Netflix has reworked its Conductor workflow orchestration engine to handle larger workloads, increasing supported workflow size from about 2,500 to 30,000 tasks and reducing p99 workflow evaluation latency by about 40%. Conductor 4.0 separates workflow metadata from task data, moves evaluation to asynchronous processing, and introduces dynamic worker allocation and concurrency controls.

By Leela Kumili

Nature Medicine, Published online: 11 September 2026; doi:10.1038/s41591-026-04642-w

In the randomized phase 2 ImmunoPRISM trial, patients with high-risk smoldering multiple myeloma (MM) showed higher rates of complete clinical responses in response to treatment with teclistamab compared with lenalidomide–dexamethasone, although longer follow-up is required to determine durable prevention of progression to MM.

Cell Death Discovery, Published online: 09 September 2026; doi:10.1038/s41420-026-03332-3

Multi-omic profiling reveals metabolic vulnerabilities in enzalutamide resistant prostate cancer

Science, Ahead of Print.

Transduction efficiency is a critical determinant of CAR T-cell manufacturing quality. Analysis of 204 clinical CAR T-cell products revealed that transduction efficiency is shaped primarily by manufacturing workflows and protocol-dependent starting material composition. Higher transduction efficiency was associated with early memory-like cellular states, providing insights into optimizing CAR T-cell.

He and colleagues developed a transient, non-gene-editing platform for off-the-shelf allogeneic TCR-T therapy. By conferring tacrolimus resistance characteristics to IL-2/4/7 expanded TCR-T cells that display reduced alloreactivity, He et al. provided a proof-of-concept for an allogeneic TCR-T therapy approach that addresses both manufacturability, and unwanted graft and host alloreactivity concerns.

Small extracellular vesicles from differentiating human skeletal muscle cells are enriched in miR-193b-3p, which contributes to myogenic responses through AP2M1 regulation. These findings establish a miR-193b-3p–AP2M1 axis connecting extracellular vesicles to muscle regeneration and highlight its potential role in regulating myogenic processes.

Et1Ψ-modified mRNA shows UUU-dependent translational sensitivity, but targeted UUU-to-UUC recoding restores protein expression. With this sequence constraint addressed, Et1Ψ reduces early innate immune activation while preserving vaccine-induced humoral, cellular, and neutralizing responses, thereby establishing codon–modification compatibility as a practical design principle for mRNA therapeutics.

Oncolytic herpes simplex virus 1 (oHSV) is a promising viro-immunotherapy that directly lyses tumor cells while reshaping the tumor microenvironment (TME) and stimulates anti-tumor immunity. However, despite encouraging preclinical and clinical activity, treatment-induced adaptations in tumor cells and the surrounding microenvironment can promote survival, repair, repopulation, immune escape, and recurrence, thereby limiting durable therapeutic benefit. In our recent article published in Cell Death & Disease,1 we asked why oHSV often fails to achieve durable tumor control and whether the adaptive resistance it induces can be therapeutically overcome.

Yuzaki and colleagues identify biallelic CBLN1 variants as a cause of early-onset hereditary ataxia and show that loss of extracellular CBLN1 disrupts cerebellar synapses. Astrocyte-targeted AAV delivery restores synaptic CBLN1 and rescues circuit and motor dysfunction, establishing extracellular synaptic organizer replacement as a therapeutic strategy.

Lee and colleagues identify MFT251 as a synthetic small-molecule TBK1 agonist that directly activates type I interferon signaling. MFT251 induces broad antiviral defenses and reshapes the tumor microenvironment to enhance antitumor immunity, establishing pharmacologic TBK1 activation as a strategy for innate immune modulation in infection and cancer.

Red blood cell-derived extracellular vesicles (RBCEVs) provide a scalable, non-viral platform for gene therapy. High-grade RBCEVs purified using tangential flow filtration can deliver sizable plasmids and mediate sustained in vivo expression of therapeutic proteins, including factor IX and Herceptin, highlighting their potential use for safe and efficient gene therapy.

Liu and colleagues developed a robust in cellulo plasmid DNA replication system in human cells for replicating plasmid-borne adeno-associated virus (AAV) Rep/Cap genes during recombinant AAV (rAAV) production. This new approach not only enables a 10- to 20-fold plasmid reduction to significantly lower manufacturing costs but also substantially enhances rAAV potency, titer, and purity.

Song and colleagues report an enterovirus-derived capless self-amplifying mRNA vaccine platform that uses internal ribosome entry site-mediated translation to eliminate 5′ capping. When encoding H5 hemagglutinin, CLsamRNA induces robust humoral and cellular immunity and dose-sparing protection against lethal H5N8 challenge in mice, supporting a distinct RNA vaccine architecture.

Lee and colleagues develop anti-TLR2 nanobodies and scFvs and establish a PLGA-nanoparticle-mediated gene therapy platform for sustained antibody expression. A single intrathecal injection of these PLGA nanoparticles reduces spinal inflammatory responses and provides durable analgesia in a mouse model of neuropathic pain.

Subretinal fibrosis causes irreversible vision loss in neovascular age-related macular degeneration (AMD). This study shows that proline metabolism, particularly P4HA1-mediated proline hydroxylation, is activated in JR5558 mice and human AMD tissues. Diethyl pythiDC reduced collagen turnover and fibrovascular lesion expansion, with potential added benefit when combined with aflibercept.

CAR T cells engineered to secrete tumor-localized anti-EpCAM bispecific T cell engagers (BTCEs) overcome antigen escape and heterogeneity across multiple epithelial carcinomas in preclinical models, achieving complete tumor eradication where conventional single-target CAR T cell therapies often failed, supporting broad translational potential for solid tumor immunotherapy.

This article demonstrates the use of adenine base editor nickase activity for precise transgene cargo integration while simultaneously carrying out multiplex gene knockout. This single-step platform achieves efficient knockin and >90% quadplex gene knockout without detectable translocations and low levels of off-target editing, producing highly functional, customizable chimeric antigen receptor T cells.

Nature Nanotechnology, Published online: 03 September 2026; doi:10.1038/s41565-026-02267-1

Impurities in a quantum exciton condensate create bound electronic states, as visualized in Ta2Pd3Te5, that are analogous to spin impurities in superconductors, enabling microscopic control of excitonic quantum matter.

arXiv:2609.09324v1 Announce Type: cross Abstract: Link Adaptation (LA) in 5G NR is inherently reactive, relying on channel measurements and HARQ feedback that may become quickly obsolete when the channel changes quickly. This data is also noisy, making it hard to track accurately, and has to be fed to real-time controllers with feedback-loop effects which are hard to troubleshoot. This explains why most practical deployments select simple but robust algorithms, which accept that the lag can leave the scheduler operating at overly aggressive or unnecessarily conservative rates, trading spectrum efficiency for predictable performance. In this paper, we improve on this status-quo with NOSTRAdAMUS, a predictive LA framework which adds foresight to existing algorithms without replacing or redesigning them. NOSTRAdAMUS predicts whether a retransmission will occur in the next radio frame from recent HARQ history, and applies corrections to the Modulation and Coding Scheme (MCS) selected by the underlying policy. We benchmark several ML models and show that Gradient Boosting achieves 82.9% accuracy overall with high-confidence interventions that are correct 94.2% of the time, and an inference latency of 5.5 {\mu}s. We train the model based on data collected Over-the-Air (OTA) on the X5G testbed, using the open-source OpenAirInterface (OAI) 5G stack, NVIDIA Aerial, and COTS O-RAN Radio Units and User Equipments. The model is then deployed as a dApp, which we evaluate OTA as well as on various channels with hardware-in-the-loop channel emulators. This includes 3GPP TDL and CDL channels, SISO and MIMO configurations, and pedestrian and vehicular mobility. Our evaluation shows that without retraining, and across this variety of scenarios, the dApp augments two SOTA LA algorithms, and increases goodput by up to 71.5% while reducing retransmissions by up to 71.8%. This demonstrates the robustness and generalization capabilities of our approach.