Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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RESCUE-BENCH: Towards Relation-Aware Multi-Party Emotional Support Conversation Systems
arXiv:2609.09657v1 Announce Type: new Abstract: Existing emotional support conversation systems mainly focus on one-on-one seeker-supporter interactions and individual emotional states, leaving interpersonal relations in multi-party scenarios underexplored. In this work, we introduce relation-aware emotional support conversation, a new task that evaluates whether LLMs can capture and utilize the evolving dynamics of relationships to offer more effective emotional support. We construct RESCUE (R
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Omics In Lung
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Early stage nonsmall cell lung cancer: Toward a risk-adaptive paradigm in the era of biologic precision
CA Cancer J Clin. 2026 Sep-Oct;76(5):e70100. doi: 10.3322/caac.70100.ABSTRACTThe clinical landscape of early stage nonsmall cell lung cancer is at transformative crossroads. Driven by the widespread adoption of low-dose computed tomography screening, the frequent detection of ground-glass opacities, and a rising incidence among never-smokers, the diagnostic center of gravity has shifted toward earlier, potentially curable disease. This shift has been accompanied by equally important therapeutic
Early stage nonsmall cell lung cancer: Toward a risk-adaptive paradigm in the era of biologic precision
CA Cancer J Clin. 2026 Sep-Oct;76(5):e70100. doi: 10.3322/caac.70100.
ABSTRACT
The clinical landscape of early stage nonsmall cell lung cancer is at transformative crossroads. Driven by the widespread adoption of low-dose computed tomography screening, the frequent detection of ground-glass opacities, and a rising incidence among never-smokers, the diagnostic center of gravity has shifted toward earlier, potentially curable disease. This shift has been accompanied by equally important therapeutic advances, including parenchyma-sparing surgical techniques, minimally invasive platforms enhanced by digital navigation, and the transformative integration of perioperative immunotherapy and targeted agents. Concurrently, noninvasive monitoring approaches, such as liquid biopsy, have emerged as powerful tools to guide precision management. Despite this progress, substantial barriers to achieving a universal cure persist. Clinicians continue to face uncertainty in the management of ground-glass opacities, the anatomy-based TNM staging system fails to capture the biologic heterogeneity of early tumors, and global disparities in access to innovation remain unresolved. To address these challenges, the authors propose a shift toward a risk-adaptive management paradigm that harnesses artificial intelligence-driven analytics and multi-omics profiling to tailor treatment intensity according to each patient's biologic risk. Such an approach would enable appropriate escalation for high-risk individuals while permitting safe de-escalation for those at low risk. This holistic, lifespan-oriented strategy must be embraced to deliver equitable and durable cures for patients with early stage nonsmall cell lung cancer.
PMID:42713910 | PMC:PMC13555834 | DOI:10.3322/caac.70100
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Early stage nonsmall cell lung cancer: Toward a risk-adaptive paradigm in the era of biologic precision
CA Cancer J Clin. 2026 Sep-Oct;76(5):e70100. doi: 10.3322/caac.70100.ABSTRACTThe clinical landscape of early stage nonsmall cell lung cancer is at transformative crossroads. Driven by the widespread adoption of low-dose computed tomography screening, the frequent detection of ground-glass opacities, and a rising incidence among never-smokers, the diagnostic center of gravity has shifted toward earlier, potentially curable disease. This shift has been accompanied by equally important therapeutic
Early stage nonsmall cell lung cancer: Toward a risk-adaptive paradigm in the era of biologic precision
CA Cancer J Clin. 2026 Sep-Oct;76(5):e70100. doi: 10.3322/caac.70100.
ABSTRACT
The clinical landscape of early stage nonsmall cell lung cancer is at transformative crossroads. Driven by the widespread adoption of low-dose computed tomography screening, the frequent detection of ground-glass opacities, and a rising incidence among never-smokers, the diagnostic center of gravity has shifted toward earlier, potentially curable disease. This shift has been accompanied by equally important therapeutic advances, including parenchyma-sparing surgical techniques, minimally invasive platforms enhanced by digital navigation, and the transformative integration of perioperative immunotherapy and targeted agents. Concurrently, noninvasive monitoring approaches, such as liquid biopsy, have emerged as powerful tools to guide precision management. Despite this progress, substantial barriers to achieving a universal cure persist. Clinicians continue to face uncertainty in the management of ground-glass opacities, the anatomy-based TNM staging system fails to capture the biologic heterogeneity of early tumors, and global disparities in access to innovation remain unresolved. To address these challenges, the authors propose a shift toward a risk-adaptive management paradigm that harnesses artificial intelligence-driven analytics and multi-omics profiling to tailor treatment intensity according to each patient's biologic risk. Such an approach would enable appropriate escalation for high-risk individuals while permitting safe de-escalation for those at low risk. This holistic, lifespan-oriented strategy must be embraced to deliver equitable and durable cures for patients with early stage nonsmall cell lung cancer.
PMID:42713910 | DOI:10.3322/caac.70100
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Omics In Lung
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From the invasive front to organotropic pre-metastatic niches: spatial immune regulatory networks governing cholangiocarcinoma dissemination and metastasis-intercepting immunotherapy
Front Immunol. 2026 Aug 20;17:1919864. doi: 10.3389/fimmu.2026.1919864. eCollection 2026.ABSTRACTCholangiocarcinoma is an aggressive biliary tract malignancy in which metastatic relapse and primary or acquired resistance to immunotherapy remain major causes of mortality. Although immune checkpoint inhibitors have improved first-line treatment for advanced biliary tract cancer, most patients do not achieve durable benefit, indicating that immune failure is not explained by a single checkpoint pat
From the invasive front to organotropic pre-metastatic niches: spatial immune regulatory networks governing cholangiocarcinoma dissemination and metastasis-intercepting immunotherapy
Front Immunol. 2026 Aug 20;17:1919864. doi: 10.3389/fimmu.2026.1919864. eCollection 2026.
ABSTRACT
Cholangiocarcinoma is an aggressive biliary tract malignancy in which metastatic relapse and primary or acquired resistance to immunotherapy remain major causes of mortality. Although immune checkpoint inhibitors have improved first-line treatment for advanced biliary tract cancer, most patients do not achieve durable benefit, indicating that immune failure is not explained by a single checkpoint pathway. In this Review, we propose a spatial immune-regulatory continuum for cholangiocarcinoma dissemination. Most direct single-cell and spatial evidence currently derives from intrahepatic cholangiocarcinoma, and its applicability to perihilar and distal disease remains to be established. This continuum begins in the tumor core and invasive front, where malignant cells, cancer-associated fibroblasts, tumor-associated macrophages, endothelial and lymphatic cells, regulatory T cells, immature neutrophils and excluded or dysfunctional cytotoxic T cells form a pro-invasive ecosystem. It then extends through extracellular vesicles, soluble mediators and lymphovascular routes that may educate organotropic pre-metastatic niches. Finally, lymph node, lung, liver, peritoneal and bone microenvironments provide organ-specific extracellular matrix, myeloid and stromal programs that enable immune evasion and metastatic colonization. By integrating clinical evidence, multi-omics studies, single-cell and spatial transcriptomics, extracellular vesicle biology, pre-metastatic niche concepts and emerging therapeutic strategies, we argue that cholangiocarcinoma metastasis should be targeted before overt dissemination whenever possible. In this Review, "metastasis-intercepting immunotherapy" is used as an author-defined conceptual framework for strategies intended to prevent or disrupt the immune-stromal conditions that enable dissemination and colonization, rather than merely shrink established metastatic lesions. Metastasis-intercepting immunotherapy will likely require rational combinations that reprogram the invasive front, restore dendritic-cell-mediated antigen presentation, block tumor-stroma-myeloid circuits, disrupt EV-mediated communication that may contribute to niche formation and select patients using spatial biomarkers rather than bulk immune markers alone.
PMID:42694469 | PMC:PMC13539491 | DOI:10.3389/fimmu.2026.1919864
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(Multiomics OR Omics) AND (Pancreatic)
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Nitrogen dioxide exposure promotes CD8(+)T cell infiltration and contributes to increased susceptibility to ulcerative colitis: An integrative multi-omics, artificial intelligence, and mouse model study
J Hazard Mater. 2026 Sep 15;516:143449. doi: 10.1016/j.jhazmat.2026.143449. Epub 2026 Aug 30.ABSTRACTThe global incidence of ulcerative colitis (UC) has significantly increased in rapidly industrializing nations, with numerous studies highlighting environmental exposures, particularly nitrogen dioxide (NO2), as potential contributors to disease susceptibility. However, the clinical implications and molecular mechanisms linking NO2 exposure to UC susceptibility remain poorly understood. This stud
Nitrogen dioxide exposure promotes CD8(+)T cell infiltration and contributes to increased susceptibility to ulcerative colitis: An integrative multi-omics, artificial intelligence, and mouse model study
J Hazard Mater. 2026 Sep 15;516:143449. doi: 10.1016/j.jhazmat.2026.143449. Epub 2026 Aug 30.
ABSTRACT
The global incidence of ulcerative colitis (UC) has significantly increased in rapidly industrializing nations, with numerous studies highlighting environmental exposures, particularly nitrogen dioxide (NO2), as potential contributors to disease susceptibility. However, the clinical implications and molecular mechanisms linking NO2 exposure to UC susceptibility remain poorly understood. This study investigated the associations between NO2 and UC by integrating multi-omics data. We identified a CD8+ T cell subpopulation with a distinct phenotype characterized by perforin production, which potentially exacerbated colonic inflammation related to NO2 exposure. To validate this hypothesis, we established mouse models exposed to NO2, confirming increased CD8+ T cell infiltration and elevated perforin secretion through immunofluorescent (IF) staining. Employing artificial intelligence techniques, we identified Cell Division Cycle 25B (CDC25B) as a gene of interest correlated with putative NO2-related UC signatures. Finally, through molecular docking (MD) and molecular dynamics simulations (MDS), we identified ozanimod as one of several computationally nominated compounds associated with the CDC25B‑related network; however, none of these computational predictions were experimentally validated in the present study. Collectively, these findings suggest a correlative link between perforin or CD8+ T cell-associated colonic inflammation and NO2-associated UC susceptibility, and nominate CDC25B as a candidate gene for further investigation.
PMID:42679583 | DOI:10.1016/j.jhazmat.2026.143449
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cs.AI, q-bio.NC updates on arXiv.org
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Dynamic Dual-Granularity Skill Bank for Agentic RL
arXiv:2603.28716v2 Announce Type: replace Abstract: Agentic RL can benefit substantially from reusable experience, yet existing skill-based methods mainly extract trajectory-level guidance and often lack principled mechanisms for maintaining an evolving skill memory. We propose D2Skill, a dynamic dual-granularity skill bank for agentic RL that organizes reusable experience into task skills for high-level guidance and step skills for fine-grained decision support and error correction. D2Skill jo
Dynamic Dual-Granularity Skill Bank for Agentic RL
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cs.AI, q-bio.NC updates on arXiv.org
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SEA-Eval: A Benchmark for Evaluating Self-Evolving Agents Beyond Episodic Assessment
arXiv:2604.08988v3 Announce Type: replace Abstract: Current LLM-based agents demonstrate strong performance in episodic task execution but remain constrained by static toolsets and episodic amnesia, failing to accumulate experience across task boundaries. This paper formalizes the Self-Evolving Agent (SEA) from the perspective of digital embodiment and continuous cross-task evolution, introduces the Evolutionary Flywheel as its minimal sufficient architecture, and presents SEA-Eval -- the first
SEA-Eval: A Benchmark for Evaluating Self-Evolving Agents Beyond Episodic Assessment
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cs.AI, q-bio.NC updates on arXiv.org
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JAEGER: Joint 3D Audio-Visual Grounding and Reasoning in Simulated Physical Environments
arXiv:2602.18527v2 Announce Type: replace-cross Abstract: Current audio-visual large language models (AV-LLMs) are predominantly restricted to 2D perception, relying on RGB video and monaural audio. This design choice introduces a fundamental dimensionality mismatch that precludes reliable source localization and spatial reasoning in complex 3D environments. We address this limitation by presenting JAEGER, a framework that extends AV-LLMs to 3D space, to enable joint spatial grounding and reaso
JAEGER: Joint 3D Audio-Visual Grounding and Reasoning in Simulated Physical Environments
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cs.AI, q-bio.NC updates on arXiv.org
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Data Difficulty and the Generalization--Extrapolation Tradeoff in LLM Fine-Tuning
arXiv:2605.12906v2 Announce Type: replace-cross Abstract: Data selection during supervised fine-tuning (SFT) can critically change the behavior of large language models (LLMs). Although existing work has studied the effect of selecting data based on heuristics such as perplexity, difficulty, or length, the reported findings are often inconsistent or context-dependent. In this work, we systematically study the role of data difficulty in fine-tuning from both empirical and theoretical perspective
Data Difficulty and the Generalization--Extrapolation Tradeoff in LLM Fine-Tuning
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Omics in Gastric
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FDX1 as a predictive biomarker and therapeutic target for lymph node metastasis in gastric cancer
Clin Exp Med. 2026 May 10. doi: 10.1007/s10238-026-02160-0. Online ahead of print.ABSTRACTThe prognostic values of cuproptosis-related genes (CRGs) in gastric cancer with lymph node metastasis (GCLM), especially in the tumor immune microenvironment (TIME), remain unclear. We analyzed the expression, mutation, immunity, drug sensitivity, and prognostic value of CRGs in GCLM using TCGA and GEO cohorts. Consensus clustering was performed to identify CRG subtypes, with differences characterized by m
FDX1 as a predictive biomarker and therapeutic target for lymph node metastasis in gastric cancer
Clin Exp Med. 2026 May 10. doi: 10.1007/s10238-026-02160-0. Online ahead of print.
ABSTRACT
The prognostic values of cuproptosis-related genes (CRGs) in gastric cancer with lymph node metastasis (GCLM), especially in the tumor immune microenvironment (TIME), remain unclear. We analyzed the expression, mutation, immunity, drug sensitivity, and prognostic value of CRGs in GCLM using TCGA and GEO cohorts. Consensus clustering was performed to identify CRG subtypes, with differences characterized by multi-omics analysis. A CRG-based prognostic risk score and immune score were constructed for individualized assessment, and the role of CRGs was validated through in vitro and in vivo experiments. Consensus clustering revealed that CRGs were significantly enriched in biological processes related to mitosis and energy metabolism, as well as in immune-related and cancer-associated pathways. Four distinct CRG subtypes were identified, showing marked differences in expression profiles, prognosis, genetic alterations, TIME, and chemotherapeutic drug sensitivity. We developed an exploratory CRG-based prognostic risk score for preliminary individualized assessment, and the functional relevance of CRGs in GCLM was further validated through in vitro experiments. Among these, FDX1, LIAS, DLAT, MTF1, and GLS were identified as key determinants of overall survival in patients with GCLM, with FDX1 emerging as a potential independent prognostic factor. Notably, upregulation of FDX1 significantly suppressed lymph node metastasis of gastric cancer cells in a mouse popliteal lymph node metastasis model. Our data uncovers FDX1 might be a potential favorable prognostic factors in GCLM patients. These findings may improve our understanding of CRGs in GCLM and provide new in-sights for assessing prognosis and developing more effective treatment strategies.
PMID:42107026 | DOI:10.1007/s10238-026-02160-0
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cs.AI, q-bio.NC updates on arXiv.org
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ActionNex: A Virtual Outage Manager for Cloud
arXiv:2604.03512v1 Announce Type: new Abstract: Outage management in large-scale cloud operations remains heavily manual, requiring rapid triage, cross-team coordination, and experience-driven decisions under partial observability. We present \textbf{ActionNex}, a production-grade agentic system that supports end-to-end outage assistance, including real-time updates, knowledge distillation, and role- and stage-conditioned next-best action recommendations. ActionNex ingests multimodal operationa
ActionNex: A Virtual Outage Manager for Cloud
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cs.AI, q-bio.NC updates on arXiv.org
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Schema-Aware Planning and Hybrid Knowledge Toolset for Reliable Knowledge Graph Triple Verification
arXiv:2604.04190v1 Announce Type: new Abstract: Knowledge Graphs (KGs) serve as a critical foundation for AI systems, yet their automated construction inevitably introduces noise, compromising data trustworthiness. Existing triple verification methods, based on graph embeddings or language models, often suffer from single-source bias by relying on either internal structural constraints or external semantic evidence, and usually follow a static inference paradigm. As a result, they struggle with
Schema-Aware Planning and Hybrid Knowledge Toolset for Reliable Knowledge Graph Triple Verification
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cs.AI, q-bio.NC updates on arXiv.org
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Diagonal-Tiled Mixed-Precision Attention for Efficient Low-Bit MXFP Inference
arXiv:2604.03950v1 Announce Type: cross Abstract: Transformer-based large language models (LLMs) have demonstrated remarkable performance across a wide range of real-world tasks, but their inference cost remains prohibitively high due to the quadratic complexity of attention and the memory bandwidth limitations of high-precision operations. In this work, we present a low-bit mixed-precision attention kernel using the microscaling floating-point (MXFP) data format, utilizing the computing capabi
Diagonal-Tiled Mixed-Precision Attention for Efficient Low-Bit MXFP Inference
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cs.AI, q-bio.NC updates on arXiv.org
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ROSClaw: A Hierarchical Semantic-Physical Framework for Heterogeneous Multi-Agent Collaboration
arXiv:2604.04664v1 Announce Type: cross Abstract: The integration of large language models (LLMs) with embodied agents has improved high-level reasoning capabilities; however, a critical gap remains between semantic understanding and physical execution. While vision-language-action (VLA) and vision-language-navigation (VLN) systems enable robots to perform manipulation and navigation tasks from natural language instructions, they still struggle with long-horizon sequential and temporally struct
ROSClaw: A Hierarchical Semantic-Physical Framework for Heterogeneous Multi-Agent Collaboration
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cs.AI, q-bio.NC updates on arXiv.org
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Mind Your HEARTBEAT! Claw Background Execution Inherently Enables Silent Memory Pollution
arXiv:2603.23064v3 Announce Type: replace-cross Abstract: We identify a critical security vulnerability in mainstream Claw personal AI agents: untrusted content encountered during heartbeat-driven background execution can silently pollute agent memory and subsequently influence user-facing behavior without the user's awareness. This vulnerability arises from an architectural design shared across the Claw ecosystem: heartbeat background execution runs in the same session as user-facing conversat
Mind Your HEARTBEAT! Claw Background Execution Inherently Enables Silent Memory Pollution
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cs.AI, q-bio.NC updates on arXiv.org
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Grounded Token Initialization for New Vocabulary in LMs for Generative Recommendation
arXiv:2604.02324v1 Announce Type: cross Abstract: Language models (LMs) are increasingly extended with new learnable vocabulary tokens for domain-specific tasks, such as Semantic-ID tokens in generative recommendation. The standard practice initializes these new tokens as the mean of existing vocabulary embeddings, then relies on supervised fine-tuning to learn their representations. We present a systematic analysis of this strategy: through spectral and geometric diagnostics, we show that mean
Grounded Token Initialization for New Vocabulary in LMs for Generative Recommendation
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npj Digital Medicine
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Multidimensional evaluation of large language models in radiology report readability
npj Digital Medicine, Published online: 01 April 2026; doi:10.1038/s41746-026-02589-3Multidimensional evaluation of large language models in radiology report readability
Multidimensional evaluation of large language models in radiology report readability
npj Digital Medicine, Published online: 01 April 2026; doi:10.1038/s41746-026-02589-3
Multidimensional evaluation of large language models in radiology report readability-
cs.AI, q-bio.NC updates on arXiv.org
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ATP-Bench: Towards Agentic Tool Planning for MLLM Interleaved Generation
arXiv:2603.29902v1 Announce Type: new Abstract: Interleaved text-and-image generation represents a significant frontier for Multimodal Large Language Models (MLLMs), offering a more intuitive way to convey complex information. Current paradigms rely on either image generation or retrieval augmentation, yet they typically treat the two as mutually exclusive paths, failing to unify factuality with creativity. We argue that the next milestone in this field is Agentic Tool Planning, where the model
ATP-Bench: Towards Agentic Tool Planning for MLLM Interleaved Generation
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cs.AI, q-bio.NC updates on arXiv.org
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MultiGen: Level-Design for Editable Multiplayer Worlds in Diffusion Game Engines
arXiv:2603.06679v2 Announce Type: replace Abstract: Video world models have shown immense promise for interactive simulation and entertainment, but current systems still struggle with two important aspects of interactivity: user control over the environment for reproducible, editable experiences, and shared inference where players hold influence over a common world. To address these limitations, we introduce an explicit external memory into the system, a persistent state operating independent o
MultiGen: Level-Design for Editable Multiplayer Worlds in Diffusion Game Engines
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cs.AI, q-bio.NC updates on arXiv.org
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QuestA: Expanding Reasoning Capacity in LLMs via Question Augmentation
arXiv:2507.13266v4 Announce Type: replace-cross Abstract: Reinforcement learning (RL) has emerged as a central paradigm for training large language models (LLMs) in reasoning tasks. Yet recent studies question RL's ability to incentivize reasoning capacity beyond the base model. This raises a key challenge: how can RL be adapted to solve harder reasoning problems more effectively? To address this challenge, we propose a simple yet effective strategy via Question Augmentation: introduce partial