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Long-Document QA with Chain-of-Structured-Thought and Fine-Tuned SLMs

arXiv:2603.29232v1 Announce Type: cross Abstract: Large language models (LLMs) are widely applied to data analytics over documents, yet direct reasoning over long, noisy documents remains brittle and error-prone. Hence, we study document question answering (QA) that consolidates dispersed evidence into a structured output (e.g., a table, graph, or chunks) to support reliable, verifiable QA. We propose a two-pillar framework, LiteCoST, to achieve both high accuracy and low latency with small language models (SLMs). Pillar 1: Chain-of-Structured-Thought (CoST). We introduce a CoST template, a schema-aware instruction that guides a strong LLM to produce both a step-wise CoST trace and the corresponding structured output. The process induces a minimal structure, normalizes entities/units, aligns records, serializes the output, and verifies/refines it, yielding auditable supervision. Pillar 2: SLM fine-tuning. The compact models are trained on LLM-generated CoST data in two stages: Supervised Fine-Tuning for structural alignment, followed by Group Relative Policy Optimization (GRPO) incorporating triple rewards for answer/format quality and process consistency. By distilling structure-first behavior into SLMs, this approach achieves LLM-comparable quality on multi-domain long-document QA using 3B/7B SLMs, while delivering 2-4x lower latency than GPT-4o and DeepSeek-R1 (671B). The code is available at https://github.com/HKUSTDial/LiteCoST.

Dual-symmetry-guided assembly of complex lattices

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10364-3

A dual-symmetry-guided strategy is used to assemble a broad class of complex Archimedean lattices and two-dimensional quasicrystalline structures, providing a general and experimentally accessible route to complex-symmetry materials.

AI-guided multi-omics analysis identifies NPC1-modulated susceptibility to SARS-CoV-2 infection under PM(2.5) exposure

Nat Commun. 2026 Mar 30. doi: 10.1038/s41467-026-71196-3. Online ahead of print.

ABSTRACT

Exposure to airborne fine particulate matter (PM2.5) has been linked to increased risk of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, yet the underlying mechanisms remain unclear. Here, by leveraging a fine-tuned foundation model of single-cell transcriptomics, we uncover shared transcriptional signatures between PM2.5 exposure and SARS-CoV-2 infection. We further validate this association using population-level epidemiological analyses and perform genome-wide association studies (GWAS) to identify genetic variants that modulate infection risk under PM2.5 exposure. In addition, we identify NPC1 as a key modulator involved in SARS-CoV-2 infection efficiency under virus-laden PM2.5 exposure through integrative functional genomic analyses and in vitro experiments. Our findings suggest that PM2.5 facilitates viral entry through an NPC1-modulated endo-lysosomal pathway, providing a mechanistic explanation for observed pollution-related susceptibility. By integrating artificial intelligence (AI)-guided transcriptomics, epidemiology, GWAS, functional genomics, and in vitro verification, our study elucidates how environmental and genetic factors jointly influence SARS-CoV-2 susceptibility. This work highlights how AI-assisted multi-omics integration systematically decodes the health impacts of environmental exposures from molecular to population levels and informs air quality policy and infectious disease preparedness.

PMID:41912520 | DOI:10.1038/s41467-026-71196-3

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