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Received — 26 March 2026 ⏭

Nature - Issue - nature.com science feeds
Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity Sam O. Kleeman · Kevin Michalski · Xiang Zhao · Ruben Steigerwald · Miriam Ferrer · Llewelyn Levett · Ethan Ertel · Austin Schultz · Noriko Simorowski · Pamela Moody · Tse-Luen Wee · Cristina Valente · Sharon Fox · Mateusz Makuch · Selina Thomsen · Ruby Harrison · Claire Regan · Jonathan Preall · Qing Gao · Dennis Thomas · Jill Habel · Rachel Rubino · Sarosh Irani · Hiro Furukawa · Tobias Janowitz
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10278-0NMDAR expression is sufficient to induce B cell recruitment and affinity maturation, resulting in receptor-modulating antibodies that connect anti-cancer immunity and autoimmunity.
25 March 2026 at 08:00

Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity

Nature - Issue - nature.com science feeds

By: Sam O. Kleeman · Kevin Michalski · Xiang Zhao · Ruben Steigerwald · Miriam Ferrer · Llewelyn Levett · Ethan Ertel · Austin Schultz · Noriko Simorowski · Pamela Moody · Tse-Luen Wee · Cristina Valente · Sharon Fox · Mateusz Makuch · Selina Thomsen · Ruby Harrison · Claire Regan · Jonathan Preall · Qing Gao · Dennis Thomas · Jill Habel · Rachel Rubino · Sarosh Irani · Hiro Furukawa · Tobias Janowitz

25 March 2026 at 08:00

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10278-0

NMDAR expression is sufficient to induce B cell recruitment and affinity maturation, resulting in receptor-modulating antibodies that connect anti-cancer immunity and autoimmunity.