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Received — 2 April 2026 ⏭

Nature - Issue - nature.com science feeds
A µ-opioid receptor superagonist analgesic with minimal adverse effects Juan L. Gomez · Emilya N. Ventriglia · Zachary J. Frangos · Agnieszka Sulima · Michael J. Robertson · Michael D. Sacco · Reece C. Budinich · Ilinca M. Giosan · Tongzhen Xie · Oscar Solis · Anna E. Tischer · Jennifer M. Bossert · Kiera E. Caldwell · Hannah Bonbrest · Amelie Essmann · Zelai M. Garçon-Poca · Shinbe Choi · Michael R. Noya · Feonil Limiac · Ali Arce · Grant C. Glatfelter · Margaret Robinson · Li Chen · Angelina A. Mullarkey · Dain R. Brademan · Garrett Enten · William Dunne · César Quiroz · Ingrid Schoenborn · Chae Bin Lee · Rana Rais · Daniel P. Holt · Robert F. Dannals · Lei Shi · Ruth Hüttenhain · Sergi Ferré · Eugene Kiyatkin · Jordi Bonaventura · Yavin Shaham · Venetia Zachariou · Michael H. Baumann · Georgios Skiniotis · Kenner C. Rice · Michael Michaelides
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10299-9N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.
1 April 2026 at 08:00

A µ-opioid receptor superagonist analgesic with minimal adverse effects

Nature - Issue - nature.com science feeds

By: Juan L. Gomez · Emilya N. Ventriglia · Zachary J. Frangos · Agnieszka Sulima · Michael J. Robertson · Michael D. Sacco · Reece C. Budinich · Ilinca M. Giosan · Tongzhen Xie · Oscar Solis · Anna E. Tischer · Jennifer M. Bossert · Kiera E. Caldwell · Hannah Bonbrest · Amelie Essmann · Zelai M. Garçon-Poca · Shinbe Choi · Michael R. Noya · Feonil Limiac · Ali Arce · Grant C. Glatfelter · Margaret Robinson · Li Chen · Angelina A. Mullarkey · Dain R. Brademan · Garrett Enten · William Dunne · César Quiroz · Ingrid Schoenborn · Chae Bin Lee · Rana Rais · Daniel P. Holt · Robert F. Dannals · Lei Shi · Ruth Hüttenhain · Sergi Ferré · Eugene Kiyatkin · Jordi Bonaventura · Yavin Shaham · Venetia Zachariou · Michael H. Baumann · Georgios Skiniotis · Kenner C. Rice · Michael Michaelides

1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10299-9

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.