Zhang and colleagues engineered the poly(A) tail as a programmable regulatory element, showing that embedding cell-type-specific microRNA target sites directly within it confers robust, position-dependent silencing in off-target tissues while preserving activity in target cells. This strategy offers a new modular tool to enhance mRNA therapeutic safety and precision.

Gene therapy is transforming hereditary hematological disorders. This review summarizes approved gene addition, editing, and silencing strategies for sickle cell disease, thalassemia, and hemophilia, highlights curative potential, and discusses remaining challenges such as immune responses, cost, and accessibility

Yuan and colleagues demonstrate that inhaled biodegradable nanosilica activates an alveolar macrophage–NK axis, triggering an IL-12/15/18 triad that programs memory-like NK cells. This non-fibrotic, cell-free strategy suppresses melanoma growth, prevents postsurgical recurrence, and synergizes with anti-PD-1, establishing a robust framework for in vivo NK cell immunotherapy.

The efficacy of vaccines remains suboptimal in many settings, underscoring the need for new strategies. Baydemir and colleagues show that modulation of acetyl-CoA metabolism reshapes metabolic and epigenetic programs underlying Bacille Calmette-Guérin-induced trained immunity, enhancing cellular innate immune responses and identifying immunometabolic targeting as a promising approach to improve vaccine efficacy.

In the infection courses of different SARS-CoV-2 variants, disease outcomes and signatures were delineated by physiological changes, viral load, pathology, and pulmonary transcriptome analysis. This multi-dimensional landscape of disease outcomes and underlying mechanisms might provide important clues for immunotherapy of SARS-CoV-2 infection and pneumonia caused by other respiratory viruses.

MNK1 acts as a structural shield on MYH9, preventing YAP1-mediated platelet activation. Developing MD2 to lock this MNK1-MYH9 complex introduces a safe antithrombotic strategy, shifting the therapeutic paradigm from kinase inhibition to stabilizing protein-protein interactions against immunothrombosis.

Nature Biomedical Engineering, Published online: 31 August 2026; doi:10.1038/s41551-026-01779-4

This large-scale study of white matter structural connectivity during development reveals biomarkers associated with attention deficit hyperactivity disorder in youth that track symptom trajectories and predict differential treatment response.

Nature Nanotechnology, Published online: 08 September 2026; doi:10.1038/s41565-026-02288-w

Publisher Correction: Edge-sharing RuO₂ single layer for stable and low overpotential acidic water electrolysis

arXiv:2609.09928v1 Announce Type: new Abstract: Latent reasoning approaches enhance token-level efficiency and robustness by replacing verbose, explicit chain-of-thought (CoT) tokens with compact continuous-space embeddings. However, existing methods lack direct process supervision over these latent embeddings, which often leads to representation collapse and uneven information distribution. To address this, we propose Prototype-Mediated Process Supervision (PMPS), which introduces learnable reasoning prototypes as semantic anchors to provide structural process-level supervision for latent reasoning. PMPS projects latent embeddings and explicit CoT embeddings into a shared prototype space, achieving many-to-many soft alignment between unequal-length representations through prototype assignment. Meanwhile, we introduce a Progressive Sequential Alignment (PSA) module to further guide training: positional priors initially encourage sequential alignment structure, then gradually relax to permit adaptive matching. Experimental results show that PMPS compresses output token length to under 50% of explicit CoT on GSM8K-Aug. Compared to leading baseline SIM-CoT, our method achieves average accuracy gains of 2.08% across different model families. On GPT-2, PMPS even surpasses CoT-SFT. On larger models and a more challenging task, PMPS consistently attains the highest accuracy among all latent reasoning methods with comparable output length.

arXiv:2609.10263v1 Announce Type: new Abstract: Persistent language agents need stored experience to remain available across time, while each answer requires evidence suited to a particular question. A superseded fact can mislead a current-state answer and still be essential for a historical query. We present RD-Forget, a training-free framework that separates what an agent stores from what it uses. A retained source archive preserves observations, and a query-conditioned memory view controls their influence on the current answer. A frozen language-model curator extracts relevant evidence, groups facts into semantic slots, and preserves the relations needed for multi-hop reasoning. Same-slot replacement links suppress superseded values in current-state contexts, while intent-aware retrieval makes earlier evidence eligible again. A rate-distortion formulation guides construction of the answer-time view within a memory budget. Experiments span conversational memory, knowledge updating, fact consolidation, long-context reasoning, and personalization under a shared answering pipeline. The results associate accurate answers with both query-relevant evidence construction and control over obsolete alternatives. Configurations without forgetting or query conditioning have the largest score deficits, while slot grouping, historical access, and relation preservation contribute complementary functions. Retaining history while selectively controlling its use offers a practical way to accommodate changing facts and future questions.

arXiv:2609.09626v1 Announce Type: cross Abstract: Open-world object detection (OWOD) extends closed-set detection by requiring models to identify unknown objects and incrementally learn them once annotations become available. In remote sensing imagery, object categories often exhibit latent hierarchical relationships that may be inadequately represented in the Euclidean spaces commonly adopted by existing methods, limiting unknown-object recall and incremental-learning performance. To address this issue, we investigate hyperbolic geometry for OWOD in remote sensing imagery and propose HyRS-OWOD. To improve unknown object recall, we design a two-step unknown-object discovery mechanism: a Decoupled Objectness Learning (DOL) module that disentangles foreground perception from semantic information to separate foreground proposals from background regions, followed by a Hyperbolic Uncertainty Learning (HUL) component that leverages the radius of hyperbolic embeddings as an uncertainty-aware cue for known-unknown discrimination. For incremental learning, we develop a Hyperbolic Metric Learning (HML) strategy that enhances inter-class separability, facilitating the incorporation of novel categories while mitigating catastrophic forgetting. Experiments on three remote sensing benchmarks demonstrate consistent improvements in unknown recall and incremental learning over state-of-the-art OWOD methods.

arXiv:2609.09798v1 Announce Type: cross Abstract: Large language models (LLMs) have been ex- ploited to generate malware, but the effective- ness of guardrails for code generation secu- rity remains unclear. We introduce CS-Guard, the first benchmark to systematically evalu- ate guardrails for code generation security. It covers 1) text-to-code generation with 1000 high-quality malware-generation prompts, 7 jailbreak attacks, and a novel fictional scenario attack (FSA) that embeds malicious intent in a legitimate fictional software-development sce- nario; and 2) code-to-code generation with 331 code prompts spanning code infilling, code completion, and code translation. We empiri- cally evaluate 9 guardrails across seven LLMs. We find that current guardrails perform poorly against malicious code-generation re- quests: for text-to-code, the average attack success rate (ASR) after jailbreaks reaches about 50% for many guardrails; for code-to- code, average ASR approaches 100% on base LLMs and remains high across many guardrails (14.4% to nearly 100%). Our FSA also achieves ASR close to 100% across many guardrails, raising major reliability concerns for real-world software development. To sup- port future research, CS-Guard uses a modular three-layer guardrail taxonomy that lets devel- opers register guardrails for evaluation. We release the benchmark and data to enable fur- ther community evaluation.

arXiv:2609.09883v1 Announce Type: cross Abstract: Depth pruning reduces large language model (LLM) inference cost by removing complete Transformer blocks. Activation-based methods collect hidden states through forward passes on calibration data, while existing forward-free methods score each Transformer block separately without measuring similarity between blocks. We propose Weight-Redundancy Pruning (WRP), a forward-free depth-pruning method that estimates inter-layer redundancy from checkpoint weights to select blocks without calibration data or model forward passes. WRP compares attention output and MLP down-projection weights across layers and combines their pairwise similarities with relative projection-scale information. The resulting all-pairs similarity matrix guides layer grouping and block selection. Across multiple pruning settings, model families, and downstream tasks, WRP consistently outperforms existing forward-free magnitude pruning and approaches the performance of activation-based methods.

arXiv:2609.10108v1 Announce Type: cross Abstract: Aging clocks quantify biological aging and help characterize individual health status. What protein interactions are important for accurate aging clocks, and are they zeroth-order or higher-order? Addressing these questions requires learning from large molecular datasets distributed across medical centers, where privacy constraints prevent centralized data sharing. Federated learning offers a natural solution but faces four challenges in this setting: limited local sample sizes, sparse and directional inter-center trust, the need to retain discriminative age prediction while supporting interpretation, and model drift and forgetting under heterogeneous cross-center data. We propose TNFL, a trust-network-based federated learning framework that progressively propagates models along directed pairwise trust relations without centralized aggregation. TNFL combines an age-aware mixture-of-experts model with generative replay to preserve previously learned information and reduce forgetting and drift. Experiments across multiple molecular datasets show that TNFL enables effective aging-clock prediction with limited local data, provides interpretable age-dependent prediction patterns, and maintains stable performance across interaction orders. To investigate the biological questions, we analyze TNFL-identified pairwise protein interactions and their higher-order organization through functional and network analyses. The identified interactions repeatedly form coordinated higher-order subnetworks spanning multiple aging-related biological systems, with several proteins recurring across subnetworks. These findings suggest that TNFL captures molecular relationships beyond isolated pairwise associations and reveals coherent higher-order biological organization associated with aging.

arXiv:2609.10142v1 Announce Type: cross Abstract: Large language models remain fragile against malicious fine-tuning, motivating training-time defenses against harmful persona drift. Preventative Steering injects undesirable-trait persona vectors during fine-tuning and removes them at evaluation time, yet the mechanism behind its lasting protection remains unclear. Analyzing its temporal optimization dynamics, we find that the defense emerges from an early compensatory adaptation phase followed by a steady-state phase where the corrective signal decays; in parameter space, attention output projections emerge as the dominant residual-write route for defensive updates. Through Intervention Delta Preservation (IDP) and IDP Continuation experiments, we further show that preserving or reinjecting the weight offset fails to maintain protection, indicating that preventative steering relies on active adaptation rather than a static defense. Motivated by this finding, we propose Progressive Intensity Scheduling (PIS), which starts with a moderate injection strength and increases it after static-strength alignment begins to decay. Across the evaluated Qwen2.5 and Gemma-3 models, PIS improves safety robustness over static-strength steering while reducing harmful trait expression.

arXiv:2609.10305v1 Announce Type: cross Abstract: Language models under one million parameters matter for edge deployment, domain adaptation, and reproducible research, yet a two-layer LSTM or Transformer at embedding width d = 128 still spends roughly one third of its capacity on the output matrix W_out in R^(d x |V|). We propose Riemannian Language Models (RiLM), which remove that layer entirely: context unfolds as a trajectory on a Riemannian manifold, and next-token probabilities arise from squared geodesic distance between the current state and vocabulary embeddings. The same embedding map serves input and output -- decoding is geometry. We instantiate the framework on flat R^d (Flat RiLM) and the Poincare ball H^d (HypRiLM) with a shared MLP composition map phi (~290k parameters, d = 128, |V| = 2000). Across five seeds on WikiText-2, HypRiLM reaches 54.2 +/- 0.2 validation perplexity versus 87.6 +/- 0.6 for Flat RiLM; tied and matched LSTM, Transformer, and SSM controls remain at 113-147 PPL on WT-2 -- HypRiLM leads by roughly 2x over the strongest tied recurrent baseline (SSM, 113.0 +/- 3.8). Penn Treebank and a 10k-vocabulary stress test confirm that geodesic decoding transfers across corpora and larger |V|, while hyperbolic curvature helps selectively. We also characterize boundary collapse in naive hyperbolic recurrence and show how Mobius stabilization restores trainability. Claims are scoped to controlled small-model comparisons, not full-vocabulary state of the art.

arXiv:2609.10522v1 Announce Type: cross Abstract: Foundation vision-language models (VLMs) exhibit broad intelligence about the world, yet translating this intelligence into robot control remains challenging. We present Show-Harness, an Embodied Harness that enables VLMs to "play" robots through a compact semantic interface linking intent to action. Show-Harness exposes discrete semantic action units that VLMs can naturally reason over, while embodiment-specific interpreters deterministically ground them into local robot actions, keeping the VLM directly responsible for fine-grained physical decisions. Through the same interface, Show-Harness demonstrates the feasibility of (1) directly unlocking closed-source frontier VLMs for zero-shot robot control, and (2) adapting small-scale open-source VLMs for low-cost deployment with just a few GPU-hours of fine-tuning. We further develop GUMI (GUI Manipulation Interface), which extends the same semantic action space to GUI-based demonstration collection, allowing humans and agents to "play" robots across embodiments without specialized teleoperation hardware. Extensive experiments show that Show-Harness-equipped VLM agents generalize robustly across tasks, embodiments, and environments, outperforming representative agentic and VLA paradigms. These results suggest that the right interface can unlock substantial embodied capability from foundation VLMs, without requiring additional model capacity or costly embodiment-specific pretraining.

arXiv:2607.12455v2 Announce Type: replace Abstract: Quantitative strategy optimization remains largely manual, requiring domain experts to identify weak signals, tune risk-control rules, and repeatedly validate iterative revisions. Large language models can accelerate this process, but directly relying on them to rewrite trading strategies often introduces hallucinated edits, strategy drift, and backtest overfitting. We propose EVOQUANT, a self-Evolving Verifier-guided framework for strategy Optimization in Quantitative trading. Our method utilizes LLMs to deeply diagnose performance bottlenecks, generates semantically controlled candidate edits, selects the best strategy through a multi-stage verification pipeline, and distills optimization experience into reusable knowledge for continual self-improvement. We evaluate our method using seven representative strategies: four from the A-share market and three from the Crypto market. Experimental results show that our method significantly improves the Sharpe ratio across all tested strategies: the average test Sharpe increases from -0.298 to 0.538, and the best-performing strategy achieves a 199% relative improvement. Ablation studies and stress tests under stricter conditions further validate the effectiveness and robustness of the framework. Overall, this work transforms quantitative strategy optimization from costly manual trial and error into an automated and verifiable iterative paradigm, offering a new path for applying large language models to financial strategy research.

arXiv:2607.27231v3 Announce Type: replace Abstract: Modern AI systems depend on specialized accelerator kernels, whose development is complicated by increasingly diverse operators and hardware. LLMs and agentic systems promise to automate this work, but existing evaluations do not show whether their performance transfers across operator sources and hardware platforms, or what such transfer costs. We present KernelGenBench, the first unified multi-source and multi-chip infrastructure for evaluating LLM- and agent-generated Triton kernels. With a common Triton target spanning six hardware platforms, it provides the broadest cross-vendor hardware coverage among existing kernel-generation benchmarks. We report two controlled analytical views: KernelGenBench-MS (Multi-Source) covers 210 operators from PyTorch ATen, production vLLM operators, and proprietary cuBLAS routines, while KernelGenBench-MC (Multi-Chip) evaluates a semantically stable 110-operator subset across six hardware platforms. Our evaluation consumed over 15 billion tokens. Agentic execution improved correctness, but no method dominated across sources and platforms: vLLM posed the strongest correctness challenge, cuBLAS set the highest performance ceiling, and AutoKernel accuracy fell from 87% on NVIDIA to 25% on Iluvatar CoreX. These improvements were costly: specialized agents averaged 4.99 million tokens per successful operator, rising to 6.25 million for CUDA Optimized Skill. The results establish operator source, hardware platform, and agentic scaffold as distinct dimensions of kernel-generation capability, and show that success in a familiar source-hardware setting is not a reliable proxy for deployment readiness.

arXiv:2608.06411v2 Announce Type: replace Abstract: Multimodal large language models (MLLMs) achieve strong performance across diverse vision-language tasks, but their efficiency is limited by the cost of processing numerous visual tokens. Visual token pruning can reduce this cost, but requires accurate token importance estimates. Recent studies have demonstrated that text-to-vision attention from middle language model layers can effectively guide visual token pruning, typically using attention from a predefined middle layer to select the visual tokens to retain. Two problems therefore remain. First, our analysis shows that the layer whose attention is most responsive to the question varies substantially across samples, making a fixed layer suboptimal. Second, obtaining attention from the appropriate middle layer requires processing numerous visual tokens through several language model layers, by which point considerable computation has already been spent. To address both problems, we propose Middle-layer Attention Prediction (MAP), which uses Question Contrastive Teacher Selection to identify a sample-specific teacher layer by contrasting attention under the original and reference questions, and distills attention from the selected layer into a lightweight predictor that estimates visual token importance from multi-modal input features. During inference, MAP combines the predicted importance scores with a diversity criterion to prune visual tokens before the first language model layer. Thus, MAP requires no attention maps for pruning and remains compatible with existing inference acceleration techniques. Across ten benchmarks on LLaVA-NeXT-7B, MAP retains 97.5% of the unpruned model performance with only 5.56% of the visual tokens, yielding a 3.09x end-to-end speedup.