Gene therapy is transforming hereditary hematological disorders. This review summarizes approved gene addition, editing, and silencing strategies for sickle cell disease, thalassemia, and hemophilia, highlights curative potential, and discusses remaining challenges such as immune responses, cost, and accessibility

(Molecular Therapy 31, 1596–1614; June 2023)

Zhang and colleagues reveal that GPX4 serves as a critical regulator of NRF2-mediated otoprotection against aminoglycoside-induced hair cell injury. Their findings identify a GPX4-dependent antioxidant mechanism that enables therapeutic activation of NRF2 and provides new insights into strategies for preventing drug-induced hearing loss.

(Molecular Therapy 31, 344–361; February 2023)

In the infection courses of different SARS-CoV-2 variants, disease outcomes and signatures were delineated by physiological changes, viral load, pathology, and pulmonary transcriptome analysis. This multi-dimensional landscape of disease outcomes and underlying mechanisms might provide important clues for immunotherapy of SARS-CoV-2 infection and pneumonia caused by other respiratory viruses.

AAV-WM04, an AAV vector identified through in-vivo-directed screening in the adult cochlea, enables highly efficient and selective inner hair cell transduction. Dual-AAV delivery of OTOF using AAV-WM04 restores hearing in a DFNA9 deafness mouse model at low doses, highlighting its translational potential for gene therapy.

Nature Nanotechnology, Published online: 09 September 2026; doi:10.1038/s41565-026-02294-y

Author Correction: Nanopore-enabled time-resolved monitoring of catecholamine-related phenylalanine metabolism

Nature Nanotechnology, Published online: 09 September 2026; doi:10.1038/s41565-026-02264-4

This Review discusses photonic platforms that have already shown programmability, high integration density, and stability, and that can support large-scale AI models, edge computing, and logic and scientific computing.

Nature Nanotechnology, Published online: 07 September 2026; doi:10.1038/s41565-026-02271-5

Single copper atoms on boron nanosheets dynamically and reversibly switch to clusters, enabling the direct conversion of methane to acetic acid with 97% selectivity and high activity without the requirement for carbon monoxide.

arXiv:2609.09589v1 Announce Type: new Abstract: Deep neural networks exhibit regular macroscopic behavior despite highly nonlinear dynamics in vast parameter spaces. We develop a statistical-mechanical description of learning directly in function space, treating parameter configurations as microscopic realizations and functions with their dynamical operators as macroscopic variables. For mean-squared loss, the exact error dynamics are governed by the learning operator \(M=JJ^\ast\). Combining the dynamical Boltzmann weight of the conditional stochastic dynamics with the parameter-space density of states, whose local curvature defines a statistical operator \(B\), and integrating over local fluctuations yields $$ \Phi_{\mathrm{fluc}}(M;B)=\frac{\sigma_\xi^2}{2}\log\det(M^{-1}+B)+\mathrm{const}. $$ At fixed spectrum, this term is rotationally stationary when \([M,B]=0\), is minimized by pairing large eigenvalues of \(M\) with small eigenvalues of \(B\), and generates a local restoring contribution against rotational mismatch. For ReLU-type function spaces under mild stable statistical conditions, \(B=\sigma_\xi^2L^\ast\mathcal K L\), where \(L\) measures coarse-grained second-order structure. Thus the low-\(B\) sector corresponds, up to bounded anisotropy of \(\mathcal K\), to low structural curvature, implying a preference for faster relaxation along smooth, data-adaptive directions. These results identify function space as a natural macroscopic level for studying stable collective organization in learning.

arXiv:2609.09646v1 Announce Type: new Abstract: Semantic-gradient-based prompt optimization (SGPO) improves agent harnesses using execution feedback, but its local update rule leaves the choice of edit scope and operation unresolved. We introduce RobustSGPO, which specifies the requested edit, constructs and checks the patch, and continues search from either the incumbent or retained snapshots. We evaluate permission scheduling, cumulative controls, and task-family transfer in the AgentX brainstorming workflow using 120 tasks, 95 runs, and 7,350 candidate attempts. Periodic $1\to2\to3$ scheduling exceeds fixed maximum permission by 0.28 test-score points. RobustSGPO increases completion on 30 held-out tasks from 60.0% to 80.0% and improves test quality from 3.77 to 4.14 under a 20-million-token budget. Category retention reduces source-task degradation after a shift, whereas random retention reaches a higher destination endpoint. Search-space control benefits quality through executable edits and alternative starting points, with measurable retention overhead.

arXiv:2609.09678v1 Announce Type: new Abstract: Clinical diagnosis agents must decide not only what test to request next, but also when to diagnose or defer. Existing agent benchmarks largely evaluate accuracy after fixed or unconstrained interaction, leaving autonomous stopping reliability implicit. We present Cros, a risk-constrained stopping layer combining state-wise error ranking, policy design on disjoint development splits, and LTT-style exact tests of selective diagnostic error and minimum autonomous coverage for complete sequential policies. Its finite-sample guarantee requires the candidate family, testing rule, and any randomization to be frozen before calibration labels are accessed. On a 1,834-episode MIMIC-derived abdominal-pain benchmark, the full ranker achieves exploratory state-error AUROC 0.853, compared with 0.715 for maximum class probability and 0.552 for the backbone's native stop score. On the previously viewed 367-episode evaluation split, analytically averaging over the frozen Cros weights yields 16.9% selective error at 78.8% coverage, cost 5.57, and 0.68 tests, versus 30.8% error at 100% coverage, cost 8.14, and 1.53 tests under native stopping. Forced continuation is non-monotone: error is 28.3% with HPI alone and 34.3% after full workup. However, the uniform-weight mixture ablation is cheaper on this viewed split despite missing the locked development margins, and Cros nominally satisfies the joint criterion in only 6 of 20 development resplits. Because evaluation labels were inspected during earlier development, these findings provide exploratory feasibility and audit evidence, not a confirmatory safety certificate.

arXiv:2609.09735v1 Announce Type: new Abstract: Healthcare systems, mental health, and public well-being are increasingly affected by cyberbullying and harmful online interactions. This paper presents CareGuard, an early-warning framework designed to support healthcare-driven mental health protection and proactive online safety through the detection of cyberbullying-related content using advanced natural language processing techniques. CareGuard integrates zero-shot semantic labeling with fine-tuned transformer-based models, including BERT, DistilBERT, and RoBERTa, to enable robust and context-aware classification across sensitive cyberbullying categories. To improve efficiency and reduce unnecessary computation in healthcare-oriented monitoring settings, the framework incorporates an emotion-aware filtering mechanism alongside cosine similarity-based semantic screening, allowing the system to focus on semantically relevant and emotionally salient content. Experimental results on benchmark datasets demonstrate that CareGuard effectively balances detection accuracy and computational efficiency, highlighting its potential for scalable deployment in healthcare systems, mental health monitoring, and online safety applications.

arXiv:2609.10092v1 Announce Type: new Abstract: Large language models (LLMs) increasingly act as research agents, yet their ability to track shifts in research attention is difficult to evaluate because reviews and research ideas lack uniquely verifiable outcomes. We introduce Research Attention Prediction (RAP), a rolling benchmark covering 278 AI/ML fields and 1,390 episodes. At each cut-off, an LLM agent searches a temporally restricted arXiv corpus and predicts the next six months' paper shares across eight frozen research directions. Search generally helps, but all four diagnostic models perform worse than an exact-count exponentially weighted moving average (EWMA) baseline in compositional accuracy. We identify two linked bottlenecks. Under cumulative-history access, State carry-forward outperforms direct Forecast for all four diagnostic models; frozen-evidence replay links a shared component of this reversal to Forecast-oriented policies retrieving a smaller share of recent evidence. Even with exact historical activity, future-specific updating remains limited, with only GPT-5.5 plus reopened Search slightly surpassing EWMA. Fine-tuning on realised outcomes improves Qwen3-4B's forecast Spearman correlation by 0.105 on held-out fields at later origins, with gains also on change-rich episodes.

arXiv:2609.09212v1 Announce Type: cross Abstract: This paper presents an end-to-end evaluation framework for image-triggered command injection against computer-use agents (CUAs). The goal is to test whether a local visual patch can induce verifiable environmental consequences along the full chain of screenshot input, VLM generation, action parsing, and environment execution. We train and deploy patches on author-controlled GitHub Pages pages and a locally deployed CSDN clone, and evaluate them in real environments across five open-source or publicly available GUI-agent or vision-language-model (VLM) backends. Our experiment aggregates 600 instance-level online cases, with T-ASR, TAPR, and E2E-ASR reaching 84.5%, 47.0%, and 20.3%, respectively. Trajectory analysis further shows that in some successful cases the agent first executes a malicious terminal command and then continues the original benign task. These results indicate that optimized local visual signals can affect not only VLM outputs but also propagate through the execution pipeline of open CUAs and create real environmental risk.

arXiv:2609.09388v1 Announce Type: cross Abstract: Brain-age prediction models are commonly evaluated by predictive accuracy, yet accurate predictions alone do not establish that a model relies on reproducible or neurobiologically supported mechanisms. Post-hoc explanation methods can expose these mechanisms, but existing workflows typically stop at diagnosis or require correction targets to be specified before model analysis. We propose XAI-Refine, an automated explanation-knowledge loop for brain-age prediction from resting-state functional connectivity. At each iteration, XAI-Refine consolidates complementary post-hoc analyses across repeated training runs into reliable, structured model explanations. It converts each reliable explanation into a neutral neurobiological question, retrieves and verifies relevant literature, and compiles the verified evidence into an admissible set in the same typed explanation space. The target for refinement is defined as the minimal projection of the current model explanation onto the admissible set induced by applicable verified knowledge. This revised explanation is then translated into a differentiable constraint while preserving the originating model variable, measurement operator, and applicable scope. Candidate updates are promoted only when multi-seed validation confirms target-directed explanatory movement, predictive performance remains within a prespecified guardrail, and non-target explanatory drift remains bounded. Experiments on functional-connectivity-based brain-age prediction evaluate predictive performance, explanation reliability, literature alignment, and target-specific model revision, illustrating a structured route from post-hoc analysis to evidence-guided model refinement.

arXiv:2609.09591v1 Announce Type: cross Abstract: Sixth-generation (6G) wireless networks are expected to provide a key infrastructure for large-scale embodied intelligence, where heterogeneous robots collaborate through low-latency connectivity, edge intelligence, and distributed sensing. Vision-language-action (VLA) models offer a foundation by integrating visual perception, language understanding, and action generation into a unified closed-loop policy. However, training and adapting VLA models to distributed robotic agents introduce challenges in privacy protection, communication efficiency, and model heterogeneity. Existing federated learning (FL) methods overlook the intrinsic differences among vision, language, and action pathways in parameter scale, privacy exposure, update dynamics, and tolerance to compression or perturbation. To address this issue, this article proposes FedMVLA, a modality-decoupled FL framework for privacy-preserving embodied intelligence in 6G networks. FedMVLA incorporates three mechanisms: modality-aware federated aggregation (MAFA), modality-aware privacy allocation (MAPA), and modality-aware communication compression (MACO), together with a modality-sliced transport design that routes the precision-critical action stream through a protected ultra-reliable low-latency slice. A case study on federated robotic manipulation over the Third Generation Partnership Project (3GPP)-based wireless substrate, covering fading, co-channel interference, and malicious jamming, shows that FedMVLA achieves an 84.8% task success rate, exceeds FedAvg by 22.2 percentage points, sustains a widening margin when scaling to 128 clients across eight cells, and reduces the schedule-averaged per-client uplink model-update payload by 95.6% (approximately 96%), while keeping the 95th percentile (p95) of the round-critical uplink completion time near 1.5s.

arXiv:2609.09595v1 Announce Type: cross Abstract: Teacher-student systems, in which a teacher neural network generates training labels so that a student neural network can learn to implement the same function, are widely used as an abstract setting to study learning. However, the structure of the teachers is often overlooked by assuming randomly-generated, normally-distributed parameters. This hides substantial variation in how learnable different teachers are. We formalize learnability as the success rate of converging to the global minimum, as a function of overparameterization, learning algorithm, student initialization distribution, and teacher geometry. We both identify an easy distribution that maximizes node dissimilarity and a hard distribution that minimizes it, and show that these two distributions induce markedly different success rates across a large range of settings and for different activation functions. To explain the gap, we study the loss landscape of small neural networks that contain two distinct kinds of suboptimal local minima, out-of-bounds (OOB) minima at the edge of the data distribution and interior minima within. Assuming infinite data and a fast readout layer, we analytically reduce the loss landscape of small networks to two dimensions, showing that the region of attraction of interior minima changes as a function of teacher structure. In larger networks, maximally dissimilar teachers induce more interior minima, while minimally dissimilar teachers induce more OOB minima. Motivated by these analyses, we show that differentially increasing the learning rate of the readout layer and decreasing the learning rate of the inner biases increases success rates. These findings provide an important step in narrowing the gap between the study of teacher-student networks and more structured functions that arise in practice.

arXiv:2609.09626v1 Announce Type: cross Abstract: Open-world object detection (OWOD) extends closed-set detection by requiring models to identify unknown objects and incrementally learn them once annotations become available. In remote sensing imagery, object categories often exhibit latent hierarchical relationships that may be inadequately represented in the Euclidean spaces commonly adopted by existing methods, limiting unknown-object recall and incremental-learning performance. To address this issue, we investigate hyperbolic geometry for OWOD in remote sensing imagery and propose HyRS-OWOD. To improve unknown object recall, we design a two-step unknown-object discovery mechanism: a Decoupled Objectness Learning (DOL) module that disentangles foreground perception from semantic information to separate foreground proposals from background regions, followed by a Hyperbolic Uncertainty Learning (HUL) component that leverages the radius of hyperbolic embeddings as an uncertainty-aware cue for known-unknown discrimination. For incremental learning, we develop a Hyperbolic Metric Learning (HML) strategy that enhances inter-class separability, facilitating the incorporation of novel categories while mitigating catastrophic forgetting. Experiments on three remote sensing benchmarks demonstrate consistent improvements in unknown recall and incremental learning over state-of-the-art OWOD methods.

arXiv:2609.09684v1 Announce Type: cross Abstract: Medical question-answering datasets often contain answer labels, whereas high-quality rationales remain scarce, noisy, or costly to validate. This changes the acquisition question: rather than asking which questions should be labeled, we ask which already-labeled questions should receive rationale supervision under a fixed token budget. We study an offline version of this problem in which candidate rationales are visible to the selector but withheld from downstream training unless selected. We propose root-mean-square Robustness-based Sample Prioritization (RMS-RSP), which perturbs hidden states only at rationale tokens and measures the resulting shift in the gold-versus-best-distractor margin. Across five medical QA datasets, MedGemma-4B-IT, three training seeds, ten budgeted non-RSP selectors, and an unbudgeted full-supervision reference, RMS-RSP provides a deliberately qualified result. Its locked-budget accuracy is 60.61% on average versus 60.08% for Random, with a statistically resolved gain only on AfriMed-QA (+1.44 points). Its full-budget accuracy area is not better than Random. However, after three answer-option reorderings, RMS-RSP improves robust accuracy and semantic consistency by 1.91 and 2.85 points on average, respectively, with the same direction on all five datasets. Training on every pool rationale raises macro accuracy to 63.74%, but consumes 29--254 times more rationale tokens and does not uniformly improve robustness. These findings do not establish universal accuracy gains; they instead suggest that rationale-local boundary sensitivity can identify supervision that improves invariance to semantically equivalent formatting changes.