Normal view
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Journal of Medical Internet Research
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Design Guidelines for Online Health Forums: User-Centered Design Approach
Background: Online health forums are used widely, yet evidence of their effectiveness is inconsistent. Evidence-based forum design guidance grounded in theory and lived experience could improve the efficacy and outcomes of these forums for the many people using them worldwide. Objective: This study aimed to draw on the experience of online forum users and staff, and insights from existing research on technology design and self-determination theory, to generate a set of theoretically grounded gui
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InfoQ

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Java News Roundup: New OpenJDK JEPs, CDI 5.0, Spring, Open Liberty, RefactorFirst, ADK for Kotlin
This week's Java roundup for September 7th, 2026, features news highlighting: new JEPs for ahead-of-time compilation and structured concurrency; GA releases of Jakarta CDI 5.0 and ADK for Kotlin 1.0; the September 2026 edition of Open Liberty; point releases of TornadoVM and RefactorFirst; a maintenance release of Micronaut; and first releases candidates of Groovy 6.0 and Gradle 9.8. By Michael Redlich
Java News Roundup: New OpenJDK JEPs, CDI 5.0, Spring, Open Liberty, RefactorFirst, ADK for Kotlin
This week's Java roundup for September 7th, 2026, features news highlighting: new JEPs for ahead-of-time compilation and structured concurrency; GA releases of Jakarta CDI 5.0 and ADK for Kotlin 1.0; the September 2026 edition of Open Liberty; point releases of TornadoVM and RefactorFirst; a maintenance release of Micronaut; and first releases candidates of Groovy 6.0 and Gradle 9.8.
By Michael Redlich-
Journal of Medical Internet Research
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Evaluation of the Square Eyes Model as a Screening Tool for Identifying Digital Technologies in Wearable Camera Images Among Children: Laboratory Study
Background: Accurate measurements of children’s digital technology use are essential for understanding its potential implications on health and well-being. Wearable cameras can provide such measurements, but image coding is a high burden for researchers. Machine learning–based object-recognition models have the potential to reduce this burden by identifying images containing technology. Objective: This study aims to evaluate the performance of an object recognition model, the Square Eyes model,
Evaluation of the Square Eyes Model as a Screening Tool for Identifying Digital Technologies in Wearable Camera Images Among Children: Laboratory Study
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TechCrunch
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Volkswagen’s crazy-efficient EV borrows an idea from Slate
Volkswagen's new efficiency-minded halo car is almost twice as efficient as the most efficient production car, the Lucid Air.
Volkswagen’s crazy-efficient EV borrows an idea from Slate
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Journal of Medical Internet Research
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Digitally Adapting LGBTQ-Affirmative Cognitive Behavioral Therapy for Chinese Men Who Have Sex With Men Living With HIV: User-Centered Design Approach
Background: Chinese men who have sex with men living with HIV (MSMLWH) experience substantial psychological distress driven by minority stress and HIV-related challenges. However, culturally tailored digital mental health interventions that address HIV-specific maladaptive cognitive schemas and culturally specific psychosocial stressors remain scarce in China. Objective: This study aimed to systematically adapt an evidence-based cognitive behavioral therapy (CBT) intervention Effective Skills to
Digitally Adapting LGBTQ-Affirmative Cognitive Behavioral Therapy for Chinese Men Who Have Sex With Men Living With HIV: User-Centered Design Approach
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MIT Technology Review
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Donated livers can be made biologically younger
Once an organ is removed from a donor’s body, the clock starts ticking. Surgeons usually flush the organ with a preservative solution, bag it, and put it on ice—where it immediately starts to degrade. The team has a matter of hours to get it into a recipient’s body. There’s another option—one that has been growing in popularity in recent years, especially for donated organs that aren’t in the healthiest state. Some hospitals opt to put them on machines that pump them with nutrients and rem
Donated livers can be made biologically younger
Once an organ is removed from a donor’s body, the clock starts ticking. Surgeons usually flush the organ with a preservative solution, bag it, and put it on ice—where it immediately starts to degrade. The team has a matter of hours to get it into a recipient’s body.
There’s another option—one that has been growing in popularity in recent years, especially for donated organs that aren’t in the healthiest state. Some hospitals opt to put them on machines that pump them with nutrients and remove waste products, usually for around six to 12 hours. It’s a bit like being back in a body.
This allows doctors to assess the organs, and some recent studies suggest that time spent on these perfusion machines helps them do better once they’re transplanted. Now, scientists have found that perfused organs seem to get younger, at least at a molecular level.
The research, shared with MIT Technology Review, provides molecular clues as to why organs from younger donors are known to have a higher success rate. It might also help explain why perfused organs are less likely to fail once they make it into a recipient.
The researchers behind the study hope to find new ways to test the health of donated organs and potentially develop additional tools to repair organs that might otherwise be discarded. “If [we] can improve the utilization of organs beyond what the current systems can do, then that’s a win in my book,” says Jesse Poganik, who studies aging at Brigham and Women’s Hospital in Boston and coauthored the study.
Clocking organs
Poganik—along with colleagues including Heidi Yeh and Alban Longchamp, transplant surgeons at Mass General Brigham—used “aging clocks” to assess donated livers. These are scientific tools designed to measure biological age—a result that is meant to convey more about the health status of an organ (or person) than chronological age.
In an initial experiment, the team used a clock to look at the patterns of chemical marks on DNA in 37 samples taken from 19 donated livers. Such epigenetic patterns are known to change as we age. But when the team compared samples from livers kept on ice and those that were perfused, the team found a “striking” pattern in the latter.
“Machine-perfused livers, in spite of being older or having other disadvantageous characteristics, had a biological age that was lower than [non-perfused] livers that were chronologically younger,” says Yeh, who led the work.
To investigate further, Yeh and her colleagues analyzed another 208 samples from 103 donated livers. This time, they used different aging clocks—ones that essentially measure how genes are working. They studied samples biopsied from the livers after they had been stored for up to around six hours either in cold storage or on machine perfusion.
In most cases, they also assessed a second sample taken around an hour after the livers had been transplanted into a recipient. Once the organ’s blood supply is reestablished in the body, “you have a few other things to do,” says Longchamp. “Then you just do a quick biopsy before you close.”
According to the clocks, which were developed to measure age and risk of death, the machine-perfused livers were biologically younger, the team found. “Pumping them at 34 degrees with oxygen and nutrients actually reversed the biological age,” says Longchamp. The results have been been shared with colleagues at an industry conference, he says.
“If you adjust out chronological age … to have a fair head-to-head comparison, the difference between the two is on the order of 30%,” says Poganik. “It’s logical to say that perfusion drives this effect.”
The biological ages of all the livers tended to increase as soon as they were put into a recipient’s body, probably as a result of stresses on the organs. But still, the effect endured—the perfused organs remained biologically younger.
Nathanael Raschzok, a transplant surgeon at Charité Universitätsmedizin Berlin in Germany who was not involved in the research, says the work is impressive. But it’s not yet clear what these changes might mean for the recipients of these organs, he says. The organs in the study were donated by people in their 30s, 40s, and 50s. Raschzok wants to know the effect of perfusion on the liver of an 80-year-old. “Every so often, we use organs from 70-, 80-, 85-year-old donors,” he says.
A better understanding of why the organs appear to be getting biologically younger might lead to therapies that achieve the same effect with a drug that could potentially be used to treat a donated organ for a fraction of the price, he adds. That’s important because perfusion is expensive—Raschzok says it costs around €10,000 in Germany (a quarter of the budget for a transplant), while the cost in the US comes to around $80,000 to $100,000 per organ, says Yeh.
Molecular repair
Yeh and her colleagues weren’t able to study most of the livers before perfusion. That’s because donated organs are generally not considered to be under the purview of the hospital until they’ve been placed on perfusion machines, she says. (Organ procurement procedures vary, but for the team as Mass General Brigham, donated organs are put on perfusion devices at the donor’s hospital. “There’s this sort of nebulous period where it’s not clear who the organ belongs to,” says Yeh.)
Still, by looking at the genes and molecular pathways that seem to be altered in perfused organs, she and her colleagues can garner some clues. At a molecular level, the team saw changes in cell pathways linked to inflammation and the structure of tissues, for example. They also saw more activity in a pathway that allows cells to remove and recycle damaged cell parts, says Yeh.
Poganik hopes to develop some kind of test that would determine which organs, on the basis of their biological age, are suitable for transplantation. He and his colleagues are also experimenting with potential drug treatments that might push the biological age of an organ even lower.
In the meantime, any liver that is not from a “perfect, young, brain-dead donor” could probably benefit from perfusion, says Yeh. The devices are already transforming transplant surgery. Just a few years ago, she says, she and her colleagues would avoid using livers from people who’d suffered a circulatory death (when the heart stops beating and there’s a damaging lack of blood flow to organs) and were over 40. Today, they use livers from such donors over the age of 70. “Perfusion has completely changed the landscape of transplantation in the last three years,” she says.
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InfoQ

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Podcast: How Will We Train Developers If AI Does the Routine Work: A Conversation with Scott Hanselman
In this podcast, Michael Stiefel spoke to Scott Hanselman about developing new software engineers when artificial intelligence agents are doing most of the work on which junior developers were trained. Hanselman suggests the software industry should adopt a preceptorship model similar to the nursing profession. By Scott Hanselman
Podcast: How Will We Train Developers If AI Does the Routine Work: A Conversation with Scott Hanselman
In this podcast, Michael Stiefel spoke to Scott Hanselman about developing new software engineers when artificial intelligence agents are doing most of the work on which junior developers were trained. Hanselman suggests the software industry should adopt a preceptorship model similar to the nursing profession.
By Scott Hanselman-
Omics in Gastric
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Unveiling the Gastric Microbiome: Novel Insights into Early Detection and Pathogenesis of Gastric Cancer
Probiotics Antimicrob Proteins. 2026 Sep 14. doi: 10.1007/s12602-026-11134-3. Online ahead of print.ABSTRACTGastric cancer (GC) remains a major global health burden and is frequently diagnosed at advanced stages owing to the limited sensitivity, invasiveness, and restricted availability of current screening strategies. Increasing evidence indicates that the gastric microbiome including Helicobacter pylori and diverse non-H. pylori bacteria, fungi, and viruses actively contribute to gastric carci
Unveiling the Gastric Microbiome: Novel Insights into Early Detection and Pathogenesis of Gastric Cancer
Probiotics Antimicrob Proteins. 2026 Sep 14. doi: 10.1007/s12602-026-11134-3. Online ahead of print.
ABSTRACT
Gastric cancer (GC) remains a major global health burden and is frequently diagnosed at advanced stages owing to the limited sensitivity, invasiveness, and restricted availability of current screening strategies. Increasing evidence indicates that the gastric microbiome including Helicobacter pylori and diverse non-H. pylori bacteria, fungi, and viruses actively contribute to gastric carcinogenesis by modulating mucosal immunity, chronic inflammation, epithelial barrier integrity, and metabolism. High-throughput sequencing has revealed reproducible dysbiosis signatures in GC, characterized by enrichment of taxa such as Lactobacillus, Streptococcus, and Fusobacterium, and depletion of beneficial commensals, including Bifidobacterium and short-chain fatty acid producing anaerobes, some of which show promise as diagnostic or prognostic biomarkers. This review summarizes current knowledge on bacterial, fungal, and viral inhabitants of gastric tumors, highlighting their mechanistic roles in tumor initiation and progression and their potential as microbial indicators of disease. It further evaluates noninvasive and minimally invasive early detection strategies based on fecal and salivary microbiota profiling, urinary extracellular vesicles, and metabolomic fingerprints, alongside multi-omics integration and machine-learning models that combine microbial and host features to improve risk stratification. Finally, the review discusses therapeutic avenues including microbiota modulation, immunotherapy microbiome interactions, and personalized medicine frameworks that incorporate microbial signatures into clinical decision-making, underscoring the need for standardized, multicenter studies to translate gastric microbiome insights into robust tools for early detection and targeted intervention in GC.
PMID:42734869 | DOI:10.1007/s12602-026-11134-3
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Unveiling the Gastric Microbiome: Novel Insights into Early Detection and Pathogenesis of Gastric Cancer
Probiotics Antimicrob Proteins. 2026 Sep 14. doi: 10.1007/s12602-026-11134-3. Online ahead of print.ABSTRACTGastric cancer (GC) remains a major global health burden and is frequently diagnosed at advanced stages owing to the limited sensitivity, invasiveness, and restricted availability of current screening strategies. Increasing evidence indicates that the gastric microbiome including Helicobacter pylori and diverse non-H. pylori bacteria, fungi, and viruses actively contribute to gastric carci
Unveiling the Gastric Microbiome: Novel Insights into Early Detection and Pathogenesis of Gastric Cancer
Probiotics Antimicrob Proteins. 2026 Sep 14. doi: 10.1007/s12602-026-11134-3. Online ahead of print.
ABSTRACT
Gastric cancer (GC) remains a major global health burden and is frequently diagnosed at advanced stages owing to the limited sensitivity, invasiveness, and restricted availability of current screening strategies. Increasing evidence indicates that the gastric microbiome including Helicobacter pylori and diverse non-H. pylori bacteria, fungi, and viruses actively contribute to gastric carcinogenesis by modulating mucosal immunity, chronic inflammation, epithelial barrier integrity, and metabolism. High-throughput sequencing has revealed reproducible dysbiosis signatures in GC, characterized by enrichment of taxa such as Lactobacillus, Streptococcus, and Fusobacterium, and depletion of beneficial commensals, including Bifidobacterium and short-chain fatty acid producing anaerobes, some of which show promise as diagnostic or prognostic biomarkers. This review summarizes current knowledge on bacterial, fungal, and viral inhabitants of gastric tumors, highlighting their mechanistic roles in tumor initiation and progression and their potential as microbial indicators of disease. It further evaluates noninvasive and minimally invasive early detection strategies based on fecal and salivary microbiota profiling, urinary extracellular vesicles, and metabolomic fingerprints, alongside multi-omics integration and machine-learning models that combine microbial and host features to improve risk stratification. Finally, the review discusses therapeutic avenues including microbiota modulation, immunotherapy microbiome interactions, and personalized medicine frameworks that incorporate microbial signatures into clinical decision-making, underscoring the need for standardized, multicenter studies to translate gastric microbiome insights into robust tools for early detection and targeted intervention in GC.
PMID:42734869 | DOI:10.1007/s12602-026-11134-3
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cs.AI, q-bio.NC updates on arXiv.org
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Occamy-1.0: Open Pareto-frontier 35B Intelligence for Co-work
arXiv:2609.11977v1 Announce Type: new Abstract: Co-work agents execute complex workflows that combine information gathering, tool use, coding, and file manipulation across many model invocations. Because cost and latency accumulate over the full episode, their practical value depends not only on peak capability but also on how efficiently that capability is delivered. Yet many steps in everyday work emphasize state tracking, coordination, recovery, and follow-through rather than frontier-scale
Occamy-1.0: Open Pareto-frontier 35B Intelligence for Co-work
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cs.AI, q-bio.NC updates on arXiv.org
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The Computational Primitives of Adaptation
arXiv:2609.11989v1 Announce Type: new Abstract: Research on adaptive systems has traditionally focused on behavior (what organisms do) and mechanism (how their machinery works). This paper focuses on a third level, computation, which considers what adaptive systems must compute to survive and reproduce. It is proposed that adaptation has its own computational structure, comprising a small set of primitive operations common to all adaptive systems, regardless of their physical form. Six primitiv
The Computational Primitives of Adaptation
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cs.AI, q-bio.NC updates on arXiv.org
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DU-NO: A Parameter-Efficient Double U-Shaped Neural Operator for Phase-Resolving Wave Modeling
arXiv:2609.12115v1 Announce Type: new Abstract: Phase-resolving wave models such as FUNWAVE-TVD are the accuracy standard for nearshore dynamics, resolving the shoaling, refraction, and breaking of individual waves, but their cost rules them out for the ensembles, uncertainty quantification, and real-time warning that operational forecasting demands. Neural operators promise solver-level accuracy at a fraction of that cost, yet on wave-dominated fields the accurate ones are large: hybrid spectr
DU-NO: A Parameter-Efficient Double U-Shaped Neural Operator for Phase-Resolving Wave Modeling
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cs.AI, q-bio.NC updates on arXiv.org
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GLARE: Generative Learning via Adversarial Reward Estimation For Social Dynamics Forecasting
arXiv:2609.12165v1 Announce Type: new Abstract: Meeting continuation requires tracking the agenda, speaker roles, participant intentions, and disagreement across long multi-party discussions. We introduce the Meeting Dynamic Forecasting Benchmark (MDFB), constructed from 2,207 real-world meetings and 24,794 future-facing queries. Given a transcript prefix and an active question, a model generates a plausible multi-turn continuation in one call. We evaluate utility---progress toward the question
GLARE: Generative Learning via Adversarial Reward Estimation For Social Dynamics Forecasting
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cs.AI, q-bio.NC updates on arXiv.org
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WinSyn: An Automated Pipeline for Realistic Enterprise Question-Answering Evaluation
arXiv:2609.12171v1 Announce Type: new Abstract: Enterprise settings provide a challenging environment for question-answering agents, which often rely on Retrieval-Augmented Generation, Deep Research (DR), and related techniques. Much of this challenge comes from the complexity of enterprise data: information is often spread across evolving and potentially conflict- ing emails, chat messages, documents, and other artifacts. Existing benchmarks typically have limited real-world complexity, short-
WinSyn: An Automated Pipeline for Realistic Enterprise Question-Answering Evaluation
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cs.AI, q-bio.NC updates on arXiv.org
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Soft Symbol Grounding for Prototypical Concepts
arXiv:2609.12247v1 Announce Type: new Abstract: Neuro-symbolic models are usually trained with supervision only on final labels, leaving the intermediate concepts unobserved. Since many concept assignments are consistent with a given label, training can predict labels correctly while recovering the wrong concepts, a failure known as a reasoning shortcut. Prototypical networks reduce shortcuts by anchoring each concept to a few labeled examples, but existing methods still couple perception and r
Soft Symbol Grounding for Prototypical Concepts
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cs.AI, q-bio.NC updates on arXiv.org
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GTA: Graph Theory Agent and Benchmark for Algorithmic Graph Reasoning with LLMs
arXiv:2609.12265v1 Announce Type: new Abstract: Large Language Models (LLMs) are increasingly asked to reason over structured data such as graphs, yet how reliably they can carry out multi-step graph algorithms in language remains unclear. Existing evaluations tend to use simple tasks on small graphs, to score code generation rather than reasoning over the graph itself, or to fix a single input format. We introduce Graph Theory Bench (GT Bench), a benchmark covering 24 classical graph problems
GTA: Graph Theory Agent and Benchmark for Algorithmic Graph Reasoning with LLMs
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cs.AI, q-bio.NC updates on arXiv.org
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Robust Prototypical Networks for Few-Shot Sensor Fault Diagnosis
arXiv:2609.12287v1 Announce Type: new Abstract: Industrial fault diagnosis often operates with only a handful of labeled fault examples, making few-shot learning attractive for sensor monitoring. Standard prototypical networks are simple and effective; however, their class prototypes may become unstable in the very-low-shot regime because each decision relies on a small support set. We propose \emph{Multi-Episode Prototypical Networks} (MEPN), which aggregate prototypes from multiple disjoint s
Robust Prototypical Networks for Few-Shot Sensor Fault Diagnosis
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cs.AI, q-bio.NC updates on arXiv.org
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Hybrid Physics-AI Framework of Body Center of Mass Dynamics from Wrist-Worn Sensors
arXiv:2609.12304v1 Announce Type: new Abstract: Wrist-worn IMU has been widely used for daily-life health monitoring. Yet, it does not fully represent whole-body dynamics, for which the body center of mass (COM) is considered the physiological reference standard. Therefore, this work proposes a simplified kinematic model (KM), which is designed to map the wrist IMU to the COM acceleration. It is built upon several reductive assumptions that enable the solvability of the dynamic equations based
Hybrid Physics-AI Framework of Body Center of Mass Dynamics from Wrist-Worn Sensors
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cs.AI, q-bio.NC updates on arXiv.org
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AIM: A Privacy-Aware Interoperable Memory Framework for Multi-Agent Multi-User LLM Systems
arXiv:2609.12320v1 Announce Type: new Abstract: Traditional large language models (LLMs) are scoped to individual user sessions, limiting their knowledge to a single conversation and preventing them from learning user preferences that evolve over time. Existing agentic memory systems address this limitation but generally operate at the individual-user level, restricting the public knowledge that could be shared across users to improve downstream responses. We introduce AIM (Agentic Interoperabl
AIM: A Privacy-Aware Interoperable Memory Framework for Multi-Agent Multi-User LLM Systems
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cs.AI, q-bio.NC updates on arXiv.org
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Toward Robust Personalized Alignment for LLMs: Mitigating Persona Drift in Multi-Turn Dialogue
arXiv:2609.12373v1 Announce Type: new Abstract: Persona drift remains a central challenge for personalized language models, as user profiles evolve over long interactions rather than remain permanently fixed. Models must therefore revise persistent persona states when preferences genuinely change, while avoiding updates driven by transient, ambiguous, or unresolved observations. We propose CORE, which separates turn-local evidence from persistent persona-state revision and selectively updates g