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cs.AI, q-bio.NC updates on arXiv.org
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A Learning-Based Cooperative Coevolution Framework for Heterogeneous Large-Scale Global Optimization
arXiv:2604.01241v1 Announce Type: cross Abstract: Cooperative Coevolution (CC) effectively addresses Large-Scale Global Optimization (LSGO) via decomposition but struggles with the emerging class of Heterogeneous LSGO (H-LSGO) problems arising from real-world applications, where subproblems exhibit diverse dimensions and distinct landscapes. The prevailing CC paradigm, relying on a fixed low-dimensional optimizer, often fails to navigate this heterogeneity. To address this limitation, we propos
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cs.AI, q-bio.NC updates on arXiv.org
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ExpertFlow: Efficient Mixture-of-Experts Inference via Predictive Expert Caching and Token Scheduling
arXiv:2410.17954v2 Announce Type: replace Abstract: Sparse Mixture-of-Experts (MoE) models can outperform dense large language models at similar computation by activating only a small set of experts per token. However, stacking many expert modules introduces substantial parameter memory, which makes MoE models difficult to deploy in memory-constrained environments such as single-GPU devices. Offloading alleviates this issue by storing inactive experts in CPU memory and loading them on demand, b
ExpertFlow: Efficient Mixture-of-Experts Inference via Predictive Expert Caching and Token Scheduling
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cs.AI, q-bio.NC updates on arXiv.org
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Trace2Skill: Distill Trajectory-Local Lessons into Transferable Agent Skills
arXiv:2603.25158v3 Announce Type: replace Abstract: Equipping Large Language Model (LLM) agents with domain-specific skills is critical for tackling complex tasks. Yet, manual authoring creates a severe scalability bottleneck. Conversely, automated skill generation often yields fragile or fragmented results because it either relies on shallow parametric knowledge or sequentially overfits to non-generalizable trajectory-local lessons. To overcome this, we introduce Trace2Skill, a framework that
Trace2Skill: Distill Trajectory-Local Lessons into Transferable Agent Skills
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Nature - Issue - nature.com science feeds
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Dual-symmetry-guided assembly of complex lattices
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10364-3A dual-symmetry-guided strategy is used to assemble a broad class of complex Archimedean lattices and two-dimensional quasicrystalline structures, providing a general and experimentally accessible route to complex-symmetry materials.
Dual-symmetry-guided assembly of complex lattices
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10364-3
A dual-symmetry-guided strategy is used to assemble a broad class of complex Archimedean lattices and two-dimensional quasicrystalline structures, providing a general and experimentally accessible route to complex-symmetry materials.-
(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy
Nat Commun. 2026 Mar 23. doi: 10.1038/s41467-026-70798-1. Online ahead of print.ABSTRACTGlioblastoma (GBM) remains a lethal brain tumor due to therapy resistance. While autophagy contributes to temozolomide (TMZ) resistance, its regulation is incompletely understood. This study investigates the role of replication factor RFC4, which is associated with poor prognosis and TMZ resistance in GBM. Multi-omics analyses and molecular experiments reveal that TMZ-induced chromatin accessibility enables t
RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy
Nat Commun. 2026 Mar 23. doi: 10.1038/s41467-026-70798-1. Online ahead of print.
ABSTRACT
Glioblastoma (GBM) remains a lethal brain tumor due to therapy resistance. While autophagy contributes to temozolomide (TMZ) resistance, its regulation is incompletely understood. This study investigates the role of replication factor RFC4, which is associated with poor prognosis and TMZ resistance in GBM. Multi-omics analyses and molecular experiments reveal that TMZ-induced chromatin accessibility enables transcription factor YY1 to bind the RFC4 promoter and upregulate its expression. RFC4, in turn, stabilizes the kinase STK38, which is essential for autophagosome formation. The RFC4-STK38 interaction facilitates BECN1 recruitment, thereby activating autophagy. Phosphorylation of STK38 at T444 stabilizes this complex, whereas a phospho-deficient mutant impairs autophagy. In vivo, RFC4 overexpression confers TMZ resistance, reversible by autophagy inhibition. Thus, our findings identify the RFC4-STK38-BECN1 axis as a mechanism underlying TMZ resistance and a potential target for precision therapy in GBM.
PMID:41872171 | DOI:10.1038/s41467-026-70798-1
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Nature Biotechnology - Issue - nature.com science feeds
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Sustained nitric oxide production by engineered <i>E. coli</i> remodels the tumor microenvironment and potentiates immunotherapy
Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03054-ySolid tumors are sensitized to anti‑PD‑L1 immunotherapy by engineered E. coli to produce nitric oxide.
Sustained nitric oxide production by engineered <i>E. coli</i> remodels the tumor microenvironment and potentiates immunotherapy
Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03054-y
Solid tumors are sensitized to anti‑PD‑L1 immunotherapy by engineered E. coli to produce nitric oxide.-
(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Diverse genomic and transcriptomic heterogeneity in EGFR-mutant lung adenocarcinoma between exon 19 del and exon 21 L858R
Cell Commun Signal. 2026 Mar 14. doi: 10.1186/s12964-026-02793-4. Online ahead of print.NO ABSTRACTPMID:41826981 | DOI:10.1186/s12964-026-02793-4
Diverse genomic and transcriptomic heterogeneity in EGFR-mutant lung adenocarcinoma between exon 19 del and exon 21 L858R
Cell Commun Signal. 2026 Mar 14. doi: 10.1186/s12964-026-02793-4. Online ahead of print.
NO ABSTRACT
PMID:41826981 | DOI:10.1186/s12964-026-02793-4
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cs.AI, q-bio.NC updates on arXiv.org
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ResearchEnvBench: Benchmarking Agents on Environment Synthesis for Research Code Execution
arXiv:2603.06739v1 Announce Type: cross Abstract: Autonomous agents are increasingly expected to support scientific research, and recent benchmarks report progress in code repair and autonomous experimentation. However, these evaluations typically assume a pre-configured execution environment, which requires resolving complex software dependencies, aligning hardware and framework versions, and configuring distributed execution, yet this capability remains largely unbenchmarked. We introduce Res
ResearchEnvBench: Benchmarking Agents on Environment Synthesis for Research Code Execution
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cs.AI, q-bio.NC updates on arXiv.org
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ARLArena: A Unified Framework for Stable Agentic Reinforcement Learning
arXiv:2602.21534v2 Announce Type: replace Abstract: Agentic reinforcement learning (ARL) has rapidly gained attention as a promising paradigm for training agents to solve complex, multi-step interactive tasks. Despite encouraging early results, ARL remains highly unstable, often leading to training collapse. This instability limits scalability to larger environments and longer interaction horizons, and constrains systematic exploration of algorithmic design choices. In this paper, we first prop
ARLArena: A Unified Framework for Stable Agentic Reinforcement Learning
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cs.AI, q-bio.NC updates on arXiv.org
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Puppet-CNN: Continuous Parameter Dynamics for Input-Adaptive Convolutional Networks
arXiv:2411.12876v2 Announce Type: replace-cross Abstract: Modern convolutional neural networks (CNNs) organize computation as a discrete stack of layers whose parameters are independently stored and learned, with the number of layers fixed as an architectural hyperparameter. In this work, we explore an alternative perspective: can network parameterization itself be modeled as a continuous dynamical system? We introduce Puppet-CNN, a framework that represents convolutional layer parameters as st
Puppet-CNN: Continuous Parameter Dynamics for Input-Adaptive Convolutional Networks
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cs.AI, q-bio.NC updates on arXiv.org
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Input-Adaptive Generative Dynamics in Diffusion Models
arXiv:2411.15199v2 Announce Type: replace-cross Abstract: Diffusion models typically generate data through a fixed denoising trajectory that is shared across all samples. However, generation targets can differ in complexity, suggesting that a single pre-defined diffusion process may not be optimal for every input. In this work, we investigate input-adaptive generative dynamics for diffusion models, where the generation process itself adapts to the conditions of each sample. Instead of relying o
Input-Adaptive Generative Dynamics in Diffusion Models
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cs.AI, q-bio.NC updates on arXiv.org
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LifeBench: A Benchmark for Long-Horizon Multi-Source Memory
arXiv:2603.03781v1 Announce Type: new Abstract: Long-term memory is fundamental for personalized agents capable of accumulating knowledge, reasoning over user experiences, and adapting across time. However, existing memory benchmarks primarily target declarative memory, specifically semantic and episodic types, where all information is explicitly presented in dialogues. In contrast, real-world actions are also governed by non-declarative memory, including habitual and procedural types, and need
LifeBench: A Benchmark for Long-Horizon Multi-Source Memory
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cs.AI, q-bio.NC updates on arXiv.org
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Beyond Pixel Histories: World Models with Persistent 3D State
arXiv:2603.03482v1 Announce Type: cross Abstract: Interactive world models continually generate video by responding to a user's actions, enabling open-ended generation capabilities. However, existing models typically lack a 3D representation of the environment, meaning 3D consistency must be implicitly learned from data, and spatial memory is restricted to limited temporal context windows. This results in an unrealistic user experience and presents significant obstacles to down-stream tasks suc
Beyond Pixel Histories: World Models with Persistent 3D State
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cs.AI, q-bio.NC updates on arXiv.org
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Forecasting as Rendering: A 2D Gaussian Splatting Framework for Time Series Forecasting
arXiv:2603.02220v1 Announce Type: cross Abstract: Time series forecasting (TSF) remains a challenging problem due to the intricate entanglement of intraperiod-fluctuations and interperiod-trends. While recent advances have attempted to reshape 1D sequences into 2D period-phase representations, they suffer from two principal limitations.Firstly, treating reshaped tensors as static images results in a topological mismatch, as standard spatial operators sever chronological continuity at grid bound
Forecasting as Rendering: A 2D Gaussian Splatting Framework for Time Series Forecasting
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cs.AI, q-bio.NC updates on arXiv.org
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JAEGER: Joint 3D Audio-Visual Grounding and Reasoning in Simulated Physical Environments
arXiv:2602.18527v1 Announce Type: cross Abstract: Current audio-visual large language models (AV-LLMs) are predominantly restricted to 2D perception, relying on RGB video and monaural audio. This design choice introduces a fundamental dimensionality mismatch that precludes reliable source localization and spatial reasoning in complex 3D environments. We address this limitation by presenting JAEGER, a framework that extends AV-LLMs to 3D space, to enable joint spatial grounding and reasoning thr
JAEGER: Joint 3D Audio-Visual Grounding and Reasoning in Simulated Physical Environments
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cs.AI, q-bio.NC updates on arXiv.org
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Think with Grounding: Curriculum Reinforced Reasoning with Video Grounding for Long Video Understanding
arXiv:2602.18702v1 Announce Type: cross Abstract: Long video understanding is challenging due to rich and complicated multimodal clues in long temporal range.Current methods adopt reasoning to improve the model's ability to analyze complex video clues in long videos via text-form reasoning.However,the existing literature suffers from the fact that the text-only reasoning under fixed video context may exacerbate hallucinations since detailed crucial clues are often ignored under limited video co
Think with Grounding: Curriculum Reinforced Reasoning with Video Grounding for Long Video Understanding
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cs.AI, q-bio.NC updates on arXiv.org
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LQA: A Lightweight Quantized-Adaptive Framework for Vision-Language Models on the Edge
arXiv:2602.07849v2 Announce Type: replace Abstract: Deploying Vision-Language Models (VLMs) on edge devices is challenged by resource constraints and performance degradation under distribution shifts. While test-time adaptation (TTA) can counteract such shifts, existing methods are too resource-intensive for on-device deployment. To address this challenge, we propose LQA, a lightweight, quantized-adaptive framework for VLMs that combines a modality-aware quantization strategy with gradient-free