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Journal of Medical Internet Research
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Robot-Assisted Therapy for Upper Limb Rehabilitation After Stroke: Umbrella Review
Background: Stroke is a leading cause of long-term upper limb disability, severely impacting patients’ independence and quality of life. Robot-assisted therapy (RAT) has emerged as a promising, high-intensity rehabilitation alternative. However, conclusions from existing systematic reviews on its efficacy are inconsistent and often lack a holistic framework, limiting their use for guiding personalized clinical decisions. Objective: This study aims to systematically synthesize recent evidence on
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cs.AI, q-bio.NC updates on arXiv.org
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FAAR: Format-Aware Adaptive Rounding for NVFP4
arXiv:2603.22370v1 Announce Type: cross Abstract: Deploying large language models (LLMs) on edge devices requires extremely low-bit quantization. Ultra-low precision formats such as NVFP4 offer a promising solution for reducing memory footprint and accelerating computation. However, existing quantization methods typically rely on conventional rounding strategies and fail to account for the non-uniformity of the NVFP4 numerical grid, resulting in suboptimal rounding decisions and amplified quant
FAAR: Format-Aware Adaptive Rounding for NVFP4
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cs.AI, q-bio.NC updates on arXiv.org
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An Accurate and Interpretable Framework for Trustworthy Process Monitoring
arXiv:2302.10426v3 Announce Type: replace Abstract: Trustworthy process monitoring seeks to build an accurate and interpretable monitoring framework, which is critical for ensuring the safety of energy conversion plant (ECP) that operates under extreme working conditions such as high pressure and temperature. Contemporary self-attentive models, however, fall short in this domain for two main reasons. First, they rely on step-wise correlations that fail to involve physically meaningful semantics
An Accurate and Interpretable Framework for Trustworthy Process Monitoring
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cs.AI, q-bio.NC updates on arXiv.org
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From Context to Intent: Reasoning-Guided Function-Level Code Completion
arXiv:2508.09537v2 Announce Type: replace-cross Abstract: The growing capabilities of Large Language Models (LLMs) have led to their widespread adoption for function completion within code repositories. Recent studies on such tasks show promising results when explicit instructions, often in the form of docstrings, are available to guide the completion. However, in real-world scenarios, clear docstrings are frequently absent. Under such conditions, LLMs typically fail to produce accurate complet
From Context to Intent: Reasoning-Guided Function-Level Code Completion
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Omics in Gastric
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19-Hydroxybufalin Inhibits Gastric Cancer Cell Proliferation by Modulating Metabolic Reprogramming
J Proteome Res. 2026 Apr 3;25(4):2014-2023. doi: 10.1021/acs.jproteome.5c00983. Epub 2026 Mar 17.ABSTRACTOBJECTIVE: 19-Hydroxybufalin (19-H) is a natural bioactive compound with anticancer potential, but its molecular target and mechanism of action remain unclear. This study aimed to systematically evaluate its antigastric cancer activity and identify potential molecular targets.METHODS: The antitumor effect of 19-H was evaluated in both in vitro and in vivo models. Multiomics analysis, thermal
19-Hydroxybufalin Inhibits Gastric Cancer Cell Proliferation by Modulating Metabolic Reprogramming
J Proteome Res. 2026 Apr 3;25(4):2014-2023. doi: 10.1021/acs.jproteome.5c00983. Epub 2026 Mar 17.
ABSTRACT
OBJECTIVE: 19-Hydroxybufalin (19-H) is a natural bioactive compound with anticancer potential, but its molecular target and mechanism of action remain unclear. This study aimed to systematically evaluate its antigastric cancer activity and identify potential molecular targets.
METHODS: The antitumor effect of 19-H was evaluated in both in vitro and in vivo models. Multiomics analysis, thermal proteome profiling, molecular docking, and molecular dynamics simulations were employed to elucidate the mechanism of action. Functional assays were further conducted to validate the key target.
RESULTS: 19-H exhibited nanomolar-level inhibitory activity against various gastric cancer cell lines, significantly suppressing tumor growth in subcutaneous xenograft and patient-derived xenograft models. Multiomics analysis revealed that 19-H reshaped metabolic pathways in gastric cancer. TPP screening identified PLPP2 as a potential target with significantly increased thermal stability upon 19-H treatment. Molecular simulations further revealed that 19-H binds stably to the α-helical region of PLPP2.
CONCLUSIONS: 19-H exerts its antigastric cancer effect by targeting PLPP2 and remodeling the metabolic network. PLPP2 may represent a novel therapeutic target for gastric cancer.
PMID:41842934 | DOI:10.1021/acs.jproteome.5c00983