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cs.AI, q-bio.NC updates on arXiv.org
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Embedding Enhancement via Fine-Tuned Language Models for Learner-Item Cognitive Modeling
arXiv:2604.04088v1 Announce Type: cross Abstract: Learner-item cognitive modeling plays a central role in the web-based online intelligent education system by enabling cognitive diagnosis (CD) across diverse online educational scenarios. Although ID embedding remains the mainstream approach in cognitive modeling due to its effectiveness and flexibility, recent advances in language models (LMs) have introduced new possibilities for incorporating rich semantic representations to enhance CD perfor
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cs.AI, q-bio.NC updates on arXiv.org
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RAE-AR: Taming Autoregressive Models with Representation Autoencoders
arXiv:2604.01545v1 Announce Type: new Abstract: The latent space of generative modeling is long dominated by the VAE encoder. The latents from the pretrained representation encoders (e.g., DINO, SigLIP, MAE) are previously considered inappropriate for generative modeling. Recently, RAE method lights the hope and reveals that the representation autoencoder can also achieve competitive performance as the VAE encoder. However, the integration of representation autoencoder into continuous autoregre
RAE-AR: Taming Autoregressive Models with Representation Autoencoders
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Nature Cancer
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Leptomeningeal metastatic cancer cells induce a permissive choroid plexus vasculature through extracellular-vesicle-derived 5-HIAA signaling
Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01145-yHuang, Hou, Yang et al. demonstrate that leptomeningeal metastatic cells favor the formation of a premetastatic niche by remodeling the choroid plexus vasculature through the serotonin metabolite 5-hydroxyindoleacetic acid, which signals into endothelial cells through the aryl hydrocarbon receptor.
Leptomeningeal metastatic cancer cells induce a permissive choroid plexus vasculature through extracellular-vesicle-derived 5-HIAA signaling
Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01145-y
Huang, Hou, Yang et al. demonstrate that leptomeningeal metastatic cells favor the formation of a premetastatic niche by remodeling the choroid plexus vasculature through the serotonin metabolite 5-hydroxyindoleacetic acid, which signals into endothelial cells through the aryl hydrocarbon receptor.-
Omics In Lung
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Low-dose intestinal irradiation enhances the efficacy and prognosis of PD-1 blockade in metastatic non-small cell lung cancer
Clin Cancer Res. 2026 Mar 18. doi: 10.1158/1078-0432.CCR-25-4153. Online ahead of print.ABSTRACTPURPOSE: Intestinal low-dose irradiation (ILDR) may enhance immunotherapy efficacy by modulating the gut microbiota and metabolism; however, its role in metastatic non-small cell lung cancer (mNSCLC), particularly in the first-line setting, remains unclear.EXPERIMENTAL DESIGN: This multicenter retrospective and prospective study included mNSCLC patients receiving first- and second-line programmed cell
Low-dose intestinal irradiation enhances the efficacy and prognosis of PD-1 blockade in metastatic non-small cell lung cancer
Clin Cancer Res. 2026 Mar 18. doi: 10.1158/1078-0432.CCR-25-4153. Online ahead of print.
ABSTRACT
PURPOSE: Intestinal low-dose irradiation (ILDR) may enhance immunotherapy efficacy by modulating the gut microbiota and metabolism; however, its role in metastatic non-small cell lung cancer (mNSCLC), particularly in the first-line setting, remains unclear.
EXPERIMENTAL DESIGN: This multicenter retrospective and prospective study included mNSCLC patients receiving first- and second-line programmed cell death protein 1 (PD-1) inhibitors along with abdominopelvic radiotherapy between 2018 and 2025. Patients were stratified by the mean intestinal radiation dose into <1 Gy, 1-3 Gy, and >3 Gy groups and treatment outcomes were compared. The blood and fecal samples were subjected to multi-omics profiling.
RESULTS: g>309 patients were included in the retrospective analysis. Optimal efficacy was observed with a small intestinal mean radiation dose (SIMRD) of 1-3 Gy, showing longer progression-free survival (PFS, 10.2 months) and overall survival (OS, 22.8 months) (P < 0.01), which was consistent across subgroups. Compared with 1-3 Gy, SIMRD >3 Gy (Hazard ratio [HR] = 4.87, P < 0.001) and <1 Gy (HR = 1.85, P < 0.001) independently predicted worse OS. Prospective results confirmed the best disease control rate (P = 0.041) and PFS (P = 0.046) with SIMRD of 1-3 Gy. Responders were enriched in Bacillota, Clostridia, and indole derivatives, particularly indole-3-carboxylic acid. Moreover, the 1-3 Gy group exhibited increased circulating macrophage inflammatory protein-3α and reduced circulating α4β7+ regulatory T cells.
CONCLUSIONS: ILDR influences the efficacy of PD-1 blockade in patients with mNSCLC, particularly when SIMRD is maintained within the 1-3 Gy range, likely through modulation of the gut microbiota-metabolite-immune axis.
PMID:41849236 | DOI:10.1158/1078-0432.CCR-25-4153
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cs.AI, q-bio.NC updates on arXiv.org
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FedMomentum: Preserving LoRA Training Momentum in Federated Fine-Tuning
arXiv:2603.08014v1 Announce Type: cross Abstract: Federated fine-tuning of large language models (LLMs) with low-rank adaptation (LoRA) offers a communication-efficient and privacy-preserving solution for task-specific adaptation. Naive aggregation of LoRA modules introduces noise due to mathematical incorrectness when averaging the downsampling and upsampling matrices independently. However, existing noise-free aggregation strategies inevitably compromise the structural expressiveness of LoRA,
FedMomentum: Preserving LoRA Training Momentum in Federated Fine-Tuning
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cs.AI, q-bio.NC updates on arXiv.org
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Exploring Diffusion Models' Corruption Stage in Few-Shot Fine-tuning and Mitigating with Bayesian Neural Networks
arXiv:2405.19931v2 Announce Type: replace-cross Abstract: Few-shot fine-tuning of Diffusion Models (DMs) is a key advancement, significantly reducing training costs and enabling personalized AI applications. However, we explore the training dynamics of DMs and observe an unanticipated phenomenon: during the training process, image fidelity initially improves, then unexpectedly deteriorates with the emergence of noisy patterns, only to recover later with severe overfitting. We term the stage wit
Exploring Diffusion Models' Corruption Stage in Few-Shot Fine-tuning and Mitigating with Bayesian Neural Networks
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cs.AI, q-bio.NC updates on arXiv.org
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CAPT: Confusion-Aware Prompt Tuning for Reducing Vision-Language Misalignment
arXiv:2603.02557v1 Announce Type: cross Abstract: Vision-language models like CLIP have achieved remarkable progress in cross-modal representation learning, yet suffer from systematic misclassifications among visually and semantically similar categories. We observe that such confusion patterns are not random but persistently occur between specific category pairs, revealing the model's intrinsic bias and limited fine-grained discriminative ability. To address this, we propose CAPT, a Confusion-A
CAPT: Confusion-Aware Prompt Tuning for Reducing Vision-Language Misalignment
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cs.AI, q-bio.NC updates on arXiv.org
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pFedNavi: Structure-Aware Personalized Federated Vision-Language Navigation for Embodied AI
arXiv:2602.14401v1 Announce Type: cross Abstract: Vision-Language Navigation VLN requires large-scale trajectory instruction data from private indoor environments, raising significant privacy concerns. Federated Learning FL mitigates this by keeping data on-device, but vanilla FL struggles under VLNs' extreme cross-client heterogeneity in environments and instruction styles, making a single global model suboptimal. This paper proposes pFedNavi, a structure-aware and dynamically adaptive persona