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CVEvolve: Autonomous Algorithm Discovery for Unstructured Scientific Data Processing

arXiv:2605.11359v2 Announce Type: replace Abstract: Scientific data processing often requires task-specific algorithms or AI models, creating a barrier for domain scientists who need to analyze their data but may not have extensive computing or image-processing expertise. This barrier is especially pronounced when data are noisy, have a high dynamic range, are sparsely labeled, or are only loosely specified. We introduce CVEvolve, an autonomous agentic harness with a zero-code interface for scientific data-processing algorithm discovery. CVEvolve combines a multi-round search strategy with tools for code execution, evaluation implementation, history management, holdout testing, and optional inspection of scientific data and visual outputs. The search alternates between discovery and improvement actions, and uses lineage-aware stochastic candidate sampling to balance exploration and exploitation. We demonstrate CVEvolve on x-ray fluorescence microscopy image registration, Bragg peak detection, and high-energy diffraction microscopy image segmentation. Across these tasks, CVEvolve discovers algorithms that improve over baseline methods, while holdout test tracking helps identify candidates that generalize better than later over-optimized alternatives. These results show that zero-code, autonomous LLM-powered algorithm development can help domain scientists turn unstructured scientific image data into practical algorithms and downstream scientific discoveries.

Toward Artificial Intelligence Enabled Earth System Coupling

arXiv:2604.03289v1 Announce Type: cross Abstract: Coupling constitutes a foundational mechanism in the Earth system, regulating the interconnected physical, chemical, and biological processes that link its spheres. This review examines how emerging artificial intelligence (AI) methods create new opportunities to enhance Earth system coupling and address long-standing limitations in multi-component models. Rather than surveying next-generation modelling efforts broadly, we focus specifically on how state-of-the-art AI techniques can strengthen cross-domain interactions, support more coherent multi-component representations, and enable progress toward unified Earth system frameworks. The scope extends beyond climate models to include any modelling system in which Earth spheres interact. We outline emerging opportunities, persistent limitations, and conceptual pathways through which AI may enhance physical consistency, interpretability, and integration across domains. In doing so, this review provides a structured foundation for understanding the role of AI in advancing coupled Earth system modelling.

PATHFINDER: Multi-objective discovery in structural and spectral spaces

arXiv:2604.04194v1 Announce Type: cross Abstract: Automated decision-making is becoming key for automated characterization including electron and scanning probe microscopies and nano indentation. Most machine learning driven workflows optimize a single predefined objective and tend to converge prematurely on familiar responses, overlooking rare but scientifically important states. More broadly, the challenge is not only where to measure next, but how to coordinate exploration across structural, spectral, and measurement spaces under finite experimental budgets while balancing target-driven optimization with novelty discovery. Here we introduce PATHFINDER, a framework for autonomous microscopy that combines novelty driven exploration with optimization, helping the system discover more diverse and useful representations across structural, spectral, and measurement spaces. By combining latent space representations of local structure, surrogate modeling of functional response, and Pareto-based acquisition, the framework selects measurements that balance novelty discovery in feature and object space and are informative and experimentally actionable. Benchmarked on pre acquired STEM EELS data and realized experimentally in scanning probe microscopy of ferroelectric materials, this approach expands the accessible structure property landscape and avoids collapse onto a single apparent optimum. These results point to a new mode of autonomous microscopy that is not only optimization-driven, but also discovery-oriented, broad in its search, and responsive to human guidance.

Thermodynamic connectivity reveals functional specialization and multiplex organization of extrasynaptic signaling

arXiv:2604.02057v1 Announce Type: new Abstract: Neural communication operates on both fast synaptic transmission and slower, diffusive extrasynaptic signaling, yet how these two modes jointly organize brain function remains unclear. Here, using the complete synaptic and neuropeptidergic connectomes of \emph{Caenorhabditis elegans}, we develop a unified multiplex framework linking anatomical wiring to functional communication. We infer structure-derived functional connectivity from the synaptic connectome using equilibrium principles from statistical physics, yielding a probabilistic map of information flow across all synaptic pathways, and compare this functional layer directly with the extrasynaptic connectome. This reveals a principled functional specialization across four communication regimes: (i) a topology-dependent layer that reinforces and stabilizes synaptic motor circuits, (ii) a topology-resilient modulatory layer supporting global regulation and behavioral state control, (iii) a purely extrasynaptic network sustaining survival and homeostasis, and (iv) a purely synaptic regime mediating rapid, low-latency sensorimotor processing. Together, these findings reveal that synaptic and extrasynaptic signaling form complementary architectures optimized for speed, modulation, robustness, and survival, and provide a general strategy for integrating structural and modulatory connectomes to understand how distinct communication modes cooperate to sustain coherent brain function.

A mathematical theory for understanding when abstract representations emerge in neural networks

arXiv:2510.09816v2 Announce Type: replace Abstract: Recent experiments in neuroscience reveal that task-relevant variables are often encoded in approximately orthogonal subspaces of neural population activity. These disentangled, or abstract, representations have been observed in multiple brain areas and across different species. These representations have been shown to support out of distribution generalization and rapid learning of novel tasks. The mechanisms by which these representations emerge remain poorly understood, especially in the case of supervised task behavior. Here, we show mathematically that abstract representations of latent variables are guaranteed to appear in the hidden layer of feedforward nonlinear networks when they are trained on tasks that depend directly on these latent variables. These learned abstract representations reflect the semantics of the input stimuli. To show this, we reformulate the usual optimization over the network weights into a mean field optimization problem over the distribution of neural preactivations. We then apply this framework to finite-width ReLU networks and show that the hidden layer of these networks will exhibit an abstract representation at all global minima of the task objective. Finally, we extend our findings to two broad families of activation functions as well as deep feedforward architectures. Together, our results provide an explanation for the widely observed abstract representations in both the brain and artificial neural networks. In addition, the general framework that we develop here provides a mathematically tractable toolkit for understanding the emergence of different kinds of representations in task-optimized, feature-learning network models.

Absolute abstraction: a renormalisation group approach

arXiv:2407.01656v5 Announce Type: replace-cross Abstract: Abstraction is the process of extracting the essential features from raw data while ignoring irrelevant details. It is well known that abstraction emerges with depth in neural networks, where deep layers capture abstract characteristics of data by combining lower level features encoded in shallow layers (e.g. edges). Yet we argue that depth alone is not enough to develop truly abstract representations. We advocate that the level of abstraction crucially depends on how broad the training set is. We address the issue within a renormalisation group approach where a representation is expanded to encompass a broader set of data. We take the unique fixed point of this transformation -- the Hierarchical Feature Model -- as a candidate for a representation which is absolutely abstract. This theoretical picture is tested in numerical experiments based on Deep Belief Networks and auto-encoders trained on data of different breadth. These show that representations in neural networks approach the Hierarchical Feature Model as the data get broader and as depth increases, in agreement with theoretical predictions.
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