Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
VectorArk: Learning Practical Image Vectorization with Rounded Polygon Representation
arXiv:2605.24398v1 Announce Type: cross Abstract: Recent vision-language model (VLM)-based approaches have achieved impressive results on image vectorization tasks. However, they are typically evaluated on synthetic benchmarks, where clean SVGs are rasterized at high resolution and then re-vectorized. As a result, these methods generalize poorly to real-world scenarios, such as images with unknown rasterization methods or those generated by text-to-image models. We introduce VectorArk, a new VL
-
cs.AI, q-bio.NC updates on arXiv.org
-
Step-TP: A Grounded, Step-Level Dataset with Chain-of-Thought Reasoning for LLM-Guided Tensor Program Optimization
arXiv:2605.25954v1 Announce Type: cross Abstract: Despite the strong reasoning capabilities of large language models (LLMs), optimizing the execution efficiency of tensor programs remains challenging due to the need for precise, composable transformation decisions. Recent LLM-guided approaches frame tensor program optimization as an iterative decision process, but existing datasets provide only end-to-end optimized program pairs using token-inefficient representations, lacking verifiable step-l
Step-TP: A Grounded, Step-Level Dataset with Chain-of-Thought Reasoning for LLM-Guided Tensor Program Optimization
-
cs.AI, q-bio.NC updates on arXiv.org
-
HiTeC: Hierarchical Contrastive Learning on Text-Attributed Hypergraph with Semantic-Aware Augmentation
arXiv:2508.03104v3 Announce Type: replace-cross Abstract: Contrastive learning (CL) has become a dominant paradigm for self-supervised hypergraph learning, enabling effective training without costly labels. However, node entities in real-world hypergraphs are often associated with rich textual information, which has been largely ignored in prior works. Directly applying existing CL-based methods to such text-attributed hypergraphs (TAHGs) leads to three key limitations: (1) The common use of gr
HiTeC: Hierarchical Contrastive Learning on Text-Attributed Hypergraph with Semantic-Aware Augmentation
-
Nature Cancer
-
CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8<sup>+</sup> T cells
Nature Cancer, Published online: 15 May 2026; doi:10.1038/s43018-026-01169-4Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses.
CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8<sup>+</sup> T cells
Nature Cancer, Published online: 15 May 2026; doi:10.1038/s43018-026-01169-4
Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses.-
Omics in Gastric
-
An Orally Deliverable, Food-Compatible Lyophilized Recombinant Whole-Cell Catalyst for Alcohol-Associated Liver Injury
Microorganisms. 2026 Mar 26;14(4):746. doi: 10.3390/microorganisms14040746.ABSTRACTEffective oral interventions for alcohol-induced metabolic stress and liver injury remain limited. Pre-absorptive gastrointestinal alcohol handling is gaining interest as a non-pharmacological strategy to reduce hepatic burden. In this study, we developed a formulation-integrated, food-compatible lyophilized recombinant whole-cell catalyst based on Escherichia coli Nissle 1917 engineered to express alcohol dehydro
An Orally Deliverable, Food-Compatible Lyophilized Recombinant Whole-Cell Catalyst for Alcohol-Associated Liver Injury
Microorganisms. 2026 Mar 26;14(4):746. doi: 10.3390/microorganisms14040746.
ABSTRACT
Effective oral interventions for alcohol-induced metabolic stress and liver injury remain limited. Pre-absorptive gastrointestinal alcohol handling is gaining interest as a non-pharmacological strategy to reduce hepatic burden. In this study, we developed a formulation-integrated, food-compatible lyophilized recombinant whole-cell catalyst based on Escherichia coli Nissle 1917 engineered to express alcohol dehydrogenase and acetaldehyde dehydrogenase. Rather than focusing exclusively on strain-level genetic modification, the engineered cells were protected by lyophilization combined with a food-grade chitosan-alginate layer-by-layer coating, forming an artificial cell wall designed to enhance survivability during oral delivery. The formulation resisted simulated gastric acid, sodium taurocholate, and ethanol, retained enzymatic activity after storage, and demonstrated formulation stability. In alcohol-exposed mice, oral administration reduced blood ethanol and acetaldehyde levels, improved liver biochemical parameters, attenuated hepatic steatosis, and partially restored oxidative stress indicators. Integrated multi-omics analyses indicated coordinated gut-associated metabolic and inflammatory responses to alcohol and intervention, rather than a single dominant pathway. These findings provide hypothesis-generating evidence; causality remains to be established. Overall, this study demonstrates a proof-of-concept, food-compatible lyophilized recombinant whole-cell catalyst that integrates enzymatic function with formulation stability and gastrointestinal resilience, highlighting an applied, food-compatible microbial framework for exploring alcohol-related metabolic stress.
PMID:42075143 | PMC:PMC13119499 | DOI:10.3390/microorganisms14040746
-
Cell
-
Respiratory viral infections prime accelerated lung cancer growth
Severe COVID-19 is associated with an increased subsequent risk of lung cancer. Viral pneumonia induces durable lung epigenetic imprinting that promotes tumor-supportive neutrophils and impairs T cell immunity, which is reversible with combined CXCR2 inhibition and PD-L1 blockade.
Respiratory viral infections prime accelerated lung cancer growth
-
Nature - Issue - nature.com science feeds
-
Asymmetric selection of a rice immune module and rebuild of disease resistance
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10361-6Stacking XA48-mediated effector-triggered immunity with XA21-mediated pattern-triggered immunity in Oryza sativa japonica reconstitutes the broad-spectrum resistance from wild rice.
Asymmetric selection of a rice immune module and rebuild of disease resistance
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10361-6
Stacking XA48-mediated effector-triggered immunity with XA21-mediated pattern-triggered immunity in Oryza sativa japonica reconstitutes the broad-spectrum resistance from wild rice.-
cs.AI, q-bio.NC updates on arXiv.org
-
TSPO: Breaking the Double Homogenization Dilemma in Multi-turn Search Policy Optimization
arXiv:2601.22776v2 Announce Type: replace Abstract: Multi-turn tool-integrated reasoning enables Large Language Models (LLMs) to solve complex tasks through iterative information retrieval. However, current reinforcement learning (RL) frameworks for search-augmented reasoning predominantly rely on sparse outcome-level rewards, leading to a "Double Homogenization Dilemma." This manifests as (1) Process homogenization, where the thinking, reasoning, and tooling involved in generation are ignored.
TSPO: Breaking the Double Homogenization Dilemma in Multi-turn Search Policy Optimization
-
cs.AI, q-bio.NC updates on arXiv.org
-
Enhancing Foundation VLM Robustness to Missing Modality: Scalable Diffusion for Bi-directional Feature Restoration
arXiv:2602.03151v2 Announce Type: replace Abstract: Vision Language Model (VLM) typically assume complete modality input during inference. However, their effectiveness drops sharply when certain modalities are unavailable or incomplete. Current research on missing modality primarily faces two dilemmas: Prompt-based methods struggle to restore missing yet indispensable features and degrade the generalizability of VLM. Imputation-based approaches, lacking effective guidance, are prone to generati
Enhancing Foundation VLM Robustness to Missing Modality: Scalable Diffusion for Bi-directional Feature Restoration
-
cs.AI, q-bio.NC updates on arXiv.org
-
AeroTherm-GPT: A Verification-Centered LLM Framework for Thermal Protection System Engineering Workflows
arXiv:2604.01738v1 Announce Type: new Abstract: Integrating Large Language Models (LLMs) into hypersonic thermal protection system (TPS) design is bottlenecked by cascading constraint violations when generating executable simulation artifacts. General-purpose LLMs, treating generation as single-pass text completion, fail to satisfy the sequential, multi-gate constraints inherent in safety-critical engineering workflows. To address this, we propose AeroTherm-GPT, the first TPS-specialized LLM Ag
AeroTherm-GPT: A Verification-Centered LLM Framework for Thermal Protection System Engineering Workflows
-
cs.AI, q-bio.NC updates on arXiv.org
-
NCCL EP: Towards a Unified Expert Parallel Communication API for NCCL
arXiv:2603.13606v3 Announce Type: replace-cross Abstract: Mixture-of-Experts (MoE) architectures have become essential for scaling large language models, driving the development of specialized device-initiated communication libraries such as DeepEP, Hybrid-EP, and others. These libraries demonstrate the performance benefits of GPU-initiated RDMA for MoE dispatch and combine operations. This paper presents NCCL EP (Expert Parallelism), a ground-up MoE communication library built entirely on NC
NCCL EP: Towards a Unified Expert Parallel Communication API for NCCL
-
Cell
-
Ferritin aggregation cell engager for CAR T avidity engineering against refractory leukemias
Li et al. developed a ferritin aggregation cell engager that helps CAR T cells better recognize and attack leukemia cells without re-engineering the CAR itself. This versatile platform overcomes antigen modulation and enables combination with chemotherapy.
Ferritin aggregation cell engager for CAR T avidity engineering against refractory leukemias
-
Cell
-
Hijacking ERAD for targeted degradation of transmembrane proteins
Development of an ERAD-hijacking technology overcomes the challenges of current targeted protein degradation approaches to achieve degradation of transmembrane proteins.
Hijacking ERAD for targeted degradation of transmembrane proteins
-
Nature Biotechnology - Issue - nature.com science feeds
-
Sustained nitric oxide production by engineered <i>E. coli</i> remodels the tumor microenvironment and potentiates immunotherapy
Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03054-ySolid tumors are sensitized to anti‑PD‑L1 immunotherapy by engineered E. coli to produce nitric oxide.
Sustained nitric oxide production by engineered <i>E. coli</i> remodels the tumor microenvironment and potentiates immunotherapy
Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03054-y
Solid tumors are sensitized to anti‑PD‑L1 immunotherapy by engineered E. coli to produce nitric oxide.-
cs.AI, q-bio.NC updates on arXiv.org
-
FCMBench: The First Large-scale Financial Credit Multimodal Benchmark for Real-world Applications
arXiv:2601.00150v3 Announce Type: replace-cross Abstract: FCMBench is the first large-scale and privacy-compliant multimodal benchmark for real-world financial credit applications, covering tasks and robustness challenges from domain specific workflows and constraints. The current version of FCMBench covers 26 certificate types, with 5198 privacy-compliant images and 13806 paired VQA samples. It evaluates models on Perception and Reasoning tasks under real-world Robustness interferences, includ
FCMBench: The First Large-scale Financial Credit Multimodal Benchmark for Real-world Applications
-
cs.AI, q-bio.NC updates on arXiv.org
-
DARC: Disagreement-Aware Alignment via Risk-Constrained Decoding
arXiv:2603.08145v1 Announce Type: cross Abstract: Preference-based alignment methods (e.g., RLHF, DPO) typically optimize a single scalar objective, implicitly averaging over heterogeneous human preferences. In practice, systematic annotator and user-group disagreement makes mean-reward maximization brittle and susceptible to proxy over-optimization. We propose **Disagreement-Aware Alignment via Risk-Constrained Decoding (DARC)**, a retraining-free inference-time method that frames response sel
DARC: Disagreement-Aware Alignment via Risk-Constrained Decoding
-
cs.AI, q-bio.NC updates on arXiv.org
-
DeepXiv-SDK: An Agentic Data Interface for Scientific Literature
arXiv:2603.00084v2 Announce Type: replace-cross Abstract: LLM-agents are increasingly used to accelerate the progress of scientific research. Yet a persistent bottleneck is data access: agents not only lack readily available tools for retrieval, but also have to work with unstrcutured, human-centric data on the Internet, such as HTML web-pages and PDF files, leading to excessive token consumption, limit working efficiency, and brittle evidence look-up. This gap motivates the development of \tex
DeepXiv-SDK: An Agentic Data Interface for Scientific Literature
-
cs.AI, q-bio.NC updates on arXiv.org
-
VecFormer: Towards Efficient and Generalizable Graph Transformer with Graph Token Attention
arXiv:2602.19622v1 Announce Type: cross Abstract: Graph Transformer has demonstrated impressive capabilities in the field of graph representation learning. However, existing approaches face two critical challenges: (1) most models suffer from exponentially increasing computational complexity, making it difficult to scale to large graphs; (2) attention mechanisms based on node-level operations limit the flexibility of the model and result in poor generalization performance in out-of-distribution
VecFormer: Towards Efficient and Generalizable Graph Transformer with Graph Token Attention
-
cs.AI, q-bio.NC updates on arXiv.org
-
(PASS) Visual Prompt Locates Good Structure Sparsity through a Recurrent HyperNetwork
arXiv:2407.17412v2 Announce Type: replace-cross Abstract: Large-scale neural networks have demonstrated remarkable performance in different domains like vision and language processing, although at the cost of massive computation resources. As illustrated by compression literature, structural model pruning is a prominent algorithm to encourage model efficiency, thanks to its acceleration-friendly sparsity patterns. One of the key questions of structural pruning is how to estimate the channel sig