arXiv:2604.03571v1 Announce Type: new Abstract: Large Reasoning Models (LRMs) generate structured chains of thought (CoTs) before producing final answers, making them especially vulnerable to knowledge leakage through intermediate reasoning steps. Yet, the memorization of sensitive information in the training data such as copyrighted and private content has led to ethical and legal concerns. To address these issues, selective forgetting (also known as machine unlearning) has emerged as a potential remedy for LRMs. However, existing unlearning methods primarily target final answers and may degrade the overall reasoning ability of LRMs after forgetting. Additionally, directly applying unlearning on the entire CoTs could degrade the general reasoning capabilities. The key challenge for LRM unlearning lies in achieving precise unlearning of targeted knowledge while preserving the integrity of general reasoning capabilities. To bridge this gap, we in this paper propose a novel LRM unlearning framework that selectively removes sensitive reasoning components while preserving general reasoning capabilities. Our approach leverages multiple LLMs with retrieval-augmented generation (RAG) to analyze CoT traces, identify forget-relevant segments, and replace them with benign placeholders that maintain logical structure. We also introduce a new feature replacement unlearning loss for LRMs, which can simultaneously suppress the probability of generating forgotten content while reinforcing structurally valid replacements. Extensive experiments on both synthetic and medical datasets verify the desired properties of our proposed method.

arXiv:2512.10821v2 Announce Type: replace Abstract: From content moderation to content curation, applications requiring vision classifiers for visual concepts are rapidly expanding. Existing human-in-the-loop approaches typically assume users begin with a clear, stable concept understanding to be able to provide high-quality supervision. In reality, users often start with a vague idea and must iteratively refine it through "concept deliberation", a practice we uncovered through structured interviews with content moderation experts. We operationalize the common strategies in deliberation used by real content moderators into a human-in-the-loop framework called "Agile Deliberation" that explicitly supports evolving and subjective concepts. The system supports users in defining the concept for themselves by exposing them to borderline cases. The system does this with two deliberation stages: (1) concept scoping, which decomposes the initial concept into a structured hierarchy of sub-concepts, and (2) concept iteration, which surfaces semantically borderline examples for user reflection and feedback to iteratively align an image classifier with the user's evolving intent. Since concept deliberation is inherently subjective and interactive, we painstakingly evaluate the framework through 18 user sessions, each 1.5h long, rather than standard benchmarking datasets. We find that Agile Deliberation achieves 7.5% higher F1 scores than automated decomposition baselines and more than 3% higher than manual deliberation, while participants reported clearer conceptual understanding and lower cognitive effort.

arXiv:2510.06800v3 Announce Type: replace-cross Abstract: As large language models (LLMs) advance in role-playing (RP) tasks, existing benchmarks quickly become obsolete due to their narrow scope, outdated interaction paradigms, and limited adaptability across diverse application scenarios. To address this gap, we introduce FURINA-Builder, a novel multi-agent collaboration pipeline that automatically constructs fully customizable RP benchmarks at any scale. It enables evaluation of arbitrary characters across diverse scenarios and prompt formats, as the first benchmark builder in RP area for adaptable assessment. FURINA-Builder simulates dialogues between a test character and other characters drawn from a well-constructed character-scene pool, while an LLM judge selects fine-grained evaluation dimensions and adjusts the test character's responses into final test utterances. Using this pipeline, we build FURINA-Bench, a new comprehensive role-playing benchmark featuring both established and synthesized test characters, each assessed with dimension-specific evaluation criteria. Human evaluation and preliminary separability analysis justify our pipeline and benchmark design. We conduct extensive evaluations of cutting-edge LLMs and find that o3 and DeepSeek-R1 achieve the best performance on English and Chinese RP tasks, respectively. Across all models, established characters consistently outperform synthesized ones, with reasoning capabilities further amplifying this disparity. Interestingly, we observe that model scale does not monotonically reduce hallucinations. More critically, for reasoning LLMs, we uncover a novel trade-off: reasoning improves RP performance but simultaneously increases RP hallucinations. This trade-off extends to a broader Pareto frontier between RP performance and reliability for all LLMs. These findings demonstrate the effectiveness of FURINA-Builder and the challenge posed by FURINA-Bench.

arXiv:2509.12643v3 Announce Type: replace Abstract: Large Language Model (LLM)-based optimization has recently shown promise for autonomous problem solving, yet most approaches still cast LLMs as passive constraint checkers rather than proactive strategy designers, limiting their effectiveness on complex Constraint Optimization Problems (COPs). To address this, we present AutoCO, an end-to-end Automated Constraint Optimization method that tightly couples operations-research principles of constraint relaxation with LLM reasoning. A core innovation is a unified triple-representation that binds relaxation strategies, algorithmic principles, and executable codes. This design enables the LLM to synthesize, justify, and instantiate relaxation strategies that are both principled and executable. To navigate fragmented solution spaces, AutoCO employs a bidirectional global-local coevolution mechanism, synergistically coupling Monte Carlo Tree Search (MCTS) for global relaxation-trajectory exploration with Evolutionary Algorithms (EAs) for local solution intensification. This continuous exchange of priors and feedback explicitly balances diversification and intensification, thus preventing premature convergence. Extensive experiments on three challenging COP benchmarks validate AutoCO's consistent effectiveness and superior performance, especially in hard regimes where current methods degrade. Results highlight AutoCO as a principled and effective path toward proactive, verifiable LLM-driven optimization.

Li et al. developed a ferritin aggregation cell engager that helps CAR T cells better recognize and attack leukemia cells without re-engineering the CAR itself. This versatile platform overcomes antigen modulation and enables combination with chemotherapy.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10296-y

In mice, a circuit between the spinal cord and various regions of the brain, centring on spinal-cord-projecting neurons in the rostral ventromedial medulla, has a key role in driving chronic pain.

npj Digital Medicine, Published online: 24 March 2026; doi:10.1038/s41746-026-02568-8

Performance of DeepSeek in the generation of in-training examination questions in radiology resident education

arXiv:2601.12349v2 Announce Type: replace-cross Abstract: Large multimodal model powered GUI agents are emerging as high-privilege operators on mobile platforms, entrusted with perceiving screen content and injecting inputs. However, their design operates under the implicit assumption of Visual Atomicity: that the UI state remains invariant between observation and action. We demonstrate that this assumption is fundamentally invalid in Android, creating a critical attack surface. We present Action Rebinding, a novel attack that allows a seemingly-benign app with zero dangerous permissions to rebind an agent's execution. By exploiting the inevitable observation-to-action gap inherent in the agent's reasoning pipeline, the attacker triggers foreground transitions to rebind the agent's planned action toward the target app. We weaponize the agent's task-recovery logic and Android's UI state preservation to orchestrate programmable, multi-step attack chains. Furthermore, we introduce an Intent Alignment Strategy (IAS) that manipulates the agent's reasoning process to rationalize UI states, enabling it to bypass verification gates (e.g., confirmation dialogs) that would otherwise be rejected. We evaluate Action Rebinding Attacks on six widely-used Android GUI agents across 15 tasks. Our results demonstrate a 100% success rate for atomic action rebinding and the ability to reliably orchestrate multi-step attack chains. With IAS, the success rate in bypassing verification gates increases (from 0% to up to 100%). Notably, the attacker application requires no sensitive permissions and contains no privileged API calls, achieving a 0% detection rate across malware scanners (e.g., VirusTotal). Our findings reveal a fundamental architectural flaw in current agent-OS integration and provide critical insights for the secure design of future agent systems. To access experimental logs and demonstration videos, please contact yi_qian@smail.nju.edu.cn.

arXiv:2602.14401v1 Announce Type: cross Abstract: Vision-Language Navigation VLN requires large-scale trajectory instruction data from private indoor environments, raising significant privacy concerns. Federated Learning FL mitigates this by keeping data on-device, but vanilla FL struggles under VLNs' extreme cross-client heterogeneity in environments and instruction styles, making a single global model suboptimal. This paper proposes pFedNavi, a structure-aware and dynamically adaptive personalized federated learning framework tailored for VLN. Our key idea is to personalize where it matters: pFedNavi adaptively identifies client-specific layers via layer-wise mixing coefficients, and performs fine-grained parameter fusion on the selected components (e.g., the encoder-decoder projection and environment-sensitive decoder layers) to balance global knowledge sharing with local specialization. We evaluate pFedNavi on two standard VLN benchmarks, R2R and RxR, using both ResNet and CLIP visual representations. Across all metrics, pFedNavi consistently outperforms the FedAvg-based VLN baseline, achieving up to 7.5% improvement in navigation success rate and up to 7.8% gain in trajectory fidelity, while converging 1.38x faster under non-IID conditions.