Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
Causal Tongue-Tie: LLMs Can Encode Causal Direction, But Their Yes/No Outputs Fail to Express
arXiv:2605.25891v1 Announce Type: cross Abstract: We find a mismatch between what large language models encode about a causal question and what they answer. On anti-commonsense CLadder items, a fixed linear probe recovers the evidence-supported answer from the model's hidden state (accuracy approximately 0.97), while the spoken Yes/No reverts to the commonsense one (accuracy approximately 0.5). We call this approximately +0.5 gap Causal Tongue-Tie: a wrong Yes/No decomposes into two separable f
-
(Multiomics OR Omics) AND (Pancreatic)
-
Baseline cellular state dictates the molecular impact of KRAS mutant variants in pancreatic cancer cells
bioRxiv [Preprint]. 2026 Mar 12:2026.03.10.710185. doi: 10.64898/2026.03.10.710185.ABSTRACTKRAS is mutated in over 90% of pancreatic ductal adenocarcinomas (PDAC), where hotspot alterations in codons 12, 13, and 61 drive tumor initiation and progression. Although distinct biochemical properties have been described for individual KRAS mutants, whether they generate unique allele-specific signaling programs in PDAC cells remains unresolved. Here, we systematically interrogated the molecular conseq
Baseline cellular state dictates the molecular impact of KRAS mutant variants in pancreatic cancer cells
bioRxiv [Preprint]. 2026 Mar 12:2026.03.10.710185. doi: 10.64898/2026.03.10.710185.
ABSTRACT
KRAS is mutated in over 90% of pancreatic ductal adenocarcinomas (PDAC), where hotspot alterations in codons 12, 13, and 61 drive tumor initiation and progression. Although distinct biochemical properties have been described for individual KRAS mutants, whether they generate unique allele-specific signaling programs in PDAC cells remains unresolved. Here, we systematically interrogated the molecular consequences of seven common KRAS mutant variants in reconstituted isogenic, KRAS-deficient PDAC cell lines by integrated transcriptomic, proteomic, and phosphoproteomic profiling. We found that baseline cellular state, rather than allele identity, was the predominant driver of molecular variation. Comparisons with established KRAS reference signatures revealed significant but moderate overlap at the mRNA level and less so at the proteome level. Pathway analyses highlighted interferon response and mitochondrial translation as recurrently altered across alleles, while phosphoproteomic data confirmed robust ERK1/2 activity and suppression of DYRK kinase substrates by mutant KRAS expression. Importantly, no robust allele-specific molecular programs were identified. Together, our study establishes a comprehensive multi-omics resource for KRAS signaling in PDAC and demonstrates that cellular context exerts a stronger influence than allele identity in shaping molecular profiles, with implications for interpreting putative allele-specific signaling dependencies and therapeutic vulnerabilities.
PMID:41959224 | PMC:PMC13060958 | DOI:10.64898/2026.03.10.710185
-
Nature - Issue - nature.com science feeds
-
The 1000 Chinese Pangenome empowers medical and population genetics
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10315-yDevelopment of the pangenome-informed genome assembly (PIGA) workflow enabled the generation of 1,116 diploid genome assemblies (55 de novo and 1,061 pangenome-informed), representing an extensive resource of medically relevant genic variations.
The 1000 Chinese Pangenome empowers medical and population genetics
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10315-y
Development of the pangenome-informed genome assembly (PIGA) workflow enabled the generation of 1,116 diploid genome assemblies (55 de novo and 1,061 pangenome-informed), representing an extensive resource of medically relevant genic variations.-
cs.AI, q-bio.NC updates on arXiv.org
-
ObjChangeVR: Object State Change Reasoning from Continuous Egocentric Views in VR Environments
arXiv:2603.06648v1 Announce Type: cross Abstract: Recent advances in multimodal large language models (MLLMs) offer a promising approach for natural language-based scene change queries in virtual reality (VR). Prior work on applying MLLMs for object state understanding has focused on egocentric videos that capture the camera wearer's interactions with objects. However, object state changes may occur in the background without direct user interaction, lacking explicit motion cues and making them
ObjChangeVR: Object State Change Reasoning from Continuous Egocentric Views in VR Environments
-
cs.AI, q-bio.NC updates on arXiv.org
-
Uni-NTFM: A Unified Foundation Model for EEG Signal Representation Learning
arXiv:2509.24222v2 Announce Type: replace-cross Abstract: Current foundation models for electroencephalography (EEG) rely on architectures adapted from computer vision or natural language processing, typically treating neural signals as pixel grids or token sequences. This approach overlooks that the neural activity is activated by diverse sparse coding across a complex geometric topological cortex. Inspired by biological neural mechanisms, we propose the Unified Neural Topological Foundation M