Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Stabilizing Unsupervised Self-Evolution of MLLMs via Continuous Softened Retracing reSampling
arXiv:2604.03647v1 Announce Type: cross Abstract: In the unsupervised self-evolution of Multimodal Large Language Models, the quality of feedback signals during post-training is pivotal for stable and effective learning. However, existing self-evolution methods predominantly rely on majority voting to select the most frequent output as the pseudo-golden answer, which may stem from the model's intrinsic biases rather than guaranteeing the objective correctness of the reasoning paths. To countera
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cs.AI, q-bio.NC updates on arXiv.org
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A Self-Evolving Defect Detection Framework for Industrial Photovoltaic Systems
arXiv:2603.14869v2 Announce Type: replace Abstract: Reliable photovoltaic (PV) power generation requires timely detection of module defects that may reduce energy yield, accelerate degradation, and increase lifecycle operation and maintenance costs during field operation. Electroluminescence (EL) imaging has therefore been widely adopted for PV module inspection. However, automated defect detection in real operational environments remains challenging due to heterogeneous module geometries, low-
A Self-Evolving Defect Detection Framework for Industrial Photovoltaic Systems
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Advances in Metabolic Reprogramming and Immune Regulatory Mechanisms in Lung Cancer
Oncol Res. 2026 Mar 23;34(4):11. doi: 10.32604/or.2026.076176. eCollection 2026.ABSTRACTLung cancer remains the leading cause of cancer-related mortality worldwide, primarily driven by metabolic reprogramming and immune evasion mechanisms within tumor cells. To adapt to the nutrient-deprived tumor microenvironment (TME), lung cancer cells undergo profound metabolic reprogramming, characterized by enhanced glycolysis (the Warburg effect), increased glutamine dependency (mediated by GLS1), and acc
Advances in Metabolic Reprogramming and Immune Regulatory Mechanisms in Lung Cancer
Oncol Res. 2026 Mar 23;34(4):11. doi: 10.32604/or.2026.076176. eCollection 2026.
ABSTRACT
Lung cancer remains the leading cause of cancer-related mortality worldwide, primarily driven by metabolic reprogramming and immune evasion mechanisms within tumor cells. To adapt to the nutrient-deprived tumor microenvironment (TME), lung cancer cells undergo profound metabolic reprogramming, characterized by enhanced glycolysis (the Warburg effect), increased glutamine dependency (mediated by GLS1), and accelerated lipid synthesis (involving enzymes such as FASN). These metabolic alterations not only remodel the TME but also dampen antitumor immune responses by promoting immunosuppressive cell populations (e.g., Tregs and M2 macrophages) and inhibiting effector functions of CD8+ T cells and natural killer (NK) cells. Critically, a bidirectional crosstalk operates between tumor cell metabolism and the immunosuppressive TME: metabolic reprogramming drives immune suppression through metabolite accumulation, whereas the immunosuppressive TME, in turn, promotes tumor cell adaptability-thus forming a positive feedback loop that reinforces immune evasion and therapy resistance. This review elucidates key molecular pathways governing metabolic reprogramming in lung cancer-spanning glucose, amino acid, and lipid metabolism-and their dynamic crosstalk with immune regulation, including epigenetic modifications and non-coding RNA-mediated mechanisms. Additionally, it evaluates emerging therapeutic strategies targeting the metabolic-immune axis, such as inhibitors of HK2 or GLS1 combined with anti-PD-1/PD-L1 agents, which aim to reverse immunosuppression and improve clinical outcomes. By synthesizing recent advances, this work provides a theoretical framework for precision oncology interventions, highlighting the potential of metabolic immunotherapies and future directions integrating AI and multi-omics data to overcome resistance in lung cancer.
PMID:41930159 | PMC:PMC13040304 | DOI:10.32604/or.2026.076176
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Omics In Lung
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Advances in Metabolic Reprogramming and Immune Regulatory Mechanisms in Lung Cancer
Oncol Res. 2026 Mar 23;34(4):11. doi: 10.32604/or.2026.076176. eCollection 2026.ABSTRACTLung cancer remains the leading cause of cancer-related mortality worldwide, primarily driven by metabolic reprogramming and immune evasion mechanisms within tumor cells. To adapt to the nutrient-deprived tumor microenvironment (TME), lung cancer cells undergo profound metabolic reprogramming, characterized by enhanced glycolysis (the Warburg effect), increased glutamine dependency (mediated by GLS1), and acc
Advances in Metabolic Reprogramming and Immune Regulatory Mechanisms in Lung Cancer
Oncol Res. 2026 Mar 23;34(4):11. doi: 10.32604/or.2026.076176. eCollection 2026.
ABSTRACT
Lung cancer remains the leading cause of cancer-related mortality worldwide, primarily driven by metabolic reprogramming and immune evasion mechanisms within tumor cells. To adapt to the nutrient-deprived tumor microenvironment (TME), lung cancer cells undergo profound metabolic reprogramming, characterized by enhanced glycolysis (the Warburg effect), increased glutamine dependency (mediated by GLS1), and accelerated lipid synthesis (involving enzymes such as FASN). These metabolic alterations not only remodel the TME but also dampen antitumor immune responses by promoting immunosuppressive cell populations (e.g., Tregs and M2 macrophages) and inhibiting effector functions of CD8+ T cells and natural killer (NK) cells. Critically, a bidirectional crosstalk operates between tumor cell metabolism and the immunosuppressive TME: metabolic reprogramming drives immune suppression through metabolite accumulation, whereas the immunosuppressive TME, in turn, promotes tumor cell adaptability-thus forming a positive feedback loop that reinforces immune evasion and therapy resistance. This review elucidates key molecular pathways governing metabolic reprogramming in lung cancer-spanning glucose, amino acid, and lipid metabolism-and their dynamic crosstalk with immune regulation, including epigenetic modifications and non-coding RNA-mediated mechanisms. Additionally, it evaluates emerging therapeutic strategies targeting the metabolic-immune axis, such as inhibitors of HK2 or GLS1 combined with anti-PD-1/PD-L1 agents, which aim to reverse immunosuppression and improve clinical outcomes. By synthesizing recent advances, this work provides a theoretical framework for precision oncology interventions, highlighting the potential of metabolic immunotherapies and future directions integrating AI and multi-omics data to overcome resistance in lung cancer.
PMID:41930159 | PMC:PMC13040304 | DOI:10.32604/or.2026.076176
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cs.AI, q-bio.NC updates on arXiv.org
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CORAL: Towards Autonomous Multi-Agent Evolution for Open-Ended Discovery
arXiv:2604.01658v1 Announce Type: new Abstract: Large language model (LLM)-based evolution is a promising approach for open-ended discovery, where progress requires sustained search and knowledge accumulation. Existing methods still rely heavily on fixed heuristics and hard-coded exploration rules, which limit the autonomy of LLM agents. We present CORAL, the first framework for autonomous multi-agent evolution on open-ended problems. CORAL replaces rigid control with long-running agents that e
CORAL: Towards Autonomous Multi-Agent Evolution for Open-Ended Discovery
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cs.AI, q-bio.NC updates on arXiv.org
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ATBench: A Diverse and Realistic Trajectory Benchmark for Long-Horizon Agent Safety
arXiv:2604.02022v1 Announce Type: new Abstract: Evaluating the safety of LLM-based agents is increasingly important because risks in realistic deployments often emerge over multi-step interactions rather than isolated prompts or final responses. Existing trajectory-level benchmarks remain limited by insufficient interaction diversity, coarse observability of safety failures, and weak long-horizon realism. We introduce ATBench, a trajectory-level benchmark for structured, diverse, and realistic
ATBench: A Diverse and Realistic Trajectory Benchmark for Long-Horizon Agent Safety
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cs.AI, q-bio.NC updates on arXiv.org
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Accelerating Diffusion Large Language Models with SlowFast Sampling: The Three Golden Principles
arXiv:2506.10848v3 Announce Type: replace-cross Abstract: Diffusion-based language models (dLLMs) have emerged as a promising alternative to traditional autoregressive LLMs by enabling parallel token generation and significantly reducing inference latency. However, existing sampling strategies for dLLMs, such as confidence-based or semi-autoregressive decoding, often suffer from static behavior, leading to suboptimal efficiency and limited flexibility. In this paper, we propose SlowFast Samplin
Accelerating Diffusion Large Language Models with SlowFast Sampling: The Three Golden Principles
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Nature - Issue - nature.com science feeds
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Author Correction: Signatures of ambient pressure superconductivity in thin film La<sub>3</sub>Ni<sub>2</sub>O<sub>7</sub>
Nature, Published online: 31 March 2026; doi:10.1038/s41586-026-10335-8Author Correction: Signatures of ambient pressure superconductivity in thin film La3Ni2O7
Author Correction: Signatures of ambient pressure superconductivity in thin film La<sub>3</sub>Ni<sub>2</sub>O<sub>7</sub>
Nature, Published online: 31 March 2026; doi:10.1038/s41586-026-10335-8
Author Correction: Signatures of ambient pressure superconductivity in thin film La3Ni2O7-
MRD
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Dynamic Targetable Extracellular Vesicle Surface Proteins Monitor Depth of Response to CAR T Therapy
Res Sq [Preprint]. 2026 Mar 18:rs.3.rs-8913641. doi: 10.21203/rs.3.rs-8913641/v1.ABSTRACTExtracellular vesicles (EVs) represent a promising liquid biopsy platform in multiple myeloma (MM). We developed an MM EV Surface Protein Assay to quantify and dynamically monitor four MM EV subpopulations defined by targetable MM surface proteins (BCMA, CD38, GPRC5D, and CD319) across 336 serial blood samples from 45 relapsed/refractory MM (RRMM) patients treated with anti-BCMA chimeric antigen receptor (CA
Dynamic Targetable Extracellular Vesicle Surface Proteins Monitor Depth of Response to CAR T Therapy
Res Sq [Preprint]. 2026 Mar 18:rs.3.rs-8913641. doi: 10.21203/rs.3.rs-8913641/v1.
ABSTRACT
Extracellular vesicles (EVs) represent a promising liquid biopsy platform in multiple myeloma (MM). We developed an MM EV Surface Protein Assay to quantify and dynamically monitor four MM EV subpopulations defined by targetable MM surface proteins (BCMA, CD38, GPRC5D, and CD319) across 336 serial blood samples from 45 relapsed/refractory MM (RRMM) patients treated with anti-BCMA chimeric antigen receptor (CAR) T-cell therapy. All four MM EV subpopulations significantly decreased in 43 patients with initial response, while BCMA+, GPRC5D+, and CD319+ MM EVs increased in 19 patients with progression, and antigen escape was detected by BCMA+ MM EVs. MM EV subpopulations differentiated minimal residual disease (MRD) status and complemented MRD for detecting early relapse before clinical progression. Notably, CD319+ MM EVs were early predictors of progression-free and overall survival in MRD-negative patients. This assay enables noninvasive monitoring of deep response, progression, and antigen escape, and stratifies survival in MRD-negative patients with RRMM.
PMID:41890853 | PMC:PMC13015583 | DOI:10.21203/rs.3.rs-8913641/v1
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Omics in Gastric
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Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35
Cell Oncol (Dordr). 2026 Mar 23;49(2):60. doi: 10.1007/s13402-026-01194-6.ABSTRACTGlycolytic reprogramming is closely associated with the occurrence and progression of gastric cancer. Specifically, the energy derived from glucose metabolism and the cellular proteins by its intermediate products influence gastric cancer development. However, as an important branch of glucose metabolism, sialic acid metabolism and its mediated sialylation modifications remain insufficiently studied in gastric canc
Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35
Cell Oncol (Dordr). 2026 Mar 23;49(2):60. doi: 10.1007/s13402-026-01194-6.
ABSTRACT
Glycolytic reprogramming is closely associated with the occurrence and progression of gastric cancer. Specifically, the energy derived from glucose metabolism and the cellular proteins by its intermediate products influence gastric cancer development. However, as an important branch of glucose metabolism, sialic acid metabolism and its mediated sialylation modifications remain insufficiently studied in gastric cancer, and their specific relationship with malignant tumor progression requires further exploration. This study employed a multi‑omics approach, integrating metabolomics, single‑cell RNA sequencing, and bulk RNA sequencing analyses, to investigate the metabolic landscape of gastric cancer and its associated alterations. The results indicated that sialic acid is a characteristic metabolite in malignant gastric cancer tissues. It modulates biological functions such as immune response, proliferative activity, and metabolic remodeling within gastric cancer tissues by influencing sialylation modifications. Furthermore, we identified the drug WZ35, which can inhibit the malignant proliferation of gastric cancer by targeting both sialic acid metabolism and sialylated protein modifications. We put forward a conjecture that the metabolism and modification of sialic acid promote the malignant development of gastric cancer, and we discovered that the drug WZ35 has an inhibitory effect on the sialic acid metabolism of gastric cancer.
GRAPHICAL ABSTRACT:
PMID:41870836 | PMC:PMC13009457 | DOI:10.1007/s13402-026-01194-6
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cs.AI, q-bio.NC updates on arXiv.org
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Towards Self-Evolving Benchmarks: Synthesizing Agent Trajectories via Test-Time Exploration under Validate-by-Reproduce Paradigm
arXiv:2510.00415v3 Announce Type: replace Abstract: Recent advances in large language models (LLMs) and agent system designs have empowered agents with unprecedented levels of capability. However, existing agent benchmarks are showing a trend of rapid ceiling-hitting by newly developed agents, making it difficult to meet the demands for evaluating agent abilities. To address this problem, we propose the Trajectory-based Validated-by-Reproducing Agent-benchmark Complexity Evolution (TRACE) frame
Towards Self-Evolving Benchmarks: Synthesizing Agent Trajectories via Test-Time Exploration under Validate-by-Reproduce Paradigm
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cs.AI, q-bio.NC updates on arXiv.org
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When Models Judge Themselves: Unsupervised Self-Evolution for Multimodal Reasoning
arXiv:2603.21289v2 Announce Type: replace-cross Abstract: Recent progress in multimodal large language models has led to strong performance on reasoning tasks, but these improvements largely rely on high-quality annotated data or teacher-model distillation, both of which are costly and difficult to scale. To address this, we propose an unsupervised self-evolution training framework for multimodal reasoning that achieves stable performance improvements without using human-annotated answers or ex
When Models Judge Themselves: Unsupervised Self-Evolution for Multimodal Reasoning
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Nature Medicine
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In vivo generation of anti-BCMA CAR-T cells in relapsed or refractory multiple myeloma: a phase 1 study
Nature Medicine, Published online: 25 March 2026; doi:10.1038/s41591-026-04244-6In a phase 1 trial, the in vivo generation of anti-BCMA CAR-T cells by lentiviral delivery was feasible and did not lead to dose-limiting toxicities in five patients with relapsed or refractory multiple myeloma.
In vivo generation of anti-BCMA CAR-T cells in relapsed or refractory multiple myeloma: a phase 1 study
Nature Medicine, Published online: 25 March 2026; doi:10.1038/s41591-026-04244-6
In a phase 1 trial, the in vivo generation of anti-BCMA CAR-T cells by lentiviral delivery was feasible and did not lead to dose-limiting toxicities in five patients with relapsed or refractory multiple myeloma.-
(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35
Cell Oncol (Dordr). 2026 Mar 23;49(2):60. doi: 10.1007/s13402-026-01194-6.NO ABSTRACTPMID:41870836 | DOI:10.1007/s13402-026-01194-6
Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35
Cell Oncol (Dordr). 2026 Mar 23;49(2):60. doi: 10.1007/s13402-026-01194-6.
NO ABSTRACT
PMID:41870836 | DOI:10.1007/s13402-026-01194-6
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Cell
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Hijacking ERAD for targeted degradation of transmembrane proteins
Development of an ERAD-hijacking technology overcomes the challenges of current targeted protein degradation approaches to achieve degradation of transmembrane proteins.
Hijacking ERAD for targeted degradation of transmembrane proteins
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cs.AI, q-bio.NC updates on arXiv.org
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PIRA-Bench: A Transition from Reactive GUI Agents to GUI-based Proactive Intent Recommendation Agents
arXiv:2603.08013v1 Announce Type: new Abstract: Current Graphical User Interface (GUI) agents operate primarily under a reactive paradigm: a user must provide an explicit instruction for the agent to execute a task. However, an intelligent AI assistant should be proactive, which is capable of anticipating user intentions directly from continuous visual inputs, such as mobile or desktop screenshots, and offering timely recommendations without explicit user prompting. Transitioning to this proact
PIRA-Bench: A Transition from Reactive GUI Agents to GUI-based Proactive Intent Recommendation Agents
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cs.AI, q-bio.NC updates on arXiv.org
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HEARTS: Benchmarking LLM Reasoning on Health Time Series
arXiv:2603.06638v1 Announce Type: cross Abstract: The rise of large language models (LLMs) has shifted time series analysis from narrow analytics to general-purpose reasoning. Yet, existing benchmarks cover only a small set of health time series modalities and tasks, failing to reflect the diverse domains and extensive temporal dependencies inherent in real-world physiological modeling. To bridge these gaps, we introduce HEARTS (Health Reasoning over Time Series), a unified benchmark for evalua
HEARTS: Benchmarking LLM Reasoning on Health Time Series
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cs.AI, q-bio.NC updates on arXiv.org
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CCR-Bench: A Comprehensive Benchmark for Evaluating LLMs on Complex Constraints, Control Flows, and Real-World Cases
arXiv:2603.07886v1 Announce Type: cross Abstract: Enhancing the ability of large language models (LLMs) to follow complex instructions is critical for their deployment in real-world applications. However, existing evaluation methods often oversimplify instruction complexity as a mere additive combination of atomic constraints, failing to adequately capture the high-dimensional complexity arising from the intricate interplay of content and format, logical workflow control, and real-world applica
CCR-Bench: A Comprehensive Benchmark for Evaluating LLMs on Complex Constraints, Control Flows, and Real-World Cases
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cs.AI, q-bio.NC updates on arXiv.org
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Your Agent May Misevolve: Emergent Risks in Self-evolving LLM Agents
arXiv:2509.26354v2 Announce Type: replace Abstract: Advances in Large Language Models (LLMs) have enabled a new class of self-evolving agents that autonomously improve through interaction with the environment, demonstrating strong capabilities. However, self-evolution also introduces novel risks overlooked by current safety research. In this work, we study the case where an agent's self-evolution deviates in unintended ways, leading to undesirable or even harmful outcomes. We refer to this as M
Your Agent May Misevolve: Emergent Risks in Self-evolving LLM Agents
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cs.AI, q-bio.NC updates on arXiv.org
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BoxMind: Closed-loop AI strategy optimization for elite boxing validated in the 2024 Olympics
arXiv:2601.11492v2 Announce Type: replace Abstract: Competitive sports require sophisticated tactical analysis, yet combat disciplines like boxing remain underdeveloped in AI-driven analytics due to the complexity of action dynamics and the lack of structured tactical representations. To address this, we present BoxMind, a closed-loop AI expert system validated in elite boxing competition. By defining atomic punch events with precise temporal boundaries and spatial and technical attributes, we