Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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ResoSeg: Resonance Tagger using Transformer and Segment Model
arXiv:2609.12610v1 Announce Type: cross Abstract: Deep learning has been widely applied across many areas of experimental high-energy physics, yet existing models address only event-level classification or object tagging and therefore still require reconstruction algorithms tailored to each decay channel. We present the first application of segmentation to resonance tagging at BESIII and introduce ResoSeg, a deep learning model that jointly performs particle-level segmentation and event-level c
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Omics In Lung
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Immune-endothelial-coagulation crosstalk as a driver of multi-organ dysfunction in severe viral pneumonia
Front Immunol. 2026 Aug 21;17:1878054. doi: 10.3389/fimmu.2026.1878054. eCollection 2026.ABSTRACTViral burden or pathogen identity alone cannot adequately explain the progression of severe viral pneumonia from a compartmentalized respiratory infection to acute respiratory distress syndrome, multi-organ failure, and death. Maladaptive immunity, endothelial damage, and coagulation dysregulation are all functionally integrated in a host-driven pathological mechanism that mediates disease escalation
Immune-endothelial-coagulation crosstalk as a driver of multi-organ dysfunction in severe viral pneumonia
Front Immunol. 2026 Aug 21;17:1878054. doi: 10.3389/fimmu.2026.1878054. eCollection 2026.
ABSTRACT
Viral burden or pathogen identity alone cannot adequately explain the progression of severe viral pneumonia from a compartmentalized respiratory infection to acute respiratory distress syndrome, multi-organ failure, and death. Maladaptive immunity, endothelial damage, and coagulation dysregulation are all functionally integrated in a host-driven pathological mechanism that mediates disease escalation. Systemic microvascular damage and pulmonary inflammation are linked by immune-endothelial-coagulation interaction. This review investigates the ways in which immunothrombosis and microcirculatory dysfunction are propagated by defective antiviral immunity, alveolar-capillary barrier failure, damage-associated molecular pattern and neutrophil extracellular trap release, endothelial glycocalyx degradation, complement-platelet interactions, coagulation cascade activation, and impaired fibrinolysis. Lung-derived inflammatory signals cause endothelial activation and procoagulant reprogramming in distal organs following systemic dissemination, resulting in organ-specific phenotypes such as acute kidney injury, secondary myocardial injury, ARDS in the lung, neurovascular unit dysfunction, and barrier-disruption-associated inflammatory amplification along the liver-gut axis. This framework may provide a rationale for exploring stage-adapted and phenotype-guided approaches to severe viral pneumonia, including early antiviral therapy, immunomodulation during disease progression, endothelial-coagulation axis targeting, and host-directed strategies. Further longitudinal cohorts, multi-omics analyses, mechanism-based stratification studies, and mechanism-embedded clinical trials will be needed to determine whether immune-endothelial-coagulation coupling can be translated from a mechanistic model into a clinically actionable framework for precision intervention.
PMID:42698821 | PMC:PMC13542883 | DOI:10.3389/fimmu.2026.1878054
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Journal of Medical Internet Research
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Integrating a Large Language Model to Streamline Nursing Handover Documentation Across Multiple Hospitals in Taiwan: Development and Implementation Study
Background: The global nursing shortage, exacerbated by heavy workloads and high turnover rates associated with the COVID-19 pandemic, continues to undermine care quality and nurse well-being. Although digital health technologies have enhanced coordination, improved communication, and reduced clinical errors in nursing practice, they have also increased nursesβ documentation burden. Advances in large language models (LLMs) and other generative artificial intelligence (GenAI) tools facilitate the
Integrating a Large Language Model to Streamline Nursing Handover Documentation Across Multiple Hospitals in Taiwan: Development and Implementation Study
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cs.AI, q-bio.NC updates on arXiv.org
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Nano-EmoX: Unifying Multimodal Emotional Intelligence from Perception to Empathy
arXiv:2603.02123v2 Announce Type: replace Abstract: The development of affective multimodal language models (MLMs) has long been constrained by a gap between low-level perception and high-level interaction, leading to fragmented affective capabilities and limited generalization. To bridge this gap, we propose a cognitively inspired three-level hierarchy that organizes affective tasks according to their cognitive depth-perception, understanding, and interaction-and provides a unified conceptual