Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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OrpQuant: Geometric Orthogonal Residual Projection for Multiplier-Free Power-of-Two Transformer Quantization
arXiv:2605.26092v1 Announce Type: cross Abstract: The deployment of Large Language Models (LLMs) and Vision Transformers (ViTs) on edge devices is significantly constrained by memory limitations and the critical timing bottlenecks introduced by dense Multiply-Accumulate (MAC) arrays. In the ultra-low bit regime, logarithmic Power-of-Two (PoT) quantization provides a hardware-efficient alternative by replacing MAC operations with bit-shifts. However, the non-uniform exponential lattice is inhere
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cs.AI, q-bio.NC updates on arXiv.org
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Rethinking the Comparison Unit in Sequence-Level Reinforcement Learning: An Equal-Length Paired Training Framework from Loss Correction to Sample Construction
arXiv:2604.17328v2 Announce Type: replace-cross Abstract: This paper investigates the length problem in sequence-level relative reinforcement learning. We observe that, although existing methods partially alleviate length-related phenomena, a more fundamental issue remains insufficiently characterized: the comparison units used during training lack inherent comparability. Building on this observation, we propose a new perspective: the length problem should not be viewed merely as a loss-scaling
Rethinking the Comparison Unit in Sequence-Level Reinforcement Learning: An Equal-Length Paired Training Framework from Loss Correction to Sample Construction
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cs.AI, q-bio.NC updates on arXiv.org
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Internalizing Outcome Supervision into Process Supervision: A New Paradigm for Reinforcement Learning for Reasoning
arXiv:2605.05226v2 Announce Type: replace-cross Abstract: The central challenge of reinforcement learning for reasoning lies not only in the sparsity of outcome-level supervision, but more fundamentally in how to transform feedback provided only at the end of a sequence into fine-grained learning signals that can guide intermediate reasoning steps. Existing approaches either rely on outcome-level rewards for sequence-level optimization, which makes precise credit assignment difficult, or depend
Internalizing Outcome Supervision into Process Supervision: A New Paradigm for Reinforcement Learning for Reasoning
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Cell Death Discovery nature.com science feeds
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Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma
Cell Death Discovery, Published online: 26 May 2026; doi:10.1038/s41420-026-03165-0Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma
Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma
Cell Death Discovery, Published online: 26 May 2026; doi:10.1038/s41420-026-03165-0
Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma-
Pulmonary nodule
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Integrated single-cell and bulk RNA sequencing reveals novel biomarkers of invasive adenocarcinoma subtypes in lung adenocarcinoma
Transl Cancer Res. 2026 Apr 30;15(4):314. doi: 10.21037/tcr-2025-aw-2503. Epub 2026 Mar 20.ABSTRACTBACKGROUND: Lung adenocarcinoma (LUAD) is one of the most common lung cancer subtypes worldwide, and its aggressive subtype invasive adenocarcinoma (IAC) has low survival rates. The precise identification of IAC is vital for the clinical diagnosis and treatment. The purpose of this study is to identify novel biomarkers for LUAD using single-cell and bulk RNA sequencing, so as to provide theoretical
Integrated single-cell and bulk RNA sequencing reveals novel biomarkers of invasive adenocarcinoma subtypes in lung adenocarcinoma
Transl Cancer Res. 2026 Apr 30;15(4):314. doi: 10.21037/tcr-2025-aw-2503. Epub 2026 Mar 20.
ABSTRACT
BACKGROUND: Lung adenocarcinoma (LUAD) is one of the most common lung cancer subtypes worldwide, and its aggressive subtype invasive adenocarcinoma (IAC) has low survival rates. The precise identification of IAC is vital for the clinical diagnosis and treatment. The purpose of this study is to identify novel biomarkers for LUAD using single-cell and bulk RNA sequencing, so as to provide theoretical basis and practical support for the diagnosis, treatment and prognosis evaluation of lung invasive adenocarcinoma.
METHODS: We employed a combination of transcriptomic analysis and single-cell analysis to investigate the molecular characteristics and immune microenvironment of four subtypes of LUAD, including atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and IAC, with the aim of screening for biomarkers to differentiate pre-invasive lesions from invasive lesions.
RESULTS: Transcriptomic and single-cell analyses revealed that IAC subtypes demonstrated the most substantial molecular differences, particularly in immune cell infiltration and immune-related gene expression. Three genes-CD27, TIGIT, and TNFRSF18-that were significantly upregulated in IAC, predominantly expressed in immune cells and closely linked to immune regulatory pathways. We further analyzed T cell subpopulations in the IAC subtype and explored the expression of transcription factors (TFs) corresponding to these three genes, revealing their critical roles in immune cell function. Additionally, communication between T cells and other cells showed significantly enhanced signaling pathways, particularly those related to immune co-stimulatory molecules and inflammation pathways. Immunohistochemical validation of clinical samples showed that these three genes have high diagnostic value in IAC subtypes. These findings establish a crucial biological foundation for diagnosis, classification, and immunotherapy of LUAD, which contributes to the development of individualized treatment strategies.
CONCLUSIONS: This study identifies a three-gene signature (CD27, TIGIT, and TNFRSF18) that not only distinguishes invasive from pre-invasive LUAD with high precision by capturing the immune checkpoint disequilibrium characteristic of IAC, but also provides a clinically actionable biomarker panel for preoperative diagnosis and personalized immunotherapy strategies.
PMID:42180871 | PMC:PMC13190665 | DOI:10.21037/tcr-2025-aw-2503
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Nature - Issue - nature.com science feeds
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Carbonyl swapping converts cyclic ketones to saturated heterocycles
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10508-5Carbonyl swapping converts cyclic ketones to saturated heterocycles
Carbonyl swapping converts cyclic ketones to saturated heterocycles
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10508-5
Carbonyl swapping converts cyclic ketones to saturated heterocycles-
Nature - Issue - nature.com science feeds
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Can China’s Great Green Wall shape efforts to keep the world’s deserts at bay?
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01102-wGrand anti-desertification schemes often fail when trees die and funding dries up — yet one project has broken the mould.
Can China’s Great Green Wall shape efforts to keep the world’s deserts at bay?
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01102-w
Grand anti-desertification schemes often fail when trees die and funding dries up — yet one project has broken the mould.-
cs.AI, q-bio.NC updates on arXiv.org
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Can LLMs Learn to Reason Robustly under Noisy Supervision?
arXiv:2604.03993v1 Announce Type: cross Abstract: Reinforcement Learning with Verifiable Rewards (RLVR) effectively trains reasoning models that rely on abundant perfect labels, but its vulnerability to unavoidable noisy labels due to expert scarcity remains critically underexplored. In this work, we take the first step toward a systematic analysis of noisy label mechanisms in RLVR. In contrast to supervised classification, most RLVR algorithms incorporate a rollout-based condition: a label's i
Can LLMs Learn to Reason Robustly under Noisy Supervision?
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cs.AI, q-bio.NC updates on arXiv.org
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VLBiasBench: A Comprehensive Benchmark for Evaluating Bias in Large Vision-Language Model
arXiv:2406.14194v3 Announce Type: replace-cross Abstract: The emergence of Large Vision-Language Models (LVLMs) marks significant strides towards achieving general artificial intelligence. However, these advancements are accompanied by concerns about biased outputs, a challenge that has yet to be thoroughly explored. Existing benchmarks are not sufficiently comprehensive in evaluating biases due to their limited data scale, single questioning format and narrow sources of bias. To address this p
VLBiasBench: A Comprehensive Benchmark for Evaluating Bias in Large Vision-Language Model
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cs.AI, q-bio.NC updates on arXiv.org
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TRACE-Bot: Detecting Emerging LLM-Driven Social Bots via Implicit Semantic Representations and AIGC-Enhanced Behavioral Patterns
arXiv:2604.02147v1 Announce Type: new Abstract: Large Language Model-driven (LLM-driven) social bots pose a growing threat to online discourse by generating human-like content that evades conventional detection. Existing methods suffer from limited detection accuracy due to overreliance on single-modality signals, insufficient sensitivity to the specific generative patterns of Artificial Intelligence-Generated Content (AIGC), and a failure to adequately model the interplay between linguistic pa
TRACE-Bot: Detecting Emerging LLM-Driven Social Bots via Implicit Semantic Representations and AIGC-Enhanced Behavioral Patterns
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cs.AI, q-bio.NC updates on arXiv.org
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SHOE: Semantic HOI Open-Vocabulary Evaluation Metric
arXiv:2604.01586v1 Announce Type: cross Abstract: Open-vocabulary human-object interaction (HOI) detection is a step towards building scalable systems that generalize to unseen interactions in real-world scenarios and support grounded multimodal systems that reason about human-object relationships. However, standard evaluation metrics, such as mean Average Precision (mAP), treat HOI classes as discrete categorical labels and fail to credit semantically valid but lexically different predictions
SHOE: Semantic HOI Open-Vocabulary Evaluation Metric
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cs.AI, q-bio.NC updates on arXiv.org
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Think, Act, Build: An Agentic Framework with Vision Language Models for Zero-Shot 3D Visual Grounding
arXiv:2604.00528v2 Announce Type: replace-cross Abstract: 3D Visual Grounding (3D-VG) aims to localize objects in 3D scenes via natural language descriptions. While recent advancements leveraging Vision-Language Models (VLMs) have explored zero-shot possibilities, they typically suffer from a static workflow relying on preprocessed 3D point clouds, essentially degrading grounding into proposal matching. To bypass this reliance, our core motivation is to decouple the task: leveraging 2D VLMs to
Think, Act, Build: An Agentic Framework with Vision Language Models for Zero-Shot 3D Visual Grounding
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cs.AI, q-bio.NC updates on arXiv.org
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Do Phone-Use Agents Respect Your Privacy?
arXiv:2604.00986v2 Announce Type: replace-cross Abstract: We study whether phone-use agents respect privacy while completing benign mobile tasks. This question has remained hard to answer because privacy-compliant behavior is not operationalized for phone-use agents, and ordinary apps do not reveal exactly what data agents type into which form entries during execution. To make this question measurable, we introduce MyPhoneBench, a verifiable evaluation framework for privacy behavior in mobile a
Do Phone-Use Agents Respect Your Privacy?
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cs.AI, q-bio.NC updates on arXiv.org
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FlowPIE: Test-Time Scientific Idea Evolution with Flow-Guided Literature Exploration
arXiv:2603.29557v1 Announce Type: new Abstract: Scientific idea generation (SIG) is critical to AI-driven autonomous research, yet existing approaches are often constrained by a static retrieval-then-generation paradigm, leading to homogeneous and insufficiently divergent ideas. In this work, we propose FlowPIE, a tightly coupled retrieval-generation framework that treats literature exploration and idea generation as a co-evolving process. FlowPIE expands literature trajectories via a flow-guid
FlowPIE: Test-Time Scientific Idea Evolution with Flow-Guided Literature Exploration
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cs.AI, q-bio.NC updates on arXiv.org
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Owl-AuraID 1.0: An Intelligent System for Autonomous Scientific Instrumentation and Scientific Data Analysis
arXiv:2603.29828v1 Announce Type: new Abstract: Scientific discovery increasingly depends on high-throughput characterization, yet automation is hindered by proprietary GUIs and the limited generalizability of existing API-based systems. We present Owl-AuraID, a software-hardware collaborative embodied agent system that adopts a GUI-native paradigm to operate instruments through the same interfaces as human experts. Its skill-centric framework integrates Type-1 (GUI operation) and Type-2 (data
Owl-AuraID 1.0: An Intelligent System for Autonomous Scientific Instrumentation and Scientific Data Analysis
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cs.AI, q-bio.NC updates on arXiv.org
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WAter: A Workload-Adaptive Knob Tuning System based on Workload Compression
arXiv:2603.28809v1 Announce Type: cross Abstract: Selecting appropriate values for the configurable parameters of Database Management Systems (DBMS) to improve performance is a significant challenge. Recent machine learning (ML)-based tuning systems have shown strong potential, but their practical adoption is often limited by the high tuning cost. This cost arises from two main factors: (1) the system needs to evaluate a large number of configurations to identify a satisfactory one, and (2) for
WAter: A Workload-Adaptive Knob Tuning System based on Workload Compression
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cs.AI, q-bio.NC updates on arXiv.org
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InCoder-32B: Code Foundation Model for Industrial Scenarios
arXiv:2603.16790v3 Announce Type: replace-cross Abstract: Recent code large language models have achieved remarkable progress on general programming tasks. Nevertheless, their performance degrades significantly in industrial scenarios that require reasoning about hardware semantics, specialized language constructs, and strict resource constraints. To address these challenges, we introduce InCoder-32B (Industrial-Coder-32B), the first 32B-parameter code foundation model unifying code intelligenc
InCoder-32B: Code Foundation Model for Industrial Scenarios
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Nature - Issue - nature.com science feeds
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Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10264-6Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.
Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10264-6
Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.-
Omics In Lung
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Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis
Nat Commun. 2026 Mar 20;17(1):2655. doi: 10.1038/s41467-026-70193-w.ABSTRACTPulmonary fibrosis represents a progressive interstitial lung disease marked by excessive extracellular matrix deposition and architectural distortion. Vascular endothelial cells critically contribute to fibrogenesis through paracrine secretion of pro-fibrotic mediators, yet their mechanobiological regulation remains elusive. Using integrated single-cell multi-omics profiling of human pulmonary fibrosis specimens and exp
Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis
Nat Commun. 2026 Mar 20;17(1):2655. doi: 10.1038/s41467-026-70193-w.
ABSTRACT
Pulmonary fibrosis represents a progressive interstitial lung disease marked by excessive extracellular matrix deposition and architectural distortion. Vascular endothelial cells critically contribute to fibrogenesis through paracrine secretion of pro-fibrotic mediators, yet their mechanobiological regulation remains elusive. Using integrated single-cell multi-omics profiling of human pulmonary fibrosis specimens and experimental fibrosis models induced by bleomycin or silica, we identify mechanosensitive Piezo1 upregulation in Endothelial cells as a hallmark of fibrotic progression. Endothelial-specific Piezo1 knockout significantly attenuates Bleomycin-induced fibrotic remodeling in male mice, establishing its pathogenic necessity. Mechanistically, PIEZO1 activation promotes pulmonary fibrosis development via CAPN2-mediated STAT3 phosphorylation, which may regulate the secretion of the pro-fibrotic molecule interleukin-33. These findings suggest that the endothelial PIEZO1-CAPN2-STAT3-IL33 axis is a potential therapeutic target for PF intervention.
PMID:41862476 | PMC:PMC13004862 | DOI:10.1038/s41467-026-70193-w
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Nature Biotechnology - Issue - nature.com science feeds
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Generalist biological artificial intelligence in modeling the language of life
Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03064-wThis Review discusses the promises and pitfalls of biological AI algorithms and presents a vision for generalist biological artificial intelligence, in which models can perform diverse tasks across biological domains.
Generalist biological artificial intelligence in modeling the language of life
Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03064-w
This Review discusses the promises and pitfalls of biological AI algorithms and presents a vision for generalist biological artificial intelligence, in which models can perform diverse tasks across biological domains.