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cs.AI, q-bio.NC updates on arXiv.org
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Occamy-1.0: Open Pareto-frontier 35B Intelligence for Co-work
arXiv:2609.11977v1 Announce Type: new Abstract: Co-work agents execute complex workflows that combine information gathering, tool use, coding, and file manipulation across many model invocations. Because cost and latency accumulate over the full episode, their practical value depends not only on peak capability but also on how efficiently that capability is delivered. Yet many steps in everyday work emphasize state tracking, coordination, recovery, and follow-through rather than frontier-scale
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cs.AI, q-bio.NC updates on arXiv.org
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Beyond ID Embeddings: Process-Grounded Language Modeling for Cognitive Diagnosis
arXiv:2609.12403v1 Announce Type: new Abstract: Cognitive Diagnosis Models (CDMs) play a pivotal role in personalized online learning. Traditional CDMs rely on discrete, ID-based embeddings to represent students, exercises, and concepts. This paradigm diverges from the nature of learner cognition, where knowledge is not stored and retrieved as isolated symbols. As a result, CDMs suffer from semantic limitations when new exercises or concepts appear. In this paper, we propose a Process-aware Lan
Beyond ID Embeddings: Process-Grounded Language Modeling for Cognitive Diagnosis
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cs.AI, q-bio.NC updates on arXiv.org
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LightNav-0: Eliciting VLM Spatial Intelligence for Generalist Embodied Navigation
arXiv:2608.30935v2 Announce Type: replace-cross Abstract: Embodied navigation requires agents to translate heterogeneous goals and visual observations into actions across tasks, environments, and robot embodiments. Modern vision-language models (VLMs) already encode spatial priors for visual grounding, spatial reasoning, and pointing, but these capabilities are rarely elicited directly for robot control. Existing navigation systems instead rely on task- or embodiment-specific components, fragme
LightNav-0: Eliciting VLM Spatial Intelligence for Generalist Embodied Navigation
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Omics in Hepatocellular
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Integrated single-cell multi-omics characterization reveals lipid-associated macrophage-mediated immunosuppression in neoadjuvant immunotherapy of hepatocellular carcinoma
Nat Commun. 2026 Jul 31;17(1):9381. doi: 10.1038/s41467-026-75949-y.ABSTRACTHepatocellular carcinoma (HCC) is a cancer with high incidence and mortality rate. Although immune checkpoint inhibitors (ICIs) improved survival outcomes for HCC patients, limited objective response rate highlights the urgency of investigating determinants of immunotherapy. Here, we explore HCC resistance mechanisms following neoadjuvant αPD-1 immunotherapy by constructing a comprehensive multi-modal single-cell transcr
Integrated single-cell multi-omics characterization reveals lipid-associated macrophage-mediated immunosuppression in neoadjuvant immunotherapy of hepatocellular carcinoma
Nat Commun. 2026 Jul 31;17(1):9381. doi: 10.1038/s41467-026-75949-y.
ABSTRACT
Hepatocellular carcinoma (HCC) is a cancer with high incidence and mortality rate. Although immune checkpoint inhibitors (ICIs) improved survival outcomes for HCC patients, limited objective response rate highlights the urgency of investigating determinants of immunotherapy. Here, we explore HCC resistance mechanisms following neoadjuvant αPD-1 immunotherapy by constructing a comprehensive multi-modal single-cell transcriptomic atlas consisting of 14 HCC patients treated with αPD-1 from our cohort (ClinicalTrials.gov ID: NCT06571396) and 60 external HCC cases with heterogeneous treatment backgrounds. Supervised by clinical outcomes of our cohort, we identify positive and negative regulators of immunotherapy within the tumor immune microenvironment (TIME), especially lipid-associated macrophages (LAM) with increased lipid metabolic state in non-responders and characterized by C1QA, FABP1, and APOA1 expression. We further show the presence, exogenous inducements and immunosuppressive functions of LAM, along with regulation strategies of its lipid-associated condition, including lycopene and chiglitazar. Furthermore, we construct interaction networks of immune regulators across responders and non-responders, showing distinct ligand-receptor landscapes with intervention targets. We reveal the TIME components including immunosuppressive LAMs that influence immunotherapy outcomes, thus providing evidence and insights for exploring immune landscape and therapeutic strategies for HCC immunotherapy. ClinicalTrials.gov ID: NCT06571396.
PMID:42680737 | PMC:PMC13534469 | DOI:10.1038/s41467-026-75949-y
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cs.AI, q-bio.NC updates on arXiv.org
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Generative structure search for efficient and diverse discovery of molecular and crystal structures
arXiv:2604.27636v2 Announce Type: replace Abstract: Predicting stable and metastable structures is central to molecular and materials discovery, but remains limited by the cost of searching high-dimensional energy landscapes. Deep generative models offer efficient structure sampling, yet their outputs remain shaped by training data and can underexplore minima that are rare but physically relevant. We introduce generative structure search (GSS), a unified framework that formulates diffusion-base
Generative structure search for efficient and diverse discovery of molecular and crystal structures
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cs.AI, q-bio.NC updates on arXiv.org
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LLMs Judge Themselves: A Game-Theoretic Framework for Human-Aligned Evaluation
arXiv:2510.15746v2 Announce Type: replace-cross Abstract: Ideal or real - that is the question.In this work, we explore whether principles from game theory can be effectively applied to the evaluation of large language models (LLMs). This inquiry is motivated by the growing inadequacy of conventional evaluation practices, which often rely on fixed-format tasks with reference answers and struggle to capture the nuanced, subjective, and open-ended nature of modern LLM behavior. To address these c
LLMs Judge Themselves: A Game-Theoretic Framework for Human-Aligned Evaluation
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cs.AI, q-bio.NC updates on arXiv.org
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UIS-Digger: Towards Comprehensive Research Agent Systems for Real-world Unindexed Information Seeking
arXiv:2603.08117v1 Announce Type: new Abstract: Recent advancements in LLM-based information-seeking agents have achieved record-breaking performance on established benchmarks. However, these agents remain heavily reliant on search-engine-indexed knowledge, leaving a critical blind spot: Unindexed Information Seeking (UIS). This paper identifies and explores the UIS problem, where vital information is not captured by search engine crawlers, such as overlooked content, dynamic webpages, and embe
UIS-Digger: Towards Comprehensive Research Agent Systems for Real-world Unindexed Information Seeking
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cs.AI, q-bio.NC updates on arXiv.org
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HybridStitch: Pixel and Timestep Level Model Stitching for Diffusion Acceleration
arXiv:2603.07815v1 Announce Type: cross Abstract: Diffusion models have demonstrated a remarkable ability in Text-to-Image (T2I) generation applications. Despite the advanced generation output, they suffer from heavy computation overhead, especially for large models that contain tens of billions of parameters. Prior work has illustrated that replacing part of the denoising steps with a smaller model still maintains the generation quality. However, these methods only focus on saving computation
HybridStitch: Pixel and Timestep Level Model Stitching for Diffusion Acceleration
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cs.AI, q-bio.NC updates on arXiv.org
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Gradually Excavating External Knowledge for Implicit Complex Question Answering
arXiv:2603.08148v1 Announce Type: cross Abstract: Recently, large language models (LLMs) have gained much attention for the emergence of human-comparable capabilities and huge potential. However, for open-domain implicit question-answering problems, LLMs may not be the ultimate solution due to the reasons of: 1) uncovered or out-of-date domain knowledge, 2) one-shot generation and hence restricted comprehensiveness. To this end, this work proposes a gradual knowledge excavation framework for op
Gradually Excavating External Knowledge for Implicit Complex Question Answering
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cs.AI, q-bio.NC updates on arXiv.org
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Ego-Vision World Model for Humanoid Contact Planning
arXiv:2510.11682v2 Announce Type: replace-cross Abstract: Enabling humanoid robots to exploit physical contact, rather than simply avoid collisions, is crucial for autonomy in unstructured environments. Traditional optimization-based planners struggle with contact complexity, while on-policy reinforcement learning (RL) is sample-inefficient and has limited multi-task ability. We propose a framework combining a learned world model with sampling-based Model Predictive Control (MPC), trained on a
Ego-Vision World Model for Humanoid Contact Planning
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cs.AI, q-bio.NC updates on arXiv.org
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Intelligent Pathological Diagnosis of Gestational Trophoblastic Diseases via Visual-Language Deep Learning Model
arXiv:2603.02704v1 Announce Type: cross Abstract: The pathological diagnosis of gestational trophoblastic disease(GTD) takes a long time, relies heavily on the experience of pathologists, and the consistency of initial diagnosis is low, which seriously threatens maternal health and reproductive outcomes. We developed an expert model for GTD pathological diagnosis, named GTDoctor. GTDoctor can perform pixel-based lesion segmentation on pathological slides, and output diagnostic conclusions and p
Intelligent Pathological Diagnosis of Gestational Trophoblastic Diseases via Visual-Language Deep Learning Model
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cs.AI, q-bio.NC updates on arXiv.org
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Proximity-Based Multi-Turn Optimization: Practical Credit Assignment for LLM Agent Training
arXiv:2602.19225v1 Announce Type: new Abstract: Multi-turn LLM agents are becoming pivotal to production systems, spanning customer service automation, e-commerce assistance, and interactive task management, where accurately distinguishing high-value informative signals from stochastic noise is critical for sample-efficient training. In real-world scenarios, a failure in a trivial task may reflect random instability, whereas success in a high-difficulty task signifies a genuine capability break
Proximity-Based Multi-Turn Optimization: Practical Credit Assignment for LLM Agent Training
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cs.AI, q-bio.NC updates on arXiv.org
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ShallowJail: Steering Jailbreaks against Large Language Models
arXiv:2602.07107v2 Announce Type: replace-cross Abstract: Large Language Models(LLMs) have been successful in numerous fields. Alignment has usually been applied to prevent them from harmful purposes. However, aligned LLMs remain vulnerable to jailbreak attacks that deliberately mislead them into producing harmful outputs. Existing jailbreaks are either black-box, using carefully crafted, unstealthy prompts, or white-box, requiring resource-intensive computation. In light of these challenges, w