Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Occamy-1.0: Open Pareto-frontier 35B Intelligence for Co-work
arXiv:2609.11977v1 Announce Type: new Abstract: Co-work agents execute complex workflows that combine information gathering, tool use, coding, and file manipulation across many model invocations. Because cost and latency accumulate over the full episode, their practical value depends not only on peak capability but also on how efficiently that capability is delivered. Yet many steps in everyday work emphasize state tracking, coordination, recovery, and follow-through rather than frontier-scale
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Omics in Hepatocellular
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Integrated single-cell multi-omics characterization reveals lipid-associated macrophage-mediated immunosuppression in neoadjuvant immunotherapy of hepatocellular carcinoma
Nat Commun. 2026 Jul 31;17(1):9381. doi: 10.1038/s41467-026-75949-y.ABSTRACTHepatocellular carcinoma (HCC) is a cancer with high incidence and mortality rate. Although immune checkpoint inhibitors (ICIs) improved survival outcomes for HCC patients, limited objective response rate highlights the urgency of investigating determinants of immunotherapy. Here, we explore HCC resistance mechanisms following neoadjuvant αPD-1 immunotherapy by constructing a comprehensive multi-modal single-cell transcr
Integrated single-cell multi-omics characterization reveals lipid-associated macrophage-mediated immunosuppression in neoadjuvant immunotherapy of hepatocellular carcinoma
Nat Commun. 2026 Jul 31;17(1):9381. doi: 10.1038/s41467-026-75949-y.
ABSTRACT
Hepatocellular carcinoma (HCC) is a cancer with high incidence and mortality rate. Although immune checkpoint inhibitors (ICIs) improved survival outcomes for HCC patients, limited objective response rate highlights the urgency of investigating determinants of immunotherapy. Here, we explore HCC resistance mechanisms following neoadjuvant αPD-1 immunotherapy by constructing a comprehensive multi-modal single-cell transcriptomic atlas consisting of 14 HCC patients treated with αPD-1 from our cohort (ClinicalTrials.gov ID: NCT06571396) and 60 external HCC cases with heterogeneous treatment backgrounds. Supervised by clinical outcomes of our cohort, we identify positive and negative regulators of immunotherapy within the tumor immune microenvironment (TIME), especially lipid-associated macrophages (LAM) with increased lipid metabolic state in non-responders and characterized by C1QA, FABP1, and APOA1 expression. We further show the presence, exogenous inducements and immunosuppressive functions of LAM, along with regulation strategies of its lipid-associated condition, including lycopene and chiglitazar. Furthermore, we construct interaction networks of immune regulators across responders and non-responders, showing distinct ligand-receptor landscapes with intervention targets. We reveal the TIME components including immunosuppressive LAMs that influence immunotherapy outcomes, thus providing evidence and insights for exploring immune landscape and therapeutic strategies for HCC immunotherapy. ClinicalTrials.gov ID: NCT06571396.
PMID:42680737 | PMC:PMC13534469 | DOI:10.1038/s41467-026-75949-y
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cs.AI, q-bio.NC updates on arXiv.org
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Generative structure search for efficient and diverse discovery of molecular and crystal structures
arXiv:2604.27636v2 Announce Type: replace Abstract: Predicting stable and metastable structures is central to molecular and materials discovery, but remains limited by the cost of searching high-dimensional energy landscapes. Deep generative models offer efficient structure sampling, yet their outputs remain shaped by training data and can underexplore minima that are rare but physically relevant. We introduce generative structure search (GSS), a unified framework that formulates diffusion-base
Generative structure search for efficient and diverse discovery of molecular and crystal structures
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cs.AI, q-bio.NC updates on arXiv.org
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UIS-Digger: Towards Comprehensive Research Agent Systems for Real-world Unindexed Information Seeking
arXiv:2603.08117v1 Announce Type: new Abstract: Recent advancements in LLM-based information-seeking agents have achieved record-breaking performance on established benchmarks. However, these agents remain heavily reliant on search-engine-indexed knowledge, leaving a critical blind spot: Unindexed Information Seeking (UIS). This paper identifies and explores the UIS problem, where vital information is not captured by search engine crawlers, such as overlooked content, dynamic webpages, and embe
UIS-Digger: Towards Comprehensive Research Agent Systems for Real-world Unindexed Information Seeking
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cs.AI, q-bio.NC updates on arXiv.org
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Gradually Excavating External Knowledge for Implicit Complex Question Answering
arXiv:2603.08148v1 Announce Type: cross Abstract: Recently, large language models (LLMs) have gained much attention for the emergence of human-comparable capabilities and huge potential. However, for open-domain implicit question-answering problems, LLMs may not be the ultimate solution due to the reasons of: 1) uncovered or out-of-date domain knowledge, 2) one-shot generation and hence restricted comprehensiveness. To this end, this work proposes a gradual knowledge excavation framework for op
Gradually Excavating External Knowledge for Implicit Complex Question Answering
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cs.AI, q-bio.NC updates on arXiv.org
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Proximity-Based Multi-Turn Optimization: Practical Credit Assignment for LLM Agent Training
arXiv:2602.19225v1 Announce Type: new Abstract: Multi-turn LLM agents are becoming pivotal to production systems, spanning customer service automation, e-commerce assistance, and interactive task management, where accurately distinguishing high-value informative signals from stochastic noise is critical for sample-efficient training. In real-world scenarios, a failure in a trivial task may reflect random instability, whereas success in a high-difficulty task signifies a genuine capability break