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cs.AI, q-bio.NC updates on arXiv.org
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VBVR-Pro: A Scalable and Verifiable Suite for Native Visual Reasoning
arXiv:2608.26105v2 Announce Type: replace-cross Abstract: Native visual reasoning treats visual generation as the medium of reasoning itself: visual states (i.e. images and videos) are not merely inputs to be understood or outputs to be rendered, but first-class substrates for problem solving beyond language. Yet progress remains bottlenecked by the lack of scalable training tasks, reliable feedback, and controlled comparisons across generative substrates. In this work, we introduce VBVR-Pro, a
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Omics in Hepatocellular
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Stromal ACTA2 Counteracts TCDD-Induced Hepatocarcinogenesis via Suppression of the PI3K-AKT-mTOR Pathway
J Hepatocell Carcinoma. 2026 May 10;13:586916. doi: 10.2147/JHC.S586916. eCollection 2026.ABSTRACTPURPOSE: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental pollutant that promotes hepatocellular carcinoma (HCC) through non-genotoxic mechanisms. However, stromal regulatory factors that counteract its tumor-promoting effects remain poorly defined. This study aimed to elucidate the role of actin alpha-2 (ACTA2) in TCDD-associated hepatocarcinogenesis.METHODS: An integrative
Stromal ACTA2 Counteracts TCDD-Induced Hepatocarcinogenesis via Suppression of the PI3K-AKT-mTOR Pathway
J Hepatocell Carcinoma. 2026 May 10;13:586916. doi: 10.2147/JHC.S586916. eCollection 2026.
ABSTRACT
PURPOSE: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental pollutant that promotes hepatocellular carcinoma (HCC) through non-genotoxic mechanisms. However, stromal regulatory factors that counteract its tumor-promoting effects remain poorly defined. This study aimed to elucidate the role of actin alpha-2 (ACTA2) in TCDD-associated hepatocarcinogenesis.
METHODS: An integrative strategy combining network toxicology, Mendelian randomization, multi-omics and single-cell analyses, molecular docking and molecular dynamics simulations, along with in vitro experiments, was employed to investigate the functional role of ACTA2.
RESULTS: ACTA2 was identified as a stromal-associated factor linked to reduced HCC risk and improved patient survival. Single-cell and multi-omics analyses revealed that ACTA2 is predominantly expressed in hepatic stellate cells and fibroblast-like populations, reflecting tumor microenvironment composition rather than tumor cell-intrinsic expression. Functional enrichment analyses indicated that ACTA2 is associated with extracellular matrix remodeling and PI3K-AKT signaling. Molecular simulations demonstrated stable binding of TCDD to ACTA2 (ΔG_bind ≈ -7.05 kcal/mol), suggesting potential structural perturbation. In vitro experiments showed that TCDD downregulated ACTA2 expression, promoted proliferation of LX-2 and cancer-associated fibroblasts (CAFs), and activated PI3K-AKT-mTOR signaling, whereas ACTA2 overexpression attenuated these effects.
CONCLUSION: ACTA2 acts as a context-dependent stromal regulator that modulates PI3K-AKT-mTOR signaling in TCDD-induced hepatocarcinogenesis. These findings highlight the importance of stromal remodeling in environmental carcinogenesis and suggest ACTA2 as a potential biomarker and therapeutic target in dioxin-associated HCC.
PMID:42148320 | PMC:PMC13175077 | DOI:10.2147/JHC.S586916
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cs.AI, q-bio.NC updates on arXiv.org
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DriveDreamer-Policy: A Geometry-Grounded World-Action Model for Unified Generation and Planning
arXiv:2604.01765v1 Announce Type: cross Abstract: Recently, world-action models (WAM) have emerged to bridge vision-language-action (VLA) models and world models, unifying their reasoning and instruction-following capabilities and spatio-temporal world modeling. However, existing WAM approaches often focus on modeling 2D appearance or latent representations, with limited geometric grounding-an essential element for embodied systems operating in the physical world. We present DriveDreamer-Policy
DriveDreamer-Policy: A Geometry-Grounded World-Action Model for Unified Generation and Planning
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cs.AI, q-bio.NC updates on arXiv.org
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Adaptation of Agentic AI: A Survey of Post-Training, Memory, and Skills
arXiv:2512.16301v3 Announce Type: replace Abstract: Large language model (LLM) agents are moving beyond prompting alone. ChatGPT marked the rise of general-purpose LLM assistants, DeepSeek showed that on-policy reinforcement learning with verifiable rewards can improve reasoning and tool use, and OpenClaw highlights a newer direction in which agents accumulate persistent memory and reusable skills. Yet the research landscape remains fragmented across post-training, retrieval, memory, and skill
Adaptation of Agentic AI: A Survey of Post-Training, Memory, and Skills
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cs.AI, q-bio.NC updates on arXiv.org
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DrivingGen: A Comprehensive Benchmark for Generative Video World Models in Autonomous Driving
arXiv:2601.01528v2 Announce Type: replace-cross Abstract: Video generation models, as one form of world models, have emerged as one of the most exciting frontiers in AI, promising agents the ability to imagine the future by modeling the temporal evolution of complex scenes. In autonomous driving, this vision gives rise to driving world models: generative simulators that imagine ego and agent futures, enabling scalable simulation, safe testing of corner cases, and rich synthetic data generation.
DrivingGen: A Comprehensive Benchmark for Generative Video World Models in Autonomous Driving
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cs.AI, q-bio.NC updates on arXiv.org
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Joint Training Across Multiple Activation Sparsity Regimes
arXiv:2603.03131v1 Announce Type: cross Abstract: Generalization in deep neural networks remains only partially understood. Inspired by the stronger generalization tendency of biological systems, we explore the hypothesis that robust internal representations should remain effective across both dense and sparse activation regimes. To test this idea, we introduce a simple training strategy that applies global top-k constraints to hidden activations and repeatedly cycles a single model through mul