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Detecting Structural Heart Disease from Electrocardiograms via a Generalized Additive Model of Interpretable Foundation-Model Predictors

arXiv:2603.02616v1 Announce Type: cross Abstract: Structural heart disease (SHD) is a prevalent condition with many undiagnosed cases, and early detection is often limited by the high cost and accessibility constraints of echocardiography (ECHO). Recent studies show that artificial intelligence (AI)-based analysis of electrocardiograms (ECGs) can detect SHD, offering a scalable alternative. However, existing methods are fully black-box models, limiting interpretability and clinical adoption. To address these challenges, we propose an interpretable and effective framework that integrates clinically meaningful ECG foundation-model predictors within a generalized additive model, enabling transparent risk attribution while maintaining strong predictive performance. Using the EchoNext benchmark of over 80,000 ECG-ECHO pairs, the method demonstrates relative improvements of +0.98% in AUROC, +1.01% in AUPRC, and +1.41% in F1 score over the latest state-of-the-art deep-learning baseline, while achieving slightly better performance even with only 30% of the training data. Subgroup analyses confirm robust performance across heterogeneous populations, and the estimated entry-wise functions provide interpretable insights into the relationships between risks of traditional ECG diagnoses and SHD. This work illustrates a complementary paradigm between classical statistical modeling and modern AI, offering a pathway to interpretable, high-performing, and clinically actionable ECG-based SHD screening.

CoFL: Continuous Flow Fields for Language-Conditioned Navigation

arXiv:2603.02854v1 Announce Type: cross Abstract: Language-conditioned navigation pipelines often rely on brittle modular components or costly action-sequence generation. To address these limitations, we present CoFL, an end-to-end policy that directly maps a bird's-eye view (BEV) observation and a language instruction to a continuous flow field for navigation. Instead of predicting discrete action tokens or sampling action chunks via iterative denoising, CoFL outputs instantaneous velocities that can be queried at arbitrary 2D projected locations. Trajectories are obtained by numerical integration of the predicted field, producing smooth motion that remains reactive under closed-loop execution. To enable large-scale training, we build a dataset of over 500k BEV image-instruction pairs, each procedurally annotated with a flow field and a trajectory derived from BEV semantic maps built on Matterport3D and ScanNet. By training on a mixed distribution, CoFL significantly outperforms modular Vision-Language Model (VLM)-based planners and generative policy baselines on strictly unseen scenes. Finally, we deploy CoFL zero-shot in real-world experiments with overhead BEV observations across multiple layouts, maintaining reliable closed-loop control and a high success rate.

NeuroWise: A Multi-Agent LLM "Glass-Box" System for Practicing Double-Empathy Communication with Autistic Partners

arXiv:2602.18962v2 Announce Type: replace-cross Abstract: The double empathy problem frames communication difficulties between neurodivergent and neurotypical individuals as arising from mutual misunderstanding, yet most interventions focus on autistic individuals. We present NeuroWise, a multi-agent LLM-based coaching system that supports neurotypical users through stress visualization, interpretation of internal experiences, and contextual guidance. In a between-subjects study (N=30), NeuroWise was rated as helpful by all participants and showed a significant condition-time effect on deficit-based attributions (p=0.02): NeuroWise users reduced deficit framing, while baseline users shifted toward blaming autistic "deficits" after difficult interactions. NeuroWise users also completed conversations more efficiently (37% fewer turns, p=0.03). These findings suggest that AI-based interpretation can support attributional change by helping users recognize communication challenges as mutual.
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