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Not All Tokens Are Created Equal: Query-Efficient Jailbreak Fuzzing for LLMs

arXiv:2603.23269v1 Announce Type: cross Abstract: Large Language Models(LLMs) are widely deployed, yet are vulnerable to jailbreak prompts that elicit policy-violating outputs. Although prior studies have uncovered these risks, they typically treat all tokens as equally important during prompt mutation, overlooking the varying contributions of individual tokens to triggering model refusals. Consequently, these attacks introduce substantial redundant searching under query-constrained scenarios, reducing attack efficiency and hindering comprehensive vulnerability assessment. In this work, we conduct a token-level analysis of refusal behavior and observe that token contributions are highly skewed rather than uniform. Moreover, we find strong cross-model consistency in refusal tendencies, enabling the use of a surrogate model to estimate token-level contributions to the target model's refusals. Motivated by these findings, we propose TriageFuzz, a token-aware jailbreak fuzzing framework that adapts the fuzz testing approach with a series of customized designs. TriageFuzz leverages a surrogate model to estimate the contribution of individual tokens to refusal behaviors, enabling the identification of sensitive regions within the prompt. Furthermore, it incorporates a refusal-guided evolutionary strategy that adaptively weights candidate prompts with a lightweight scorer to steer the evolution toward bypassing safety constraints. Extensive experiments on six open-source LLMs and three commercial APIs demonstrate that TriageFuzz achieves comparable attack success rates (ASR) with significantly reduced query costs. Notably, it attains a 90% ASR with over 70% fewer queries compared to baselines. Even under an extremely restrictive budget of 25 queries, TriageFuzz outperforms existing methods, improving ASR by 20-40%.

Graph Structure Learning with Privacy Guarantees for Open Graph Data

arXiv:2507.19116v3 Announce Type: replace-cross Abstract: Publishing open graph data while preserving individual privacy remains challenging when data publishers and data users are distinct entities. Although differential privacy (DP) provides rigorous guarantees, most existing approaches enforce privacy during model training rather than at the data publishing stage. This limits the applicability to open-data scenarios. We propose a privacy-preserving graph structure learning framework that integrates Gaussian Differential Privacy (GDP) directly into the data release process. Our mechanism injects structured Gaussian noise into raw data prior to publication and provides formal $\mu$-GDP guarantees, leading to tight $(\varepsilon, \delta)$-differential privacy bounds. Despite the distortion introduced by privatization, we prove that the original sparse inverse covariance structure can be recovered through an unbiased penalized likelihood formulation. We further extend the framework to discrete data using discrete Gaussian noise while preserving privacy guarantees. Extensive experiments on synthetic and real-world datasets demonstrate strong privacy-utility trade-offs, maintaining high graph recovery accuracy under rigorous privacy budgets. Our results establish a formal connection between differential privacy theory and privacy-preserving data publishing for graphical models.

Spatial Omics in Gastrointestinal Oncology: Recent Advances, Therapeutic Insights, and Clinical Translation

J Cancer. 2026 Jan 30;17(3):515-523. doi: 10.7150/jca.127381. eCollection 2026.

ABSTRACT

Gastrointestinal (GI) cancers remain a leading cause of cancer-related morbidity and mortality worldwide, largely due to their molecular heterogeneity, complex tumor microenvironment (TME), and variable treatment responses. In recent years, the emergence of spatially resolved omics technologies-encompassing spatial transcriptomics, proteomics, metabolomics, and epigenomics-has revolutionized the ability to interrogate tumor architecture with unprecedented resolution. These methods enable precise mapping of cellular and molecular interactions within intact tissue contexts, thereby uncovering spatially defined niches that influence tumor progression, immune evasion, and therapeutic resistance. In GI malignancies such as colorectal, gastric, and esophageal cancers, spatial omics have provided critical insights into cancer-stromal-immune crosstalk, identified predictive biomarkers for immunotherapy and targeted agents, and guided the development of novel therapeutic strategies. This review synthesizes the latest advances in spatial omics applied to GI oncology over the past five years, with an emphasis on their integration into early diagnosis, treatment stratification, and real-time monitoring of therapeutic efficacy. We also discuss current challenges, including standardization, data integration, and clinical validation, as well as future directions for incorporating spatial profiling into routine oncology practice. By bridging the gap between bench discoveries and bedside applications, spatial omics hold transformative potential for achieving truly personalized treatment in gastrointestinal cancers.

PMID:41869445 | PMC:PMC13003551 | DOI:10.7150/jca.127381

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