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cs.AI, q-bio.NC updates on arXiv.org
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SenseMath: Do LLMs Have Number Sense? Evaluating Shortcut Use, Judgment, and Generation
arXiv:2604.01988v1 Announce Type: new Abstract: Large language models often default to step-by-step computation even when efficient numerical shortcuts are available. This raises a basic question: do they exhibit number sense in a human-like behavioral sense, i.e., the ability to recognize numerical structure, apply shortcuts when appropriate, and avoid them when they are not? We introduce SenseMath, a controlled benchmark for evaluating structure-sensitive numerical reasoning in LLMs. SenseMat
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cs.AI, q-bio.NC updates on arXiv.org
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VOID: Video Object and Interaction Deletion
arXiv:2604.02296v1 Announce Type: cross Abstract: Existing video object removal methods excel at inpainting content "behind" the object and correcting appearance-level artifacts such as shadows and reflections. However, when the removed object has more significant interactions, such as collisions with other objects, current models fail to correct them and produce implausible results. We present VOID, a video object removal framework designed to perform physically-plausible inpainting in these c
VOID: Video Object and Interaction Deletion
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Omics In Lung
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Tumorigenesis and Tumor Microenvironment in Lung Cancer
Curr Issues Mol Biol. 2026 Feb 26;48(3):247. doi: 10.3390/cimb48030247.ABSTRACTLung cancer remains a leading cause of cancer mortality worldwide and continues to impose substantial clinical and economic burdens. Beyond tumor-intrinsic oncogenic drivers, disease progression and therapy response are shaped by the tumor microenvironment (TME), including immune cells, cancer-associated fibroblasts (CAFs), endothelial cells, extracellular matrix, inflammatory mediators, etc. In lung cancer, chronic i
Tumorigenesis and Tumor Microenvironment in Lung Cancer
Curr Issues Mol Biol. 2026 Feb 26;48(3):247. doi: 10.3390/cimb48030247.
ABSTRACT
Lung cancer remains a leading cause of cancer mortality worldwide and continues to impose substantial clinical and economic burdens. Beyond tumor-intrinsic oncogenic drivers, disease progression and therapy response are shaped by the tumor microenvironment (TME), including immune cells, cancer-associated fibroblasts (CAFs), endothelial cells, extracellular matrix, inflammatory mediators, etc. In lung cancer, chronic injury from tobacco smoke, airway disease, and treatment itself remodels local tissue programs that can either support antitumor immunity or promote immune exclusion, fibrosis, and metastatic seeding. Here, we analyze recent evidence linking lung tumorigenesis to TME ecology across histologies, with emphasis on CAF heterogeneity, spatial organization of immune niches, and the distinct microenvironments that govern organ-specific metastasis (including brain metastasis). We also evaluate emerging therapeutic strategies that aim to target or reprogram the TME, including perioperative immune checkpoint blockade, combined immunotherapy-radiotherapy approaches, and pathways such as IL-6 and TGF-Ξ² that coordinate immune suppression and stromal remodeling. Finally, we outline key gaps and potential future directions, such as longitudinal and spatial multi-omics, better biomarkers of stromal state, and trial designs that account for dynamic microenvironmental adaptation.
PMID:41899399 | PMC:PMC13025777 | DOI:10.3390/cimb48030247
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cs.AI, q-bio.NC updates on arXiv.org
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Making Slow Thinking Faster: Compressing LLM Chain-of-Thought via Step Entropy
arXiv:2508.03346v2 Announce Type: replace Abstract: Large Language Models (LLMs) using Chain-of-Thought (CoT) prompting excel at complex reasoning but generate verbose thought processes with considerable redundancy, leading to increased inference costs and reduced efficiency. We introduce a novel CoT compression framework based on step entropy, a metric that quantifies \emph{the informational contribution of individual reasoning steps} to identify redundancy. Through theoretical analysis and ex