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In Search of the Ingredients of Open-Endedness: Replicating Picbreeder with Large Vision-Language Models

arXiv:2605.23908v1 Announce Type: new Abstract: We are in the midst of large-scale industrial and academic efforts to automate the processes of scientific, technological and creative production through AI-driven assistants. Historically, a fundamental property of these processes in their human form has been their open-endedness: their capacity for generating a seemingly endless supply of novel and meaningful new forms. Do artificial agents have any capacity for such fruitful unguided discovery? To answer this question, we turn to Picbreeder, the canonical exemplar of human-driven open-ended search, in which users collaboratively generated a diverse library of images through interactive evolution of small neural networks. We replicate Picbreeder, replacing human users with frontier Vision Language Models (VLMs). We observe clear qualitative differences between the output of our system and the historical human baseline, and attempt to characterize them using metrics of phylogenetic complexity and visual and semantic salience and novelty. In an effort to identify some of the causal factors contributing these differences, we study the addition of exploratory noise to the agents' selection process, of behavioral diversity between agents, and of narrative momentum in the form of memory of past actions. We make our code available at https://github.com/smearle/picbreeder-vlm.

Reason--Imagine--Act: Closed-Loop LLM Decision Making with World Models for Autonomous Driving

arXiv:2605.24004v1 Announce Type: new Abstract: Large language models (LLMs) are promising for autonomous driving, but semantics-only decision policies can yield physically unsafe behavior in dynamic traffic. Existing methods either perform online language reasoning without explicit dynamics verification or use world models mainly in offline pipelines, leaving a gap between semantic intent and physical feasibility at decision time. We propose Reason--Imagine--Act (RIA), a closed-loop framework that couples an LLM reasoner with an action-conditioned world model for online safety verification. At each step, the LLM proposes an action template and candidate sub-actions, the world model performs short-horizon rollouts, and a safety scorer selects the safest executable action with feedback to the next reasoning step. Under a unified CARLA point-goal protocol (1000 episodes), RIA achieves 80.05% route completion, 51.10% arrival rate, and 0.20% collision rate. Under the same closed-loop interface, RIA consistently outperforms training-free baselines, including CARLA TM and MADA, on core closed-loop metrics. For reproducibility, code is available at https://github.com/pku-smart-city/source_code/tree/main/RIA.

Lattice theory and algebraic models for deep convolutional learning based on mathematical morphology

arXiv:2605.24608v1 Announce Type: new Abstract: We develop a rigorous algebraic framework for deep convolutional architectures, CNNs, ResNets, and encoder--decoder networks such as UNet, grounded in lattice theory and mathematical morphology. The central tool is the Matheron--Maragos--Banon--Barrera (MMBB) universal representation theory for translation-invariant operators, which we apply systematically to every layer of a standard deep network. The principal finding is that the standard CNN pipeline (linear convolution~$+$ ReLU~$+$ flat max-pooling) is a cross-lattice operator: the convolution is an erosion in the Fourier inf-semilattice while ReLU is a lattice-join closing and max-pooling is a dilation in the pointwise max-plus lattice, and their composition is a morphological opening in neither. A second finding is that the upper adjoint of ReLU in the pointwise lattice is a global (non-local) operator, the identity on globally non-negative functions and $-\infty$ otherwise, so no local morphological erosion can form an adjunction pair with ReLU. These two results together provide the precise algebraic reason why depth in standard CNNs introduces genuine representational power: the composed layer is not idempotent. Three layer designs that are genuine idempotent openings are identified and fully characterised: the pure max-plus morphological layer (pointwise lattice), the spectral Wiener layer (Fourier lattice), and the self-dual morphological layer. We establish a complete fixed-point and convergence theory. The framework also unifies max-pooling, strided convolution, and the Laplacian pyramid under the Goutsias--Heijmans adjoint pyramid theory, and gives the Activation--Pooling Dilation (APD) factorisation with its correct adjoint.

AVBench: Human-Aligned and Automated Evaluation Benchmark for Audio-Video Generative Models

arXiv:2605.24652v1 Announce Type: new Abstract: Rapid advances in audio-video (AV) generation have enabled high-fidelity synthesis with synchronized sound, particularly for human-related scenarios involving speech and interactions. Yet evaluation for AV generation remains at an early stage, with only a few coarse-grained benchmarks for human-related scenarios and relying on limited preset evaluations with generic multimodal LLMs, leading to inaccurate assessments of model capabilities. To address these issues, we introduce AVBench, a fully automated benchmark tailored for human-centric AV generation. AVBench is built on two key designs for comprehensive and accurate evaluation: (i) Human-centric and fine-grained metrics. AVBench integrates ten evaluation dimensions designed for human-centered real-world scenarios, covering visual quality, audio quality, and multi-level consistency across modalities. These practical metrics capture human-related details that existing benchmarks often overlook. (ii) Specialized evaluators via preference learning. To address the lack of specialized training data, we construct large-scale supervision by transforming real-world videos into diverse training pairs with controlled perturbations. After fine-tuning on this high-quality dataset, the evaluators learn to reliably detect subtle cross-modal inconsistencies. Crucially, instead of producing discrete textual judgment, AVBench derives continuous evaluation scores from the model's prediction confidence on binary decisions. This probabilistic scoring mechanism enables a more reliable assessment than traditional VQA-style evaluation and aligns closely with human judgment. Taken together, AVBench offers automated evaluation for AV generation, demonstrates strong potential for data filtering, and serves as a differentiable reward signal for Reinforcement Learning from Human Feedback (RLHF).

Mitigating Object Hallucinations in Vision-Language Models through Region-Aware Attention Recalibration

arXiv:2605.24957v1 Announce Type: new Abstract: The generation of factually incorrect objects, commonly known as object hallucination, remains a persistent challenge in Large Vision-Language Models (LVLMs). Current approaches to address this issue - ranging from expensive data-driven fine-tuning and high-latency contrastive decoding to rigid attention head truncation - frequently compromise either computational efficiency or the continuity of the model's feature space. To overcome these limitations, we introduce a novel, training-free inference strategy that operates as a region-aware adaptive weighting mechanism to dynamically correct semantic drift without relying on abrupt heuristic truncations. By computing an outlier-resistant statistical midpoint across various attention heads, we establish a stable anchor for reliable visual representations. We then utilize the inter-head disagreement mapped across regions to dynamically determine intervention budgets, gently suppressing hallucination-inducing attention paths through a continuous penalty modulation. This recalibration process effectively rectifies visual-semantic misalignments while fully preserving generative fluency and language priors. Comprehensive evaluations on standard multimodal benchmarks, including CHAIR, POPE, and MME, reveal that our strategy substantially curtails both instance- and sentence-level hallucinations. The results demonstrate state-of-the-art performance against contemporary baselines, confirming our method's efficiency and algorithmic robustness. Our code will be public.

NeurIPS: Neuro-anatomical Inductive Priors for Sphere-based Brain Decoding

arXiv:2605.24993v1 Announce Type: new Abstract: Current fMRI decoders face a performance-fidelity trade-off where efficient ID encoders outperform geometrically faithful surface-based models. We argue this is partly driven by inefficient surface tokenization and the failure to use anatomy as a predictive signal. We present NeurIPS, a framework that improves surface-based decoding by reframing anatomical variation from a nuisance to a powerful inductive prior. NeurIPS unites two innovations: a Selective ROI Spherical Tokenizer (SRST) for efficient geometric encoding, and a Structure-Guided Mixture of Experts (SG-MoE) that explicitly models individual anatomy using cortical features. On the Natural Scenes Dataset, NeurIPS establishes a new state-of-the-art for surface decoders and achieves performance comparable to strong 1D baselines. This is achieved with unprecedented efficiency, as the model converges dramatically faster (10 vs. 600 epochs). This efficiency enables rapid adaptation to new subjects using only 20% of data and ensures robust scalability as the training cohort is expanded. Ablations provide causal evidence that these gains are driven by the model's use of cortical features, not by memorizing subject IDs. By leveraging anatomical priors, NeurIPS provides a principled and scalable path toward robust, generalizable brain decoding.

Parameter Efficient Multi-Class Intelligent Scheduling for Multimodal Online Distributed Industrial Anomaly Detection

arXiv:2605.23984v1 Announce Type: cross Abstract: Industrial anomaly detection has attracted significant attention as a fundamental challenge in industrial systems. The rapid advancement of heterogeneous industrial sensors has driven industrial anomaly detection from unimodal to multimodal paradigms. However, existing methods are primarily designed for centralized and offline settings, overlooking the distributed and continuously generated data characteristic of real-world industrial environments. With the advancement of edge intelligence, modern edge devices are increasingly capable of not only data acquisition but also distributed model training, enabling collaborative intelligence across the system. Industrial anomaly detection represents a critical application in this context. Motivated by these challenges, we propose a novel framework termed Multimodal Online Distributed Industrial Anomaly Detection (MODIAD). We first present a comprehensive workflow for MODIAD and then formulate a Multi-class Intelligent Scheduling (MIS) problem to coordinate cross class model updates by balancing data sufficiency and class update frequency. To efficiently solve this problem, we design a Sequential Marginal Gain Greedy (SMG) algorithm that enables effective multi-class training under resource constraints. Furthermore, to improve the computational and communication efficiency during training, we propose an Resource Efficient Class-Wise Low Rank Adaptation (REC-LoRA) strategy, which significantly reduces system overhead while preserving detection performance. Extensive experiments on two representative multimodal industrial anomaly detection datasets, MVTec 3D-AD and Eyecandies demonstrate that the proposed approach achieves superior performance and efficiency under the MODIAD scenario.

A World Model of Radiologist Reading for Medical Image Representation Learning

arXiv:2605.23992v1 Announce Type: cross Abstract: Radiologist eye-tracking data provide a rich record of how experts search, compare, and accumulate evidence during image reading; yet, existing methods exploit this signal only partially, either as a static spatial prior or as an auxiliary prediction target decoupled from diagnosis. We propose GazeWorld, a medical imaging world model that treats the image as the world and the radiologist's fixation sequence as a trajectory through it. GazeWorld autoregressively predicts the latent representation of the next fixated patch from all previously visited ones, while a spatial-completion branch covers unvisited regions. At inference, GazeWorld generates a sequence of patch representations from the image alone without requiring real gaze data. Frozen GazeWorld features achieve state-of-the-art diagnostic accuracy across all nine supervised settings on CheXpert, RSNA Pneumonia, and SIIM-ACR Pneumothorax, as well as the highest zero-shot accuracy on all three benchmarks. On the GazeSearch benchmark, a generic decoder trained on the same frozen features outperforms the purpose-built LogitGaze-Med by over 16\% in ScanMatch and 22\% in SED, despite not being explicitly trained to predict gaze. GazeWorld demonstrates that modeling how experts read, not just what they conclude, offers a promising pretraining paradigm for medical imaging AI.

Nano World Models: A Minimalist Implementation of Future Video Prediction

arXiv:2605.23993v1 Announce Type: cross Abstract: World models have become a central paradigm for learning predictive simulators that support generation, planning, and decision-making. Yet, despite rapid progress in industry-scale interactive video generation, the broader research community still lacks compact, reproducible, and easily extensible implementations for studying the design choices underlying modern world models. We introduce Nano World Models, a minimalist codebase for future video prediction centered around diffusion forcing. Nano World Models provides a unified interface for generative objectives, model scales, action-conditioning mechanisms, latent observation spaces, datasets, evaluation protocols, and long-horizon rollout procedures. This design enables controlled studies of world-modeling components that are often entangled across separate implementations. Through experiments across simple control environments, game simulation, and real-robot data, we examine how prediction parameterization, architecture scale, action injection, sampling budget, and domain complexity affect video prediction quality and autoregressive rollout behavior. By releasing code, configurations, evaluation scripts, and pretrained checkpoints, Nano World Models aims to provide a compact yet extensible experimental substrate for open, reproducible, and scientific world-model research.

RAW: Robust Avatar Watermarking -- Benchmarking and Baseline

arXiv:2605.23994v1 Announce Type: cross Abstract: Digital avatar watermarking presents unique challenges: avatars are routinely post-processed with background replacement, reframing, and format conversion before deployment. We introduce \textbf{RAW} (Robust Avatar Watermarking), a benchmark comprising 50 synthetic avatar videos from 5 commercial providers and 6 attacks simulating real-world avatar workflows. Evaluating 7 existing methods reveals that avatar-specific attacks such as background removal significantly degrade watermark recovery. We propose \textbf{WALT} (Watermarking Avatars with Learned Textures), which embeds watermarks in UV texture space via 3D face reconstruction. WALT achieves the highest robustness to zoom attacks (92.4\%) while maintaining strong performance on background removal (95.6\%). We release our benchmark to facilitate research into avatar-specific watermarking.

Task-Aligned Self-Supervised Learning for Medical Image Analysis: A Systematic Review and Practical Design Guidelines

arXiv:2605.23995v1 Announce Type: cross Abstract: Self-supervised learning (SSL) has emerged as a promising paradigm for addressing the annotation bottleneck in medical imaging by learning representations from unlabeled data. However, its effectiveness depends heavily on the design of the pretext task and its alignment with the downstream clinical objective. We present a systematic, task-oriented review of SSL in medical imaging, examining how different pretext-task formulations influence performance across classification, segmentation, detection, and other tasks. Following PRISMA guidelines, we analyze 75 studies published between 2017 and 2025 and organize them into four paradigms: contrastive, non-contrastive and predictive, generative and reconstruction-based, and hybrid learning. Rather than cataloguing methods by architecture, we map each paradigm to the downstream objectives it best supports. Our analysis shows there is no universally optimal SSL strategy; instead, performance is governed by the alignment between the pretext task, the imaging modality, and the target task. Contrastive methods learn global discriminative features and align well with classification, but may overlook subtle pathological patterns. Generative and spatial prediction-based approaches better preserve local anatomical structure, making them more suitable for segmentation and other dense prediction tasks, while hybrid methods offer the most balanced performance. We further show that modality-specific design is critical and that SSL provides its greatest benefit in low-label and few-shot regimes. Finally, we distill these findings into practical design guidelines and outline open challenges, including pathology-aware pretext task design, resource-efficient training for high-dimensional data, and standardized evaluation protocols. This work offers practical guidance for designing more effective and clinically relevant SSL frameworks in medical imaging.

IVR-R1: Refining Trajectories through Iterative Visual-Grounded Reasoning in Reinforcement Learning

arXiv:2605.23997v1 Announce Type: cross Abstract: Multimodal large language models via reinforcement learning (RL) have demonstrated remarkable capabilities in complex visual reasoning tasks, yet they remain limited in long-horizon multimodal scenarios, often suffering from visual hallucination and logical error. Current methods typically pre-encode high-dimensional visual scenes into discrete textual proxies to facilitate downstream reasoning. As the reasoning chain unfolds, however, the inherent information asymmetry between text and visual scenes tends to erode visual grounding, resulting in misguided reasoning and erroneous outputs. To address this issue, we introduce IVR-R1 (Iterative Visual-grounded Reasoning), a novel RL training framework that facilitates dynamic visual re-alignment that actively rectifies reasoning trajectories to guide policy optimization. Specifically, by leveraging a reward-driven screening mechanism to identify flawed rollouts, IVR-R1 executes a fine-grained, step-level error attribution within the multimodal context. By iteratively cross-referencing intermediate reasoning states against pristine visual priors, a Re-Reasoning Loop enables automated trajectory rectification, effectively synthesizing expert-level demonstrations that serve as high-fidelity reasoning templates for the policy model. Our experiments across diverse multimodal benchmarks demonstrate that IVR-R1 consistently outperforms existing reinforcement learning methods, establishing a superior paradigm for maintaining logical and visual consistency in complex multimodal reasoning.

Diff-Instruct with Diffused Reward: Towards Principled One-step Generator RL

arXiv:2605.24001v2 Announce Type: cross Abstract: Recent advances in one-step text-to-image generation have enabled real-time synthesis with remarkable efficiency and quality. Previous reinforcement learning methods for one-step generators combine image-space reward optimization with diffusion noisy-space distribution matching. This paradigm brings challenges due to a mismatch between terminal reward optimization and the underlying generative dynamics. As a result, optimization tends to exploit stochastic degrees of freedom, often improving reward at the expense of image fidelity. To address this issue, we propose Diff-Instruct with Diffused Reward (DIDR), a data-free trajectory-level alignment framework derived from Integral KL minimization. DIDR propagates the RLHF-optimal reward-tilted clean-image distribution across all noise levels along the diffusion trajectory. We show that this objective admits the same minimizer as clean-image RLHF, while naturally inducing the Diffused Reward Score (DRS), which acts as a reward-driven correction to the reference score function. To make this practical, we further introduce the Diffused Reward Proxy (DRP), an efficient estimator of DRS based on differentiable short-step denoising. Extensive experiments demonstrate that DIDR consistently Pareto-dominates existing one-step SDXL baselines. Moreover, when transferred to a 6B DiT backbone (Z-Image), DIDR surpasses its 50-step teacher in preference alignment while requiring only a single generation step.

Remote sensing data imputation using deep learning for multispectral imagery

arXiv:2605.24003v1 Announce Type: cross Abstract: Remote sensing techniques have been increasingly utilised in aquatic applications in recent years. A common challenge in using optical satellite data is the presence of missing observations due to cloud cover. These data gaps can lead to missed detection of critical events, such as algal blooms, in lakes of high interest to water authorities. As a result, enhancing the completeness of optical satellite datasets is crucial for improving the monitoring and prediction of algal blooms. In this study, we compared a traditional data imputation method (i.e., linear interpolation) with deep learning models for reconstructing missing spectral bands across four lakes with historical records of algal blooms. The deep learning models adopted include CNN-based architectures (i.e., CNN, Inception Resnet, and Autoencoder) and CNN-LSTM-based architectures (i.e., CNN-LSTM, Resnet-LSTM, and Autoencoder-LSTM). Our results demonstrated that deep learning models substantially outperformed the baseline linear interpolation method in imputing spectral band values within artificially masked regions. Among these models, CNN delivered the best performance across most lakes. Furthermore, we evaluated the performance of algal bloom indices (i.e., Green/Red and NDCI) derived from the imputed imagery by comparing them with the observed data. Our results demonstrate that deep learning models are effective for imputing missing data in PlanetScope SuperDove imagery, enabling more reliable applications in water monitoring.

ActQuant: Sub-4-bit Action-Guided Quantization for Vision-Language-Action Models

arXiv:2605.24011v1 Announce Type: cross Abstract: Vision-Language-Action (VLA) models exhibit remarkable action generation for embodied intelligence, but their heavy compute make deployment on edge platforms impractical. Aggressive, sub-4-bit weight quantization is the natural solution, yet existing post-training quantization (PTQ) methods suffer severe performance degradation in this regime. To address this, we introduce ActQuant, an action-guided mixed-precision PTQ framework that operates in two stages: (1) an inter-tensor bit allocator that assigns each weight matrix a single bit-width based on how much it contributes to predicting the agent's actions; (2) an intra-tensor scale optimizer tunes per-block quantization scales using action-aware curvature, so that dynamic range is concentrated on the weights most influential for control. To deliver the on-device benefits of our aggressive quantization, we further introduce OmniModel.cpp, an agentic conversion pipeline that ports architectures into a native C/C++ runtime with efficient low-bit kernels. We evaluate ActQuant both in simulation and on a real-world 6-DoF UR3 arm, with all models deployed through OmniModel.cpp. On the LIBERO benchmark, ActQuant is the only method that operates at or below 3 bits-per-weight, retaining 95.0% on OpenVLA-OFT and 94.8% on $\pi_{0.5}$. Pushed further, ActQuant reaches 2.5 bpw at 90.1% on OpenVLA-OFT, compressing the backbone from 14.3 GB to 2.7 GB (5.3$\times$). On the physical UR3 arm, $\pi_{0.5}$ quantized with ActQuant retains the baseline's success rate while reducing the memory footprint by 2.5$\times$.

Machine Intelligence that Understands Visual and Linguistic Information and Interacts with Humans and Environments

arXiv:2605.24020v1 Announce Type: cross Abstract: Advancements at the intersection of computer vision and natural language processing are crucial for applications like assistive tech, multimedia querying, and robotics. This dissertation proposes novel architectures to improve intelligent agents across three key vision-language tasks: image captioning, visual dialog, and interactive instruction following. First, we address limitations in visual representation for image captioning. Traditional models rely on region-based features from CNN detectors, which lack global context and suffer from high computational overhead. We propose GRIT (Grid and Region-based Image captioning Transformer), a transformer-only architecture. By integrating grid and region features using a DETR-based detector, GRIT enables end-to-end training and out-performs prior methods in both inference accuracy and speed. Second, we tackle visual dialog, which requires multi-turn conversation about an image. The challenge lies in efficiently modeling interactions between multiple inputs (image, question, history). We introduce LTMI (Light-weight Transformer for Many Inputs). Utilizing a specialized attention block, an LTMI layer matches the representational power of a standard Transformer extension while utilizing less than one-tenth of its parameters, as validated on the VisDial dataset. Finally, we study interactive instruction-following for embodied AI using the ALFRED dataset. We propose a framework featuring a two-stage instruction interpretation: it first decodes language directives independently of visual context to predict a tentative action-object sequence, which is then fused with visual features for final execution. Using multiple egocentric views and hierarchical attention, our method accurately localizes objects and achieves a state-of-the-art unseen success rate of 8.37%.

Mode-as-Sequence: Translating Multimodal Motion Prediction into Unified Sequential Mode Modeling

arXiv:2605.24037v1 Announce Type: cross Abstract: Multimodal motion forecasting is inherently under-supervised: each training scene provides only one realized future, yet multiple plausible futures exist. This sparse supervision often leads to mode collapse (redundant hypotheses and insufficient mode coverage) and unreliable confidence ranking when predicting a small set of trajectories. We propose Mode-as-Sequence, a unified decoding framework that translates an unordered mode set into an ordered mode sequence and explicitly models mode-to-mode dependency. Under this framework, we develop two complementary instantiations. ModeSeq performs recurrent mode decoding, where each mode is generated conditioned on the previously generated modes, encouraging diverse, non-redundant hypotheses with calibrated confidence ordering. To remove the mode-by-mode autoregressive bottleneck, we further propose Parallel ModeSeq, which preserves the same causal dependency using masked mode-to-mode self-attention while decoding all modes in a single forward pass, enabling efficient large-$K$ inference and scalable joint-scene prediction. To learn representative modes and calibrated confidence under sparse labels, we introduce Early-Match-Take-All (EMTA) and its joint-scene extension MA-EMTA, together with a lightweight ranking regularizer that reduces confidence inversions. Extensive experiments on large-scale benchmarks demonstrate consistent improvements in both ranking-oriented metrics and best-of-K accuracy across datasets, horizons, and object types. In the Waymo Open Dataset challenges, ModeSeq achieves 1st place in the 2024 LiDAR-free motion prediction track, and Parallel ModeSeq achieves 1st place in the 2025 Interaction Prediction Challenge, validating the effectiveness of Mode-as-Sequence for both accuracy and efficiency.

Filtered Posterior Mean Collections: A Unified Framework for Analytical Models of Diffusion Generalization

arXiv:2605.24192v1 Announce Type: cross Abstract: The neural-network denoising functions which form the backbone of image diffusion models are remarkably consistent in their generalization behaviour across a wide variety of network architectures and training procedure hyperparameters. A recent line of research has sought to model the outputs of these networks by aggregating posterior weighted averages of training dataset patches. In this work, we consolidate these approaches into a unified model class which we call Filtered Posterior Mean Collections (FPMCs). We define this model class using query precision vectors, response weights, and source distributions, and illustrate that existing methods are recoverable with specific choices of these design axes. Investigating each axis in turn, we find that FPMC performance can be improved with soft relaxations of prior patch-based methods, and through augmentations of source distributions. Applying these findings to an existing FPMC, we demonstrate consistent sample improvement across three natural image datasets.

GIBLy: Improving 3D Semantic Segmentation through an Architecture-Agnostic Lightweight Geometric Inductive Bias Layer

arXiv:2605.24243v1 Announce Type: cross Abstract: In 3D scene understanding, deep learning models rely on large models and extensive training to capture basic geometric structures that are present in the 3D data. However, existing methods lack explicit mechanisms to incorporate geometric information, such as learnable primitive shapes, often necessitating large models and more training data which in turn increases cost and can limit generalization. We introduce GIBLy, a lightweight geometric inductive bias layer that integrates learnable geometric priors into 3D segmentation pipelines. GIBLy enhances existing architectures -- whether MLP-based, convolution-based, or transformer-based -- by providing features aligned with simple geometric shapes (and thus human-interpretable) that improve segmentation performance with minimal computational overhead. We validate our approach across multiple 3D semantic segmentation benchmarks, demonstrating consistent performance gains, including up to +11.5% mIoU on TS40K with PTV3, while adding only 58K extra parameters. Our results highlight the benefit of explicitly encoding geometric structure to support accurate and efficient 3D scene understanding, with a lightweight add-on layer

CRISP -- Clustering-Based Redundancy-Reduced Instance Sampling for Pathology Case Representation and Retrieval

arXiv:2605.24253v1 Announce Type: cross Abstract: Digital pathology archives increasingly contain multiple whole-slide images (WSIs) per case, capturing spatially distinct tumour regions and reflecting intrinsic morphological heterogeneity. However, most existing approaches rely on a single pathologist-selected slide, thereby discarding potentially informative evidence distributed across the remaining WSIs. To date, no autonomous framework has been proposed for comprehensive multi-WSI case processing. Here, we present an unsupervised framework for case-level analysis that integrates information from all available slides within a case. Rather than relying on a single designated slide, the proposed approach constructs case-level representations by selectively distilling informative patches across WSIs. We introduce Clustering-Based Redundancy-Reduced Instance Sampling for Pathology (CRISP), a two-stage framework that first reduces redundancy within individual WSIs and subsequently applies clustering-based sampling to select a compact yet representative set of patches for the entire case. The resulting patch set captures case-level heterogeneity while avoiding exhaustive processing of gigapixel images, and directly serves as a retrieval index. Using two Mayo Clinic breast cancer datasets for diagnosis and treatment planning, we demonstrate that CRISP consistently matches or surpasses the current standard practice of combined model and pathologist slide selection for patient/case search and retrieval. By automating case-level processing and eliminating subjective WSI selection, CRISP potentially enables the exploitation of clinically relevant information distributed across multiple WSIs that is currently overlooked.
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