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cs.AI, q-bio.NC updates on arXiv.org
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Characterizing Text Branch Sensitivity in Medical Vision-Language Segmentation via Evidence Decoupling
arXiv:2609.02663v1 Announce Type: cross Abstract: Pretrained vision-language models (VLMs) have shown promising performance in medical image segmentation by incorporating clinical text. However, it remains unclear how much textual information actually contributes to pixel-level predictions. In this work, we systematically investigate the role of text in multimodal medical image segmentation. We first analyze several commonly used fusion strategies and find that segmentation performance is large
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cs.AI, q-bio.NC updates on arXiv.org
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EditCaption: Human-Refined SFT and HAE-DPO for Image Editing Instruction Synthesis
arXiv:2604.08213v2 Announce Type: replace-cross Abstract: High-quality source-target image pairs with precise editing instructions are essential for instruction-guided image editing, yet constructing such training triplets at scale remains costly. Recent pipelines often rely on vision-language models to synthesize editing instructions automatically, but we find that strong VLMs still struggle to describe visual transformations between image pairs. In particular, they exhibit three recurring fai
EditCaption: Human-Refined SFT and HAE-DPO for Image Editing Instruction Synthesis
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Omics in Gastric
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Refined immune-based molecular subtypes of gastric cancer: Integrating mismatch repair status and tumor microenvironment for enhanced immunotherapy prediction
Chin J Cancer Res. 2026 Apr 30;38(2):234-251. doi: 10.21147/j.issn.1000-9604.2026.02.09.ABSTRACTOBJECTIVE: Gastric cancer (GC) is heterogeneous, and current mismatch repair (MMR)-based classifications incompletely predict response to immune checkpoint inhibitors (ICIs).METHODS: RNA sequencing (RNA-seq) and immune infiltration profiles from 189 resected GC were used to derive four refined immune-MMR subtypes (R1-R4) by integrating MMR status, survival, and tumor microenvironment (TME) features. M
Refined immune-based molecular subtypes of gastric cancer: Integrating mismatch repair status and tumor microenvironment for enhanced immunotherapy prediction
Chin J Cancer Res. 2026 Apr 30;38(2):234-251. doi: 10.21147/j.issn.1000-9604.2026.02.09.
ABSTRACT
OBJECTIVE: Gastric cancer (GC) is heterogeneous, and current mismatch repair (MMR)-based classifications incompletely predict response to immune checkpoint inhibitors (ICIs).
METHODS: RNA sequencing (RNA-seq) and immune infiltration profiles from 189 resected GC were used to derive four refined immune-MMR subtypes (R1-R4) by integrating MMR status, survival, and tumor microenvironment (TME) features. Multi-omics profiling and pathway analysis defined subtype biology. External transcriptomic cohorts and an ICI-treated cohort were classified with Nearest Template Prediction (NTP). Immune response-associated genes were identified from responder vs. non-responder comparisons within the ICI-sensitive subtype and validated by multiplex immunohistochemistry (mIHC).
RESULTS: R1 showed the best prognosis and highest immunotherapy response with objective response rate (ORR) 54.5%, while R4 had the worst prognosis. R2 represented an immune-unresponsive deficient mismatch repair (dMMR) subset, and R3 captured an immune-active proficient mismatch repair (pMMR) subgroup with moderate therapy sensitivity. Multi-omics integration revealed subtype-specific pathways (e.g., ECM remodeling in R1, metabolic reprogramming in R2). Reclassification of pMMR tumors based on transcriptional similarity to R1 identified a New R3 subset with enhanced immune features and higher ICI response. Eight immune response-associated genes (e.g., CXCL10, CXCL11, ELN, GAD1, IL32, MT1E, OR2I1P, SLC3A1) were identified and validated by mIHC for predictive relevance.
CONCLUSIONS: This immune-based molecular framework refines risk stratification beyond conventional MMR categories, identifies ICI-sensitive subsets among both dMMR and pMMR tumors, and proposes candidate biomarkers for patient selection.
PMID:42147371 | PMC:PMC13171420 | DOI:10.21147/j.issn.1000-9604.2026.02.09
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cs.AI, q-bio.NC updates on arXiv.org
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Xpertbench: Expert Level Tasks with Rubrics-Based Evaluation
arXiv:2604.02368v3 Announce Type: replace Abstract: As Large Language Models (LLMs) exhibit plateauing performance on conventional benchmarks, a pivotal challenge persists: evaluating their proficiency in complex, open-ended tasks characterizing genuine expert-level cognition. Existing frameworks suffer from narrow domain coverage, reliance on generalist tasks, or self-evaluation biases. To bridge this gap, we present XpertBench, a high-fidelity benchmark engineered to assess LLMs across authen
Xpertbench: Expert Level Tasks with Rubrics-Based Evaluation
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cs.AI, q-bio.NC updates on arXiv.org
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ClawSafety: "Safe" LLMs, Unsafe Agents
arXiv:2604.01438v1 Announce Type: new Abstract: Personal AI agents like OpenClaw run with elevated privileges on users' local machines, where a single successful prompt injection can leak credentials, redirect financial transactions, or destroy files. This threat goes well beyond conventional text-level jailbreaks, yet existing safety evaluations fall short: most test models in isolated chat settings, rely on synthetic environments, and do not account for how the agent framework itself shapes s
ClawSafety: "Safe" LLMs, Unsafe Agents
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cs.AI, q-bio.NC updates on arXiv.org
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Interpretable Classification via a Rule Network with Selective Logical Operators
arXiv:2408.11918v2 Announce Type: replace-cross Abstract: We introduce the Rule Network with Selective Logical Operators (RNS), a novel neural architecture that employs \textbf{selective logical operators} to adaptively choose between AND and OR operations at each neuron during training. Unlike existing approaches that rely on fixed architectural designs with predetermined logical operations, our selective logical operators treat weight parameters as hard selectors, enabling the network to auto
Interpretable Classification via a Rule Network with Selective Logical Operators
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cs.AI, q-bio.NC updates on arXiv.org
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CLAUSE: Agentic Neuro-Symbolic Knowledge Graph Reasoning via Dynamic Learnable Context Engineering
arXiv:2509.21035v2 Announce Type: replace Abstract: Knowledge graphs provide structured context for multi-hop question answering, but deployed systems must balance answer accuracy with strict latency and cost targets while preserving provenance. Static k-hop expansions and "think-longer" prompting often over-retrieve, inflate context, and yield unpredictable runtime. We introduce CLAUSE, an agentic three-agent neuro-symbolic framework that treats context construction as a sequential decision pr
CLAUSE: Agentic Neuro-Symbolic Knowledge Graph Reasoning via Dynamic Learnable Context Engineering
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cs.AI, q-bio.NC updates on arXiv.org
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JFTA-Bench: Evaluate LLM's Ability of Tracking and Analyzing Malfunctions Using Fault Trees
arXiv:2603.22978v1 Announce Type: new Abstract: In the maintenance of complex systems, fault trees are used to locate problems and provide targeted solutions. To enable fault trees stored as images to be directly processed by large language models, which can assist in tracking and analyzing malfunctions, we propose a novel textual representation of fault trees. Building on it, we construct a benchmark for multi-turn dialogue systems that emphasizes robust interaction in complex environments, ev
JFTA-Bench: Evaluate LLM's Ability of Tracking and Analyzing Malfunctions Using Fault Trees
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Journal of Medical Internet Research
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Investigating the Effect of Hospital Infection Control Informatization on Optimizing Microbiological Specimen Submission Before Antibiotic Therapy: Failure Mode and Effects Analysis
Background: Antimicrobial resistance (AMR) poses a critical global health threat, with inappropriate antibiotic use being a major driver. Timely microbiological specimen submission before initiating antibiotic therapy is a cornerstone of antimicrobial stewardship (AMS), enabling pathogen-directed therapy and reducing unnecessary broad-spectrum exposure. However, suboptimal compliance remains common due to workflow interruptions, technological barriers, and behavioral factors. Failure Mode and Ef