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cs.AI, q-bio.NC updates on arXiv.org
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Mitigating Object Hallucinations in Vision-Language Models through Region-Aware Attention Recalibration
arXiv:2605.24957v1 Announce Type: new Abstract: The generation of factually incorrect objects, commonly known as object hallucination, remains a persistent challenge in Large Vision-Language Models (LVLMs). Current approaches to address this issue - ranging from expensive data-driven fine-tuning and high-latency contrastive decoding to rigid attention head truncation - frequently compromise either computational efficiency or the continuity of the model's feature space. To overcome these limitat
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cs.AI, q-bio.NC updates on arXiv.org
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NeurIPS: Neuro-anatomical Inductive Priors for Sphere-based Brain Decoding
arXiv:2605.24993v1 Announce Type: new Abstract: Current fMRI decoders face a performance-fidelity trade-off where efficient ID encoders outperform geometrically faithful surface-based models. We argue this is partly driven by inefficient surface tokenization and the failure to use anatomy as a predictive signal. We present NeurIPS, a framework that improves surface-based decoding by reframing anatomical variation from a nuisance to a powerful inductive prior. NeurIPS unites two innovations: a S
NeurIPS: Neuro-anatomical Inductive Priors for Sphere-based Brain Decoding
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cs.AI, q-bio.NC updates on arXiv.org
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Cascade-KDE: Robust Time-Series Restoration under Out-of-Distribution Impulse Corruptions
arXiv:2605.24055v1 Announce Type: cross Abstract: Real-world time-series data in industrial sensing, healthcare, and energy systems is often corrupted by a mixture of Gaussian noise and occasional large-magnitude impulse outliers. For tasks that depend on local shape, such as ECG morphology analysis and battery degradation monitoring, the main requirement is not only low reconstruction error but also preservation of derivative peaks and task-critical features. We propose Cascade-KDE, a training
Cascade-KDE: Robust Time-Series Restoration under Out-of-Distribution Impulse Corruptions
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cs.AI, q-bio.NC updates on arXiv.org
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Cross-Domain Energy-Guided Diffusion Generation for Off-Dynamics Reinforcement Learning
arXiv:2605.24810v1 Announce Type: cross Abstract: Off-dynamics offline reinforcement learning seeks to learn a target-domain policy from a large source dataset and a limited target dataset under mismatched transition dynamics. Existing approaches such as reward augmentation and data filtering are constrained to the source dataset and cannot synthesize new target behavior to improve coverage beyond the collected source trajectories. While recent model-based methods attempt to address this by lea
Cross-Domain Energy-Guided Diffusion Generation for Off-Dynamics Reinforcement Learning
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cs.AI, q-bio.NC updates on arXiv.org
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Inference-Time Alignment of Diffusion Models via Trust-Region Iterative Twisted Sequential Monte Carlo
arXiv:2605.25123v1 Announce Type: cross Abstract: We study inference-time alignment for diffusion-based generative models, aiming to steer a base model toward high-reward outputs without updating its weights. Recent Sequential Monte Carlo (SMC)-based steering methods approximate reward-tilted target distributions in a principled way, but their proposals remain largely tied to the base sampler. Since reward information is mainly used after propagation through particle reweighting and resampling,
Inference-Time Alignment of Diffusion Models via Trust-Region Iterative Twisted Sequential Monte Carlo
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cs.AI, q-bio.NC updates on arXiv.org
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AutoResearchClaw: Self-Reinforcing Autonomous Research with Human-AI Collaboration
arXiv:2605.20025v2 Announce Type: replace Abstract: Automating scientific discovery requires more than generating papers from ideas. Real research is iterative: hypotheses are challenged from multiple perspectives, experiments fail and inform the next attempt, and lessons accumulate across cycles. Existing autonomous research systems often model this process as a linear pipeline: they rely on single-agent reasoning, stop when execution fails, and do not carry experience across runs. We present
AutoResearchClaw: Self-Reinforcing Autonomous Research with Human-AI Collaboration
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cs.AI, q-bio.NC updates on arXiv.org
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Memorize Theorems, Not Instances: Probing SFT Generalization through Mathematical Reasoning
arXiv:2605.09270v2 Announce Type: replace-cross Abstract: Supervised Fine-Tuning (SFT) is widely used for task-specific adaptation, yet recent work shows it systematically undermines reasoning generalization. We argue the root cause is not memorization itself, but its target: vanilla SFT drives models to exploit and memorize spurious surface correlations in problem-solution pairs, leaving them brittle to superficial input variations. To address this, we propose Theorem-SFT, which reorients supe
Memorize Theorems, Not Instances: Probing SFT Generalization through Mathematical Reasoning
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Omics In Lung
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Epigenome-wide Mendelian randomization with multi-omics validation identifies epigenetic drivers of idiopathic pulmonary fibrosis
Commun Biol. 2026 Apr 11. doi: 10.1038/s42003-026-10033-1. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a complex disease without clear etiology or effective therapy. While DNA methylation has been implicated in IPF pathogenesis, the tissue-specific causal effects of the epigenetic factors on IPF remain undetermined. Here, we perform epigenome-wide Mendelian randomization using blood-based methylation quantitative trait loci of 420,509 CpG sites and genome-wide associatio
Epigenome-wide Mendelian randomization with multi-omics validation identifies epigenetic drivers of idiopathic pulmonary fibrosis
Commun Biol. 2026 Apr 11. doi: 10.1038/s42003-026-10033-1. Online ahead of print.
ABSTRACT
Idiopathic pulmonary fibrosis (IPF) is a complex disease without clear etiology or effective therapy. While DNA methylation has been implicated in IPF pathogenesis, the tissue-specific causal effects of the epigenetic factors on IPF remain undetermined. Here, we perform epigenome-wide Mendelian randomization using blood-based methylation quantitative trait loci of 420,509 CpG sites and genome-wide association study for IPF to elucidate the causal effects of the CpG sites on IPF. Totally, 452 CpG sites has shown putative causal effects on IPF risk after Bonferroni correction. Among them, 13 CpG sites have shown strong colocalization evidence with genetic factors associated with IPF. Specifically, DNA methylation at CpG sites within MAN2A2 and TRIM27 shows significant differences between IPF lungs and controls, correlating with altered mRNA expressions of these genes in lung tissues. The CpG site in MAN2A2 is a binding site of ZNF384 according to transcription factor databases. RNA sequencing in the TGFβ1-induced alveolar epithelia confirms significantly reduced expression of MAN2A2 and ZNF384 comparing to the controls. Collectively, our study suggests a putative causal link between DNA methylation within MAN2A2 and IPF risk, wherein lung-specific DNA methylation in MAN2A2 may perturb the interaction between ZNF384 and MAN2A2, revealing novel roles for these genes in IPF pathogenesis.
PMID:41965819 | DOI:10.1038/s42003-026-10033-1
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Epigenome-wide Mendelian randomization with multi-omics validation identifies epigenetic drivers of idiopathic pulmonary fibrosis
Commun Biol. 2026 Apr 11. doi: 10.1038/s42003-026-10033-1. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a complex disease without clear etiology or effective therapy. While DNA methylation has been implicated in IPF pathogenesis, the tissue-specific causal effects of the epigenetic factors on IPF remain undetermined. Here, we perform epigenome-wide Mendelian randomization using blood-based methylation quantitative trait loci of 420,509 CpG sites and genome-wide associatio
Epigenome-wide Mendelian randomization with multi-omics validation identifies epigenetic drivers of idiopathic pulmonary fibrosis
Commun Biol. 2026 Apr 11. doi: 10.1038/s42003-026-10033-1. Online ahead of print.
ABSTRACT
Idiopathic pulmonary fibrosis (IPF) is a complex disease without clear etiology or effective therapy. While DNA methylation has been implicated in IPF pathogenesis, the tissue-specific causal effects of the epigenetic factors on IPF remain undetermined. Here, we perform epigenome-wide Mendelian randomization using blood-based methylation quantitative trait loci of 420,509 CpG sites and genome-wide association study for IPF to elucidate the causal effects of the CpG sites on IPF. Totally, 452 CpG sites has shown putative causal effects on IPF risk after Bonferroni correction. Among them, 13 CpG sites have shown strong colocalization evidence with genetic factors associated with IPF. Specifically, DNA methylation at CpG sites within MAN2A2 and TRIM27 shows significant differences between IPF lungs and controls, correlating with altered mRNA expressions of these genes in lung tissues. The CpG site in MAN2A2 is a binding site of ZNF384 according to transcription factor databases. RNA sequencing in the TGFβ1-induced alveolar epithelia confirms significantly reduced expression of MAN2A2 and ZNF384 comparing to the controls. Collectively, our study suggests a putative causal link between DNA methylation within MAN2A2 and IPF risk, wherein lung-specific DNA methylation in MAN2A2 may perturb the interaction between ZNF384 and MAN2A2, revealing novel roles for these genes in IPF pathogenesis.
PMID:41965819 | DOI:10.1038/s42003-026-10033-1
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cs.AI, q-bio.NC updates on arXiv.org
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Unifying Group-Relative and Self-Distillation Policy Optimization via Sample Routing
arXiv:2604.02288v1 Announce Type: cross Abstract: Reinforcement learning with verifiable rewards (RLVR) has become a standard paradigm for post-training large language models. While Group Relative Policy Optimization (GRPO) is widely adopted, its coarse credit assignment uniformly penalizes failed rollouts, lacking the token-level focus needed to efficiently address specific deviations. Self-Distillation Policy Optimization (SDPO) addresses this by providing denser, more targeted logit-level su
Unifying Group-Relative and Self-Distillation Policy Optimization via Sample Routing
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cs.AI, q-bio.NC updates on arXiv.org
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When Models Judge Themselves: Unsupervised Self-Evolution for Multimodal Reasoning
arXiv:2603.21289v2 Announce Type: replace-cross Abstract: Recent progress in multimodal large language models has led to strong performance on reasoning tasks, but these improvements largely rely on high-quality annotated data or teacher-model distillation, both of which are costly and difficult to scale. To address this, we propose an unsupervised self-evolution training framework for multimodal reasoning that achieves stable performance improvements without using human-annotated answers or ex
When Models Judge Themselves: Unsupervised Self-Evolution for Multimodal Reasoning
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Cell Death Discovery nature.com science feeds
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Lysine attenuates acute lung injury by restoring α-tubulin acetylation and ciliary activity
Cell Death Discovery, Published online: 16 March 2026; doi:10.1038/s41420-026-03025-xLysine attenuates acute lung injury by restoring α-tubulin acetylation and ciliary activity
Lysine attenuates acute lung injury by restoring α-tubulin acetylation and ciliary activity
Cell Death Discovery, Published online: 16 March 2026; doi:10.1038/s41420-026-03025-x
Lysine attenuates acute lung injury by restoring α-tubulin acetylation and ciliary activity-
cs.AI, q-bio.NC updates on arXiv.org
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Deconstructing Multimodal Mathematical Reasoning: Towards a Unified Perception-Alignment-Reasoning Paradigm
arXiv:2603.08291v1 Announce Type: new Abstract: Multimodal Mathematical Reasoning (MMR) has recently attracted increasing attention for its capability to solve mathematical problems that involve both textual and visual modalities. However, current models still face significant challenges in real-world visual math tasks. They often misinterpret diagrams, fail to align mathematical symbols with visual evidence, and produce inconsistent reasoning steps. Moreover, existing evaluations mainly focus
Deconstructing Multimodal Mathematical Reasoning: Towards a Unified Perception-Alignment-Reasoning Paradigm
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cs.AI, q-bio.NC updates on arXiv.org
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\$OneMillion-Bench: How Far are Language Agents from Human Experts?
arXiv:2603.07980v1 Announce Type: cross Abstract: As language models (LMs) evolve from chat assistants to long-horizon agents capable of multi-step reasoning and tool use, existing benchmarks remain largely confined to structured or exam-style tasks that fall short of real-world professional demands. To this end, we introduce \$OneMillion-Bench \$OneMillion-Bench, a benchmark of 400 expert-curated tasks spanning Law, Finance, Industry, Healthcare, and Natural Science, built to evaluate agents a
\$OneMillion-Bench: How Far are Language Agents from Human Experts?
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cs.AI, q-bio.NC updates on arXiv.org
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Performance of Conventional EEG Biomarkers Across Different Clinical Phases of Major Depressive Disorder: A Comprehensive Evaluation
arXiv:2603.03864v1 Announce Type: new Abstract: While EEG features differentiate Major Depressive Disorder (MDD) from healthy controls (HC), their clinical utility as biomarkers depends on a monotonic trajectory across the disease spectrum, from the acute (AC) phase to the maintenance (MA) phase and finally to the healthy baseline. However, the progression of the MA phase remains poorly understood in traditional marker analysis. Analyzing EEG data from 74 individuals (24 AC, 23 MA, and 27 HC),
Performance of Conventional EEG Biomarkers Across Different Clinical Phases of Major Depressive Disorder: A Comprehensive Evaluation
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cs.AI, q-bio.NC updates on arXiv.org
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Pushing the Limits of Inverse Lithography with Generative Reinforcement Learning
arXiv:2602.19027v1 Announce Type: cross Abstract: Inverse lithography (ILT) is critical for modern semiconductor manufacturing but suffers from highly non-convex objectives that often trap optimization in poor local minima. Generative AI has been explored to warm-start ILT, yet most approaches train deterministic image-to-image translators to mimic sub-optimal datasets, providing limited guidance for escaping non-convex traps during refinement. We reformulate mask synthesis as conditional sampl
Pushing the Limits of Inverse Lithography with Generative Reinforcement Learning
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cs.AI, q-bio.NC updates on arXiv.org
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MemOCR: Layout-Aware Visual Memory for Efficient Long-Horizon Reasoning
arXiv:2601.21468v3 Announce Type: replace Abstract: Long-horizon agentic reasoning necessitates effectively compressing growing interaction histories into a limited context window. Most existing memory systems serialize history as text, where token-level cost is uniform and scales linearly with length, often spending scarce budget on low-value details. To this end, we introduce MemOCR, a multimodal memory agent that improves long-horizon reasoning under tight context budgets by allocating memor
MemOCR: Layout-Aware Visual Memory for Efficient Long-Horizon Reasoning
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cs.AI, q-bio.NC updates on arXiv.org
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Lean Finder: Semantic Search for Mathlib That Understands User Intents
arXiv:2510.15940v2 Announce Type: replace-cross Abstract: We present Lean Finder, a semantic search engine for Lean and mathlib that understands and aligns with the intents of mathematicians. Progress in formal theorem proving is often hindered by the difficulty of locating relevant theorems and the steep learning curve of the Lean 4 language, making advancement slow and labor-intensive. Existing Lean search engines, though helpful, rely primarily on informalizations (natural language translati