Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Improving Ensemble Forecasts of Abnormally Deflecting Tropical Cyclones with Fused Atmosphere-Ocean-Terrain Data
arXiv:2603.29200v1 Announce Type: cross Abstract: Deep learning-based tropical cyclone (TC) forecasting methods have demonstrated significant potential and application advantages, as they feature much lower computational cost and faster operation speed than numerical weather prediction models. However, existing deep learning methods still have key limitations: they can only process a single type of sequential trajectory data or homogeneous meteorological variables, and fail to achieve accurate
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cs.AI, q-bio.NC updates on arXiv.org
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Self-Improving Code Generation via Semantic Entropy and Behavioral Consensus
arXiv:2603.29292v1 Announce Type: cross Abstract: Improving the code generation capabilities of large language models (LLMs) typically relies on supervised fine-tuning or preference optimization, both of which require costly external resources such as powerful teacher models or reliable test units. However, in real-world scenarios, it is much harder to obtain reference solutions and test oracles than problem descriptions and test inputs. In this paper, we tackle a challenging yet realistic ques
Self-Improving Code Generation via Semantic Entropy and Behavioral Consensus
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cs.AI, q-bio.NC updates on arXiv.org
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KEditVis: A Visual Analytics System for Knowledge Editing of Large Language Models
arXiv:2603.29689v1 Announce Type: cross Abstract: Large Language Models (LLMs) demonstrate exceptional capabilities in factual question answering, yet they sometimes provide incorrect responses. To address this issue, knowledge editing techniques have emerged as effective methods for correcting factual information in LLMs. However, typical knowledge editing workflows struggle with identifying the optimal set of model layers for editing and rely on summary indicators that provide insufficient gu
KEditVis: A Visual Analytics System for Knowledge Editing of Large Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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LPNSR: Prior-Enhanced Diffusion Image Super-Resolution via LR-Guided Noise Prediction
arXiv:2603.21045v3 Announce Type: replace-cross Abstract: Diffusion-based image super-resolution (SR), which aims to reconstruct high-resolution (HR) images from corresponding low-resolution (LR) observations, faces a fundamental trade-off between inference efficiency and reconstruction quality. The state-of-the-art residual-shifting diffusion framework achieves efficient 4-step inference, yet suffers from severe performance degradation in compact sampling trajectories. This is mainly attribute
LPNSR: Prior-Enhanced Diffusion Image Super-Resolution via LR-Guided Noise Prediction
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Omics in Gastric
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Cellular Senescence in Gastric Cancer: Molecular Mechanisms, Microenvironment Remodeling and Therapeutic Implications
Aging Dis. 2026 Mar 19. doi: 10.14336/AD.2025.1571. Online ahead of print.ABSTRACTGastric cancer (GC) remains a leading cause of cancer-related morbidity and mortality worldwide, with poor prognosis for advanced-stage patients. Therefore, in-depth exploration of the mechanisms underlying GC initiation and progression, as well as the development of novel therapeutic strategies, is of crucial importance. Cellular senescence is a stable cell cycle arrest program that plays a dual role in GC. It exe
Cellular Senescence in Gastric Cancer: Molecular Mechanisms, Microenvironment Remodeling and Therapeutic Implications
Aging Dis. 2026 Mar 19. doi: 10.14336/AD.2025.1571. Online ahead of print.
ABSTRACT
Gastric cancer (GC) remains a leading cause of cancer-related morbidity and mortality worldwide, with poor prognosis for advanced-stage patients. Therefore, in-depth exploration of the mechanisms underlying GC initiation and progression, as well as the development of novel therapeutic strategies, is of crucial importance. Cellular senescence is a stable cell cycle arrest program that plays a dual role in GC. It exerts tumor-suppressive effects via growth arrest but also promotes tumor progression and immune evasion by remodeling the tumor microenvironment (TME) through senescence-associated secretory phenotype (SASP). This review comprehensively elucidates the molecular mechanisms of cellular senescence in GC and the core regulatory networks involving gene regulation, epigenetic modifications, metabolic reprogramming, and cell cycle arrest. Additionally, the review highlights how senescent cells foster an immunosuppressive microenvironment via SASP, forming a self-reinforcing feed-forward loop. Regarding therapeutic strategies, we summarize potential approaches targeting cellular senescence, including senescence induction, senescent cell clearance, SASP modulation, and multi-target synergistic therapy by integrating epigenetic regulation, metabolic intervention, and immune microenvironment modulation. Despite progress, numerous challenges remain. Future studies should leverage multi-omics technologies, novel models' development, and large-scale clinical trials to advance the clinical translation of GC cellular senescence research, providing new insights for improving prognosis.
PMID:41910653 | DOI:10.14336/AD.2025.1571