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cs.AI, q-bio.NC updates on arXiv.org
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Structural Process Supervision for Latent Chain-of-Thought Reasoning
arXiv:2609.09928v1 Announce Type: new Abstract: Latent reasoning approaches enhance token-level efficiency and robustness by replacing verbose, explicit chain-of-thought (CoT) tokens with compact continuous-space embeddings. However, existing methods lack direct process supervision over these latent embeddings, which often leads to representation collapse and uneven information distribution. To address this, we propose Prototype-Mediated Process Supervision (PMPS), which introduces learnable re
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Cell Death Discovery nature.com science feeds
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Lysine attenuates acute lung injury by restoring α-tubulin acetylation and ciliary activity
Cell Death Discovery, Published online: 16 March 2026; doi:10.1038/s41420-026-03025-xLysine attenuates acute lung injury by restoring α-tubulin acetylation and ciliary activity
Lysine attenuates acute lung injury by restoring α-tubulin acetylation and ciliary activity
Cell Death Discovery, Published online: 16 March 2026; doi:10.1038/s41420-026-03025-x
Lysine attenuates acute lung injury by restoring α-tubulin acetylation and ciliary activity-
Omics In Lung
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Unraveling the role of cuproptosis in pulmonary fibrosis pathogenesis and prognosis: an integrative single-cell transcriptomics and microarray analysis
Mol Cell Biochem. 2026 Mar 13. doi: 10.1007/s11010-026-05510-4. Online ahead of print.ABSTRACTPulmonary fibrosis (PF), a progressive interstitial lung disease with elusive pathogenesis, remains a therapeutic challenge. Emerging evidence suggests cuproptosis-a copper-dependent cell death pathway-may play a regulatory role in disease progression. This study aims to elucidate cuproptosis's biological function and establish a prognostic model for PF. Through integrative analysis of single-cell RNA-s
Unraveling the role of cuproptosis in pulmonary fibrosis pathogenesis and prognosis: an integrative single-cell transcriptomics and microarray analysis
Mol Cell Biochem. 2026 Mar 13. doi: 10.1007/s11010-026-05510-4. Online ahead of print.
ABSTRACT
Pulmonary fibrosis (PF), a progressive interstitial lung disease with elusive pathogenesis, remains a therapeutic challenge. Emerging evidence suggests cuproptosis-a copper-dependent cell death pathway-may play a regulatory role in disease progression. This study aims to elucidate cuproptosis's biological function and establish a prognostic model for PF. Through integrative analysis of single-cell RNA-seq data from bleomycin (BLM)-induced mouse models and bulk RNA-seq data from idiopathic pulmonary fibrosis (IPF) patients, we identified cuproptosis-related genes (CRGs) using LASSO regression and Cox regression. A novel 4-CRG signature (LIAS, LIPT1, ATP7A, PDHB) was constructed to stratify patients into distinct risk groups in the GSE70866 cohort, where high-risk individuals exhibited poorer survival and enhanced extracellular matrix/lipid metabolism activity via GO/KEGG analysis. Experimental validation in BLM-induced mouse models, TGF-β1-stimulated fibroblast-to-myofibroblast transition assays, and human IPF specimens demonstrated significant downregulation of CRGs through qRT-PCR and immunohistochemical analyses. Functional assays revealed impaired cell viability and elevated cuproptosis markers in fibrotic microenvironments. Our findings establish an inverse correlation between cuproptosis and PF progression, and propose a robust risk-score model for clinical prognosis prediction. This multi-omics approach provides new insights into copper-mediated regulatory mechanisms in fibrogenesis.
PMID:41824199 | DOI:10.1007/s11010-026-05510-4
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cs.AI, q-bio.NC updates on arXiv.org
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REVISION:Reflective Intent Mining and Online Reasoning Auxiliary for E-commerce Visual Search System Optimization
arXiv:2510.22739v2 Announce Type: replace-cross Abstract: In Taobao e-commerce visual search, user behavior analysis reveals a large proportion of no-click requests, suggesting diverse and implicit user intents. These intents are expressed in various forms and are difficult to mine and discover, thereby leading to the limited adaptability and lag in platform strategies. This greatly restricts users' ability to express diverse intents and hinders the scalability of the visual search system. This
REVISION:Reflective Intent Mining and Online Reasoning Auxiliary for E-commerce Visual Search System Optimization
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cs.AI, q-bio.NC updates on arXiv.org
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Pailitao-VL: Unified Embedding and Reranker for Real-Time Multi-Modal Industrial Search
arXiv:2602.13704v1 Announce Type: cross Abstract: In this work, we presented Pailitao-VL, a comprehensive multi-modal retrieval system engineered for high-precision, real-time industrial search. We here address three critical challenges in the current SOTA solution: insufficient retrieval granularity, vulnerability to environmental noise, and prohibitive efficiency-performance gap. Our primary contribution lies in two fundamental paradigm shifts. First, we transitioned the embedding paradigm fr