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cs.AI, q-bio.NC updates on arXiv.org
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LLM Agents as Social Scientists: A Human-AI Collaborative Platform for Social Science Automation
arXiv:2604.01520v1 Announce Type: new Abstract: Traditional social science research often requires designing complex experiments across vast methodological spaces and depends on real human participants, making it labor-intensive, costly, and difficult to scale. Here we present S-Researcher, an LLM-agent-based platform that assists researchers in conducting social science research more efficiently and at greater scale by "siliconizing" both the research process and the participant pool. To build
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Omics in Hepatocellular
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Curcumol Induces G1 Phase Arrest in SK-Hep-1 Cells by Targeting SKP2-Mediated p27 Degradation
Molecules. 2026 Mar 16;31(6):997. doi: 10.3390/molecules31060997.ABSTRACTCONTEXT: S-phase kinase-associated protein 2 (SKP2) is an oncogene and cell cycle regulator that mediates the ubiquitination of cell cycle regulators. Curcumol, a sesquiterpene natural product, has been reported to regulate SKP2-mediated ubiquitination degradation to overcome drug resistance in cancer cells. However, whether the cell cycle arrest effect of curcumol is related to SKP2's function in cancer cells and its mecha
Curcumol Induces G1 Phase Arrest in SK-Hep-1 Cells by Targeting SKP2-Mediated p27 Degradation
Molecules. 2026 Mar 16;31(6):997. doi: 10.3390/molecules31060997.
ABSTRACT
CONTEXT: S-phase kinase-associated protein 2 (SKP2) is an oncogene and cell cycle regulator that mediates the ubiquitination of cell cycle regulators. Curcumol, a sesquiterpene natural product, has been reported to regulate SKP2-mediated ubiquitination degradation to overcome drug resistance in cancer cells. However, whether the cell cycle arrest effect of curcumol is related to SKP2's function in cancer cells and its mechanisms are still unclear.
OBJECTIVE: To investigate the role of SKP2 in curcumol-induced cell cycle arrest and its underlying mechanisms.
MATERIALS AND METHODS: Transcriptomic and proteomic analyses were used to screen the ubiquitination-related factors in curcumol treated hepatocellular carcinoma cells. Lentiviral overexpression, co-immunoprecipitation assays, ubiquitination analysis, and cell-line-derived xenograft (CDX) models were used to dissect the role and mechanisms of the identified ubiquitination-related factor in the cell cycle arrest effect of curcucmol.
RESULTS: Curcumol modulated the expression of CDK4, CDK6, Cyclin D1, p27 and SKP2. SKP2 was one candidate target of curcumol selected by multi-omics. Overexpressed SKP2 partially reversed curcumol-induced growth inhibition and G1-phase arrest. The increased expression of p27 induced by curcumol was attenuated by overexpressed SKP2. Curcumol impaired the interaction between SKP2 and p27, and led to the ubiquitination and degradation of p27. In vivo, curcumol effectively reduced tumor growth, and its antitumor effect was significantly mitigated by SKP2 overexpression.
DISCUSSION AND CONCLUSIONS: Curcumol reduced SKP2 expression, weakened the interaction between SKP2 and p27, inhibited degradation of p27, and then induced G1 phase cell-cycle arrest in SK-Hep-1 cells.
PMID:41900096 | PMC:PMC13029316 | DOI:10.3390/molecules31060997
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cs.AI, q-bio.NC updates on arXiv.org
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STRUCTUREDAGENT: Planning with AND/OR Trees for Long-Horizon Web Tasks
arXiv:2603.05294v2 Announce Type: replace Abstract: Recent advances in large language models (LLMs) have enabled agentic systems for sequential decision-making. Such agents must perceive their environment, reason across multiple time steps, and take actions that optimize long-term objectives. However, existing web agents struggle on complex, long-horizon tasks due to limited in-context memory for tracking history, weak planning abilities, and greedy behaviors that lead to premature termination.
STRUCTUREDAGENT: Planning with AND/OR Trees for Long-Horizon Web Tasks
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cs.AI, q-bio.NC updates on arXiv.org
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DoAtlas-1: A Causal Compilation Paradigm for Clinical AI
arXiv:2602.19158v1 Announce Type: new Abstract: Medical foundation models generate narrative explanations but cannot quantify intervention effects, detect evidence conflicts, or validate literature claims, limiting clinical auditability. We propose causal compilation, a paradigm that transforms medical evidence from narrative text into executable code. The paradigm standardizes heterogeneous research evidence into structured estimand objects, each explicitly specifying intervention contrast, ef
DoAtlas-1: A Causal Compilation Paradigm for Clinical AI
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cs.AI, q-bio.NC updates on arXiv.org
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Pailitao-VL: Unified Embedding and Reranker for Real-Time Multi-Modal Industrial Search
arXiv:2602.13704v1 Announce Type: cross Abstract: In this work, we presented Pailitao-VL, a comprehensive multi-modal retrieval system engineered for high-precision, real-time industrial search. We here address three critical challenges in the current SOTA solution: insufficient retrieval granularity, vulnerability to environmental noise, and prohibitive efficiency-performance gap. Our primary contribution lies in two fundamental paradigm shifts. First, we transitioned the embedding paradigm fr
Pailitao-VL: Unified Embedding and Reranker for Real-Time Multi-Modal Industrial Search
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cs.AI, q-bio.NC updates on arXiv.org
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Resource-Efficient Personal Large Language Models Fine-Tuning with Collaborative Edge Computing
arXiv:2408.10746v2 Announce Type: replace-cross Abstract: Large language models (LLMs) have unlocked a plethora of powerful applications at the network edge, such as intelligent personal assistants. Data privacy and security concerns have prompted a shift towards edge-based fine-tuning of personal LLMs, away from cloud reliance. However, this raises issues of computational intensity and resource scarcity, hindering training efficiency and feasibility. While current studies investigate parameter