Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Reinforcement Learning over Patient Trajectories for Clinical Reasoning in EHR Foundation Models
arXiv:2609.12277v1 Announce Type: cross Abstract: Electronic health record (EHR) foundation models trained on longitudinal patient trajectories have demonstrated strong performance across diverse clinical prediction tasks. However, their clinical reasoning capabilities remain constrained by next-token prediction on limited and incomplete EHR data. To address this, we propose a reinforcement learning (RL) fine-tuning framework that treats EHR foundation models as generative policies over patient
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cs.AI, q-bio.NC updates on arXiv.org
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OpenFinGym: A Verifiable Multi-Task Gym Environment for Evaluating Quant Agents
arXiv:2606.26350v2 Announce Type: replace Abstract: Although large language model agents are increasingly applied to quantitative-finance workflows, their evaluation remains fragmented across isolated tasks, while the financial relevance of benchmark tasks is often overlooked. Yet financial workflows are inherently multi-stage, spanning interdependent tasks such as forecasting, strategy construction, risk management, and trading. Existing platforms typically focus on a single task, and can ther
OpenFinGym: A Verifiable Multi-Task Gym Environment for Evaluating Quant Agents
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cs.AI, q-bio.NC updates on arXiv.org
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AsyncFlow: An Asynchronous Streaming RL Framework for Efficient LLM Post-Training
arXiv:2507.01663v2 Announce Type: replace-cross Abstract: Reinforcement learning (RL) has become a pivotal technology in the post-training phase of large language models (LLMs). Traditional task-collocated RL frameworks suffer from significant scalability bottlenecks, while task-separated RL frameworks face challenges in managing complex dataflows and resolving resource idling. Furthermore, most existing frameworks are tightly coupled with LLM training or inference engines, making them difficul
AsyncFlow: An Asynchronous Streaming RL Framework for Efficient LLM Post-Training
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cs.AI, q-bio.NC updates on arXiv.org
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FEAT: A Linear-Complexity Foundation Model for Extremely Large Structured Data
arXiv:2603.16513v4 Announce Type: replace-cross Abstract: Structured data is widely used in domains such as healthcare, finance, and scientific data management. Recent studies on structured data foundation models (SFMs) aim to support data analysis and mining tasks over such data, but still face scalability and generalization challenges when applied to real-world enterprise databases. First, many SFMs rely on full self-attention, which introduces an O(N^2) computational bottleneck and limits th
FEAT: A Linear-Complexity Foundation Model for Extremely Large Structured Data
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Cell Death Discovery nature.com science feeds
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Fibronectin 1 mediated histone lactylation promotes malignant progression of GIST regulated by m<sup>6</sup>A modification
Cell Death Discovery, Published online: 11 September 2026; doi:10.1038/s41420-026-03338-xFibronectin 1 mediated histone lactylation promotes malignant progression of GIST regulated by m6A modification
Fibronectin 1 mediated histone lactylation promotes malignant progression of GIST regulated by m<sup>6</sup>A modification
Cell Death Discovery, Published online: 11 September 2026; doi:10.1038/s41420-026-03338-x
Fibronectin 1 mediated histone lactylation promotes malignant progression of GIST regulated by m6A modification-
Pulmonary nodule
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Macrophage spatiotemporal plasticity in pulmonary diseases: decoding the niche at single-cell resolution
Front Immunol. 2026 Jun 18;17:1855906. doi: 10.3389/fimmu.2026.1855906. eCollection 2026.ABSTRACTPulmonary gas exchange and host defense depend on the dynamic coordination of resident and recruited macrophage populations. Historically, macrophage functions have often been interpreted through the classic M1/M2 dichotomy; however, this binary framework does not capture the heterogeneity and context-dependent plasticity of macrophage states within the lung microenvironment. Advances in single-cell
Macrophage spatiotemporal plasticity in pulmonary diseases: decoding the niche at single-cell resolution
Front Immunol. 2026 Jun 18;17:1855906. doi: 10.3389/fimmu.2026.1855906. eCollection 2026.
ABSTRACT
Pulmonary gas exchange and host defense depend on the dynamic coordination of resident and recruited macrophage populations. Historically, macrophage functions have often been interpreted through the classic M1/M2 dichotomy; however, this binary framework does not capture the heterogeneity and context-dependent plasticity of macrophage states within the lung microenvironment. Advances in single-cell RNA sequencing and spatial multi-omics have substantially refined our understanding of this complex macrophage network. Here, we synthesize evidence from human studies and experimental models to summarize macrophage functional states in homeostasis and across chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, pulmonary hypertension, acute lung injury/acute respiratory distress syndrome, and lung cancer. We highlight how macrophage transcriptional programs are shaped by ontogeny, tissue niche, and epigenetic-metabolic regulation, and how these programs are linked to disease-specific remodeling of the pulmonary microenvironment. Across diverse respiratory diseases, persistent tissue injury and microenvironmental stress remodel resident macrophage programs and are frequently accompanied by the expansion and context-dependent differentiation of recruited monocyte-derived macrophages. These macrophage states are associated with inflammatory amplification, epithelial and endothelial barrier dysfunction, extracellular matrix remodeling, and tumor immune evasion. Ligand-receptor and spatial analyses further identify candidate communication axes linking macrophages with stromal, epithelial, endothelial, and immune cells, some of which appear partially conserved across disease contexts. Emerging macrophage-targeted strategies are increasingly being explored beyond broad depletion, with growing interest in context-specific reprogramming and niche modulation, including antibody-based, nanocarrier-mediated, and engineered-cell approaches. Decoding the spatiotemporal trajectories and cell-cell communication networks of specific macrophage subsets, while considering tissue context, species differences, and levels of experimental support, may help clarify mechanisms of tissue remodeling, therapeutic resistance, and macrophage-targeted intervention in complex pulmonary diseases.
PMID:42396453 | PMC:PMC13322945 | DOI:10.3389/fimmu.2026.1855906
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cs.AI, q-bio.NC updates on arXiv.org
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Test-Time Self-Adaptive Conditioning for Stable Audio-Driven Talking-Head Generation
arXiv:2605.25488v1 Announce Type: cross Abstract: Audio-driven talking-head generation has achieved remarkable progress with recent models such as AniTalker, FLOAT, and Sonic. Despite their success, most existing approaches rely on a single static reference image to condition the entire video generation process at inference stage. This static conditioning paradigm often creates a mismatch between fixed identity features and dynamically evolving facial motion, leading to identity drift, temporal
Test-Time Self-Adaptive Conditioning for Stable Audio-Driven Talking-Head Generation
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cs.AI, q-bio.NC updates on arXiv.org
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SAMark: A Self-Anchored Text Watermarking with Paragraph-Level Paraphrase Robustness
arXiv:2605.25796v1 Announce Type: cross Abstract: Semantic-level watermarking (SWM) improves robustness against text modifications by treating sentences as the basic unit. However, robustness to paragraph-level paraphrasing remains difficult because such attacks globally disrupt watermark signals by changing sentence order. In this work, we propose SAMark, a self-anchored watermarking framework that removes the dependency on sentence order by establishing a step-independent green region in sema
SAMark: A Self-Anchored Text Watermarking with Paragraph-Level Paraphrase Robustness
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cs.AI, q-bio.NC updates on arXiv.org
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Dynamic Dual-Granularity Skill Bank for Agentic RL
arXiv:2603.28716v2 Announce Type: replace Abstract: Agentic RL can benefit substantially from reusable experience, yet existing skill-based methods mainly extract trajectory-level guidance and often lack principled mechanisms for maintaining an evolving skill memory. We propose D2Skill, a dynamic dual-granularity skill bank for agentic RL that organizes reusable experience into task skills for high-level guidance and step skills for fine-grained decision support and error correction. D2Skill jo
Dynamic Dual-Granularity Skill Bank for Agentic RL
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cs.AI, q-bio.NC updates on arXiv.org
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AutoResearchClaw: Self-Reinforcing Autonomous Research with Human-AI Collaboration
arXiv:2605.20025v2 Announce Type: replace Abstract: Automating scientific discovery requires more than generating papers from ideas. Real research is iterative: hypotheses are challenged from multiple perspectives, experiments fail and inform the next attempt, and lessons accumulate across cycles. Existing autonomous research systems often model this process as a linear pipeline: they rely on single-agent reasoning, stop when execution fails, and do not carry experience across runs. We present
AutoResearchClaw: Self-Reinforcing Autonomous Research with Human-AI Collaboration
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cs.AI, q-bio.NC updates on arXiv.org
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Kolmogorov-Arnold Fourier Networks
arXiv:2502.06018v3 Announce Type: replace-cross Abstract: Although Kolmogorov-Arnold-based interpretable networks (KANs) possess strong theoretical expressiveness, they suffer from severe parameter explosion and limited ability to capture high-frequency features in high-dimensional tasks. To address these issues, we propose the Kolmogorov-Arnold Fourier Network (KAF), which fundamentally redefines the KAN paradigm through spectral reparameterization. Our key contributions include: (1) proposing
Kolmogorov-Arnold Fourier Networks
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Journal of Medical Internet Research
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Social Media Intervention Based on the Information-Motivation-Behavioral Skills Model Promotes HIV Testing and Reduces High-Risk Behaviors Among Men Who Have Sex With Men in Resource-Limited Settings in China: Randomized Controlled Trial
Background: Social media intervention may enhance HIV prevention among men who have sex with men, but the effect of this intervention in resource-limited settings remains unclear. Objective: This randomized controlled trial evaluated whether a social media intervention grounded in the information-motivation-behavioral skills (IMB) model could be beneficial for HIV prevention among men who have sex with men in resource-limited settings. Methods: Participants were recruited in Nanning, China, betw
Social Media Intervention Based on the Information-Motivation-Behavioral Skills Model Promotes HIV Testing and Reduces High-Risk Behaviors Among Men Who Have Sex With Men in Resource-Limited Settings in China: Randomized Controlled Trial
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cs.AI, q-bio.NC updates on arXiv.org
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Combee: Scaling Prompt Learning for Self-Improving Language Model Agents
arXiv:2604.04247v1 Announce Type: new Abstract: Recent advances in prompt learning allow large language model agents to acquire task-relevant knowledge from inference-time context without parameter changes. For example, existing methods (like ACE or GEPA) can learn system prompts to improve accuracy based on previous agent runs. However, these methods primarily focus on single-agent or low-parallelism settings. This fundamentally limits their ability to efficiently learn from a large set of col
Combee: Scaling Prompt Learning for Self-Improving Language Model Agents
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cs.AI, q-bio.NC updates on arXiv.org
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TreeGaussian: Tree-Guided Cascaded Contrastive Learning for Hierarchical Consistent 3D Gaussian Scene Segmentation and Understanding
arXiv:2604.03309v1 Announce Type: cross Abstract: 3D Gaussian Splatting (3DGS) has emerged as a real-time, differentiable representation for neural scene understanding. However, existing 3DGS-based methods struggle to represent hierarchical 3D semantic structures and capture whole-part relationships in complex scenes. Moreover, dense pairwise comparisons and inconsistent hierarchical labels from 2D priors hinder feature learning, resulting in suboptimal segmentation. To address these limitation
TreeGaussian: Tree-Guided Cascaded Contrastive Learning for Hierarchical Consistent 3D Gaussian Scene Segmentation and Understanding
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cs.AI, q-bio.NC updates on arXiv.org
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Learning Additively Compositional Latent Actions for Embodied AI
arXiv:2604.03340v1 Announce Type: cross Abstract: Latent action learning infers pseudo-action labels from visual transitions, providing an approach to leverage internet-scale video for embodied AI. However, most methods learn latent actions without structural priors that encode the additive, compositional structure of physical motion. As a result, latents often entangle irrelevant scene details or information about future observations with true state changes and miscalibrate motion magnitude. W
Learning Additively Compositional Latent Actions for Embodied AI
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cs.AI, q-bio.NC updates on arXiv.org
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Persistent Cross-Attempt State Optimization for Repository-Level Code Generation
arXiv:2604.03632v1 Announce Type: cross Abstract: Large language models (LLMs) have achieved substantial progress in repository-level code generation. However, solving the same repository-level task often requires multiple attempts, while existing methods still optimize each attempt in isolation and do not preserve or reuse task-specific state across attempts. In this paper, we propose LiveCoder, a novel framework for repository-level code generation based on cross-attempt knowledge optimizatio
Persistent Cross-Attempt State Optimization for Repository-Level Code Generation
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cs.AI, q-bio.NC updates on arXiv.org
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Agentization of Digital Assets for the Agentic Web: Concepts, Techniques, and Benchmark
arXiv:2604.04226v1 Announce Type: cross Abstract: Agentic Web, as a new paradigm that redefines the internet through autonomous, goal-driven interactions, plays an important role in group intelligence. As the foundational semantic primitives of the Agentic Web, digital assets encapsulate interactive web elements into agents, which expand the capacities and coverage of agents in agentic web. The lack of automated methodologies for agent generation limits the wider usage of digital assets and the
Agentization of Digital Assets for the Agentic Web: Concepts, Techniques, and Benchmark
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cs.AI, q-bio.NC updates on arXiv.org
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KLong: Training LLM Agent for Extremely Long-horizon Tasks
arXiv:2602.17547v2 Announce Type: replace Abstract: This paper introduces KLong, an open-source LLM agent trained to solve extremely long-horizon tasks. The principle is to first cold-start the model via trajectory-splitting SFT, then scale it via progressive RL training. Specifically, we first activate basic agentic abilities of a base model with a comprehensive SFT recipe. Then, we introduce Research-Factory, an automated pipeline that generates high-quality training data by collecting resear
KLong: Training LLM Agent for Extremely Long-horizon Tasks
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cs.AI, q-bio.NC updates on arXiv.org
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ToG-Bench: Task-Oriented Spatio-Temporal Grounding in Egocentric Videos
arXiv:2512.03666v2 Announce Type: replace-cross Abstract: A core capability towards general embodied intelligence lies in localizing task-relevant objects from an egocentric perspective, formulated as Spatio-Temporal Video Grounding (STVG). Despite recent progress, existing STVG studies remain largely confined to object-centric and descriptive instructions, neglecting the task-oriented reasoning that is crucial for embodied agents to accomplish goal-directed interactions. To bridge this gap, we
ToG-Bench: Task-Oriented Spatio-Temporal Grounding in Egocentric Videos
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cs.AI, q-bio.NC updates on arXiv.org
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CogBias: Measuring and Mitigating Cognitive Bias in Large Language Models
arXiv:2604.01366v1 Announce Type: new Abstract: Large Language Models (LLMs) are increasingly deployed in high-stakes decision-making contexts. While prior work has shown that LLMs exhibit cognitive biases behaviorally, whether these biases correspond to identifiable internal representations and can be mitigated through targeted intervention remains an open question. We define LLM cognitive bias as systematic, reproducible deviations from correct answers in tasks with computable ground-truth ba