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Received — 4 April 2026 ⏭

Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice

✇Cell
By: Haijiao Zhao · Meimei Liao · Ran Huo · Ting He · Hongni Tian · Zeqi Li · Chen Chen · Ziqing Yu · Juan Chai · Xiaocui Song · Ruichao Shao · Shuhua Ying · Wen Gao · Ling Liu · Di Sang · Qi Li · Haohong Li · Fengchao Wang · Dapeng Ju · Eric Erquan Zhang
4 March 2026 at 08:00
Enhancing circadian amplitude in mouse hypothalamic paraventricular nucleus neurons by 3′-deoxyadenosine treatment alleviates age-related pathologies and extends lifespan.

Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain

✇Cell
By: Li Zhang · Minhui Yu · Guoqing Chen · Siyuan Ge · Mengdi Wang · Xianying Zhang · Miao Zhao · Huating Gu · Meizhu Huang · Aixue Liu · Gengxin Ran · Zeyuan Liu · Tiepeng Liao · Qi Chen · Chenjian Miao · Yao Lu · Yibing Wang · Fengchao Wang · Zhihui Liu · Hongying Zhu · Qian Wu · Zhuan Zhou · Wei Xiong · Xiaoqun Wang · Peng Cao
4 March 2026 at 08:00
The development of genetically encoded fluorescent reporters, along with their corresponding knock-in mouse lines for labeling α-Syn inclusions, enables diverse applications in studying the propagation and pathological effects of α-Syn inclusions in the live brain.
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