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cs.AI, q-bio.NC updates on arXiv.org
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DR-LoRA: Dynamic Rank LoRA for Fine-Tuning Mixture-of-Experts Models
arXiv:2601.04823v5 Announce Type: replace Abstract: Mixture-of-Experts (MoE) has become a prominent paradigm for scaling Large Language Models (LLMs). Parameter-efficient fine-tuning methods, such as LoRA, are widely adopted to adapt pretrained MoE LLMs to downstream tasks. However, existing approaches typically assign identical LoRA ranks to all expert modules, ignoring the heterogeneous specialization of pretrained experts. This uniform allocation leads to a resource mismatch: task-relevant e
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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AI-guided multi-omics analysis identifies NPC1-modulated susceptibility to SARS-CoV-2 infection under PM(2.5) exposure
Nat Commun. 2026 Mar 30. doi: 10.1038/s41467-026-71196-3. Online ahead of print.ABSTRACTExposure to airborne fine particulate matter (PM2.5) has been linked to increased risk of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, yet the underlying mechanisms remain unclear. Here, by leveraging a fine-tuned foundation model of single-cell transcriptomics, we uncover shared transcriptional signatures between PM2.5 exposure and SARS-CoV-2 infection. We further validate this
AI-guided multi-omics analysis identifies NPC1-modulated susceptibility to SARS-CoV-2 infection under PM(2.5) exposure
Nat Commun. 2026 Mar 30. doi: 10.1038/s41467-026-71196-3. Online ahead of print.
ABSTRACT
Exposure to airborne fine particulate matter (PM2.5) has been linked to increased risk of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, yet the underlying mechanisms remain unclear. Here, by leveraging a fine-tuned foundation model of single-cell transcriptomics, we uncover shared transcriptional signatures between PM2.5 exposure and SARS-CoV-2 infection. We further validate this association using population-level epidemiological analyses and perform genome-wide association studies (GWAS) to identify genetic variants that modulate infection risk under PM2.5 exposure. In addition, we identify NPC1 as a key modulator involved in SARS-CoV-2 infection efficiency under virus-laden PM2.5 exposure through integrative functional genomic analyses and in vitro experiments. Our findings suggest that PM2.5 facilitates viral entry through an NPC1-modulated endo-lysosomal pathway, providing a mechanistic explanation for observed pollution-related susceptibility. By integrating artificial intelligence (AI)-guided transcriptomics, epidemiology, GWAS, functional genomics, and in vitro verification, our study elucidates how environmental and genetic factors jointly influence SARS-CoV-2 susceptibility. This work highlights how AI-assisted multi-omics integration systematically decodes the health impacts of environmental exposures from molecular to population levels and informs air quality policy and infectious disease preparedness.
PMID:41912520 | DOI:10.1038/s41467-026-71196-3
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cs.AI, q-bio.NC updates on arXiv.org
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Taming Preconditioner Drift: Unlocking the Potential of Second-Order Optimizers for Federated Learning on Non-IID Data
arXiv:2602.19271v1 Announce Type: cross Abstract: Second-order optimizers can significantly accelerate large-scale training, yet their naive federated variants are often unstable or even diverge on non-IID data. We show that a key culprit is \emph{preconditioner drift}: client-side second-order training induces heterogeneous \emph{curvature-defined geometries} (i.e., preconditioner coordinate systems), and server-side model averaging updates computed under incompatible metrics, corrupting the
Taming Preconditioner Drift: Unlocking the Potential of Second-Order Optimizers for Federated Learning on Non-IID Data
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cs.AI, q-bio.NC updates on arXiv.org
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Rethinking LoRA for Privacy-Preserving Federated Learning in Large Models
arXiv:2602.19926v1 Announce Type: cross Abstract: Fine-tuning large vision models (LVMs) and large language models (LLMs) under differentially private federated learning (DPFL) is hindered by a fundamental privacy-utility trade-off. Low-Rank Adaptation (LoRA), a promising parameter-efficient fine-tuning (PEFT) method, reduces computational and communication costs by introducing two trainable low-rank matrices while freezing pre-trained weights. However, directly applying LoRA in DPFL settings l
Rethinking LoRA for Privacy-Preserving Federated Learning in Large Models
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cs.AI, q-bio.NC updates on arXiv.org
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DP-FedAdamW: An Efficient Optimizer for Differentially Private Federated Large Models
arXiv:2602.19945v1 Announce Type: cross Abstract: Balancing convergence efficiency and robustness under Differential Privacy (DP) is a central challenge in Federated Learning (FL). While AdamW accelerates training and fine-tuning in large-scale models, we find that directly applying it to Differentially Private FL (DPFL) suffers from three major issues: (i) data heterogeneity and privacy noise jointly amplify the variance of second-moment estimator, (ii) DP perturbations bias the second-moment