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Skin-innervating glutamatergic neurons modulate aging

Within the skin, glutamatergic neurons expressing neurofilament heavy chain (Nefh) play a role in aging. Loss of Nefh during aging drives skin fibroblast senescence and collagen loss, whereas glutamate supplementation improves skin aging phenotypes.

No Attacker Needed: Unintentional Cross-User Contamination in Shared-State LLM Agents

arXiv:2604.01350v1 Announce Type: cross Abstract: LLM-based agents increasingly operate across repeated sessions, maintaining task states to ensure continuity. In many deployments, a single agent serves multiple users within a team or organization, reusing a shared knowledge layer across user identities. This shared persistence expands the failure surface: information that is locally valid for one user can silently degrade another user's outcome when the agent reapplies it without regard for scope. We refer to this failure mode as unintentional cross-user contamination (UCC). Unlike adversarial memory poisoning, UCC requires no attacker; it arises from benign interactions whose scope-bound artifacts persist and are later misapplied. We formalize UCC through a controlled evaluation protocol, introduce a taxonomy of three contamination types, and evaluate the problem in two shared-state mechanisms. Under raw shared state, benign interactions alone produce contamination rates of 57--71%. A write-time sanitization is effective when shared state is conversational, but leaves substantial residual risk when shared state includes executable artifacts, with contamination often manifesting as silent wrong answers. These results indicate that shared-state agents need artifact-level defenses beyond text-level sanitization to prevent silent cross-user failures.

SmartBench: Evaluating LLMs in Smart Homes with Anomalous Device States and Behavioral Contexts

arXiv:2603.06636v1 Announce Type: cross Abstract: Due to the strong context-awareness capabilities demonstrated by large language models (LLMs), recent research has begun exploring their integration into smart home assistants to help users manage and adjust their living environments. While LLMs have been shown to effectively understand user needs and provide appropriate responses, most existing studies primarily focus on interpreting and executing user behaviors or instructions. However, a critical function of smart home assistants is the ability to detect when the home environment is in an anomalous state. This involves two key requirements: the LLM must accurately determine whether an anomalous condition is present, and provide either a clear explanation or actionable suggestions. To enhance the anomaly detection capabilities of next-generation LLM-based smart home assistants, we introduce SmartBench, which is the first smart home dataset designed for LLMs, containing both normal and anomalous device states as well as normal and anomalous device state transition contexts. We evaluate 13 mainstream LLMs on this benchmark. The experimental results show that most state-of-the-art models cannot achieve good anomaly detection performance. For example, Claude-Sonnet-4.5 achieves only 66.1% detection accuracy on context-independent anomaly categories, and performs even worse on context-dependent anomalies, with an accuracy of only 57.8%. More experimental results suggest that next-generation LLM-based smart home assistants are still far from being able to effectively detect and handle anomalous conditions in the smart home environment. Our dataset is publicly available at https://github.com/horizonsinzqs/SmartBench.

aCAPTCHA: Verifying That an Entity Is a Capable Agent via Asymmetric Hardness

arXiv:2603.07116v1 Announce Type: cross Abstract: As autonomous AI agents increasingly populate the Internet, a novel security challenge arises: "Is this entity an AI agent?" It is a new entity-type verification problem with no established solution. We formalize the problem through a three-class entity taxonomy (Human, Script, Agent) based on a verifiable agentic capability vector (action, reasoning, and memory). A timing threshold t exploits the asymmetric hardness between human cognition and AI processing to separate the three classes. We define the Agentic Capability Verification Problem (ACVP) through three necessity primitives, each testing one capability dimension. Building on this foundation, we introduce aCAPTCHA (Agent CAPTCHA), a time-constrained security game for agent admission whose security rests on ACVP hardness under t. We instantiate aCAPTCHA through time-bounded natural-language understanding as a multi-round HTTP verification protocol, and evaluate it with preliminary agent trials that validate the protocol's soundness and completeness. aCAPTCHA provides a composable, infrastructure-free admission gate for any service where entity-type verification is required.
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