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Received β€” 26 March 2026 ⏭

Memory Bear AI Memory Science Engine for Multimodal Affective Intelligence: A Technical Report

βœ‡cs.AI, q-bio.NC updates on arXiv.org
By: Deliang Wen Β· Ke Sun Β· Yu Wang
25 March 2026 at 12:00
arXiv:2603.22306v1 Announce Type: new Abstract: Affective judgment in real interaction is rarely a purely local prediction problem. Emotional meaning often depends on prior trajectory, accumulated context, and multimodal evidence that may be weak, noisy, or incomplete at the current moment. Although multimodal emotion recognition (MER) has improved the integration of text, speech, and visual signals, many existing systems remain optimized for short-range inference and provide limited support for persistent affective memory, long-horizon dependency modeling, and robust interpretation under imperfect input. This technical report presents the Memory Bear AI Memory Science Engine, a memory-centered framework for multimodal affective intelligence. Instead of treating emotion as a transient output label, the framework models affective information as a structured and evolving variable within a memory system. It organizes processing through structured memory formation, working-memory aggregation, long-term consolidation, memory-driven retrieval, dynamic fusion calibration, and continuous memory updating. At its core, multimodal signals are transformed into structured Emotion Memory Units (EMUs), enabling affective information to be preserved, reactivated, and revised across interaction horizons. Experimental results show consistent gains over comparison systems across benchmark and business-grounded settings, with stronger accuracy and robustness, especially under noisy or missing-modality conditions. The framework offers a practical step from local emotion recognition toward more continuous, robust, and deployment-relevant affective intelligence.

Geometric Mixture-of-Experts with Curvature-Guided Adaptive Routing for Graph Representation Learning

βœ‡cs.AI, q-bio.NC updates on arXiv.org
By: Haifang Cao Β· Yu Wang Β· Timing Li Β· Xinjie Yao Β· Pengfei Zhu
25 March 2026 at 12:00
arXiv:2603.22317v1 Announce Type: cross Abstract: Graph-structured data typically exhibits complex topological heterogeneity, making it difficult to model accurately within a single Riemannian manifold. While emerging mixed-curvature methods attempt to capture such diversity, they often rely on implicit, task-driven routing that lacks fundamental geometric grounding. To address this challenge, we propose a Geometric Mixture-of-Experts framework (GeoMoE) that adaptively fuses node representations across diverse Riemannian spaces to better accommodate multi-scale topological structures. At its core, GeoMoE leverages Ollivier-Ricci Curvature (ORC) as an intrinsic geometric prior to orchestrate the collaboration of specialized experts. Specifically, we design a graph-aware gating network that assigns node-specific fusion weights, regularized by a curvature-guided alignment loss to ensure interpretable and geometry-consistent routing. Additionally, we introduce a curvature-aware contrastive objective that promotes geometric discriminability by constructing positive and negative pairs according to curvature consistency. Extensive experiments on six benchmark datasets demonstrate that GeoMoE outperforms state-of-the-art baselines across diverse graph types.

An Accurate and Interpretable Framework for Trustworthy Process Monitoring

βœ‡cs.AI, q-bio.NC updates on arXiv.org
By: Hao Wang Β· Zhiyu Wang Β· Yunlong Niu Β· Zhaoran Liu Β· Haozhe Li Β· Yilin Liao Β· Yuxin Huang Β· Xinggao Liu
25 March 2026 at 12:00
arXiv:2302.10426v3 Announce Type: replace Abstract: Trustworthy process monitoring seeks to build an accurate and interpretable monitoring framework, which is critical for ensuring the safety of energy conversion plant (ECP) that operates under extreme working conditions such as high pressure and temperature. Contemporary self-attentive models, however, fall short in this domain for two main reasons. First, they rely on step-wise correlations that fail to involve physically meaningful semantics in ECP logs, resulting in suboptimal accuracy and interpretability. Second, attention matrices are frequently cluttered with spurious correlations that obscure physically meaningful ones, further impeding effective interpretation. To overcome these issues, we propose AttentionMixer, a framework aimed at improving both accuracy and interpretability of existing methods and establish a trustworthy ECP monitoring framework. Specifically, to tackle the first issue, we employ a spatial adaptive message passing block to capture variate-wise correlations. This block is coupled with a temporal adaptive message passing block through an \textit{mixing} operator, yielding a multi-faceted representation of ECP logs accounting for both step-wise and variate-wise correlations. Concurrently, to tackle the second issue, we employ a sparse message passing regularizer to filter out spurious correlations. We validate the efficacy of AttentionMixer using two real-world datasets from the radiation monitoring network for Chinese nuclear power plants.

NUP85 as a Pan-Cancer Immune Biomarker: Integrated Multi Omics and Functional Analyses Reveal Its Role in Tumor Prognosis

βœ‡(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
By: Weihao Kong Β· Ying Hu Β· Kangjie Zhang Β· Zhipeng Zhu Β· Yajun Zou Β· Long Teng Β· Xingyu Wang Β· Jianlin Zhang
23 March 2026 at 18:00

Immunotargets Ther. 2026 Mar 17;15:541852. doi: 10.2147/ITT.S541852. eCollection 2026.

ABSTRACT

PURPOSE: NUP85 encodes protein components of the Nup107-160 subunit of the nuclear pore complex, belonging to the Nucleoporins (NUPs) family, potentially implicating its role in human cancer. This study aims to elucidate the potential involvement of NUP85 in cancer pathogenesis.

METHODS: Leveraging data from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Clinical Proteomic Tumor Analysis Consortium (CPTAC), Cancer Cell Line Encyclopedia (CCLE), Human Protein Atlas (HPA), Gene Expression Profiling Interactive Analysis (GEPIA), CellMiner, and GeneMANIA databases, we investigated the role of NUP85 across various tumors. Correlations between NUP85 expression and pathological stage, histological grade, survival, immune infiltration, tumor mutational burden (TMB), microsatellite instability (MSI), drug resistance, DNA methylation, copy number variation (CNV), and single-cell expression were analyzed. Gene functional enrichment analysis was conducted to explore NUP85-associated pathways. Molecular biology experiments including Western blotting, flow cytometry, trans-well migration, and invasion assays were performed to validate NUP85's oncogenic role in lung adenocarcinoma (LUAD) and oral squamous cell carcinoma (OSCC) cell lines.

RESULTS: Our findings reveal up-regulated expression of NUP85 in most tumor tissues, with significant correlations observed with pathological stage, survival, immune infiltration, TMB, MSI, drug resistance, DNA methylation, and CNV. Molecular biology experiments confirm NUP85's tumor-promoting role in LUAD and OSCC cell lines. Single-cell sequencing data suggest elevated NUP85 expression primarily in proliferative T cells (Tprolif).

CONCLUSION: NUP85 emerges as a potential tumor marker associated with tumor immunity and poor prognosis. These insights offer avenues for the development of novel therapeutic targets and anti-neoplastic drugs.

PMID:41869435 | PMC:PMC13005628 | DOI:10.2147/ITT.S541852

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