arXiv:2604.01455v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly explored for NP-hard combinatorial optimization problems, but most existing methods emphasize feasible-instance solution generation and do not explicitly address infeasibility detection. We propose an infeasibility-aware framework that combines certifiable dataset construction, supervised fine-tuning, and LLM-assisted downstream search. For the minor-embedding problem, we introduce a new mathematical programming formulation together with provable zero-phase infeasibility screening, which enables scalable construction of training instances labeled either as feasible with structured certificates or as certifiably infeasible. Using training data generated through this exact optimization pipeline, we show that an 8B-parameter LLM can be fine-tuned to jointly perform solution generation and infeasibility detection. We further utilize LLM outputs as warm starts for downstream local search, providing a practical way to accelerate optimization even when the LLM outputs are imperfect. Experiments show that our fine-tuned model improves overall accuracy by up to 30\% over GPT-5.2; meanwhile LLM-guided warm starts provide up to $2\times$ speedup compared with starting from scratch in downstream local search.

arXiv:2604.01647v1 Announce Type: new Abstract: Embedding LLM-driven agents into environmental FAIR data management is compelling - they can externalize operational knowledge and scale curation across heterogeneous data and evolving conventions. However, replacing deterministic components with probabilistic workflows changes the failure mode: LLM pipelines may generate plausible but incorrect outputs that pass superficial checks and propagate into irreversible actions such as DOI minting and public release. We introduce EnviSmart, a production data management system deployed on campus-wide storage infrastructure for environmental research. EnviSmart treats reliability as an architectural property through two mechanisms: a three-track knowledge architecture that externalizes behaviors (governance constraints), domain knowledge (retrievable context), and skills (tool-using procedures) as persistent, interlocking artifacts; and a role-separated multi-agent design where deterministic validators and audited handoffs restore fail-stop semantics at trust boundaries before irreversible steps. We compare two production deployments. The University's GIS Center Ecological Archive (849 curated datasets) serves as a single-agent baseline. SF2Bench, a compound flooding benchmark comprising 2,452 monitoring stations and 8,557 published files spanning 39 years, validates the multi-agent workflow. The multi-agent approach improved both efficiency - completed by a single operator in two days with repeated artifact reuse across deployments - and reliability: audited handoffs detected and blocked a coordinate transformation error affecting all 2,452 stations before publication. A representative incident (ISS-004) demonstrated boundary-based containment with 10-minute detection latency, zero user exposure, and 80-minute resolution. This paper has been accepted at PEARC 2026.

arXiv:2604.01669v1 Announce Type: cross Abstract: Embodied perception systems face severe challenges of dynamic environment distribution drift when they continuously interact in open physical spaces. However, the existing domain incremental awareness methods often rely on the domain id obtained in advance during the testing phase, which limits their practicability in unknown interaction scenarios. At the same time, the model often overfits to the context-specific perceptual noise, which leads to insufficient generalization ability and catastrophic forgetting. To address these limitations, we propose a domain-id and exemplar-free incremental learning framework for embodied multimedia systems, which aims to achieve robust continuous environment adaptation. This method designs a disentangled representation mechanism to remove non-essential environmental style interference, and guide the model to focus on extracting semantic intrinsic features shared across scenes, thereby eliminating perceptual uncertainty and improving generalization. We further use the weight fusion strategy to dynamically integrate the old and new environment knowledge in the parameter space, so as to ensure that the model adapts to the new distribution without storing historical data and maximally retains the discrimination ability of the old environment. Extensive experiments on multiple standard benchmark datasets show that the proposed method significantly reduces catastrophic forgetting in a completely exemplar-free and domain-id free setting, and its accuracy is better than the existing state-of-the-art methods.

arXiv:2604.01681v1 Announce Type: cross Abstract: Large foundation models enable powerful reasoning for autonomous systems, but mapping semantic intent to reliable real-time control remains challenging. Existing approaches either (i) let Large Language Models (LLMs) generate trajectories directly - brittle, hard to verify, and latency-prone - or (ii) adjust Model Predictive Control (MPC) objectives online - mixing slow deliberation with fast control and blurring interfaces. We propose Agentic Fast-Slow Planning, a hierarchical framework that decouples perception, reasoning, planning, and control across natural timescales. The framework contains two bridges. Perception2Decision compresses scenes into ego-centric topologies using an on-vehicle Vision-Language Model (VLM) detector, then maps them to symbolic driving directives in the cloud with an LLM decision maker - reducing bandwidth and delay while preserving interpretability. Decision2Trajectory converts directives into executable paths: Semantic-Guided A* embeds language-derived soft costs into classical search to bias solutions toward feasible trajectories, while an Agentic Refinement Module adapts planner hyperparameters using feedback and memory. Finally, MPC tracks the trajectories in real time, with optional cloud-guided references for difficult cases. Experiments in CARLA show that Agentic Fast-Slow Planning improves robustness under perturbations, reducing lateral deviation by up to 45% and completion time by over 12% compared to pure MPC and an A*-guided MPC baseline. Code is available at https://github.com/cjychenjiayi/icra2026_AFSP.

arXiv:2604.01765v1 Announce Type: cross Abstract: Recently, world-action models (WAM) have emerged to bridge vision-language-action (VLA) models and world models, unifying their reasoning and instruction-following capabilities and spatio-temporal world modeling. However, existing WAM approaches often focus on modeling 2D appearance or latent representations, with limited geometric grounding-an essential element for embodied systems operating in the physical world. We present DriveDreamer-Policy, a unified driving world-action model that integrates depth generation, future video generation, and motion planning within a single modular architecture. The model employs a large language model to process language instructions, multi-view images, and actions, followed by three lightweight generators that produce depth, future video, and actions. By learning a geometry-aware world representation and using it to guide both future prediction and planning within a unified framework, the proposed model produces more coherent imagined futures and more informed driving actions, while maintaining modularity and controllable latency. Experiments on the Navsim v1 and v2 benchmarks demonstrate that DriveDreamer-Policy achieves strong performance on both closed-loop planning and world generation tasks. In particular, our model reaches 89.2 PDMS on Navsim v1 and 88.7 EPDMS on Navsim v2, outperforming existing world-model-based approaches while producing higher-quality future video and depth predictions. Ablation studies further show that explicit depth learning provides complementary benefits to video imagination and improves planning robustness.

arXiv:2604.02289v1 Announce Type: cross Abstract: Recent multimodal large language models have achieved strong performance in unified text and image understanding and generation, yet extending such native capability to 3D remains challenging due to limited data. Compared to abundant 2D imagery, high-quality 3D assets are scarce, making 3D synthesis under-constrained. Existing methods often rely on indirect pipelines that edit in 2D and lift results into 3D via optimization, sacrificing geometric consistency. We present Omni123, a 3D-native foundation model that unifies text-to-2D and text-to-3D generation within a single autoregressive framework. Our key insight is that cross-modal consistency between images and 3D can serve as an implicit structural constraint. By representing text, images, and 3D as discrete tokens in a shared sequence space, the model leverages abundant 2D data as a geometric prior to improve 3D representations. We introduce an interleaved X-to-X training paradigm that coordinates diverse cross-modal tasks over heterogeneous paired datasets without requiring fully aligned text-image-3D triplets. By traversing semantic-visual-geometric cycles (e.g., text to image to 3D to image) within autoregressive sequences, the model jointly enforces semantic alignment, appearance fidelity, and multi-view geometric consistency. Experiments show that Omni123 significantly improves text-guided 3D generation and editing, demonstrating a scalable path toward multimodal 3D world models.

arXiv:2601.04823v5 Announce Type: replace Abstract: Mixture-of-Experts (MoE) has become a prominent paradigm for scaling Large Language Models (LLMs). Parameter-efficient fine-tuning methods, such as LoRA, are widely adopted to adapt pretrained MoE LLMs to downstream tasks. However, existing approaches typically assign identical LoRA ranks to all expert modules, ignoring the heterogeneous specialization of pretrained experts. This uniform allocation leads to a resource mismatch: task-relevant experts are under-provisioned, while less relevant ones receive redundant parameters. To address this, we propose DR-LoRA, a Dynamic Rank LoRA framework for fine-tuning pretrained MoE models. Specifically, DR-LoRA initializes all expert LoRA modules with a small active rank and uses an expert saliency score, which combines routing frequency and gradient-based rank importance, to identify which experts would benefit most from additional capacity. It then periodically expands the active ranks of the task-critical expert LoRA, progressively constructing a heterogeneous rank distribution tailored to the target task. Experiments on three MoE models across six tasks show that DR-LoRA consistently outperforms LoRA and other strong baselines, demonstrating that task-adaptive heterogeneous rank allocation is an effective strategy to improve active capacity utilization in MoE fine-tuning.

arXiv:2601.10779v2 Announce Type: replace-cross Abstract: In multi-source transfer learning, a key challenge lies in how to appropriately differentiate and utilize heterogeneous source tasks. However, existing multi-source methods typically focus on optimizing either the source weights or the amount of transferred samples, largely neglecting their joint consideration. In this work, we propose a theoretical framework, Unified Optimization of Weights and Quantities (UOWQ), that jointly determines the optimal source weights and transfer quantities for each source task. Specifically, the framework formulates multi-source transfer learning as a parameter estimation problem based on an asymptotic analysis of a Kullback--Leibler divergence--based generalization error measure, leading to two main theoretical findings: 1) using all available source samples is always optimal when the weights are properly adjusted; 2) the optimal source weights are characterized by a principled optimization problem whose structure explicitly incorporates the Fisher information, parameter discrepancy, parameter dimensionality, and transfer quantities. Building on the theoretical results, we further propose a practical algorithm for multi-source transfer learning, and extend it to multi-task learning settings where each task simultaneously serves as both a source and a target. Extensive experiments on real-world benchmarks, including DomainNet and Office-Home, demonstrate that UOWQ consistently outperforms strong baselines. The results validate both the theoretical predictions and the practical effectiveness of our framework.

arXiv:2604.00513v2 Announce Type: replace-cross Abstract: With the rapid growth of e-commerce, exploring general representations rather than task-specific ones has attracted increasing attention. Although recent multimodal large language models (MLLMs) have driven significant progress in product understanding, they are typically employed as feature extractors that implicitly encode product information into global embeddings, thereby limiting their ability to capture fine-grained attributes. Therefore, we argue that leveraging the reasoning capabilities of MLLMs to explicitly model fine-grained product attributes holds significant potential. Nevertheless, achieving this goal remains non-trivial due to several key challenges: (i) long-context reasoning tends to dilute the model's attention to salient information in the raw input; (ii) supervised fine-tuning (SFT) primarily encourages rigid imitation, limiting the exploration of effective reasoning strategies; and (iii) fine-grained details are progressively attenuated during forward propagation. To address these issues, we propose MOON3.0, the first reasoning-aware MLLM-based model for product representation learning. Our method (1) employs a multi-head modality fusion module to adaptively integrate raw signals; (2) incorporates a joint contrastive and reinforcement learning framework to autonomously explore more effective reasoning strategies; and (3) introduces a fine-grained residual enhancement module to progressively preserve local details throughout the network. Additionally, we release a large-scale multimodal e-commerce benchmark MBE3.0. Experimentally, our model demonstrates state-of-the-art zero-shot performance across various downstream tasks on both our benchmark and public datasets.

arXiv:2604.00590v2 Announce Type: replace-cross Abstract: In recent years, the scaling laws of recommendation models have attracted increasing attention, which govern the relationship between performance and parameters/FLOPs of recommenders. Currently, there are three mainstream architectures for achieving scaling in recommendation models, namely attention-based, TokenMixer-based, and factorization-machine-based methods, which exhibit fundamental differences in both design philosophy and architectural structure. In this paper, we propose a unified scaling architecture for recommendation systems, namely \textbf{UniMixer}, to improve scaling efficiency and establish a unified theoretical framework that unifies the mainstream scaling blocks. By transforming the rule-based TokenMixer to an equivalent parameterized structure, we construct a generalized parameterized feature mixing module that allows the token mixing patterns to be optimized and learned during model training. Meanwhile, the generalized parameterized token mixing removes the constraint in TokenMixer that requires the number of heads to be equal to the number of tokens. Furthermore, we establish a unified scaling module design framework for recommender systems, which bridges the connections among attention-based, TokenMixer-based, and factorization-machine-based methods. To further boost scaling ROI, a lightweight UniMixing module is designed, \textbf{UniMixing-Lite}, which further compresses the model parameters and computational cost while significantly improve the model performance. The scaling curves are shown in the following figure. Extensive offline and online experiments are conducted to verify the superior scaling abilities of \textbf{UniMixer}.

arXiv:2604.01195v2 Announce Type: replace-cross Abstract: Search agents, which integrate language models (LMs) with web search, are becoming crucial for answering complex user queries. Constructing training datasets for deep research tasks, involving multi-step retrieval and reasoning, remains challenging due to expensive human annotation, or cumbersome prerequisites. In this work, we introduce ORBIT, a training dataset with 20K reasoning-intensive queries with short verifiable answers, generated using a frugal framework without relying on paid API services. The modular framework relies on four stages: seed creation, question-answer pair generation, and two stages of verification: self and external. ORBIT spans 15 domains and each training pair requires 4-5 reasoning steps, with external search verification required from the complete web. We train Qwen3-4B as the base model on ORBIT using GRPO and evaluate it on Wikipedia question answering tasks. Extensive experiment results demonstrate that ORBIT-4B achieves strong performance among sub-4B LLMs as search agents, proving the utility of synthetic datasets. Our framework, code and datasets are open-sourced and available publicly.

npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02544-2

User-preference alignment with uncertainty-aware interactive rectification for liver organ and tumor segmentation and analysis from CT images

(Cell 188, 6283–6300.e1–e10; October 30, 2025)

Li et al. developed a ferritin aggregation cell engager that helps CAR T cells better recognize and attack leukemia cells without re-engineering the CAR itself. This versatile platform overcomes antigen modulation and enables combination with chemotherapy.

A versatile, atom-level generative AI model enables unified pocket-interacting tasks, from docking to de novo design, and demonstrates robust experimental validation for both small-molecule and peptide therapeutics.