Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Dynamic Expert Quantization for Scalable Mixture-of-Experts Inference
arXiv:2511.15015v4 Announce Type: replace-cross Abstract: Mixture-of-Experts (MoE) has become a practical architecture for scaling LLM capacity while keeping per-token compute modest, but deploying MoE models on a single, memory-limited GPU remains difficult because expert weights dominate the HBM footprint. Existing expert offloading and prefetching systems reduce the resident set, yet they often pay expert-loading costs on the critical path when activation becomes dense. Post-training quantiz
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cs.AI, q-bio.NC updates on arXiv.org
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Denoising as Projection: Constrained Optimization with Gradient-Guided Diffusion
arXiv:2608.29507v2 Announce Type: replace-cross Abstract: Diffusion models are increasingly used not only for sampling from learned data distributions, but also for generating samples that optimize task-specific objectives. A common approach is to guide the reverse diffusion process using gradients of an external objective. However, when the data distribution is supported on a structured feasible set, such as a manifold or a constraint set, gradient guidance can move samples away from the learn
Denoising as Projection: Constrained Optimization with Gradient-Guided Diffusion
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cs.AI, q-bio.NC updates on arXiv.org
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Adaptive Entangled Game Modules in Artificial General Intelligence
arXiv:2609.09226v1 Announce Type: new Abstract: We introduce a probability-wave framework for modeling the collective behavior of interacting adaptive agents, deriving testable eigenmodes through a generalized behavioral intelligence (GBI) nonlocal probability-wave equation. This framework captures a broad range of human intelligence behaviors with analytical mechanisms and offers an indirect method to examine the Liu-Chen-Ao (LCA) hypothesis of nonlocal entangled nerve fibers in the brain thro
Adaptive Entangled Game Modules in Artificial General Intelligence
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Omics In Lung
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Early stage nonsmall cell lung cancer: Toward a risk-adaptive paradigm in the era of biologic precision
CA Cancer J Clin. 2026 Sep-Oct;76(5):e70100. doi: 10.3322/caac.70100.ABSTRACTThe clinical landscape of early stage nonsmall cell lung cancer is at transformative crossroads. Driven by the widespread adoption of low-dose computed tomography screening, the frequent detection of ground-glass opacities, and a rising incidence among never-smokers, the diagnostic center of gravity has shifted toward earlier, potentially curable disease. This shift has been accompanied by equally important therapeutic
Early stage nonsmall cell lung cancer: Toward a risk-adaptive paradigm in the era of biologic precision
CA Cancer J Clin. 2026 Sep-Oct;76(5):e70100. doi: 10.3322/caac.70100.
ABSTRACT
The clinical landscape of early stage nonsmall cell lung cancer is at transformative crossroads. Driven by the widespread adoption of low-dose computed tomography screening, the frequent detection of ground-glass opacities, and a rising incidence among never-smokers, the diagnostic center of gravity has shifted toward earlier, potentially curable disease. This shift has been accompanied by equally important therapeutic advances, including parenchyma-sparing surgical techniques, minimally invasive platforms enhanced by digital navigation, and the transformative integration of perioperative immunotherapy and targeted agents. Concurrently, noninvasive monitoring approaches, such as liquid biopsy, have emerged as powerful tools to guide precision management. Despite this progress, substantial barriers to achieving a universal cure persist. Clinicians continue to face uncertainty in the management of ground-glass opacities, the anatomy-based TNM staging system fails to capture the biologic heterogeneity of early tumors, and global disparities in access to innovation remain unresolved. To address these challenges, the authors propose a shift toward a risk-adaptive management paradigm that harnesses artificial intelligence-driven analytics and multi-omics profiling to tailor treatment intensity according to each patient's biologic risk. Such an approach would enable appropriate escalation for high-risk individuals while permitting safe de-escalation for those at low risk. This holistic, lifespan-oriented strategy must be embraced to deliver equitable and durable cures for patients with early stage nonsmall cell lung cancer.
PMID:42713910 | PMC:PMC13555834 | DOI:10.3322/caac.70100
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Early stage nonsmall cell lung cancer: Toward a risk-adaptive paradigm in the era of biologic precision
CA Cancer J Clin. 2026 Sep-Oct;76(5):e70100. doi: 10.3322/caac.70100.ABSTRACTThe clinical landscape of early stage nonsmall cell lung cancer is at transformative crossroads. Driven by the widespread adoption of low-dose computed tomography screening, the frequent detection of ground-glass opacities, and a rising incidence among never-smokers, the diagnostic center of gravity has shifted toward earlier, potentially curable disease. This shift has been accompanied by equally important therapeutic
Early stage nonsmall cell lung cancer: Toward a risk-adaptive paradigm in the era of biologic precision
CA Cancer J Clin. 2026 Sep-Oct;76(5):e70100. doi: 10.3322/caac.70100.
ABSTRACT
The clinical landscape of early stage nonsmall cell lung cancer is at transformative crossroads. Driven by the widespread adoption of low-dose computed tomography screening, the frequent detection of ground-glass opacities, and a rising incidence among never-smokers, the diagnostic center of gravity has shifted toward earlier, potentially curable disease. This shift has been accompanied by equally important therapeutic advances, including parenchyma-sparing surgical techniques, minimally invasive platforms enhanced by digital navigation, and the transformative integration of perioperative immunotherapy and targeted agents. Concurrently, noninvasive monitoring approaches, such as liquid biopsy, have emerged as powerful tools to guide precision management. Despite this progress, substantial barriers to achieving a universal cure persist. Clinicians continue to face uncertainty in the management of ground-glass opacities, the anatomy-based TNM staging system fails to capture the biologic heterogeneity of early tumors, and global disparities in access to innovation remain unresolved. To address these challenges, the authors propose a shift toward a risk-adaptive management paradigm that harnesses artificial intelligence-driven analytics and multi-omics profiling to tailor treatment intensity according to each patient's biologic risk. Such an approach would enable appropriate escalation for high-risk individuals while permitting safe de-escalation for those at low risk. This holistic, lifespan-oriented strategy must be embraced to deliver equitable and durable cures for patients with early stage nonsmall cell lung cancer.
PMID:42713910 | DOI:10.3322/caac.70100
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Nature - Issue - nature.com science feeds
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Imaging cellular activity across all organs reveals body-wide circuits
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10979-6An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.
Imaging cellular activity across all organs reveals body-wide circuits
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10979-6
An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.-
Cell
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Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer
By selectively targeting peripheral 5-HT2AR without inducing psychedelic effects, a non-brain-penetrant agonist boosts antitumor CD8+ T cell immunity and improves immunotherapy responses in preclinical models of colorectal cancer.
Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer
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cs.AI, q-bio.NC updates on arXiv.org
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Neural Scalable Symbolic Search Framework for Complex Logical Queries with Multiple Free Variables
arXiv:2605.25985v1 Announce Type: new Abstract: Complex Query Answering (CQA) is a fundamental knowledge representation and reasoning task over incomplete knowledge graphs (KGs). Answering existential first-order queries with $k$ free variables (i.e., $\text{EFO}_k$ queries) is a crucial yet challenging problem, as it requires ranking answer tuples in $\mathcal{E}^k$, where $\mathcal{E}$ denotes the entity set of a KG. This quickly becomes intractable as $k$ grows. Consequently, existing benchm
Neural Scalable Symbolic Search Framework for Complex Logical Queries with Multiple Free Variables
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cs.AI, q-bio.NC updates on arXiv.org
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Towards a Universal Causal Reasoner
arXiv:2605.24873v1 Announce Type: cross Abstract: Despite the importance of causal reasoning, training LLMs to reason causally remains underexplored. Existing data efforts mostly focus on benchmarking LLMs on specific aspects of causality, making them less suitable for training generalizable causal reasoners. To address this, we propose UniCo, a data generation framework that both (1) addresses 18 causal query types across Pearl's Causal Ladder and (2) translates natively symbolic examples into
Towards a Universal Causal Reasoner
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cs.AI, q-bio.NC updates on arXiv.org
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RealBench: Benchmarking Data-Driven Numerical Weather Forecasting Under Operational Conditions and Extreme Event Challenges
arXiv:2605.24945v1 Announce Type: cross Abstract: Accurate evaluation of weather forecasting models is critical for their reliable deployment in real-world applications. However, existing benchmarks predominantly rely on reanalysis products such as ERA5, which are generated through delayed data assimilation and do not reflect the constraints of real-time operational forecasting, thereby resulting in a systematic mismatch between benchmark performance and real-world forecasting. In this work, we
RealBench: Benchmarking Data-Driven Numerical Weather Forecasting Under Operational Conditions and Extreme Event Challenges
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cs.AI, q-bio.NC updates on arXiv.org
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Efficient and Scalable Neural Symbolic Search for Knowledge Graph Complex Query Answering
arXiv:2505.08155v4 Announce Type: replace Abstract: Complex Query Answering (CQA) is a crucial reasoning task over Knowledge Graphs (KGs), which aims to answer first-order logical queries from incomplete KGs. While existing neural-symbolic methods achieve strong performance, they face significant complexity bottlenecks: quadratic data complexity scaling with the number of entities, and NP-hard query complexity for cyclic queries. Consequently, these approaches struggle to scale effectively to l
Efficient and Scalable Neural Symbolic Search for Knowledge Graph Complex Query Answering
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cs.AI, q-bio.NC updates on arXiv.org
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MMUEChange: A Generalized LLM Agent Framework for Intelligent Multi-Modal Urban Environment Change Analysis
arXiv:2601.05483v2 Announce Type: replace Abstract: Understanding urban environment change is essential for sustainable development. However, current approaches, particularly remote sensing change detection, often rely on rigid, single-modal analysis. To overcome these limitations, we propose MMUEChange, a multi-modal agent framework that flexibly integrates heterogeneous urban data via a modular toolkit and a core module, Modality Controller for cross- and intra-modal alignment, enabling robus
MMUEChange: A Generalized LLM Agent Framework for Intelligent Multi-Modal Urban Environment Change Analysis
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cs.AI, q-bio.NC updates on arXiv.org
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M$^\star$: Every Task Deserves Its Own Memory Harness
arXiv:2604.11811v2 Announce Type: replace-cross Abstract: Large language model agents rely on specialized memory systems to accumulate and reuse knowledge during extended interactions. Recent architectures typically adopt a fixed memory design tailored to specific domains, such as semantic retrieval for conversations or skills reused for coding. However, a memory system optimized for one purpose frequently fails to transfer to others. To address this limitation, we introduce M$^\star$, a method
M$^\star$: Every Task Deserves Its Own Memory Harness
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Nature - Issue - nature.com science feeds
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Cities affect small and large storms differently
Nature, Published online: 20 May 2026; doi:10.1038/d41586-026-01323-zAnalysis of a 23-year record of Texan storms reveals how urban landscapes affect storm rainfall — painting a more complex picture than had been realized.
Cities affect small and large storms differently
Nature, Published online: 20 May 2026; doi:10.1038/d41586-026-01323-z
Analysis of a 23-year record of Texan storms reveals how urban landscapes affect storm rainfall — painting a more complex picture than had been realized.-
Oncogenesis - nature.com science feeds
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Ubiquitin-specific protease 11 suppresses cuproptosis in colorectal cancer by regulating the ubiquitination and stability of ISCU
Oncogenesis, Published online: 08 May 2026; doi:10.1038/s41389-026-00621-5Ubiquitin-specific protease 11 suppresses cuproptosis in colorectal cancer by regulating the ubiquitination and stability of ISCU
Ubiquitin-specific protease 11 suppresses cuproptosis in colorectal cancer by regulating the ubiquitination and stability of ISCU
Oncogenesis, Published online: 08 May 2026; doi:10.1038/s41389-026-00621-5
Ubiquitin-specific protease 11 suppresses cuproptosis in colorectal cancer by regulating the ubiquitination and stability of ISCU-
Cell
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Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models
A mitochondrial transplantation approach rescues mitochondrial deficiency and prevents mitochondrial DNA depletion syndrome, Leigh syndrome, and Parkinson’s disease in cellular and mouse models.
Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models
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Cell
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Thermodynamic prediction of RNA cellular activity from sequence via conformational ensembles
The RNA sequence of HIV-1 TAR was systematically altered to change its propensity to adopt a functional secondary structure in the ensemble, measured using 1H CEST NMR. These minor sequence changes shifted the active-state propensity by ∼500-fold, quantitatively predicting changes in protein binding and cellular transactivation. These propensities could be inferred from secondary-structure prediction algorithms and incorporated into a thermodynamic framework to quantitatively predict how sequenc
Thermodynamic prediction of RNA cellular activity from sequence via conformational ensembles
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cs.AI, q-bio.NC updates on arXiv.org
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Optimizing Service Operations via LLM-Powered Multi-Agent Simulation
arXiv:2604.04383v1 Announce Type: new Abstract: Service system performance depends on how participants respond to design choices, but modeling these responses is hard due to the complexity of human behavior. We introduce an LLM-powered multi-agent simulation (LLM-MAS) framework for optimizing service operations. We pose the problem as stochastic optimization with decision-dependent uncertainty: design choices are embedded in prompts and shape the distribution of outcomes from interacting LLM-po
Optimizing Service Operations via LLM-Powered Multi-Agent Simulation
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cs.AI, q-bio.NC updates on arXiv.org
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GUIDE: Interpretable GUI Agent Evaluation via Hierarchical Diagnosis
arXiv:2604.04399v1 Announce Type: new Abstract: Evaluating GUI agents presents a distinct challenge: trajectories are long, visually grounded, and open-ended, yet evaluation must be both accurate and interpretable. Existing approaches typically apply a single holistic judgment over the entire action-observation sequence-a strategy that proves unreliable on long-horizon tasks and yields binary verdicts offering no insight into where or why an agent fails. This opacity limits the utility of evalu
GUIDE: Interpretable GUI Agent Evaluation via Hierarchical Diagnosis
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cs.AI, q-bio.NC updates on arXiv.org
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Mind Your HEARTBEAT! Claw Background Execution Inherently Enables Silent Memory Pollution
arXiv:2603.23064v3 Announce Type: replace-cross Abstract: We identify a critical security vulnerability in mainstream Claw personal AI agents: untrusted content encountered during heartbeat-driven background execution can silently pollute agent memory and subsequently influence user-facing behavior without the user's awareness. This vulnerability arises from an architectural design shared across the Claw ecosystem: heartbeat background execution runs in the same session as user-facing conversat