arXiv:2603.03322v1 Announce Type: cross Abstract: Recent advancements in Large Language Model (LLM) agents have demonstrated remarkable potential in automatic knowledge discovery. However, rigorously evaluating an AI's capacity for knowledge discovery remains a critical challenge. Existing benchmarks predominantly rely on static datasets, leading to inevitable data contamination where models have likely seen the evaluation knowledge during training. Furthermore, the rapid release cycles of modern LLMs render static benchmarks quickly outdated, failing to assess the ability to discover truly new knowledge. To address these limitations, we propose DBench-Bio, a dynamic and fully automated benchmark designed to evaluate AI's biological knowledge discovery ability. DBench-Bio employs a three-stage pipeline: (1) data acquisition of rigorous, authoritative paper abstracts; (2) QA extraction utilizing LLMs to synthesize scientific hypothesis questions and corresponding discovery answers; and (3) QA filter to ensure quality based on relevance, clarity, and centrality. We instantiate this pipeline to construct a monthly-updated benchmark covering 12 biomedical sub-domains. Extensive evaluations of SOTA models reveal current limitations in discovering new knowledge. Our work provides the first dynamic, automatic framework for assessing the new knowledge discovery capabilities of AI systems, establishing a living, evolving resource for AI research community to catalyze the development of knowledge discovery.

arXiv:2603.02262v1 Announce Type: cross Abstract: Supervised fine-tuning (SFT) is essential for the development of medical large language models (LLMs), yet prior poisoning studies have mainly focused on the detectable backdoor attacks. We propose a novel poisoning attack targeting the reasoning process of medical LLMs during SFT. Unlike backdoor attacks, our method injects poisoned rationales into few-shot training data, leading to stealthy degradation of model performance on targeted medical topics. Results showed that knowledge overwriting was ineffective, while rationale poisoning caused significant decline on the accuracy of the target subject, as long as no correct samples of the same subject appear in the dataset. A minimum number and ratio of poisoned samples was needed to carry out an effective and stealthy attack, which was more efficient and accurate than catastrophic forgetting. We demonstrate though this study the risk of SFT-stage poisoning, hoping to spur more studies of defense in the sensitive medical domain.