A mitochondrial transplantation approach rescues mitochondrial deficiency and prevents mitochondrial DNA depletion syndrome, Leigh syndrome, and Parkinson’s disease in cellular and mouse models.

Background: Evidence-based physician-pharmacist collaborative clinics have demonstrated significant short-term benefits for patients with type 2 diabetes (T2D), but their long-term effectiveness remains unclear, especially in primary health care settings. Objective: This study aimed to explore the long-term effectiveness and cost-effectiveness of a novel, digital-driven, multifaceted physician-pharmacist collaborative model for managing patients with T2D in underresourced settings. Methods: We conducted a 12-month cluster randomized controlled trial from May 2021 to December 2022 across 6 primary health care settings in China. Guided by the theory of planned behavior, the intervention involved routine therapy from physicians along with pharmaceutical interventions from pharmacists. These were delivered through a combination of face-to-face visits and mobile health care. The intervention group received 4 face-to-face visits and biweekly remote education sessions over the 12 months. We conducted intention-to-treat analyses to estimate differences in clinical and behavior indicators between the intervention and control groups. Primary outcomes included glycosylated hemoglobin and 10-year atherosclerotic cardiovascular risk. Data were analyzed using adjusted generalized estimation equations. Results: This study included 574 patients (291 in the intervention group and 283 in the control group). Over 12 months, patients in the intervention group had significant reductions in hemoglobin A_1c (–2.57 vs –1.96, respectively; P<.001; 95% CI –1.027 to –0.238) and 10-year atherosclerotic cardiovascular risk (–1.35 vs 0.01, respectively; P<.001; 95% CI –1.690 to –0.630) compared with the control group. Substantial improvements were also observed in several secondary outcomes, including fasting blood glucose, 2-hour postprandial blood glucose, waist circumference, waist-to-hip ratio, blood pressure, triglyceride, and total cholesterol. Total diabetes-related costs decreased, and patient satisfaction improved significantly in the intervention group. There were no significant differences in BMI, high-density lipoprotein, or low-density lipoprotein. Conclusions: These findings suggest that the physician-pharmacist collaborative model could improve the long-term quality and efficiency of T2D management and reduce medical costs in underresourced areas globally. Patients with T2D, especially those with central obesity or high cardiovascular risk, may benefit more from collaborative clinics. Trial Registration: Chinese Clinical Trial Registry ChiCTR2000031839; https://www.chictr.org.cn/showproj.html?proj=51910

arXiv:2603.08048v1 Announce Type: new Abstract: Fault diagnosis is critical for the safe operation of industrial systems. Conventional diagnosis models typically produce abstract outputs such as anomaly scores or fault categories, failing to answer critical operational questions like "Why" or "How to repair". While large language models (LLMs) offer strong generalization and reasoning abilities, their training on discrete textual corpora creates a semantic gap when processing high-dimensional, temporal industrial signals. To address this challenge, we propose a Signals-to-Semantics fault diagnosis (S2S-FDD) framework that bridges high-dimensional sensor signals with natural language semantics through two key innovations: We first design a Signal-to-Semantic operator to convert abstract time-series signals into natural language summaries, capturing trends, periodicity, and deviations. Based on the descriptions, we design a multi-turn tree-structured diagnosis method to perform fault diagnosis by referencing historical maintenance documents and dynamically querying additional signals. The framework further supports human-in-the-loop feedback for continuous refinement. Experiments on the multiphase flow process show the feasibility and effectiveness of the proposed method for explainable zero-shot fault diagnosis.

arXiv:2512.24943v2 Announce Type: replace-cross Abstract: Search relevance plays a central role in web e-commerce. While large language models (LLMs) have shown significant results on relevance task, existing benchmarks lack sufficient complexity for comprehensive model assessment, resulting in an absence of standardized relevance evaluation metrics across the industry. To address this limitation, we propose Rule-Aware benchmark with Image for Relevance assessment(RAIR), a Chinese dataset derived from real-world scenarios. RAIR established a standardized framework for relevance assessment and provides a set of universal rules, which forms the foundation for standardized evaluation. Additionally, RAIR analyzes essential capabilities required for current relevance models and introduces a comprehensive dataset consists of three subset: (1) a general subset with industry-balanced sampling to evaluate fundamental model competencies; (2) a long-tail hard subset focus on challenging cases to assess performance limits; (3) a visual salience subset for evaluating multimodal understanding capabilities. We conducted experiments on RAIR using 14 open and closed-source models. The results demonstrate that RAIR presents sufficient challenges even for GPT-5, which achieved the best performance. RAIR data are now available, serving as an industry benchmark for relevance assessment while providing new insights into general LLM and Visual Language Model(VLM) evaluation.