Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
PhySense: Sensor Placement Optimization for Accurate Physics Sensing
arXiv:2505.18190v5 Announce Type: replace-cross Abstract: Physics sensing plays a central role in many scientific and engineering domains, which inherently involves two coupled tasks: reconstructing dense physical fields from sparse observations and optimizing scattered sensor placements to observe maximum information. While deep learning has made rapid advances in sparse-data reconstruction, existing methods generally omit optimization of sensor placements, leaving the mutual enhancement betwe
-
cs.AI, q-bio.NC updates on arXiv.org
-
BackWeak: Backdooring Knowledge Distillation Simply with Weak Triggers and Fine-tuning
arXiv:2511.12046v2 Announce Type: replace-cross Abstract: Knowledge Distillation (KD) is essential for compressing large models, yet relying on pre-trained "teacher" models downloaded from third-party repositories introduces serious security risks--most notably backdoor attacks. Existing KD backdoor methods are typically complex and computationally intensive: they employ surrogate student models and simulated distillation to guarantee transferability, and construct triggers similar to universal
BackWeak: Backdooring Knowledge Distillation Simply with Weak Triggers and Fine-tuning
-
Nature - Issue - nature.com science feeds
-
Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10488-6Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10488-6
Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function-
npj Digital Medicine
-
A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease
npj Digital Medicine, Published online: 30 March 2026; doi:10.1038/s41746-026-02570-0A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease
A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease
npj Digital Medicine, Published online: 30 March 2026; doi:10.1038/s41746-026-02570-0
A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease-
cs.AI, q-bio.NC updates on arXiv.org
-
Retrieval-Augmented Generation with Covariate Time Series
arXiv:2603.04951v2 Announce Type: replace Abstract: While RAG has greatly enhanced LLMs, extending this paradigm to Time-Series Foundation Models (TSFMs) remains a challenge. This is exemplified in the Predictive Maintenance of the Pressure Regulating and Shut-Off Valve (PRSOV), a high-stakes industrial scenario characterized by (1) data scarcity, (2) short transient sequences, and (3) covariate coupled dynamics. Unfortunately, existing time-series RAG approaches predominantly rely on generated
Retrieval-Augmented Generation with Covariate Time Series
-
Omics in Gastric
-
19-Hydroxybufalin Inhibits Gastric Cancer Cell Proliferation by Modulating Metabolic Reprogramming
J Proteome Res. 2026 Apr 3;25(4):2014-2023. doi: 10.1021/acs.jproteome.5c00983. Epub 2026 Mar 17.ABSTRACTOBJECTIVE: 19-Hydroxybufalin (19-H) is a natural bioactive compound with anticancer potential, but its molecular target and mechanism of action remain unclear. This study aimed to systematically evaluate its antigastric cancer activity and identify potential molecular targets.METHODS: The antitumor effect of 19-H was evaluated in both in vitro and in vivo models. Multiomics analysis, thermal
19-Hydroxybufalin Inhibits Gastric Cancer Cell Proliferation by Modulating Metabolic Reprogramming
J Proteome Res. 2026 Apr 3;25(4):2014-2023. doi: 10.1021/acs.jproteome.5c00983. Epub 2026 Mar 17.
ABSTRACT
OBJECTIVE: 19-Hydroxybufalin (19-H) is a natural bioactive compound with anticancer potential, but its molecular target and mechanism of action remain unclear. This study aimed to systematically evaluate its antigastric cancer activity and identify potential molecular targets.
METHODS: The antitumor effect of 19-H was evaluated in both in vitro and in vivo models. Multiomics analysis, thermal proteome profiling, molecular docking, and molecular dynamics simulations were employed to elucidate the mechanism of action. Functional assays were further conducted to validate the key target.
RESULTS: 19-H exhibited nanomolar-level inhibitory activity against various gastric cancer cell lines, significantly suppressing tumor growth in subcutaneous xenograft and patient-derived xenograft models. Multiomics analysis revealed that 19-H reshaped metabolic pathways in gastric cancer. TPP screening identified PLPP2 as a potential target with significantly increased thermal stability upon 19-H treatment. Molecular simulations further revealed that 19-H binds stably to the α-helical region of PLPP2.
CONCLUSIONS: 19-H exerts its antigastric cancer effect by targeting PLPP2 and remodeling the metabolic network. PLPP2 may represent a novel therapeutic target for gastric cancer.
PMID:41842934 | DOI:10.1021/acs.jproteome.5c00983
-
cs.AI, q-bio.NC updates on arXiv.org
-
FinToolBench: Evaluating LLM Agents for Real-World Financial Tool Use
arXiv:2603.08262v1 Announce Type: new Abstract: The integration of Large Language Models (LLMs) into the financial domain is driving a paradigm shift from passive information retrieval to dynamic, agentic interaction. While general-purpose tool learning has witnessed a surge in benchmarks, the financial sector, characterized by high stakes, strict compliance, and rapid data volatility, remains critically underserved. Existing financial evaluations predominantly focus on static textual analysis
FinToolBench: Evaluating LLM Agents for Real-World Financial Tool Use
-
cs.AI, q-bio.NC updates on arXiv.org
-
Regression Models Meet Foundation Models: A Hybrid-AI Approach to Practical Electricity Price Forecasting
arXiv:2603.06726v1 Announce Type: cross Abstract: Electricity market prices exhibit extreme volatility, nonlinearity, and non-stationarity, making accurate forecasting a significant challenge. While cutting-edge time series foundation models (TSFMs) effectively capture temporal dependencies, they typically underutilize cross-variate correlations and non-periodic patterns that are essential for price forecasting. Conversely, regression models excel at capturing feature interactions but are limit
Regression Models Meet Foundation Models: A Hybrid-AI Approach to Practical Electricity Price Forecasting
-
Cell Death Discovery nature.com science feeds
-
Lysophosphatidylcholine acyltransferase 1 promotes head and neck squamous cell carcinoma progression by enhancing COX17-dependent oxidative phosphorylation
Cell Death Discovery, Published online: 06 March 2026; doi:10.1038/s41420-026-02994-3Lysophosphatidylcholine acyltransferase 1 promotes head and neck squamous cell carcinoma progression by enhancing COX17-dependent oxidative phosphorylation
Lysophosphatidylcholine acyltransferase 1 promotes head and neck squamous cell carcinoma progression by enhancing COX17-dependent oxidative phosphorylation
Cell Death Discovery, Published online: 06 March 2026; doi:10.1038/s41420-026-02994-3
Lysophosphatidylcholine acyltransferase 1 promotes head and neck squamous cell carcinoma progression by enhancing COX17-dependent oxidative phosphorylation-
cs.AI, q-bio.NC updates on arXiv.org
-
Nightjar: Dynamic Adaptive Speculative Decoding for Large Language Models Serving
arXiv:2512.22420v4 Announce Type: replace-cross Abstract: Speculative decoding (SD) accelerates LLM inference by verifying draft tokens in parallel. However, this method presents a critical trade-off: it improves throughput in low-load, memory-bound systems but degrades performance in high-load, compute-bound environments due to verification overhead. Existing speculative decoding methods use fixed lengths and cannot adapt to workload changes or decide when to stop speculation. The cost of rest
Nightjar: Dynamic Adaptive Speculative Decoding for Large Language Models Serving
-
cs.AI, q-bio.NC updates on arXiv.org
-
Nightjar: Dynamic Adaptive Speculative Decoding for Large Language Models Serving
arXiv:2512.22420v3 Announce Type: replace-cross Abstract: Speculative decoding (SD) accelerates LLM inference by verifying draft tokens in parallel. However, this method presents a critical trade-off: it improves throughput in low-load, memory-bound systems but degrades performance in high-load, compute-bound environments due to verification overhead. Existing Speculative Decoding strategies typically rely on static speculative lengths, failing to adapt to fluctuating request loads or identify
Nightjar: Dynamic Adaptive Speculative Decoding for Large Language Models Serving
-
cs.AI, q-bio.NC updates on arXiv.org
-
Train Less, Learn More: Adaptive Efficient Rollout Optimization for Group-Based Reinforcement Learning
arXiv:2602.14338v1 Announce Type: cross Abstract: Reinforcement learning (RL) plays a central role in large language model (LLM) post-training. Among existing approaches, Group Relative Policy Optimization (GRPO) is widely used, especially for RL with verifiable rewards (RLVR) fine-tuning. In GRPO, each query prompts the LLM to generate a group of rollouts with a fixed group size $N$. When all rollouts in a group share the same outcome, either all correct or all incorrect, the group-normalized
Train Less, Learn More: Adaptive Efficient Rollout Optimization for Group-Based Reinforcement Learning
-
cs.AI, q-bio.NC updates on arXiv.org
-
Nightjar: Dynamic Adaptive Speculative Decoding for Large Language Models Serving
arXiv:2512.22420v2 Announce Type: replace-cross Abstract: Speculative decoding (SD) accelerates LLM inference by verifying draft tokens in parallel. However, this method presents a critical trade-off: it improves throughput in low-load, memory-bound systems but degrades performance in high-load, compute-bound environments due to verification overhead. Current SD implementations use a fixed speculative length, failing to adapt to dynamic request rates and creating a significant performance bottl