Existing methods still rely heavily on fixed heuristics and hard-coded exploration rules, which limit the autonomy of LLM agents. We present CORAL, the first framework for autonomous multi-agent evolution on open-ended problems. CORAL replaces rigid control with long-running agents that explore, reflect, and collaborate through shared persistent memory, asynchronous multi-agent execution, and heartbeat-based interventions. It also provides practical safeguards, including isolated workspaces, evaluator separation, resource management, and agent session and health management. Evaluated on diverse mathematical, algorithmic, and systems optimization tasks, CORAL sets new state-of-the-art results on 10 tasks, achieving 3-10 times higher improvement rates with far fewer evaluations than fixed evolutionary search baselines across tasks. On Anthropic's kernel engineering task, four co-evolving agents improve the best known score from 1363 to 1103 cycles. Mechanistic analyses further show how these gains arise from knowledge reuse and multi-agent exploration and communication. Together, these results suggest that greater agent autonomy and multi-agent evolution can substantially improve open-ended discovery. Code is available at https://github.com/Human-Agent-Society/CORAL.

ATBench: A Diverse and Realistic Trajectory Benchmark for Long-Horizon Agent Safety

arXiv:2604.02022v1 Announce Type: new Abstract: Evaluating the safety of LLM-based agents is increasingly important because risks in realistic deployments often emerge over multi-step interactions rather than isolated prompts or final responses. Existing trajectory-level benchmarks remain limited by insufficient interaction diversity, coarse observability of safety failures, and weak long-horizon realism. We introduce ATBench, a trajectory-level benchmark for structured, diverse, and realistic evaluation of agent safety. ATBench organizes agentic risk along three dimensions: risk source, failure mode, and real-world harm. Based on this taxonomy, we construct trajectories with heterogeneous tool pools and a long-context delayed-trigger protocol that captures realistic risk emergence across multiple stages. The benchmark contains 1,000 trajectories (503 safe and 497 unsafe), averaging 9.01 turns and 3.95k tokens, with 1,954 invoked tools drawn from pools spanning 2,084 available tools. Data quality is supported by rule-based and LLM-based filtering plus full human audit. Experiments on frontier LLMs, open-source models, and specialized guard systems show that ATBench is challenging even for strong evaluators, while enabling taxonomy-stratified analysis, cross-benchmark comparison, and diagnosis of long-horizon failure patterns.

Accelerating Diffusion Large Language Models with SlowFast Sampling: The Three Golden Principles

arXiv:2506.10848v3 Announce Type: replace-cross Abstract: Diffusion-based language models (dLLMs) have emerged as a promising alternative to traditional autoregressive LLMs by enabling parallel token generation and significantly reducing inference latency. However, existing sampling strategies for dLLMs, such as confidence-based or semi-autoregressive decoding, often suffer from static behavior, leading to suboptimal efficiency and limited flexibility. In this paper, we propose SlowFast Sampling, a novel dynamic sampling strategy that adaptively alternates between exploratory and accelerated decoding stages. Our method is guided by three golden principles: certainty principle, convergence principle, and positional principle, which govern when and where tokens can be confidently and efficiently decoded. We further integrate our strategy with dLLM-Cache to reduce redundant computation. Extensive experiments across benchmarks and models show that SlowFast Sampling achieves up to 15.63$\times$ speedup on LLaDA with minimal accuracy drop, and up to 34.22$\times$ when combined with caching. Notably, our approach outperforms strong autoregressive baselines like LLaMA3 8B in throughput, demonstrating that well-designed sampling can unlock the full potential of dLLMs for fast and high-quality generation.

Dynamic Targetable Extracellular Vesicle Surface Proteins Monitor Depth of Response to CAR T Therapy

Res Sq [Preprint]. 2026 Mar 18:rs.3.rs-8913641. doi: 10.21203/rs.3.rs-8913641/v1.

ABSTRACT

Extracellular vesicles (EVs) represent a promising liquid biopsy platform in multiple myeloma (MM). We developed an MM EV Surface Protein Assay to quantify and dynamically monitor four MM EV subpopulations defined by targetable MM surface proteins (BCMA, CD38, GPRC5D, and CD319) across 336 serial blood samples from 45 relapsed/refractory MM (RRMM) patients treated with anti-BCMA chimeric antigen receptor (CAR) T-cell therapy. All four MM EV subpopulations significantly decreased in 43 patients with initial response, while BCMA+, GPRC5D+, and CD319+ MM EVs increased in 19 patients with progression, and antigen escape was detected by BCMA+ MM EVs. MM EV subpopulations differentiated minimal residual disease (MRD) status and complemented MRD for detecting early relapse before clinical progression. Notably, CD319+ MM EVs were early predictors of progression-free and overall survival in MRD-negative patients. This assay enables noninvasive monitoring of deep response, progression, and antigen escape, and stratifies survival in MRD-negative patients with RRMM.

PMID:41890853 | PMC:PMC13015583 | DOI:10.21203/rs.3.rs-8913641/v1

Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35

Cell Oncol (Dordr). 2026 Mar 23;49(2):60. doi: 10.1007/s13402-026-01194-6.

ABSTRACT

Glycolytic reprogramming is closely associated with the occurrence and progression of gastric cancer. Specifically, the energy derived from glucose metabolism and the cellular proteins by its intermediate products influence gastric cancer development. However, as an important branch of glucose metabolism, sialic acid metabolism and its mediated sialylation modifications remain insufficiently studied in gastric cancer, and their specific relationship with malignant tumor progression requires further exploration. This study employed a multi‑omics approach, integrating metabolomics, single‑cell RNA sequencing, and bulk RNA sequencing analyses, to investigate the metabolic landscape of gastric cancer and its associated alterations. The results indicated that sialic acid is a characteristic metabolite in malignant gastric cancer tissues. It modulates biological functions such as immune response, proliferative activity, and metabolic remodeling within gastric cancer tissues by influencing sialylation modifications. Furthermore, we identified the drug WZ35, which can inhibit the malignant proliferation of gastric cancer by targeting both sialic acid metabolism and sialylated protein modifications. We put forward a conjecture that the metabolism and modification of sialic acid promote the malignant development of gastric cancer, and we discovered that the drug WZ35 has an inhibitory effect on the sialic acid metabolism of gastric cancer.

GRAPHICAL ABSTRACT:

PMID:41870836 | PMC:PMC13009457 | DOI:10.1007/s13402-026-01194-6

Towards Self-Evolving Benchmarks: Synthesizing Agent Trajectories via Test-Time Exploration under Validate-by-Reproduce Paradigm

arXiv:2510.00415v3 Announce Type: replace Abstract: Recent advances in large language models (LLMs) and agent system designs have empowered agents with unprecedented levels of capability. However, existing agent benchmarks are showing a trend of rapid ceiling-hitting by newly developed agents, making it difficult to meet the demands for evaluating agent abilities. To address this problem, we propose the Trajectory-based Validated-by-Reproducing Agent-benchmark Complexity Evolution (TRACE) framework. This framework takes an original task from an existing benchmark and encourages agents to freely explore and evolve it into a new task with higher difficulty while recording validatable agent trajectories. The framework proceeds in three stages: (1) evolutionary proposal mining, which provides task evolution proposals through preliminary exploration and divergent thinking; (2) problem formation and free exploration, where proposals are conceptualized into feasible problem candidates and the agents then explore them freely while recording their execution trajectories; and (3) multi-level validation, which ensures that the evolved tasks are accompanied by validatable and reproducible trajectories. Experiments on the GAIA benchmark demonstrate that the TRACE framework consistently enhances task complexity while improving the reliability of correctness through validatable execution trajectories. In addition, our framework can successfully adapt to and improve reasoning datasets represented by AIME-2024. This work marks a paradigm shift from static, manually curated benchmarks to dynamic, self-evolving evaluation systems, providing a sustainable and challenging runway for agent development

When Models Judge Themselves: Unsupervised Self-Evolution for Multimodal Reasoning

arXiv:2603.21289v2 Announce Type: replace-cross Abstract: Recent progress in multimodal large language models has led to strong performance on reasoning tasks, but these improvements largely rely on high-quality annotated data or teacher-model distillation, both of which are costly and difficult to scale. To address this, we propose an unsupervised self-evolution training framework for multimodal reasoning that achieves stable performance improvements without using human-annotated answers or external reward models. For each input, we sample multiple reasoning trajectories and jointly model their within group structure. We use the Actor's self-consistency signal as a training prior, and introduce a bounded Judge based modulation to continuously reweight trajectories of different quality. We further model the modulated scores as a group level distribution and convert absolute scores into relative advantages within each group, enabling more robust policy updates. Trained with Group Relative Policy Optimization (GRPO) on unlabeled data, our method consistently improves reasoning performance and generalization on five mathematical reasoning benchmarks, offering a scalable path toward self-evolving multimodal models. The code are available at https://github.com/OPPO-Mente-Lab/LLM-Self-Judge.

In vivo generation of anti-BCMA CAR-T cells in relapsed or refractory multiple myeloma: a phase 1 study

Nature Medicine, Published online: 25 March 2026; doi:10.1038/s41591-026-04244-6

In a phase 1 trial, the in vivo generation of anti-BCMA CAR-T cells by lentiviral delivery was feasible and did not lead to dose-limiting toxicities in five patients with relapsed or refractory multiple myeloma.

Hijacking ERAD for targeted degradation of transmembrane proteins

Development of an ERAD-hijacking technology overcomes the challenges of current targeted protein degradation approaches to achieve degradation of transmembrane proteins.

PIRA-Bench: A Transition from Reactive GUI Agents to GUI-based Proactive Intent Recommendation Agents

arXiv:2603.08013v1 Announce Type: new Abstract: Current Graphical User Interface (GUI) agents operate primarily under a reactive paradigm: a user must provide an explicit instruction for the agent to execute a task. However, an intelligent AI assistant should be proactive, which is capable of anticipating user intentions directly from continuous visual inputs, such as mobile or desktop screenshots, and offering timely recommendations without explicit user prompting. Transitioning to this proactive paradigm presents significant challenges. Real-world screen activity is rarely linear; it consists of long-horizon trajectories fraught with noisy browsing, meaningless actions, and multithreaded task-switching. To address this gap, we introduce PIRA-Bench (Proactive Intent Recommendation Agent Benchmark), a novel benchmark for evaluating multimodal large language models (MLLMs) on continuous, weakly-supervised visual inputs. Unlike reactive datasets, PIRA-Bench features complex trajectories with multiple interleaved intents and noisy segments with various user profile contexts, challenging agents to detect actionable events while fitting to user preferences. Furthermore, we propose the PIRF baseline, a memory-aware, state-tracking framework that empowers general MLLMs to manage multiple task threads and handle misleading visual inputs. PIRA-Bench serves as an initial step toward robust and proactive GUI-based personal assistants.

HEARTS: Benchmarking LLM Reasoning on Health Time Series

arXiv:2603.06638v1 Announce Type: cross Abstract: The rise of large language models (LLMs) has shifted time series analysis from narrow analytics to general-purpose reasoning. Yet, existing benchmarks cover only a small set of health time series modalities and tasks, failing to reflect the diverse domains and extensive temporal dependencies inherent in real-world physiological modeling. To bridge these gaps, we introduce HEARTS (Health Reasoning over Time Series), a unified benchmark for evaluating hierarchical reasoning capabilities of LLMs over general health time series. HEARTS integrates 16 real-world datasets across 12 health domains and 20 signal modalities, and defines a comprehensive taxonomy of 110 tasks grouped into four core capabilities: Perception, Inference, Generation, and Deduction. Evaluating 14 state-of-the-art LLMs on more than 20K test samples reveals intriguing findings. First, LLMs substantially underperform specialized models, and their performance is only weakly related to general reasoning scores. Moreover, LLMs often rely on simple heuristics and struggle with multi-step temporal reasoning. Finally, performance declines with increasing temporal complexity, with similar failure modes within model families, indicating that scaling alone is insufficient. By making these gaps measurable, HEARTS provides a standardized testbed and living benchmark for developing next-generation LLM agents capable of reasoning over diverse health signals.

CCR-Bench: A Comprehensive Benchmark for Evaluating LLMs on Complex Constraints, Control Flows, and Real-World Cases

arXiv:2603.07886v1 Announce Type: cross Abstract: Enhancing the ability of large language models (LLMs) to follow complex instructions is critical for their deployment in real-world applications. However, existing evaluation methods often oversimplify instruction complexity as a mere additive combination of atomic constraints, failing to adequately capture the high-dimensional complexity arising from the intricate interplay of content and format, logical workflow control, and real-world applications. This leads to a significant gap between current evaluation practices and practical demands. To bridge this gap, we introduce CCR-Bench, a novel benchmark designed to assess LLMs' adherence to complex instructions. CCR-Bench is characterized by: (1) deep entanglement of content and formatting requirements in task specifications; (2) instructions that involve intricate task decomposition, conditional reasoning, and procedural planning; and (3) evaluation samples derived entirely from real-world industrial scenarios. Extensive experiments on CCR-Bench demonstrate that even state-of-the-art models exhibit substantial performance deficiencies, clearly quantifying the gap between current LLM capabilities and the demands of realworld instruction understanding. We believe that CCR-Bench offers a more rigorous and realistic evaluation framework, advancing the development of LLMs toward the next generation of models capable of understanding and executing complex tasks in industrial applications.

Your Agent May Misevolve: Emergent Risks in Self-evolving LLM Agents

arXiv:2509.26354v2 Announce Type: replace Abstract: Advances in Large Language Models (LLMs) have enabled a new class of self-evolving agents that autonomously improve through interaction with the environment, demonstrating strong capabilities. However, self-evolution also introduces novel risks overlooked by current safety research. In this work, we study the case where an agent's self-evolution deviates in unintended ways, leading to undesirable or even harmful outcomes. We refer to this as Misevolution. To provide a systematic investigation, we evaluate misevolution along four key evolutionary pathways: model, memory, tool, and workflow. Our empirical findings reveal that misevolution is a widespread risk, affecting agents built even on top-tier LLMs (e.g., Gemini-2.5-Pro). Different emergent risks are observed in the self-evolutionary process, such as the degradation of safety alignment after memory accumulation, or the unintended introduction of vulnerabilities in tool creation and reuse. To our knowledge, this is the first study to systematically conceptualize misevolution and provide empirical evidence of its occurrence, highlighting an urgent need for new safety paradigms for self-evolving agents. Finally, we discuss potential mitigation strategies to inspire further research on building safer and more trustworthy self-evolving agents. Our code and data are available at https://github.com/ShaoShuai0605/Misevolution . Warning: this paper includes examples that may be offensive or harmful in nature.

BoxMind: Closed-loop AI strategy optimization for elite boxing validated in the 2024 Olympics

arXiv:2601.11492v2 Announce Type: replace Abstract: Competitive sports require sophisticated tactical analysis, yet combat disciplines like boxing remain underdeveloped in AI-driven analytics due to the complexity of action dynamics and the lack of structured tactical representations. To address this, we present BoxMind, a closed-loop AI expert system validated in elite boxing competition. By defining atomic punch events with precise temporal boundaries and spatial and technical attributes, we parse match footage into 18 hierarchical technical-tactical indicators. We then propose a graph-based predictive model that fuses these explicit technical-tactical profiles with learnable, time-variant latent embeddings to capture the dynamics of boxer matchups. Modeling match outcome as a differentiable function of technical-tactical indicators, we turn winning probability gradients into executable tactical adjustments. Experiments show that the outcome prediction model achieves state-of-the-art performance, with 69.8% accuracy on BoxerGraph test set and 87.5% on Olympic matches. Using this predictive model as a foundation, the system generates strategic recommendations that demonstrate proficiency comparable to human experts. BoxMind is validated through a closed-loop deployment during the 2024 Paris Olympics, directly contributing to the Chinese National Team's historic achievement of three gold and two silver medals. BoxMind establishes a replicable paradigm for transforming unstructured video data into strategic intelligence, bridging the gap between computer vision and decision support in competitive sports. Code and data is available at https://github.com/gouba2333/BoxingWeb.
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