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cs.AI, q-bio.NC updates on arXiv.org
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Diff-Instruct with Diffused Reward: Towards Principled One-step Generator RL
arXiv:2605.24001v2 Announce Type: cross Abstract: Recent advances in one-step text-to-image generation have enabled real-time synthesis with remarkable efficiency and quality. Previous reinforcement learning methods for one-step generators combine image-space reward optimization with diffusion noisy-space distribution matching. This paradigm brings challenges due to a mismatch between terminal reward optimization and the underlying generative dynamics. As a result, optimization tends to exploit
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cs.AI, q-bio.NC updates on arXiv.org
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OASES: Outcome-Aligned Search-Evaluation Co-Training for Agentic Search
arXiv:2604.03675v3 Announce Type: replace Abstract: Agentic search enables language models to solve knowledge-intensive tasks by adaptively acquiring external evidence over multiple steps. Reinforcement learning with verifiable rewards (RLVR) has emerged as a widely adopted training paradigm for search agents, yet outcome-only rewards are sparse and provide limited credit assignment for intermediate search actions. Existing process-reward methods therefore seek to densify supervision through pr
OASES: Outcome-Aligned Search-Evaluation Co-Training for Agentic Search
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cs.AI, q-bio.NC updates on arXiv.org
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UniToolCall: Unifying Tool-Use Representation, Data, and Evaluation for LLM Agents
arXiv:2604.11557v2 Announce Type: replace Abstract: Tool-use capability is a fundamental component of LLM agents, enabling them to interact with external systems through structured function calls. However, existing research exhibits inconsistent interaction representations, largely overlooks the structural distribution of tool-use trajectories, and relies on incompatible evaluation benchmarks. We present UniToolCall, a unified framework for tool learning that standardizes the entire pipeline fr
UniToolCall: Unifying Tool-Use Representation, Data, and Evaluation for LLM Agents
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Pulmonary nodule
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Dynamic microbiome-host interactions and their associations with systemic metabolism and radiological characteristics during early lung adenocarcinoma
NPJ Precis Oncol. 2026 May 12;10(1):284. doi: 10.1038/s41698-026-01471-5.ABSTRACTLung adenocarcinoma (LUAD) accounts for approximately 40% of non-small cell lung cancer. Although the microbiome may play a role in LUAD, a comprehensive understanding of its ecological landscape and interactions with the tumor host, particularly during early development of LUAD, remains lacking. Here we employed a multi-omic approach to assess the dynamics of the tumor microbiota-host interaction across stages of e
Dynamic microbiome-host interactions and their associations with systemic metabolism and radiological characteristics during early lung adenocarcinoma
NPJ Precis Oncol. 2026 May 12;10(1):284. doi: 10.1038/s41698-026-01471-5.
ABSTRACT
Lung adenocarcinoma (LUAD) accounts for approximately 40% of non-small cell lung cancer. Although the microbiome may play a role in LUAD, a comprehensive understanding of its ecological landscape and interactions with the tumor host, particularly during early development of LUAD, remains lacking. Here we employed a multi-omic approach to assess the dynamics of the tumor microbiota-host interaction across stages of early LUAD, including benign nodules, adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IAC). We found a strong and intricate interaction between the microbiome and host immune and metabolic pathways in AIS, while microbiome-host interactions substantially diminish in MIA and IAC. Serum metabolites and CT-based radiological features, such as atropaldehyde, sterculic acid, nodule morphology and maximum nodule diameter, were closely associated with the microbiome-host interaction network, suggesting they could be non-invasive markers indicating tumor ecological and pathological changes. Multi-omic integration revealed an optimal performance in classifying individual LUAD stages, particularly between AIS and MIA that was otherwise challenging to differentiate using a single data type. Our results highlight the dynamic interaction between microbiome and host during early LUAD, which can be partially reflected in systemic metabolic and radiological manifestations, providing a novel framework for understanding early-stage LUAD.
PMID:42120518 | PMC:PMC13388699 | DOI:10.1038/s41698-026-01471-5
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Cell
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Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models
A mitochondrial transplantation approach rescues mitochondrial deficiency and prevents mitochondrial DNA depletion syndrome, Leigh syndrome, and Parkinson’s disease in cellular and mouse models.
Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models
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cs.AI, q-bio.NC updates on arXiv.org
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PRAISE: Prefix-Based Rollout Reuse in Agentic Search Training
arXiv:2604.03675v1 Announce Type: new Abstract: In agentic search, large language models (LLMs) are trained to perform multi-turn retrieval and reasoning for complex tasks such as multi-hop question answering (QA). However, current search-based Reinforcement Learning (RL) methods suffer from two core limitations: expensive long-horizon rollouts are under-utilized during training, and supervision is typically available only at the final answer, resulting in severe reward sparsity. We present Pre
PRAISE: Prefix-Based Rollout Reuse in Agentic Search Training
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cs.AI, q-bio.NC updates on arXiv.org
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Robust Embodied Perception in Dynamic Environments via Disentangled Weight Fusion
arXiv:2604.01669v1 Announce Type: cross Abstract: Embodied perception systems face severe challenges of dynamic environment distribution drift when they continuously interact in open physical spaces. However, the existing domain incremental awareness methods often rely on the domain id obtained in advance during the testing phase, which limits their practicability in unknown interaction scenarios. At the same time, the model often overfits to the context-specific perceptual noise, which leads t
Robust Embodied Perception in Dynamic Environments via Disentangled Weight Fusion
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cs.AI, q-bio.NC updates on arXiv.org
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ActionParty: Multi-Subject Action Binding in Generative Video Games
arXiv:2604.02330v1 Announce Type: cross Abstract: Recent advances in video diffusion have enabled the development of "world models" capable of simulating interactive environments. However, these models are largely restricted to single-agent settings, failing to control multiple agents simultaneously in a scene. In this work, we tackle a fundamental issue of action binding in existing video diffusion models, which struggle to associate specific actions with their corresponding subjects. For this
ActionParty: Multi-Subject Action Binding in Generative Video Games
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cs.AI, q-bio.NC updates on arXiv.org
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QuestA: Expanding Reasoning Capacity in LLMs via Question Augmentation
arXiv:2507.13266v4 Announce Type: replace-cross Abstract: Reinforcement learning (RL) has emerged as a central paradigm for training large language models (LLMs) in reasoning tasks. Yet recent studies question RL's ability to incentivize reasoning capacity beyond the base model. This raises a key challenge: how can RL be adapted to solve harder reasoning problems more effectively? To address this challenge, we propose a simple yet effective strategy via Question Augmentation: introduce partial
QuestA: Expanding Reasoning Capacity in LLMs via Question Augmentation
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Nature - Issue - nature.com science feeds
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Precipitation observing network gaps limit climate change impact assessment
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10300-5At present, only 13.4% of the global land surface meets the World Meteorological Organization requirements for annual precipitation monitoring.
Precipitation observing network gaps limit climate change impact assessment
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10300-5
At present, only 13.4% of the global land surface meets the World Meteorological Organization requirements for annual precipitation monitoring.-
cs.AI, q-bio.NC updates on arXiv.org
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Motion Dreamer: Boundary Conditional Motion Reasoning for Physically Coherent Video Generation
arXiv:2412.00547v4 Announce Type: replace-cross Abstract: Recent advances in video generation have shown promise for generating future scenarios, critical for planning and control in autonomous driving and embodied intelligence. However, real-world applications demand more than visually plausible predictions; they require reasoning about object motions based on explicitly defined boundary conditions, such as initial scene image and partial object motion. We term this capability Boundary Conditi
Motion Dreamer: Boundary Conditional Motion Reasoning for Physically Coherent Video Generation
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cs.AI, q-bio.NC updates on arXiv.org
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Towards AI Search Paradigm
arXiv:2506.17188v2 Announce Type: replace-cross Abstract: In this paper, we introduce the AI Search Paradigm, a comprehensive blueprint for next-generation search systems capable of emulating human information processing and decision-making. The paradigm employs a modular architecture of four LLM-powered agents (Master, Planner, Executor and Writer) that dynamically adapt to the full spectrum of information needs, from simple factual queries to complex multi-stage reasoning tasks. These agents
Towards AI Search Paradigm
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cs.AI, q-bio.NC updates on arXiv.org
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MAGE: Meta-Reinforcement Learning for Language Agents toward Strategic Exploration and Exploitation
arXiv:2603.03680v1 Announce Type: new Abstract: Large Language Model (LLM) agents have demonstrated remarkable proficiency in learned tasks, yet they often struggle to adapt to non-stationary environments with feedback. While In-Context Learning and external memory offer some flexibility, they fail to internalize the adaptive ability required for long-term improvement. Meta-Reinforcement Learning (meta-RL) provides an alternative by embedding the learning process directly within the model. Howe
MAGE: Meta-Reinforcement Learning for Language Agents toward Strategic Exploration and Exploitation
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cs.AI, q-bio.NC updates on arXiv.org
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Emotion-LLaMAv2 and MMEVerse: A New Framework and Benchmark for Multimodal Emotion Understanding
arXiv:2601.16449v2 Announce Type: replace-cross Abstract: Understanding human emotions from multimodal signals poses a significant challenge in affective computing and human-robot interaction. While multimodal large language models (MLLMs) have excelled in general vision-language tasks, their capabilities in emotional reasoning remain limited. The field currently suffers from a scarcity of large-scale datasets with high-quality, descriptive emotion annotations and lacks standardized benchmarks
Emotion-LLaMAv2 and MMEVerse: A New Framework and Benchmark for Multimodal Emotion Understanding
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cs.AI, q-bio.NC updates on arXiv.org
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An Agentic System for Rare Disease Diagnosis with Traceable Reasoning
arXiv:2506.20430v3 Announce Type: replace-cross Abstract: Rare diseases affect over 300 million individuals worldwide, yet timely and accurate diagnosis remains an urgent challenge. Patients often endure a prolonged diagnostic odyssey exceeding five years, marked by repeated referrals, misdiagnoses, and unnecessary interventions, leading to delayed treatment and substantial emotional and economic burdens. Here we present DeepRare, a multi-agent system for rare disease differential diagnosis dec