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TechCrunch
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DuckDuckGo installs are up 30% as users reject being ‘force-fed’ Google’s AI Search
Google overhauled Search at I/O 2026, replacing blue links with AI agents. The backlash has been swift. DuckDuckGo app installs spiked 30% as users seek a way out.
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Journal of Medical Internet Research
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Self-Reported Health Outcomes in Metabolic Health YouTube Comments: Cross-Sectional Study and Rule-Based Natural Language Processing Framework Development and Validation
Background: YouTube is increasingly used for healthcasting, the sharing of evidence-based dietary and lifestyle interventions by domain experts. In the metabolic health domain, channels focused on therapeutic carbohydrate restriction have accumulated audiences of millions. A distinctive feature is the comment section, where viewers share first-person accounts of health changes, constituting a unique source of real-world outcome data at scale. However, extracting structured health information fro
Self-Reported Health Outcomes in Metabolic Health YouTube Comments: Cross-Sectional Study and Rule-Based Natural Language Processing Framework Development and Validation
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Journal of Medical Internet Research
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Large Language Model–Generated Patient Instructions for Prescriptions in Primary Health Care: Preclinical Algorithm Validation
Background: The application of generative artificial intelligence to simplify medication use instructions has the potential to enhance people’s health by improving treatment adherence. Objective: We evaluated the performance of large language models (LLMs) in generating medication usage instructions to complement prescriptions in primary health care. Methods: This randomized, blinded experimental preclinical study used prescription-inducing scenarios, assigned to 62 health care professionals, to
Large Language Model–Generated Patient Instructions for Prescriptions in Primary Health Care: Preclinical Algorithm Validation
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Journal of Medical Internet Research
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Safety of Telemedicine Versus In-Person Care for Patients With Tracheal Devices: Propensity Score–Matched Cohort Study
Background: Patients with tracheal diseases often require long-term follow-up after tracheal device placement, with a risk of adverse events that may lead to emergency care and unplanned interventions. Telemedicine has been proposed as an alternative to in-person follow-up to improve access and continuity of care. Objective: The primary objective of this study was to compare the need for emergency department (ED) visits between telemedicine and in-person groups. Secondary objectives included com
Safety of Telemedicine Versus In-Person Care for Patients With Tracheal Devices: Propensity Score–Matched Cohort Study
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MIT Technology Review

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The Download: puncturing the AI jobs panic
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. A reality check on the AI jobs hysteria Despite the growing hysteria over AI’s threat to white-collar jobs, there’s still scant evidence that the technology has had a large-scale impact on the labor market. Analysis of US labor data shows that unemployment in occupations most exposed to AI is actually lower than in less-exposed jobs. There are also no
The Download: puncturing the AI jobs panic
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.
A reality check on the AI jobs hysteria
Despite the growing hysteria over AI’s threat to white-collar jobs, there’s still scant evidence that the technology has had a large-scale impact on the labor market.
Analysis of US labor data shows that unemployment in occupations most exposed to AI is actually lower than in less-exposed jobs. There are also no signs that large numbers of workers are shifting from AI-threatened professions into supposedly safer manual-labor jobs.
It’s true that things aren’t great in the job market—but the question is why. Here’s what the data really says about AI and jobs.
—David Rotman
Opinion: It’s time to address the looming crisis in entry-level work
—Georgios Petropoulos, an assistant professor at the USC Marshall School of Business
AI has not yet produced mass unemployment. But it may be quietly weakening the first rung of the career ladder.
A recent Stanford study found that young workers in AI-exposed occupations suffered a sharp decline in employment after the spread of generative AI. The same pattern didn’t appear in low-exposure jobs, suggesting AI is replacing junior tasks that once gave young workers their first foothold.
It’s time to rethink how we train, prepare, and support young people entering the workforce. Read this op-ed on how job seekers, businesses, and society can adapt.
The must-reads
I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.
1 The Pope has called for governments to regulate AI
In his first major teaching document, Pope Leo said AI must be “disarmed.” (BBC)
+ He warned that AI fuels war and misinformation. (CNN)
+ But could also “open up a horizon extending in all directions.” (Engadget)
+ Anthropic cofounder Chris Olah also spoke at the event. (Reuters $)
2 SpaceX has launched its biggest and most powerful rocket
The Starship V3 made its test flight debut two days after Elon Musk announced SpaceX’s IPO.(Guardian)+ SpaceX pulled off the launch, but not the landing. (Ars Technica)
+ The rocket could be key to SpaceX’s valuation. (Fortune $)
+ But rivals to the company are rising. (MIT Technology Review)
3 Huawei says it can make industry-leading chips within five years
The Chinese tech giant announced a breakthrough in chip design. (Reuters $)
+ Its progress underscores Beijing’s push to neutralize US sanctions. (NBC)
+ Chinese chip stocks rallied after the announcement. (Bloomberg $)
4 A new vaccine may protect against the Ebola strain behind the current crisis
Tests have shown promising results for the mRNA vaccine. (New Scientist)
+ Another Ebola vaccine that could be ready for trials in months. (BBC)
+ But vaccines face a new problem: their name. (MIT Technology Review)
5 A swimmer broke a world record at the ‘Steroid Olympics’
Athletes at the Enhance Games were encouraged to take dope. (Wired $)
+ Silicon Valley elites have backed the competition. (WP $)
+ Which fits right into 2026’s longevity vibes. (MIT Technology Review)
6 The EU plans to fine Google a massive antitrust penalty
For allegedly favoring its own services in search results. (CNBC)
+ It would be the largest penalty for breaching the Digital Markets Act. (Reuters $)
7 US quantum computing subsidies may not be legal
Congressional critics say the funding has been misused. (Ars Technica)
8 AI is minting new billionaires—and workers want their share
The Samsung labor showdown reflects global concerns. (Rest of World)
9 China has launched artificial human embryos into orbit
To find out whether we can reproduce beyond Earth. (Gizmodo)
10 Jony Ives has designed Ferrari’s first fully-electric car
The legendary Apple designer has created a polarizing aesthetic. (FT $)
Quote of the day
“Technology is never neutral, because it takes on the characteristics of those who devise, finance, regulate, and use it.”
—Pope Leo issues a warning about AI in his first encyclical letter, entitled ‘Magnifica humanitas: On Safeguarding the Human Person in the Time of Artificial Intelligence.”
One More Thing

How climate vulnerability and the digital divide are linked
In Anacostia, a historic African-American section of Washington, DC, Monica Sanders is measuring Wi-Fi speeds. It’s below the FCC’s minimum to qualify as a broadband service. She then checks the temperature: 46.9 °F.
Sanders, an adjunct professor of law at Georgetown University, frequently records this combination of weak internet access and environmental conditions. Her work shows how underinvestment in infrastructure can leave underserved communities more exposed to climate risks like extreme heat and flooding.
Discover how the digital divide is shaping climate vulnerability in the US.
—Colleen Hagerty
We can still have nice things
A place for comfort, fun, and distraction to brighten up your day. (Got any ideas? Drop me a line.)
+ Here’s a joyful way to settle sibling squabbles: a mandatory dance-off.
+ Build the metropolis of your dreams in this browser-based city simulation game.
+ Watch this hypnotic tiny train move in a perfect, endless loop on a rotating turntable.
+ Take a nostalgic look at early computing history with this curated gallery of vintage punch cards.
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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A Non-Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development
Adv Sci (Weinh). 2026 May 26:e75839. doi: 10.1002/advs.75839. Online ahead of print.ABSTRACTLung squamous cell carcinoma (LUSC) lacks clearly defined key drivers and effective targeted therapies, reflecting an incomplete understanding of its molecular pathogenesis. Here, we identify SMAD4 as a critical regulator of three-dimensional (3D) genome organization in LUSC and uncover a mechanistic link between tumor suppressor loss and oncogenic transcriptional activation. By integrating clinical datas
A Non-Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development
Adv Sci (Weinh). 2026 May 26:e75839. doi: 10.1002/advs.75839. Online ahead of print.
ABSTRACT
Lung squamous cell carcinoma (LUSC) lacks clearly defined key drivers and effective targeted therapies, reflecting an incomplete understanding of its molecular pathogenesis. Here, we identify SMAD4 as a critical regulator of three-dimensional (3D) genome organization in LUSC and uncover a mechanistic link between tumor suppressor loss and oncogenic transcriptional activation. By integrating clinical datasets, genetically engineered mouse models, human and murine LUSC cell lines, and multi-omics analyses, we demonstrate that SMAD4 deficiency promotes LUSC progression by unleashing EP300-mediated enhancer-promoter looping at the SOX2 locus. Mechanistically, SMAD4 does not directly bind SOX2 regulatory elements but instead constrains chromatin looping by sequestering EP300 away from loop anchor regions. Loss of SMAD4 leads to enhanced H3K27ac deposition, aberrant SOX2 activation, and increased LUSC tumor cell proliferation. Together, these findings reveal a non-canonical role for a transcription factor (e.g., SMAD4) in regulating dysregulated 3D genome architecture to inhibit tumor development.
PMID:42189071 | DOI:10.1002/advs.75839
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Omics In Lung
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A Non-Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development
Adv Sci (Weinh). 2026 May 26:e75839. doi: 10.1002/advs.75839. Online ahead of print.ABSTRACTLung squamous cell carcinoma (LUSC) lacks clearly defined key drivers and effective targeted therapies, reflecting an incomplete understanding of its molecular pathogenesis. Here, we identify SMAD4 as a critical regulator of three-dimensional (3D) genome organization in LUSC and uncover a mechanistic link between tumor suppressor loss and oncogenic transcriptional activation. By integrating clinical datas
A Non-Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development
Adv Sci (Weinh). 2026 May 26:e75839. doi: 10.1002/advs.75839. Online ahead of print.
ABSTRACT
Lung squamous cell carcinoma (LUSC) lacks clearly defined key drivers and effective targeted therapies, reflecting an incomplete understanding of its molecular pathogenesis. Here, we identify SMAD4 as a critical regulator of three-dimensional (3D) genome organization in LUSC and uncover a mechanistic link between tumor suppressor loss and oncogenic transcriptional activation. By integrating clinical datasets, genetically engineered mouse models, human and murine LUSC cell lines, and multi-omics analyses, we demonstrate that SMAD4 deficiency promotes LUSC progression by unleashing EP300-mediated enhancer-promoter looping at the SOX2 locus. Mechanistically, SMAD4 does not directly bind SOX2 regulatory elements but instead constrains chromatin looping by sequestering EP300 away from loop anchor regions. Loss of SMAD4 leads to enhanced H3K27ac deposition, aberrant SOX2 activation, and increased LUSC tumor cell proliferation. Together, these findings reveal a non-canonical role for a transcription factor (e.g., SMAD4) in regulating dysregulated 3D genome architecture to inhibit tumor development.
PMID:42189071 | DOI:10.1002/advs.75839
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cs.AI, q-bio.NC updates on arXiv.org
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A Dynamical Framework for Cognitive Processes Based on Transformations and Semantic Equivalence
arXiv:2605.23942v1 Announce Type: new Abstract: This paper proposes a structural and dynamical framework for modeling cognitive processes within a cybernetic perspective. Cognitive states are represented as elements of a state space evolving through an iterative update rule of the form \[ X_{t+1} = \pi\big(F(f(X_t))\big), \] where $f$ describes internal transformations, $F$ represents interpretative mappings, and $\pi$ enforces semantic equivalence. The model is interpreted as a feedb
A Dynamical Framework for Cognitive Processes Based on Transformations and Semantic Equivalence
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cs.AI, q-bio.NC updates on arXiv.org
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Inference Time Context Sparsity: Illusion or Opportunity?
arXiv:2605.24168v1 Announce Type: new Abstract: Sparsity has long been a central theme in LLM efficiency, but its role in context processing remains unresolved. As LLM workloads shift toward longer contexts and agentic interactions, the compute and memory bottlenecks of attention become increasingly critical, raising the question of whether these constraints are fundamental. Our position is that these constraints are artificial and unnecessary, and that the future of LLM inference lies in extre
Inference Time Context Sparsity: Illusion or Opportunity?
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cs.AI, q-bio.NC updates on arXiv.org
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Beyond Final Answers: Auditing Trajectory-Level Hallucinations in Multi-Agent Industrial Workflows
arXiv:2605.24219v2 Announce Type: new Abstract: Large Language Models (LLMs) are increasingly deployed as autonomous agents that reason, use tools, and act over multiple steps. Yet most hallucination benchmarks still evaluate only the final output, missing failures that originate in intermediate Thought-Action-Observation steps. We present Trajel, a dataset and evaluation framework for auditing trajectory-level hallucinations in multi-agent industrial workflows. Trajel introduces a five-type ha
Beyond Final Answers: Auditing Trajectory-Level Hallucinations in Multi-Agent Industrial Workflows
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cs.AI, q-bio.NC updates on arXiv.org
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ConceptM$^3$oE: Concept-Guided Multimodal Mixture of Experts for Interpretable Computational Pathology
arXiv:2605.24399v1 Announce Type: new Abstract: Healthcare models are transitioning from unimodal prediction toward multimodal reasoning over heterogeneous diagnostic inputs. In computational pathology, for complex tumor subtypes where morphology alone can be challenging to distinguish, pathology reports and molecular measurements may provide additional diagnostic evidence alongside whole-slide images, yet existing models often fail to clarify how diverse signals assemble into recognizable diag
ConceptM$^3$oE: Concept-Guided Multimodal Mixture of Experts for Interpretable Computational Pathology
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cs.AI, q-bio.NC updates on arXiv.org
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Advancing Graph Few-Shot Learning via In-Context Learning
arXiv:2605.24410v1 Announce Type: new Abstract: Graph few-shot learning, which aims to classify nodes from novel classes with only a few labeled examples, is a widely studied problem in graph learning. However, existing methods often face two key limitations. First, the predominant graph few-shot learning paradigm relies on supervised tasks, failing to leverage the vast number of unlabeled nodes in the graph. Second, many approaches require complex task adaptation or fine-tuning during inferenc
Advancing Graph Few-Shot Learning via In-Context Learning
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cs.AI, q-bio.NC updates on arXiv.org
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SPACE: Unifying Symmetric and Asymmetric Routing Problems for Generalist Neural Solver
arXiv:2605.24484v1 Announce Type: new Abstract: Generalist neural routing solvers have shown great potential in solving diverse vehicle routing problems (VRPs) with a unified model. However, existing solvers are typically limited to symmetric settings or degrade in performance when switching to asymmetric settings due to input inconsistencies or inherent structural differences, substantially limiting their practicality in real-world scenarios that encompass both scenarios. To address this limit
SPACE: Unifying Symmetric and Asymmetric Routing Problems for Generalist Neural Solver
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cs.AI, q-bio.NC updates on arXiv.org
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TIGER: Text-Informed Generalized Enzyme-Reaction Retrieval
arXiv:2605.24489v1 Announce Type: new Abstract: Enzyme-reaction retrieval is a fundamental problem in computational biology, underpinning enzyme characterization, reaction mechanism elucidation, and the rational design of metabolic pathways and biocatalysts. As a bidirectional task, it entails both enzyme-to-reaction and reaction-to-enzyme mapping. However, existing approaches suffer from poor generalization across tasks and distributions, with performance highly sensitive to dataset splits and
TIGER: Text-Informed Generalized Enzyme-Reaction Retrieval
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cs.AI, q-bio.NC updates on arXiv.org
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Market Regime Council for Dynamic Credit Assignment in Multi-Agent LLM Decision Systems
arXiv:2605.24490v1 Announce Type: new Abstract: Multi-agent LLM decision systems for portfolio management still lack a principled way to assign credit across specialist agents, remain vulnerable to cold-start dominance under regime shifts, and offer limited transparency into how final allocations are formed. We propose Market Regime Council (MRC), a cooperative multi-agent decision system that computes exact Shapley credits across all single, pairwise, and Grand-coalition outputs for online age
Market Regime Council for Dynamic Credit Assignment in Multi-Agent LLM Decision Systems
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cs.AI, q-bio.NC updates on arXiv.org
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Reasoning as an Attack Surface: Adaptive Evolutionary CoT Jailbreaks for LLMs
arXiv:2605.24497v1 Announce Type: new Abstract: Large Reasoning Models (LRMs) have demonstrated remarkable capabilities in reasoning and generation tasks and are increasingly deployed in real-world applications. However, their explicit chain-of-thought (CoT) mechanism introduces new security risks, making them particularly vulnerable to jailbreak attacks. Existing approaches often rely on static CoT templates to elicit harmful outputs, but such fixed designs suffer from limited diversity, adapt
Reasoning as an Attack Surface: Adaptive Evolutionary CoT Jailbreaks for LLMs
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cs.AI, q-bio.NC updates on arXiv.org
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Hypothesis Generation and Inductive Inference in Children and Language Models
arXiv:2605.24528v1 Announce Type: new Abstract: Real world decision-making requires constructing mental models under uncertainty over evidence, over the underlying causal rules, and over the state of the world itself. Which computational principles underpin human inference under such conditions, and do LLM-based agents exhibit similar behavior given matching constraints? We address these questions using an inductive inference Box Task in which participants, human children and LLM-based agents,
Hypothesis Generation and Inductive Inference in Children and Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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GlobalDentBench: A Multinational Benchmark for Evaluating LLM Clinical Reasoning in Dentistry with Expert Calibration
arXiv:2605.24636v2 Announce Type: new Abstract: While large language models (LLMs) hold transformative potential for medicine, their reasoning robustness and safety in real-world clinical scenarios remain critically underexplored, particularly in dentistry. Here we introduce GlobalDentBench, the first multinational dental benchmark, featuring a taxonomy that encompasses 14 dental specialties across 88 countries and regions spanning six continents. The benchmark comprises 8,978 expert-validated
GlobalDentBench: A Multinational Benchmark for Evaluating LLM Clinical Reasoning in Dentistry with Expert Calibration
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cs.AI, q-bio.NC updates on arXiv.org
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Inverting the Shield: Systematically Generating Safety Tests from Policy Specifications
arXiv:2605.24883v1 Announce Type: new Abstract: The widespread integration of Large Language Models (LLMs) necessitates rigorous and systematic safety evaluation. Existing paradigms either rely on constructed benchmarks to assess safety from predefined perspectives, or employ dynamic red-teaming to probe potential vulnerabilities. While effective, these approaches face challenges, as they depend heavily on expert domain knowledge, offer limited systematic guarantees, and are vulnerable to rapid
Inverting the Shield: Systematically Generating Safety Tests from Policy Specifications
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cs.AI, q-bio.NC updates on arXiv.org
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Energy Shields for Fairness
arXiv:2605.24926v1 Announce Type: new Abstract: Runtime fairness is not a one-time constraint but a dynamic property evaluated over a sequence of decisions. To ensure fairness at runtime, it is necessary to account for past decisions, information neglected by conventional, static classifiers. Traditional fairness shields enforce runtime fairness abruptly, by intervening \emph{deterministically} whenever a sequence of decisions violates the target for a running fairness measure. This motiv