Single-cell whole-genome sequencing reveals a shared pattern of excessive somatic mutations across C9ORF72 ALS, C9ORF72 FTD, and Alzheimer’s disease, dominated by 2-bp deletions. These mutations arise from aberrant topoisomerase 1 (TOP1)-mediated mutagenesis linked to oxidative DNA damage, identifying a unifying mechanism of neuronal genomic instability in neurodegeneration.

arXiv:2604.03976v1 Announce Type: new Abstract: Prior work on trustworthy AI emphasizes model-internal properties such as bias mitigation, adversarial robustness, and interpretability. As AI systems evolve into autonomous agents deployed in open environments and increasingly connected to payments or assets, the operational meaning of trust shifts to end-to-end outcomes: whether an agent completes tasks, follows user intent, and avoids failures that cause material or psychological harm. These risks are fundamentally product-level and cannot be eliminated by technical safeguards alone because agent behavior is inherently stochastic. To address this gap between model-level reliability and user-facing assurance, we propose a complementary framework based on risk management. Drawing inspiration from financial underwriting, we introduce the \textbf{Agentic Risk Standard (ARS)}, a payment settlement standard for AI-mediated transactions. ARS integrates risk assessment, underwriting, and compensation into a single transaction framework that protects users when interacting with agents. Under ARS, users receive predefined and contractually enforceable compensation in cases of execution failure, misalignment, or unintended outcomes. This shifts trust from an implicit expectation about model behavior to an explicit, measurable, and enforceable product guarantee. We also present a simulation study analyzing the social benefits of applying ARS to agentic transactions. ARS's implementation can be found at https://github.com/t54-labs/AgenticRiskStandard.

arXiv:2604.03333v1 Announce Type: cross Abstract: Symbolic music generation has made significant progress, yet achieving fine-grained and flexible control over composer style remains challenging. Existing training-based methods for composer style conditioning depend on large labeled datasets. Besides, these methods typically support only single-composer generation at a time, limiting their applicability to more creative or blended scenarios. In this work, we propose Composer Vector, an inference-time steering method that operates directly in the model's latent space to control composer style without retraining. Through experiments on multiple symbolic music generation models, we show that Composer Vector effectively guides generations toward target composer styles, enabling smooth and interpretable control through a continuous steering coefficient. It also enables seamless fusion of multiple styles within a unified latent space framework. Overall, our work demonstrates that simple latent space steering provides a practical and general mechanism for controllable symbolic music generation, enabling more flexible and interactive creative workflows. Code and Demo are available here: https://github.com/JiangXunyi/Composer-Vector and https://jiangxunyi.github.io/composervector.github.io/

arXiv:2603.26535v2 Announce Type: replace Abstract: We propose Process-Aware Policy Optimization (PAPO), a method that integrates process-level evaluation into Group Relative Policy Optimization (GRPO) through decoupled advantage normalization, to address two limitations of existing reward designs. Outcome reward models (ORM) evaluate only final-answer correctness, treating all correct responses identically regardless of reasoning quality, and gradually lose the advantage signal as groups become uniformly correct. Process reward models (PRM) offer richer supervision, but directly using PRM scores causes reward hacking, where models exploit verbosity to inflate scores while accuracy collapses. PAPO resolves both by composing the advantage from an outcome component Aout, derived from ORM and normalized over all responses, and a process component Aproc, derived from a rubric-based PRM and normalized exclusively among correct responses. This decoupled design ensures that Aout anchors training on correctness while Aproc differentiates reasoning quality without distorting the outcome signal. Experiments across multiple model scales and six benchmarks demonstrate that PAPO consistently outperforms ORM, reaching 51.3% vs.\ 46.3% on OlympiadBench while continuing to improve as ORM plateaus and declines.

arXiv:2604.00979v2 Announce Type: replace-cross Abstract: Current aligned language models exhibit a dual failure mode we term the Evasive Servant: they sycophantically validate flawed user beliefs while deflecting responsibility with boilerplate disclaimers. We propose the Dignified Peer framework, which counters servility with anti-sycophancy and trustworthiness, and mitigates evasiveness through empathy and creativity. Realizing this agent requires overcoming significant challenges in data supervision, objective collapse, and evaluation bias. We address these issues by introducing the PersonaKnob dataset which features a compositional partial order structure of multiple persona preference. This data is utilized alongside a tolerant constrained Lagrangian DPO algorithm that dynamically balances all persona dimensions to prevent behavioral collapse. Additionally, we employ a psychometrically calibrated Item Response Theory evaluation protocol to disentangle latent model persona capability from confounders like judge biases. Extensive empirical studies demonstrate that our approach successfully build a LLM agent with both dignity and peer.

Cell Death Discovery, Published online: 24 March 2026; doi:10.1038/s41420-026-03060-8

p63 in skin homeostasis and disease: molecular mechanisms and therapeutic potentials

arXiv:2502.01534v3 Announce Type: replace-cross Abstract: Large Language Models (LLMs) as judges and LLM-based data synthesis have emerged as two fundamental LLM-driven data annotation methods in model development. While their combination significantly enhances the efficiency of model training and evaluation, little attention has been given to the potential contamination brought by this new model development paradigm. In this work, we expose preference leakage, a contamination problem in LLM-as-a-judge caused by the relatedness between the synthetic data generators and LLM-based evaluators. To study this issue, we first define three common relatednesses between the data generator LLM and the judge LLM: being the same model, having an inheritance relationship, and belonging to the same model family. Through extensive experiments, we empirically confirm the bias of judges towards their related student models caused by preference leakage across multiple LLM baselines and benchmarks. Further analysis suggests that preference leakage is a pervasive and real-world problem that is harder to detect compared to previously identified biases in LLM-as-a-judge scenarios. All of these findings imply that preference leakage is a widespread and challenging problem in the area of LLM-as-a-judge. We release all codes and data at: https://github.com/David-Li0406/Preference-Leakage.

arXiv:2505.12641v3 Announce Type: replace-cross Abstract: Single image reflection separation aims to separate the transmission and reflection layers from a mixed image. Existing methods typically combine general priors from pre-trained models with task-specific priors such as text prompts and reflection detection. However, the transmission prior, as the most direct task-specific prior for the target transmission layer, has not been effectively modeled or fully utilized, limiting performance in complex scenarios. To address this issue, we propose a dual-prior interaction framework based on lightweight transmission prior generation and effective prior fusion. First, we design a Local Linear Correction Network (LLCN) that finetunes pre-trained models based on the physical constraint T=SI+B, where S and B represent pixel-wise and channel-wise scaling and bias transformations. LLCN efficiently generates high-quality transmission priors with minimal parameters. Second, we construct a Dual-Prior Interaction Transformer (DPIT) that employs a dual-stream channel reorganization attention mechanism. By reorganizing features from general and transmission priors for attention computation, DPIT achieves deep fusion of both priors, fully exploiting their complementary information. Experimental results on multiple benchmark datasets demonstrate that the proposed method achieves state-of-the-art performance.

arXiv:2506.12362v2 Announce Type: replace-cross Abstract: Inductive link prediction with knowledge hypergraphs is the task of predicting missing hyperedges involving completely novel entities (i.e., nodes unseen during training). Existing methods for inductive link prediction with knowledge hypergraphs assume a fixed relational vocabulary and, as a result, cannot generalize to knowledge hypergraphs with novel relation types (i.e., relations unseen during training). Inspired by knowledge graph foundation models, we propose HYPER as a foundation model for link prediction, which can generalize to any knowledge hypergraph, including novel entities and novel relations. Importantly, HYPER can learn and transfer across different relation types of varying arities, by encoding the entities of each hyperedge along with their respective positions in the hyperedge. To evaluate HYPER, we construct 16 new inductive datasets from existing knowledge hypergraphs, covering a diverse range of relation types of varying arities. Empirically, HYPER consistently outperforms all existing methods in both node-only and node-and-relation inductive settings, showing strong generalization to unseen, higher-arity relational structures.